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Cited by 68Stress Responses and CortisolNeuroendocrine regulation and behaviorChild Abuse and Trauma

Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression

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Veenit, Vandana, Cordero, Maria I., Tzanoulinou, Stamatina, Sandi, Carmen·2013·Frontiers in Behavioral Neuroscience
DOI 10.3389/fnbeh.2013.00026PMC PMC3616252
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Abstract

Stress during childhood and adolescence enhances the risk of psychopathology later in life. We have previously shown that subjecting male rats to stress during the peripubertal period induces long-lasting effects on emotion and social behaviors. As corticosterone is increased by stress and known to exert important programming effects, we reasoned that increasing corticosterone might mimic the effects of peripubertal stress. To this end, we injected corticosterone (5 mg/kg) on 7 scattered days during the peripuberty period (P28-P30, P34, P36, P40, and P42), following the same experimental schedule as for stress administration in our peripubertal paradigm. We measured play behavior in the homecage and, at adulthood, the corticosterone response to novelty and behavioral responses in tests for anxiety- and depression-like behaviors, aggression, and social exploration. As compared to vehicle, corticosterone-treated animals exhibit more aggressive play behavior during adolescence, increased aggressive behavior in a resident-intruder (RI) test while reduced juvenile exploration and corticosterone reactivity at adulthood. Whereas the corticosterone treatment mimicked alterations induced by the peripuberty stress protocol in the social domain, it did not reproduce previously observed effects of peripuberty stress on increasing anxiety-like and depression-like behaviors, respectively evaluated in the elevated plus maze (EPM) and the forced swim tests. Our findings indicate that increasing corticosterone levels during peripuberty might be instrumental to program alterations in the social domain observed following stress, whereas other factors might need to be recruited for the programming of long-term changes in emotionality. Our study opens the possibility that individual differences on the degree of glucocorticoid activation during peripuberty might be central to defining differences in vulnerability to develop psychopathological disorders coursing with alterations in the social realm.

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Cited by

Sorted by citations

Authors
Veenit, V., Cordero, M. I., Tzanoulinou, S., & Sandi, C.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • University of Geneva (CH)
Corresponding author
Sandi, Carmen
ORCID
Venue
Frontiers in Behavioral Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
7
Pages
26-26
ISSN
1662-5153 (ISSN-L)
DOI
10.3389/fnbeh.2013.00026
PMC
PMC3616252
OpenAlex
W2120642714
Cited by
68
References
10
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 1
FWCI
3.80
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • National Science Foundation
  • École Polytechnique Fédérale de Lausanne (31003AB-135710)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (122691, 120791, 135710, 310000)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
corticosterone, social exploration, aggression, play behavior, resident-intruder test, anxiety-like behavior, depression-like behavior, adolescence, vulnerability to psychopathology, individual differences

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