Microglia, seen from the CX3CR1 angle

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

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ATP mediates rapid microglial response to local brain injury in vivo

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Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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Development of Monocytes, Macrophages, and Dendritic Cells

Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049

Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

A new class of membrane-bound chemokine with a CX3C motif

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

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CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,646

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622

Microglial interactions with synapses are modulated by visual experience

Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542

Control of microglial neurotoxicity by the fractalkine receptor

Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

Imai, T., Hieshima, K., Haskell, C. A., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80438-9 · Cited by 1,472

Pathological and protective roles of glia in chronic pain

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Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061

The Role of Microglia in the Healthy Brain: Figure 1.

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Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain

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Neuronal ‘On’ and ‘Off’ signals control microglia

Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

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Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

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Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

Kawasaki, Y., Xu, Z., Wang, X., Park, J. Y., Zhuang, Z., Tan, P.-H., Gao, Y., Roy, K., Corfas, G., Lo, E. H., et al. (2008) · Nature Medicine · doi:10.1038/nm1723 · Cited by 759

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

Hundhausen, C., Misztela, D., Berkhout, T. A., BROADWAY, N. M., Säftig, P., Reiß, K., Hartmann, D., Fahrenholz, F., Postina, R., Matthews, V. B., et al. (2003) · Blood · doi:10.1182/blood-2002-12-3775 · Cited by 731

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo

Matloubian, M., David, A., Engel, S., Ryan, J. E., & Cyster, J. G. (2000) · Nature Immunology · doi:10.1038/79738 · Cited by 670

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

Garton, K. J., Gough, P. J., Blobel, C., Murphy, G., Greaves, D. R., Dempsey, P. J., & Raines, E. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106434200 · Cited by 653

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Bhaskar, K., Konerth, M., Kokiko-Cochran, O. N., Cardona, A., Ransohoff, R. M., & Lamb, B. T. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.023 · Cited by 639

CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity

Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3667-11.2011 · Cited by 624

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

Fuhrmann, M., Bittner, T., Jung, C. K. E., Burgold, S., Page, R. M., Mitteregger, G., Haass, C., LaFerla, F. M., Kretzschmar, H., & Herms, J. (2010) · Nature Neuroscience · doi:10.1038/nn.2511 · Cited by 562

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

Lee, S., Varvel, N. H., Konerth, M. E., Xu, G., Cardona, A. E., Ransohoff, R. M., & Lamb, B. T. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100265 · Cited by 522 · cited 2×

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

Landsman, L., Bar‐On, L., Zernecke, A., Kim, K.-W., Krauthgamer, R., Shagdarsuren, E., Lira, S. A., Weissman, I. L., Weber, C., & Jung, S. (2008) · Blood · doi:10.1182/blood-2008-07-170787 · Cited by 505

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Clark, A. K., Yip, P. K., Grist, J., Gentry, C., Staniland, A. A., Marchand, F., Dehvari, M., Wotherspoon, G., Winter, J., Ullah, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610811104 · Cited by 491

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

Combadière, C., Potteaux, S., Gao, J.-L., Esposito, B., Casanova, S., Lee, E. J., Debré, P., Tedgui, A., Murphy, P. M., & Mallat, Z. (2003) · Circulation · doi:10.1161/01.cir.0000057548.68243.42 · Cited by 476

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

Mildner, A., Mack, M., Schmidt, H., Brück, W., Djukic, M., Zabel, M. D., Hille, A., Priller, J., & Prinz, M. (2009) · Brain · doi:10.1093/brain/awp144 · Cited by 445

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

Hoshiko, M., Arnoux, I., Avignone, E., Yamamoto, N., & Audinat, E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1167-12.2012 · Cited by 384

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

Zhuang, Z.-Y., Kawasaki, Y., Tan, P.-H., Wen, Y.-R., Huang, J., & Ji, R.-R. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.11.003 · Cited by 371

Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

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Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

Bachstetter, A. D., Morganti, J. M., Jernberg, J., Schlunk, A., Mitchell, S. H., Brewster, K. W., Hudson, C. E., Cole, M. J., Harrison, J. K., Bickford, P. C., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.022 · Cited by 364

Tumor necrosis factor-α converting enzyme

Black, R. A. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00097-8 · Cited by 346

The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood

Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., & Cardona, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100421 · Cited by 346

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · e-Neuroforum · doi:10.1515/nf-2005-0304 · Cited by 311

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

Kim, K.-W., Vallon-Eberhard, A., Zigmond, E., Farache, J., Shezen, E., Shakhar, G., Ludwig, A., Lira, S. A., & Jung, S. (2011) · Blood · doi:10.1182/blood-2011-04-348946 · Cited by 299

P2X7-Dependent Release of Interleukin-1β and Nociception in the Spinal Cord following Lipopolysaccharide

Clark, A. K., Staniland, A. A., Marchand, F., Kaan, T. K. Y., McMahon, S. B., & Malcangio, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3295-09.2010 · Cited by 291

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

Dénes, Á., Ferenczi, S., Halász, J., Környei, Z., & Kovács, K. J. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.64 · Cited by 276

CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-β Phagocytosis

Liu, Z., Condello, C., Schain, A., Harb, R., & Grutzendler, J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4403-10.2010 · Cited by 275 · cited 2×

Region‐specific expression of immunoregulatory proteins on microglia in the healthy CNS

Haas, A. H. D., Boddeke, H. W. G. M., & Biber, K. P. H. (2008) · Glia · doi:10.1002/glia.20663 · Cited by 274

Inducible Cre Mice

Feil, S. C., Valtcheva, N., & Feil, R. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_18 · Cited by 268

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

Cho, S.-H., Sun, B., Zhou, Y., Kauppinen, T. M., Halabisky, B., Wes, P., Ransohoff, R. M., & Gan, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254268 · Cited by 268

Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa

Muehlhoefer, A., Saubermann, L. J., Gu, X., Lüedtke-Heckenkamp, K., Xavier, R. J., Blumberg, R. S., Podolsky, D. K., MacDermott, R. P., & Reinecker, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3368 · Cited by 257

Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS

Hughes, P. M., Botham, M. S., Frentzel, S., Mir, A., & Perry, V. H. (2002) · Glia · doi:10.1002/glia.10037 · Cited by 252

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson’s disease

Pabon, M. M., Bachstetter, A. D., Hudson, C. E., Gemma, C., & Bickford, P. C. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-9 · Cited by 241

Tumor Necrosis Factor-α-converting Enzyme Mediates the Inducible Cleavage of Fractalkine

Tsou, C.-L., Haskell, C. A., & Charo, I. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107327200 · Cited by 229

Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo

Swinnen, N., Smolders, S., Ávila, A., Notelaers, K., Paesen, R., Ameloot, M. M., Brône, B., Legendre, P., & Rigo, J. (2012) · Glia · doi:10.1002/glia.22421 · Cited by 226

Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages

Donnelly, D. J., Longbrake, E. E., Shawler, T. M., Kigerl, K. A., Lai, W., Tovar, C. A., Ransohoff, R. M., & Popovich, P. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2114-11.2011 · Cited by 219

Visualization of microglia in living tissues using Iba1‐EGFP transgenic mice

Hirasawa, T., Ohsawa, K., Imai, Y., Ondo, Y., Akazawa, C., Uchino, S., & Kohsaka, S. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20480 · Cited by 186

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

Staniland, A. A., Clark, A. K., Wodarski, R., Sasso, O., Μaione, F., D’Acquisto, F., & Malcangio, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06837.x · Cited by 171

Metchnikoff's policemen: macrophages in development, homeostasis and regeneration

Stefater, J. A., Ren, S., Lang, R. A., & Duffield, J. S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.009 · Cited by 169

CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents

Cipriani, R., Villa, P., Chece, G., Lauro, C., Paladini, A., Micotti, E., Perego, C., De Simoni, M.-G., Fredholm, B. B., Eusebi, F., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3611-11.2011 · Cited by 166

Generation and Analysis of Mice Lacking the Chemokine Fractalkine

Cook, D. N., Chen, S., Sullivan, L. M., Manfra, D. J., Wiekowski, M., Prosser, D. M., Vassileva, G., & Lira, S. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.3159-3165.2001 · Cited by 157

CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

Maggi, L. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00022 · Cited by 149

Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues

Cardona, A. E., Sasse, M. E., Liu, L., Cardona, S. M., Mizutani, M., Savarin, C., Hu, T., & Ransohoff, R. M. (2008) · Blood · doi:10.1182/blood-2007-10-118497 · Cited by 148

The Soluble Isoform of CX3CL1 Is Necessary for Neuroprotection in a Mouse Model of Parkinson's Disease

Morganti, J. M., Nash, K. R., Grimmig, B. A., Ranjit, S., Small, B. J., Bickford, P. C., & Gemma, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0539-12.2012 · Cited by 141

Fractalkine protein localization and gene expression in mouse brain

Tarozzo, G., Bortolazzi, S., Crochemore, C., Chen, S. ‐., Lira, A. S., Abrams, J. S., & Beltramo, M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10645 · Cited by 105

Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks

Rigato, C., Buckinx, R., Corronc, H. L., Rigo, J., & Legendre, P. (2011) · Glia · doi:10.1002/glia.21140 · Cited by 102

p53 and Atherosclerosis

Tabas, I. A. (2001) · Circulation Research · doi:10.1161/hh0801.090536 · Cited by 96

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

Willemen, H. L. D. M., Eijkelkamp, N., Wang, H., Dantzer, R., Dorn, G. W., Kelley, K. W., Heijnen, C. J., & Kavelaars, A. (2010) · Pain · doi:10.1016/j.pain.2010.06.015 · Cited by 93

Fractalkine/CX3CR1 and atherosclerosis

Liu, H., & Jiang, D. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.03.036 · Cited by 73

Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1

Fujita, M., Takada, Y. K., & Takada, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200889 · Cited by 64

Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS

Hughes, P. M., Botham, M. S., Frentzel, S., et al. (2002) · Glia · doi:10.1002/glia.10037.abs · Cited by 21

Fractalkine is an epithelial and endothelial cell derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa

Muehlhoefer, A., Saubermann, L. J., Gu, X., Lüedtke-Heckenkamp, K., Xavier, R. J., Blumberg, R. S., Podolsky, D. K., & MacDermott, R. P. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)82524-x · Cited by 11

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474

Pathological pain and the neuroimmune interface

Grace, P. M., Hutchinson, M. R., Maier, S. F., & Watkins, L. R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3621 · Cited by 982

Modulators of microglial activation and polarization after intracerebral haemorrhage

Lan, X., Han, X., Li, Q., Yang, Q.-W., & Wang, J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.69 · Cited by 915

Alternatively activated microglia and macrophages in the central nervous system

Franco, R., & Fernández‐Suárez, D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.003 · Cited by 674

Reviewed by:

Wolf, Y., Yona, S., Kim, K.-W., Jung, S., Legendre, P., Pierre, U., Université, M.-E. T., Department Of, Kim, K.-W., & Department Of (2013)

Role of CX3CL1 in Synaptic Activity and Neuroprotection

Ragozzino, D., Lauro, C., & Limatola, C. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0793-6_13 · Cited by 1

Chemokine CX3C motif receptor 1 ( CX3CR1 ) promoter–dependent gene expression in microglia

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The effect of CX3CL1/ CX3CR1 signal axis on microglia in central nervous system diseases

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