Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients
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Purpose Late-life depression even in subsyndromal stages is strongly associated with Alzheimer's disease (AD). Furthermore, brain amyloidosis is an early biomarker in subjects who subsequently suffer from AD and can be sensitively detected by amyloid PET. Therefore, we aimed to compare amyloid load and glucose metabolism in subsyndromally depressed subjects with mild cognitive impairment (MCI).Methods [(18)F]AV45 PET, [(18)F]FDG PET and MRI were performed in 371 MCI subjects from the Alzheimer's Disease Neuroimaging Initiative Subjects were judged β-amyloid-positive (Aβ+; 206 patients) or β-amyloid-negative (Aβ-; 165 patients) according to [(18)F]AV45 PET. Depressive symptoms were assessed by the Neuropsychiatric Inventory Questionnaire depression item 4. Subjects with depressive symptoms (65 Aβ+, 41 Aβ-) were compared with their nondepressed counterparts. Conversion rates to AD were analysed (mean follow-up time 21.5 ± 9.1 months) with regard to coexisting depressive symptoms and brain amyloid load.Results Aβ+ depressed subjects showed large clusters with a higher amyloid load in the frontotemporal and insular cortices (p < 0.001) with coincident hypermetabolism (p < 0.001) in the frontal cortices than nondepressed subjects. Faster progression to AD was observed in subjects with depressive symptoms (p < 0.005) and in Aβ+ subjects (p < 0.001). Coincident depressive symptoms additionally shortened the conversion time in all Aβ+ subjects (p < 0.005) and to a greater extent in those with a high amyloid load (p < 0.001).Conclusion Our results clearly indicate that Aβ+ MCI subjects with depressive symptoms have an elevated amyloid load together with relative hypermetabolism of connected brain areas compared with cognitively matched nondepressed individuals. MCI subjects with high amyloid load and coexistent depressive symptoms are at high risk of faster conversion to AD.
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The presence of depressive symptoms is associated with faster progression from mild cognitive impairment to Alzheimer's disease.
“For example, the presence of depressive symptoms is associated with faster progression from mild cognitive impairment to Alzheimer's disease104.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [104]
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- Authors
- Initiative, F. T. A. D. N., Brendel, M., Pogarell, O., Xiong, G., Delker, A., Bartenstein, P., & Rominger, A.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Munich Cluster for Systems Neurology (DE)
- Corresponding author
- Rominger, Axel
- Venue
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2015-01-29
- Volume
- 42
- Issue
- 5
- Pages
- 716-724
- ISSN
- 1619-7070 (ISSN-L)
- 1619-7089
- PMC
- PMC5849231
- OpenAlex
- W2041468825
- Cited by
- 94
- References
- 46
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 2
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health (5u01ag024904-10)
- National Institute on Aging (U01-AG-024904, U19AG024904)
- National Institute of Biomedical Imaging and Bioengineering
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- depressive symptoms, mild cognitive impairment, Alzheimer's disease, amyloid-beta, amyloid PET, FDG-PET, glucose metabolism, cognitive decline, conversion to Alzheimer's disease, insula, geriatric depression
- MeSH terms
- Aged, Aged, 80 and over, Depression, Female, Humans, Male, Case-Control Studies, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Plaque, Amyloid, Cognitive Dysfunction
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