Cited by 316Neuroinflammation and Neurodegeneration MechanismsChemokine receptors and signalingNeuroscience and Neuropharmacology Research

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Microglia, seen from the CX3CR1 angle

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Wolf, Yochai, Yona, Simon, Kim, Ki-Wook, Jung, Steffen·2013·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2013.00026PMC PMC3600435

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Abstract

Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX3CR1 for microglia function and the CX3C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX3CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.

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Figure 1 (A) Schematic of CX3C chemokine family and (B) potential scenario of differential outcomes of neuronal shed and membrane-anchored CX3CL1 engagement by microglia inducing or suppressing microglial IL-1β production, respectively.CC BY · PubMed Central

Figure 2 Brain section of CX3CR1gfp:CX3CL1cherry double reporter animals (Kim et al., 2011) highlighting CX3CR1-expressing microglia and subsets of CX3CL1-expressing neurons in specific brain regions. Note that both reporters are expressed in the cytoplasm and not as fusion proteins. Thus they reflect the respective promoter activity but not the presence of the respective proteins. Hence no co-localization has to be expected.CC BY · PubMed Central

Figure 3 (A) Schematic of modified CX3CR1 loci of CX3CR1gfp mice (Jung et al., 2000) and (B) CX3CR1Cre and CX3CR1CreER mice (Yona et al., 2013); (C) Efficient YFP labeling of both spinal cord and brain microglia in CX3CR1CreER and CX3CR1Cre mice crossed with R26-YFP reporter mice. CX3CR1CreER:R26-YFP mice were treated with tamoxifen to induce the rearrangement (Yona et al., 2013); (D) Induction but subsequent progressive loss of cells harboring gene rearrangements in peripheral myeloid cells (monocytes, intestinal macrophages) and persistence of genomic modification in microglial cells.CC BY · PubMed Central

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Authors: Wolf, Y., Yona, S., Kim, K.-W., & Jung, S.
Affiliations: Weizmann Institute of Science (IL)
University College London (GB)
Yale University (US)
Corresponding author: Jung, Steffen
ORCID: Wolf, Yochai
Yona, Simon
Kim, Ki-Wook
Jung, Steffen
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2013
Volume: 7
Pages: 26-26
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2013.00026
PMC: PMC3600435
OpenAlex: W1963664876
Cited by: 316
References: 76
Citations by year: 2026: 16 · 2025: 13 · 2024: 22 · 2023: 29 · 2022: 19 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 25 · 2017: 27 · 2016: 20 · 2015: 20 · 2014: 28 · 2013: 10
FWCI: 14.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UCL Discovery (University College London) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Israel Science Foundation
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: microglia, CX3CR1, chemokine receptor signaling, CNS homeostasis

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Microglia, seen from the CX3CR1 angle

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