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Therapeutic effects of curcumin on constipation-predominant irritable bowel syndrome is associated with modulating gut microbiota and neurotransmitters

Tu, Xiaoting, Ren, Hongyan, Bu, Shurui·2023·Frontiers in Microbiology
DOI 10.3389/fmicb.2023.1274559
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Abstract

Introduction: Constipation-predominant irritable bowel syndrome (IBS-C) is a functional bowel disease that affects 10–20% of the population worldwide. Curcumin (CUR) is widely used in traditional Chinese medicine to treat IBS, but its mechanism of action needs further investigation. Methods: In this study, we used mosapride (MOS) as a positive control to evaluate the changes in gut microbiota in IBS-C rat models after treatment with CUR or MOS by analyzing 16S rDNA variation. In addition, we used enzyme immunoassay kits and immunohistochemical analysis to investigate whether CUR or MOS influenced serotonin (5-HT), substance P (SP), and vasoactive intestinal peptide (VIP) levels in the serum and colon of IBS-C rats. Results: The study showed that rats supplemented with CUR showed significantly increased fecal weight, fecal water content, small intestine transit rate and significantly decreased serum levels of 5-HT, VIP and SP compared to the IBS group (p < 0.05). In addition, treatment with CUR changed the relative abundance of Blautia, Sutterella, Acetanaerobacterium and Ruminococcus 2 in the gut microbiota. Discussion: This study showed that the efficacy of CUR on IBS-C was possibly by modulating the microbiota and lowering the serum levels of HT, SP, and VIP.

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Metadata

Authors
Tu, X., Ren, H., & Bu, S.
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2023-12-14
Volume
14
ISSN
1664-302X
DOI
10.3389/fmicb.2023.1274559
Cited by
12
References
8
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Therapeutic effects of curcumin on constipation-predominant irritable bowel syndrome is associated with modulating gut microbiota and neurotransmitters. https://app.cochat.ai/papers/10.3389/fmicb.2023.1274559
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Tu, X., Ren, H., & Bu, S. (2023). Therapeutic effects of curcumin on constipation-predominant irritable bowel syndrome is associated with modulating gut microbiota and neurotransmitters. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2023.1274559

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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