Synthetic biology in marine cyanobacteria: Advances and challenges

Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation

Rocap, G., Larimer, F. W., Lamerdin, J. E., Malfatti, S., Chain, P., Ahlgren, N. A., Arellano, A., Coleman, M. L., Hauser, L., Hess, W. R., et al. (2003) · Nature · doi:10.1038/nature01947 · Cited by 1,205 · see citing works

Prochlorococcus: the structure and function of collective diversity

Biller, S. J., Berube, P. M., Lindell, D., & Chisholm, S. W. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3378 · Cited by 602 · see citing works

Mapping Global Flows of Chemicals: From Fossil Fuel Feedstocks to Chemical Products

Levi, P. G., & Cullen, J. M. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b04573 · Cited by 397 · see citing works

Cyanobacterial photosynthesis in the oceans: the origins and significance of divergent light-harvesting strategies

Ting, C. S., Rocap, G., King, J., & Chisholm, S. W. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02319-3 · Cited by 347 · see citing works

Cpf1 Is a Versatile Tool for CRISPR Genome Editing Across Diverse Species of Cyanobacteria

Ungerer, J., & Pakrasi, H. B. (2016) · Scientific Reports · doi:10.1038/srep39681 · Cited by 308 · see citing works

Synthetic biology of cyanobacteria: unique challenges and opportunities

Berla, B. M., Saha, R., Immethun, C. M., Maranas, C. D., Moon, T. S., & Pakrasi, H. B. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00246 · Cited by 305 · see citing works

Engineering Limonene and Bisabolene Production in Wild Type and a Glycogen-Deficient Mutant of Synechococcus sp. PCC 7002

Davies, F. K., Work, V. H., Beliaev, A. S., & Posewitz, M. C. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00021 · Cited by 273 · see citing works

Ploidy in cyanobacteria

Griese, M., Lange, C., & Soppa, J. (2011) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2011.02368.x · Cited by 264 · see citing works

A Review of Microalgae- and Cyanobacteria-Based Biodegradation of Organic Pollutants

Touliabah, H. E.-S., El-Sheekh, M. M., Ismail, M. M., & El-Kassas, H. Y. (2022) · Molecules · doi:10.3390/molecules27031141 · Cited by 251 · see citing works

Multiple Gene Repression in Cyanobacteria Using CRISPRi

Yao, L., Cengic, I., Anfelt, J., & Hudson, E. P. (2016) · ACS Synthetic Biology · doi:10.1021/acssynbio.5b00264 · Cited by 246 · see citing works

Increased Production of Zeaxanthin and Other Pigments by Application of Genetic Engineering Techniques to Synechocystis sp. Strain PCC 6803

Lagarde, D., Beuf, L., & Vermaas, W. F. J. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.1.64-72.2000 · Cited by 236 · see citing works

The Essentials of Marine Biotechnology

Rotter, A., Barbier, M., Bertoni, F., Bones, A. M., Cancela, M. L., Carlsson, J., Carvalho, M. F., Cegłowska, M., Martorell, J. C., Dalay, M. C., et al. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.629629 · Cited by 234 · see citing works

CRISPR-Cas9 for the genome engineering of cyanobacteria and succinate production

Li, H., Shen, C. R., Huang, C.-H., Sung, L., Wu, M., & Hu, Y. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.09.006 · Cited by 232 · see citing works

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

Markley, A. L., Begemann, M. B., Clarke, R., Gordon, G. C., & Pfleger, B. F. (2014) · ACS Synthetic Biology · doi:10.1021/sb500260k · Cited by 212 · see citing works

Newly discovered Synechococcus sp. PCC 11901 is a robust cyanobacterial strain for high biomass production

Włodarczyk, A., Selão, T. T., Norling, B., & Nixon, P. J. (2020) · Communications Biology · doi:10.1038/s42003-020-0910-8 · Cited by 192 · see citing works

CRISPR interference as a titratable, trans-acting regulatory tool for metabolic engineering in the cyanobacterium Synechococcus sp. strain PCC 7002

Gordon, G. C., Korosh, T. C., Cameron, J. C., Markley, A. L., Begemann, M. B., & Pfleger, B. F. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.07.007 · Cited by 189 · see citing works

Broad-host-range vector system for synthetic biology and biotechnology in cyanobacteria

Taton, A., Unglaub, F., Wright, N. E., Zeng, W. Y., Paz-Yepes, J., Brahamsha, B., Palenik, B., Peterson, T. C., Haerizadeh, F., Golden, S. S., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku673 · Cited by 186 · see citing works

Cyanobacterial pigments: Perspectives and biotechnological approaches

Saini, D. K., Pabbi, S., & Shukla, P. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.002 · Cited by 184 · see citing works

Synechococcus sp. Strain PCC 7002 Transcriptome: Acclimation to Temperature, Salinity, Oxidative Stress, and Mixotrophic Growth Conditions

Ludwig, M., & Bryant, D. A. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00354 · Cited by 181 · see citing works

Evaluation of promoters and ribosome binding sites for biotechnological applications in the unicellular cyanobacterium Synechocystis sp. PCC 6803

Englund, E., Liang, F., & Lindberg, P. (2016) · Scientific Reports · doi:10.1038/srep36640 · Cited by 166 · see citing works

Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Khalifa, S. A. M., Shedid, E. S., Saied, E. M., Jassbi, A. R., Jamebozorgi, F. H., Rateb, M. E., Du, M., Abdel‐Daim, M. M., Kai, G., Alhammady, M. A., et al. (2021) · Marine Drugs · doi:10.3390/md19050241 · Cited by 133 · see citing works

Development of spirulina for the manufacture and oral delivery of protein therapeutics

Jester, B. W., Zhao, H., Gewe, M., Adame, T., Perruzza, L., Bolick, D. T., Agosti, J., Khuong, N., Kuestner, R., Gamble, C., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01249-7 · Cited by 130 · see citing works

Outdoor cultivation of a nitrogen-fixing marine cyanobacterium, Anabaena sp. ATCC 33047

Moreno, J. (2003) · Biomolecular Engineering · doi:10.1016/s1389-0344(03)00051-0 · Cited by 121 · see citing works

Systematic evasion of the restriction-modification barrier in bacteria

Johnston, C. D., Cotton, S. L., Rittling, S. R., Starr, J. R., Borisy, G. G., Dewhirst, F. E., & Lemon, K. P. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820256116 · Cited by 111 · see citing works

Genetic tools for advancement of Synechococcus sp. PCC 7002 as a cyanobacterial chassis

Ruffing, A. M., Jensen, T. J., & Strickland, L. M. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0584-6 · Cited by 110 · see citing works

Genetic Instability in Cyanobacteria – An Elephant in the Room?

Jones, P. R. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00012 · Cited by 105 · see citing works

Marine cyanobacteria in tropical regions: diversity and ecology

Hoffman, L. (1999) · European Journal of Phycology · doi:10.1080/09670269910001736432 · Cited by 104 · see citing works

A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing

Tong, Y., Jørgensen, T. S., Whitford, C. M., Weber, T., & Lee, S. Y. (2021) · Nature Communications · doi:10.1038/s41467-021-25541-3 · Cited by 104 · see citing works

Single cell genomes of Prochlorococcus, Synechococcus, and sympatric microbes from diverse marine environments

Berube, P. M., Biller, S. J., Hackl, T., Hogle, S., Satinsky, B. M., Becker, J. W., Braakman, R., Collins, S. B., Kelly, L., Berta-Thompson, J. W., et al. (2018) · Scientific Data · doi:10.1038/sdata.2018.154 · Cited by 103 · see citing works

A Genetic Toolbox for Modulating the Expression of Heterologous Genes in the Cyanobacterium Synechocystis sp. PCC 6803

Wang, B., Eckert, C. A., Maness, P., & Yu, J. (2017) · ACS Synthetic Biology · doi:10.1021/acssynbio.7b00297 · Cited by 99 · see citing works

Exploring native genetic elements as plug-in tools for synthetic biology in the cyanobacterium Synechocystis sp. PCC 6803

Liu, D., & Pakrasi, H. B. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0897-8 · Cited by 98 · see citing works

Metabolic model of Synechococcus sp. PCC 7002: Prediction of flux distribution and network modification for enhanced biofuel production

Hendry, J. I., Prasannan, C. B., Joshi, A. A., Dasgupta, S., & Wangikar, P. P. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.02.128 · Cited by 94 · see citing works

Cyanobacteria and Red Macroalgae as Potential Sources of Antioxidants and UV Radiation-Absorbing Compounds for Cosmeceutical Applications

Vega, J., Bonomi‐Barufi, J., Gómez‐Pinchetti, J. L., & Figueroa, F. L. (2020) · Marine Drugs · doi:10.3390/md18120659 · Cited by 94 · see citing works

Construction of new synthetic biology tools for the control of gene expression in the cyanobacterium Synechococcus sp. strain PCC 7002

Zess, E. K., Begemann, M. B., & Pfleger, B. F. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25713 · Cited by 79 · see citing works

An Organic Acid Based Counter Selection System for Cyanobacteria

Begemann, M. B., Zess, E. K., Walters, E. M., Schmitt, E. F., Markley, A. L., & Pfleger, B. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076594 · Cited by 72 · see citing works

Description of new genera and species of marine cyanobacteria from the Portuguese Atlantic coast

Brito, Â., Ramos, V., Mota, R., et al. (2017) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2017.03.006 · Cited by 72 · see citing works

Comparative Dose–Response Analysis of Inducible Promoters in Cyanobacteria

Behle, A., Saake, P., Germann, A. T., Dienst, D., & Axmann, I. M. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.9b00505 · Cited by 67 · see citing works

Progress and challenges in engineering cyanobacteria as chassis for light‐driven biotechnology

Hitchcock, A., Hunter, C. N., & Canniffe, D. P. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13526 · Cited by 66 · see citing works

CRISPR-based metabolic engineering in non-model microorganisms

Lu, L., Shen, X., Sun, X., Yan, Y., Wang, J., & Yuan, Q. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102698 · Cited by 66 · see citing works

Metabolic engineering of Synechococcus sp. PCC 7002 to produce poly-3-hydroxybutyrate and poly-3-hydroxybutyrate-co-4-hydroxybutyrate

Zhang, S., Liu, Y., & Bryant, D. A. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.10.001 · Cited by 65 · see citing works

Marine Cyanobacteria: A Source of Lead Compounds and their Clinically-Relevant Molecular Targets

Tan, L. T., & Phyo, M. Y. (2020) · Molecules · doi:10.3390/molecules25092197 · Cited by 65 · see citing works

Transfer and replication of RSF1010-derived plasmids in several cyanobacteria of the generaSynechocystis andSynechococcus

Mermet-Bouvier, P., Cassier‐Chauvat, C., Marraccini, P., & Chauvat, F. (1993) · Current Microbiology · doi:10.1007/bf01568955 · Cited by 63 · see citing works

Single-Stage Astaxanthin Production Enhances the Nonmevalonate Pathway and Photosynthetic Central Metabolism in Synechococcus sp. PCC 7002

Hasunuma, T., Takaki, A., Matsuda, M., Kato, Y., Vavricka, C. J., & Kondo, A. (2019) · ACS Synthetic Biology · doi:10.1021/acssynbio.9b00280 · Cited by 63 · see citing works

Emerging Species and Genome Editing Tools: Future Prospects in Cyanobacterial Synthetic Biology

Gale, G. A. R., Schiavon Osorio, A. A., Mills, L. A., Wang, B., Lea-Smith, D. J., & McCormick, A. J. (2019) · Microorganisms · doi:10.3390/microorganisms7100409 · Cited by 61 · see citing works

Marine cyanobacterium Spirulina maxima as an alternate to the animal cell culture medium supplement

Jeong, Y., Choi, W.-Y., Park, A., Lee, Y.-J., Lee, Y., Park, G.-H., Lee, S., Lee, W.-K., Ryu, Y.-K., & Kang, D.-H. (2021) · Scientific Reports · doi:10.1038/s41598-021-84558-2 · Cited by 61 · see citing works

A novel counter‐selection method for markerless genetic modification in Synechocystis sp. PCC 6803

Cheah, Y. E., Albers, S. C., & Peebles, C. A. M. (2012) · Biotechnology Progress · doi:10.1002/btpr.1661 · Cited by 59 · see citing works

Current Status and Future Strategies to Increase Secondary Metabolite Production from Cyanobacteria

Jeong, Y., Cho, S.-H., Lee, H., Choi, H., Kim, D., Lee, C., Cho, S., & Cho, B. (2020) · Microorganisms · doi:10.3390/microorganisms8121849 · Cited by 58 · see citing works

Engineering photosynthetic production of L-lysine

Korosh, T. C., Markley, A. L., Clark, R. L., McGinley, L. L., McMahon, K. D., & Pfleger, B. F. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.10.010 · Cited by 56 · see citing works

Systematic Approaches to Efficiently Produce 2,3-Butanediol in a Marine Cyanobacterium

Nozzi, N. E., Case, A. E., Carroll, A. L., & Atsumi, S. (2017) · ACS Synthetic Biology · doi:10.1021/acssynbio.7b00157 · Cited by 50 · see citing works

A Systematic Literature Review for Evidence of Aphanizomenon flos-aquae Toxigenicity in Recreational Waters and Toxicity of Dietary Supplements: 2000–2017

Lyon-Colbert, A., Su, S., & Cude, C. G. (2018) · Toxins · doi:10.3390/toxins10070254 · Cited by 48 · see citing works

Construction of a Shuttle Vector Using an Endogenous Plasmid From the Cyanobacterium Synechocystis sp. PCC6803

Jin, H., Wang, Y., Idoine, A., & Bhaya, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01662 · Cited by 46 · see citing works

Recovery of Chlorophyll a Derivative from Spirulina maxima: Its Purification and Photosensitizing Potential

Martins, M., Albuquerque, C. M., Pereira, C., Coutinho, J. A. P., Neves, M. G. P. M. S., Pinto, D. C. G. A., Faustino, M. A. F., & Ventura, S. P. M. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c07880 · Cited by 40 · see citing works

Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host

Taton, A., Ecker, A. K., Diaz, B., Moss, N. A., Anderson, B., Reher, R., Leão, T., Simkovsky, R., Dorrestein, P. C., Gerwick, L. G., et al. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00431 · Cited by 39 · see citing works

Engineering Photosynthetic Bioprocesses for Sustainable Chemical Production: A Review

Stephens, S. M., Mahadevan, R., & Allen, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.610723 · Cited by 39 · see citing works

A Library of Tunable, Portable, and Inducer-Free Promoters Derived from Cyanobacteria

Sengupta, A., Madhu, S., & Wangikar, P. P. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00152 · Cited by 34 · see citing works

Streamlining recombination-mediated genetic engineering by validating three neutral integration sites in Synechococcus sp. PCC 7002

Vogel, A. I. M., Lale, R. R., & Hohmann‐Marriott, M. F. (2017) · Journal of Biological Engineering · doi:10.1186/s13036-017-0061-8 · Cited by 33 · see citing works

Comparison of alternative integration sites in the chromosome and the native plasmids of the cyanobacterium Synechocystis sp. PCC 6803 in respect to expression efficiency and copy number

Nagy, C., Thiel, K., Mulaku, E., Mustila, H., Tamagnini, P., Aro, E.-M., Pacheco, C. C., & Kallio, P. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01622-2 · Cited by 33 · see citing works

Environmental drivers of bloom-forming cyanobacteria in the Baltic Sea: Effects of salinity, temperature, and irradiance

Śliwińska‐Wilczewska, S., Cieszyńska, A., Konik, M., Maculewicz, J., & Latała, A. (2019) · Estuarine Coastal and Shelf Science · doi:10.1016/j.ecss.2019.01.016 · Cited by 31 · see citing works

Lauric Acid Production in a Glycogen-Less Strain of Synechococcus sp. PCC 7002

Work, V. H., Melnicki, M. R., Hill, E. A., Davies, F. K., Kucek, L. A., Beliaev, A. S., & Posewitz, M. C. (2015) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00048 · Cited by 29 · see citing works

The Pharmacological Potential of Cyanobacteria

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The Development and Characterization of an Exogenous Green-Light-Regulated Gene Expression System in Marine Cyanobacteria

Badary, A., Abe, K., Ferri, S. R., Kojima, K., & Sode, K. (2015) · Marine Biotechnology · doi:10.1007/s10126-015-9616-1 · Cited by 27 · see citing works

Toward a genetic system in the marine cyanobacterium Prochlorococcus

Laurenceau, R., Bliem, C., Osburne, M. S., Becker, J. W., Biller, S. J., Cubillos-Ruiz, A., & Chisholm, S. W. (2020) · Access Microbiology · doi:10.1099/acmi.0.000107 · Cited by 26 · see citing works

Variation of Spirulina maxima biomass production in different depths of urea-used culture medium

Affan, M.-A., Lee, D.-W., Al-Harbi, S. M., Kim, H., Abdulwassi, N. I., Heo, S., Oh, C., Park, H., Woo, C., Lee, H.-Y., et al. (2015) · Brazilian Journal of Microbiology · doi:10.1590/s1517-838246420140188 · Cited by 25 · see citing works

Glycogen Production in Marine Cyanobacterial Strain Synechococcus sp. NKBG 15041c

Badary, A., Takamatsu, S., Nakajima, M., Ferri, S. R., Lindblad, P. C., & Sode, K. (2018) · Marine Biotechnology · doi:10.1007/s10126-017-9792-2 · Cited by 24 · see citing works

The “Dark Side” of Picocyanobacteria: Life as We Do Not Know It (Yet)

Callieri, C., Cabello‐Yeves, P. J., & Bertoni, F. (2022) · Microorganisms · doi:10.3390/microorganisms10030546 · Cited by 24 · see citing works

Production of ω3 fatty acids in marine cyanobacterium Synechococcus sp. strain NKBG 15041c via genetic engineering

Yoshino, T., Kakunaka, N., Yue, L., Ito, Y., Maeda, Y., Nomaguchi, T., Matsunaga, T., & Tanaka, T. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8407-1 · Cited by 19 · see citing works

Mechanistic insights into the versatile class II CRISPR toolbox

Zhang, F., & Huang, Z. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.11.007 · Cited by 19 · see citing works

Comparative Genomics and Physiological Investigation of a New Arthrospira/Limnospira Strain O9.13F Isolated from an Alkaline, Winter Freezing, Siberian Lake

Misztak, A. E., Waleron, M., Furmaniak, M., Waleron, M. M., Bazhenova, O., Daroch, M., & Waleron, K. F. (2021) · Cells · doi:10.3390/cells10123411 · Cited by 19 · see citing works

Zn 2+ -Inducible Expression Platform for Synechococcus sp. Strain PCC 7002 Based on the smtA Promoter/Operator and smtB Repressor

Pérez, A. A., Gajewski, J. P., Ferlez, B. H., Ludwig, M., Baker, C. S., Golbeck, J. H., & Bryant, D. A. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02491-16 · Cited by 18 · see citing works

Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation

Coe, A., Biller, S. J., Thomas, E., Boulias, K., Bliem, C., Arellano, A. A., Dooley, K. D., Rasmussen, A., LeGault, K. N., O’Keefe, T. J., et al. (2021) · Limnology and Oceanography · doi:10.1002/lno.11880 · Cited by 18 · see citing works

Exploiting Polyploidy for Markerless and Plasmid-Free Genome Engineering in Cyanobacteria

Jones, C. M., Parrish, S., & Nielsen, D. R. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00269 · Cited by 18 · see citing works

Photosynthetic Conversion of CO2 Into Pinene Using Engineered Synechococcus sp. PCC 7002

Yang, R., Zhu, L., Li, T., Zhu, L., Ye, Z., & Zhang, D. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.779437 · Cited by 16 · see citing works

CRISPRi as a Tool to Repress Multiple Copies of Extracellular Polymeric Substances (EPS)-Related Genes in the Cyanobacterium Synechocystis sp. PCC 6803

Santos, M., Pacheco, C. C., Yao, L., Hudson, E. P., & Tamagnini, P. (2021) · Life · doi:10.3390/life11111198 · Cited by 15 · see citing works

Molecular Characterization of Twenty-Five Marine Cyanobacteria Isolated from Coastal Regions of Ireland

Shiels, K., Browne, N., Donovan, F., et al. (2019) · Biology · doi:10.3390/biology8030059 · Cited by 14 · see citing works

Synthetic counter-selection markers and their application in genetic modification of Synechococcus elongatus UTEX2973

Chen, L., Liu, H., Wang, L., Tan, X., & Yang, S. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11391-y · Cited by 14 · see citing works

Phylogenetic relatedness among Spirulina and related cyanobacterial genera

Singh, N., & Dhar, D. W. (2010) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-010-0537-x · Cited by 13 · see citing works

Improved genetic transformation of Synechococcus elongatus PCC 7942 using linear DNA fragments in association with a DNase inhibitor

Almeida, D. V., Martens, S. B. B., Lanes, C. F. C., & Marins, L. F. (2017) · Biotechnology Research and Innovation · doi:10.1016/j.biori.2017.09.001 · Cited by 12 · see citing works

A Genome-Scale Metabolic Model of Anabaena 33047 to Guide Genetic Modifications to Overproduce Nylon Monomers

Hendry, J. I., Dinh, H. V., Sarkar, D., Wang, L., Bandyopadhyay, A., Pakrasi, H. B., & Maranas, C. D. (2021) · Metabolites · doi:10.3390/metabo11030168 · Cited by 11 · see citing works

Antenna Modification Leads to Enhanced Nitrogenase Activity in a High Light-Tolerant Cyanobacterium

Bandyopadhyay, A., Ye, Z., Benedikty, Z., Trtílek, M., & Pakrasi, H. B. (2021) · mBio · doi:10.1128/mbio.03408-21 · Cited by 9 · see citing works

Optimization of a T7-RNA polymerase system in Synechococcus sp. PCC 7002 mirrors the protein overproduction phenotype from E. coli BL21(DE3)

Jones, C. M., Korosh, T. C., Nielsen, D. R., & Pfleger, B. F. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-11085-x · Cited by 8 · see citing works

Comparative Proteomic Profiling of Marine and Freshwater Synechocystis Strains Using Liquid Chromatography-Tandem Mass Spectrometry

Kwon, D.-M., Park, J., Duong, V., Hong, S.-J., Cho, B., Lee, C., Choi, H., Kim, D., & Lee, H. (2020) · Journal of Marine Science and Engineering · doi:10.3390/jmse8100790 · Cited by 7 · see citing works

Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics

Jester, B. W., Zhao, H., Gewe, M. M., Adame, T., Perruzza, L., Bolick, D. T., Agosti, J. M., Khuong, N., Kuestner, R. E., Gamble, C., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01323-0 · Cited by 4 · see citing works

Current Metabolic Engineering Strategies for Photosynthetic Bioproduction in Cyanobacteria

Satta, A., Esquirol, L., & Ebert, B. E. (2023) · Microorganisms · doi:10.3390/microorganisms11020455 · Cited by 51 · see citing works

Application of Cyanobacteria as Chassis Cells in Synthetic Biology

Liu, X., Tang, K., & Hu, J. (2024) · Microorganisms · doi:10.3390/microorganisms12071375 · Cited by 20 · see citing works

Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products

Chen, M., Dhakal, D., Eckhardt, C. W., Luesch, H., & Ding, Y. (2025) · Natural Product Reports · doi:10.1039/d5np00009b · Cited by 21 · see citing works

dCas12a-mediated CRISPR interference for multiplex gene repression in cyanobacteria for enhanced isobutanol and 3-methyl-1-butanol production

Xie, H., Bourgade, B., Stensjö, K., & Lindblad, P. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02727-8 · Cited by 11 · see citing works

Advances and Future Perspectives of <i>Synechocystis</i> sp. as a Microbial Cell Factory for Biomanufacturing

He, H., Gao, K., Mao, B., Shi, G., Li, Y., & Deng, X. (2025) · Biotechnology Journal · doi:10.1002/biot.70162 · Cited by 4 · see citing works

Repurposing endogenous Type I-D CRISPR-Cas system for genome editing in Synechococcus sp. PCC7002

Yang, S., Zhang, Y., Li, C., & Tan, X. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127884 · Cited by 3 · see citing works

Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression

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Microfluidic device to suppress the division of large numbers of cyanobacteria

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