Nonpharmacological interventions to improve depression, anxiety, and quality of life (QoL) in people with Dementia: an overview of systematic reviews
Open accessAbstract
This overview aimed to systematically synthesize evidence from existing systematic reviews to signpost practitioners to the current evidence base on nonpharmacological interventions to improve depression, anxiety, and quality of life (QoL) in people with dementia and to discuss priorities for future research. The databases MEDLINE, PsycINFO, Scopus, and Cochrane Central Register of Controlled Trials were searched in August 2017 with an updated search in January 2019. Fourteen systematic reviews of randomized controlled trials of nonpharmacological interventions were identified. Dementia stage was rated moderate or severe in the majority of the reviews and type of dementia varied. Interventions reported to be effective were cognitive stimulation (QoL: standardized mean difference [SMD] = 0.38), music-based therapeutic interventions (depression: SMD = -0.27, anxiety: SMD = -0.43, QoL: SMD = 0.32), and psychological treatments (mainly cognitive behavior therapy; depression: SMD = -0.22, anxiety: MD = -4.57). Although health-care professionals are recommended to continue using these approaches, future research needs to focus on the type and form of interventions that are most effective for different stages and types of dementia.
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Memantine can be used in conjunction with an acetylcholinesterase inhibitor because their modes of action are complementary; the combinatorial therapy is usually beneficial to patients, with cumulative results and no rise in side effects.
“Memantine can be used in conjunction with an AChEI because their modes of action are complimentary. The said combinatorial therapy is usually beneficial to patients, with cumulative results and no rise in side effects (Kishita et al., 2020).”
From An update on the novel and approved drugs for Alzheimer disease (2022) · cites this paper as Kishita et al., 2020
Memantine can be administered in combination with an acetylcholinesterase inhibitor because they have complementary mechanisms of action.
“Memantine can be administered in combination with an AChEI, as they have complementary mechanisms of action.”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [15]
Combination of memantine and an acetylcholinesterase inhibitor benefits patients with usually additive effects, without any increase in adverse effects.
“Their combination benefits patients with usually additive effects, without any increase in adverse effects.14,15”
From Current and Future Treatments in Alzheimer Disease: An Update (2020) · cites this paper as [15]
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Anxiety Disorders in Later Life
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Etiology, risk factors, treatments and current status of AlzheimerÓ?s disease in Mexico
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- Authors
- Kishita, N., Backhouse, T., & Mioshi, E.
- Affiliations
- University of East Anglia (GB)
- Corresponding author
- Kishita, Naoko
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2019-06-16
- Volume
- 33
- Issue
- 1
- Pages
- 28-41
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2952466078
- Cited by
- 103
- References
- 47
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 21 · 2023: 26 · 2022: 16 · 2021: 13 · 2020: 11 · 2019: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Funders
- Alzheimer's Society
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Social Sciences › Arts and Humanities › Conservation › Art Therapy and Mental Health
- Keywords
- dementia, non-pharmacological treatment, depression, anxiety, quality of life, cognitive stimulation, music therapy, cognitive behavioral therapy, psychological intervention, dementia stages, dementia types
- MeSH terms
- Anxiety, Dementia, Depression, Humans, Quality of Life
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