Altered Intestinal Microbiota with Increased Abundance of Prevotella Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome
Open accessAbstract
Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and evaluated by 16S ribosomal RNA gene sequence and quantitative real-time PCR. A mouse model of postinfectious IBS (PI-IBS) was established to determine whether the altered gut microbiota was associated with increased visceral hypersensitivity. The results indicated that there were significant differences in the bacterial community profiles between IBS-D patients and healthy controls. Prevotella was more abundant in fecal samples from IBS-D patients compared with healthy controls ( p < 0.05 ). Meanwhile, there were significant reductions in the quantity of Bacteroides , Bifidobacteria , and Lactobacillus in IBS-D patients compared with healthy controls ( p < 0.05 ). Animal models similarly showed an increased abundance of Prevotella in fecal samples compared with control mice ( p < 0.05 ). Finally, after the PI-IBS mice were cohoused with control mice, both the relative abundance of Prevotella and visceral hypersensitivity of PI-IBS mice were decreased. In conclusion, the altered intestinal microbiota is associated with increased visceral hypersensitivity and enterotype enriched with Prevotella may be positively associated with high risk of IBS-D.
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Prevotella species associated with detrimental impacts on intestinal barrier integrity are enriched in IBS patients and in models of intestinal inflammation and may promote inflammatory arthritis.
“Prevotella species associated with detrimental impacts on intestinal barrier integrity are enriched in IBS patients and in models of intestinal inflammation [52, 113] and may promote inflammatory arthritis [3, 104, 126].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [113]
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“However, Su et al. (2018) and Barandouzi et al. (2021) found increased abundance of this genus in IBS individuals [63–65].”
BackgroundCommunication between the gut microbiota and peripheral nervous system in health and chronic disease
Cook, T. M., & Mansuy‐Aubert, V. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2068365 · Cited by 47 · see citing works
“conflicting findings on whether or not Prevotella are expanded in IBS patients.(15,16) Reduced bacterial diversity, richness, and stability are often reported in obesity and IBS,(10,17) but overall, identifying reliable microbial disease signatures has been a major challenge.”
BackgroundIdentification of bacterial lipopeptides as key players in IBS
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“Moreover, synbiotic consumption significantly increased Faecalibaculum rodentium, a lactic acid-producing bacteria [59] that may have anti-obesity potential and may reduce intestinal inflammation [60], while also increasing the abundance of Lachnospiraceae UCG 006, a species that has previously been shown to be reduce…”
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The neuromicrobiology of Parkinson’s disease: A unifying theory
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“However, the abundance of this taxon has been associated with gut inflammation (Iljazovic et al., 2020; Su et al., 2018).”
BackgroundWang, B., Zhu, S., Liu, Z., Wei, H., Zhang, L., He, M., Pei, F., Zhang, J., Sun, Q., & Duan, L. (2020) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2020.06.013 · Cited by 33 · see citing works
“Prevotella enrichment has been reported as a risk factor in IBS-D patients [35].”
BackgroundWu, K., Sun, W., Li, N., Chen, Y., Wei, Y., & Chen, D. (2019) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2019.1694067 · Cited by 33 · see citing works
“Su [33] discovered that enterotype enriched with Prevotella may increase risk of IBS-D.”
BackgroundEvaluation of hypoglycemic effect, safety and immunomodulation of Prevotella copri in mice
Verbrugghe, P., Brynjólfsson, J., Jing, X., Björck, I., Hållenius, F. F., & Nilsson, A. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-96161-6 · Cited by 31 · see citing works
Fluoride-Induced Alteration in the Diversity and Composition of Bacterial Microbiota in Mice Colon
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“found that Prevotella was rich in bowel patterns, which may show a positive correlation with a risk of diarrhea-type irritable bowel syndrome [34].”
Zhang, H., Zhang, Y., Zhang, Y., Jiang, Z., Cui, Y., & Wang, Q. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.118 · Cited by 25 · see citing works
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Phylogenetic analysis of Prevotella copri from fecal and mucosal microbiota of IBS and IBD patients
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Clinical Management of the Microbiome in Irritable Bowel Syndrome
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“It has been reported that alterations in intestinal permeability in IBS-D are associated with decreased expression of tight-junction proteins such as zonula occludens-1 (ZO-1) and occludin; reduced occludin expression was correlated with duration of IBS symptoms and abdominal pain severity scores (52).”
BackgroundInfluentialBiomarkers in Irritable Bowel Syndrome: Biological Rationale and Diagnostic Value
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“in IBS- D patients, while Bacteroides was more frequent in healthy subjects (Su et al., 2018).”
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“In mouse models, Prevotella enrichment was positively correlated with high risk of irritable bowel syndrome (IBD) and associated with higher susceptibility to chemically-induced colitis (52) by reducing interleukin (IL)-18 (53).”
BackgroundHartikainen, A. K., Jalanka, J., Lahtinen, P., Ponsero, A. J., Mertsalmi, T. H., Finnegan, L., Crispie, F., Cotter, P. D., Arkkila, P. E. T., & Satokari, R. M. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00549-x · Cited by 21 · see citing works
“While this bacterium has been connected to high fi ber diet 35 , there are also reports suggesting that increase of Prevotella in the gut microbiota is associated to IBS-D and rheumatoid arthritis 36 – 38 .”
BackgroundA multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits
Sarnoff, R. P., Bhatt, R. R., Osadchiy, V., Dong, T. S., Labus, J. S., Kilpatrick, L. A., Chen, Z., Subramanyam, V., Zhang, Y., Ellingson, B. M., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109381 · Cited by 21 · see citing works
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“Studies have found that Prevotella were related to pro-inflammatory responses exacerbating colitis in DSS-induced animal models by impairing the repair mechanisms of the mucosa [25,26].”
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“Studies have shown that significant differences between patients with IBS and healthy ones in gut microbiota dysbiosis and diversity, which are associated with the exacerbate of IBS [116, 117].”
Isomaltooligosaccharides Sustain the Growth of Prevotella Both In Vitro and in Animal Models
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“found that patients with diarrhea-predominant irritable bowel syndrome (IBS-D) mainly hosted P-enterotype microbiota (26).”
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“Futhermore, Ruminococcaceae and Lachnospiraceae are found to decrease significantly in IBS mice [53,54].”
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The Gastrointestinal Microbiota of the Common Marmoset (Callithrix jacchus)
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Modulation of gut microbiota in rats fed whole egg diets by processing duck egg to preserved egg
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“Certain Prevotella strains have been reported to serve as clinically pivotal pathobionts that participate in human diseases by promoting chronic inflammation, such as in intestinal disorders with HIV infection (38), irritable bowel syndrome (39), rheumatic arthritis (40) and periodontitis (41).”
BackgroundThe relationship between gut microbiota and proteolytic activity in irritable bowel syndrome
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“Recent research reported that Oscillospira is often associated with leanness (45), while Prevotella was negatively associated with the severity of diarrhea-predominant irritable bowel syndrome (46, 47).”
BackgroundTikunov, A. Y., Shvalov, A. N., Morozov, V. V., Babkin, I. V., Seledtsova, G. V., Voloshina, I. O., Ivanova, I. P., Bardasheva, A. V., Morozova, V. V., Vlassov, V. V., et al. (2022) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj21.100 · Cited by 13 · see citing works
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“Animal experiments also confirmed that Prevotella abundance was closely related to visceral hypersensitivity in IBS-D mice [57].”
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HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells
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“HPS-1 patients in this study also had no CD symptoms at their young ages, but the fecal microbiota dominant phenotype Prevotellaceae including Prevotella predisposes a higher risk of diarrhea-predominant irritable bowel syndrome (26).”
BackgroundResultSingh, A., Banerjee, T., Shukla, S. K., Upadhyay, S., & Verma, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-39382-1 · Cited by 12 · see citing works
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“The cause of IBD is multifactorial and has a complex pathogenesis which is still not completely resolved, including host and environmental factors that contribute to the disease and its severity [4].”
BackgroundInfluentialWang, Y., Qiao, M., Yao, X., Feng, Z., Hu, R., Chen, J., Liu, L., Liu, J., Sun, Y., & Guo, Y. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14677 · Cited by 10 · see citing works
Rodríguez‐Sojo, M. J., García-García, J., Ruiz‐Malagón, A. J., Diez‐Echave, P., Hidalgo‐Garcia, L., Molina‐Tijeras, J. A., González-Lozano, E., López-Escánez, L., Rodríguez‐Cabezas, M. E., Rodríguez, M. J., et al. (2022) · Nutrients · doi:10.3390/nu15010024 · Cited by 10 · see citing works
“At a genus level, the results revealed that the abundance of some bacteria, such as Prevotellaceae_UCG_001, Prevotella_g and Collinsella, was enhanced in the IBS control group when compared to Non-IBS rats (Figure 10d), in agreement with the results previously reported in experimental IBS [72,73].”
ResultDaniel, A. G. S., Pereira, C., Dorella, F. A., Pereira, F. L., Laub, R. P., Andrade, M. R., Barrera-Zarate, J. A., Gabardo, M. D. P., Otoni, L. V. A., de Macêdo, N. R., et al. (2023) · Animals · doi:10.3390/ani13162611 · Cited by 10 · see citing works
“Recently, it has been associated with irritable bowel syndrome in humans and mice [70].”
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“In this context, a negative correlation between an increase of Prevotella and the risk of IBS diarrheal phenotype was previously reported 64 .”
BackgroundMas‐Orea, X., Rey, L., Battut, L., Bories, C., Petitfils, C., Abot, A., Ghéziel, N., Wemelle, E., Blanpied, C., Motta, J., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05542-2 · Cited by 9 · see citing works
“These two latter bacterial species have been reported differentially abundant in IBS patients and healthy controls 37,38 .”
Gage, M., Vinithakumari, A. A., Mooyottu, S., & Thippeswamy, T. (2022) · Frontiers in Microbiomes · doi:10.3389/frmbi.2022.1006078 · Cited by 8 · see citing works
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Metabolic biomarkers in irritable bowel syndrome diagnosis
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“The GI symptoms of diarrhea, abdominal pain and bloating in patients with SIBO are similar to those with IBS-D (Ghoshal and Srivastava, 2014; Su et al., 2018).”
Wang, T., Li, L., Li, S., Zhao, H., Qu, J., Xia, Y., & Li, Y. (2021) · PeerJ · doi:10.7717/peerj.11585 · Cited by 9 · see citing works
Heterochronic Fecal Microbiota Transfer Reverses Hallmarks of the Aging Murine Gut, Eye and BrainPreprint
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“Research has shown that alterations in the abundance of Alistipes are associated with conditions like IBD and irritable bowel syndrome (IBS) [37 – 40].”
Characteristics of gut microbiota in male periadolescent rats with irritable bowel syndrome
Lin, W., Wu, D., Zeng, Y., Liu, Y., Yu, D., Wei, J., Cai, Y., Lin, Y., Wu, B., & Huang, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18995 · Cited by 6 · see citing works
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“27,28 In the fermented rice drink group, Blautia significantly increased by 1.5 times after consumption of the drink compared to baseline, while there was no difference in the nonfermented rice drink group.”
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Self-citationCommon Marmoset Gut Microbiome Profiles in Health and Intestinal DiseasePreprint
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Gut Microbiota Composition Correlates with Disease Severity in Myelodysplastic Syndrome
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“Several studies have reported differences in Prevotella abundance between individuals with IBS and healthy controls (HCs), with most indicating lower levels in IBS [23, 24]; however, a study conducted in China reported increased Prevotella in IBS [25].”
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“On the other hand, an increased abundance of Prevotella may be positively associated with a higher risk of IBS-D because changes in the gut microbiota are associated with increased visceral hyper-sensitivity [46].”
Correlation analysis of breast fibroadenoma and the intestinal flora based on 16S rRNA sequencing*
Wang, B., Liu, X., Bian, Y., Sun, G., Wang, H., Zhang, J., Zhang, Z., & Zou, X. (2021) · Oncology and Translational Medicine · doi:10.1007/s10330-021-0509-9 · Cited by 2 · see citing works
- Authors
- Su, T., Liu, R., Lee, A., Long, Y., Du, L., Lai, S., Chen, X., Wang, L., Si, J., Owyang, C., & Chen, S.
- Affiliations
- Sir Run Run Shaw Hospital (CN)
- Michigan Medicine (US)
- Corresponding author
- Chen, Shujie
- ORCID
- Venue
- Gastroenterology Research and Practice
- Publisher
- Wiley
- Published
- 2018-06-05
- Volume
- 2018
- Pages
- 1-9
- ISSN
- 1687-6121 (ISSN-L)
- 1687-630X
- PMC
- PMC6008816
- OpenAlex
- W2806720943
- Cited by
- 117
- References
- 43
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 20 · 2021: 25 · 2020: 17 · 2019: 13 · 2018: 2
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gastroenterology Research and Practice (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Zhejiang Province (LY18H160011, 2015ZDA015, 2017ZB064, 2016YFC0107003)
- Science Foundation of Zhejiang Traditional Medicine Bureau (LY18H160011, 2015ZDA015, 2017ZB064, 2016YFC0107003)
- National Key Research and Development Program of China (LY18H160011, 2015ZDA015, 2017ZB064, 2016YFC0107003)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- diarrhea-predominant irritable bowel syndrome, gut microbiota, Prevotella, visceral hypersensitivity, Bacteroides, Bifidobacterium, Lactobacillus, enterotypes, microbial community composition, mouse model
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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