The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Microglia, seen from the CX3CR1 angle
Open accessAbstract
Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX3CR1 for microglia function and the CX3C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX3CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.
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“Activated microglia also support neuronal survival and function by engulfing pathogens, cellular debris, or other neurotoxic entities and can synthesize various neurotrophic factors to promote tissue maintenance and repair (63, 64). However, the excessive or sustained activation of microglial cells (such as in chronic neurodegenerative diseases) usually produces significant inflammatory collateral”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [64]
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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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ATP mediates rapid microglial response to local brain injury in vivo
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Self-citationMicroglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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Self-citationCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
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Development of Monocytes, Macrophages, and Dendritic Cells
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Alternatively activated microglia and macrophages in the central nervous system
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Metadata
- Authors
- Wolf, Y., Yona, S., Kim, K.-W., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- University College London (GB)
- Yale University (US)
- Corresponding author
- Jung, Steffen
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 26-26
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3600435
- OpenAlex
- W1963664876
- Cited by
- 316
- References
- 76
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 22 · 2023: 29 · 2022: 19 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 25 · 2017: 27 · 2016: 20 · 2015: 20 · 2014: 28 · 2013: 10
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Israel Science Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- microglia, CX3CR1, chemokine receptor signaling, CNS homeostasis
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