Cited by 118Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Comparative density of CCK- and PV-GABA cells within the cortex and hippocampus

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Whissell, Paul D., Cajanding, Janine D., Fogel, Nicole, Kim, Jun Chul·2015·Frontiers in Neuroanatomy

Abstract

Cholecystokinin (CCK)- and parvalbumin (PV)-expressing neurons constitute the two major populations of perisomatic GABAergic neurons in the cortex and the hippocampus. As CCK- and PV-GABA neurons differ in an array of morphological, biochemical and electrophysiological features, it has been proposed that they form distinct inhibitory ensembles which differentially contribute to network oscillations and behavior. However, the relationship and balance between CCK- and PV-GABA neurons in the inhibitory networks of the brain is currently unclear as the distribution of these cells has never been compared on a large scale. Here, we systemically investigated the distribution of CCK- and PV-GABA cells across a wide number of discrete forebrain regions using an intersectional genetic approach. Our analysis revealed several novel trends in the distribution of these cells. While PV-GABA cells were more abundant overall, CCK-GABA cells outnumbered PV-GABA cells in several subregions of the hippocampus, medial prefrontal cortex and ventrolateral temporal cortex. Interestingly, CCK-GABA cells were relatively more abundant in secondary/association areas of the cortex (V2, S2, M2, and AudD/AudV) than they were in corresponding primary areas (V1, S1, M1, and Aud1). The reverse trend was observed for PV-GABA cells. Our findings suggest that the balance between CCK- and PV-GABA cells in a given cortical region is related to the type of processing that area performs; inhibitory networks in the secondary cortex tend to favor the inclusion of CCK-GABA cells more than networks in the primary cortex. The intersectional genetic labeling approach employed in the current study expands upon the ability to study molecularly defined subsets of GABAergic neurons. This technique can be applied to the investigation of neuropathologies which involve disruptions to the GABAergic system, including schizophrenia, stress, maternal immune activation and autism.

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Crossref · 10.3389/fnana.2015.00124

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  • The density of specific interneuron types varies substantially across cortical areas.

    “However, the density of specific types of interneuron varies substantially across cortical areas (DeFelipe, 1997; He et al., 2016; Whissell et al., 2015).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Whissell et al., 2015

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Authors
Whissell, P. D., Cajanding, J. D., Fogel, N., & Kim, J. C.
Affiliations
University of Toronto (CA)
Corresponding author
Kim, Jun Chul
Venue
Frontiers in Neuroanatomy
Published
2015-09-23
Volume
9
Pages
124-124
ISSN
1662-5129 (ISSN-L)
OpenAlex
W1811410135
Cited by
118
References
134
Citations by year
2026: 6 · 2025: 9 · 2024: 9 · 2023: 22 · 2022: 15 · 2021: 20 · 2020: 13 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 1
FWCI
2.32
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neuroanatomy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Canadian Institutes of Health Research (496401, MOP 496401, MOP 491009)
  • Natural Sciences and Engineering Research Council of Canada (MOP 491009, 491009)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cholecystokinin, parvalbumin, GABAergic neurons, perisomatic inhibition, neuronal density, hippocampus, cerebral cortex, medial prefrontal cortex, GABAergic system

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