The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
Factors regulating microglia activation
Open accessAbstract
Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the "resting" but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2). Under physiological conditions, minor changes of those factors are sufficient to cause fatal dysregulation of microglial cell homeostasis and result in severe CNS pathologies. In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“highlighting the age-dependent change in microglial plasticity [53, 55].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [55]
In the citing paper
“Further analysis revealed that microglia surface receptors for microglia-neuron crosstalk (CX3CR1, P2RY12, and TREM2) and TLRs for communication with pathogen-associated molecular patterns tended to show a negative correlation between gene expression level and age, highlighting the age-dependent change in microglial plasticity [53, 55].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [55]
In the citing paper
“suggesting their reactive state and reduced plasticity in the adult stage possibly due to repetitive exposure to infectious agents and active removal of cell debris [53, 55].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [55]
In the citing paper
“With maturation and aging, expression of pro-inflammatory genes in adult microglia increase, suggesting their reactive state and reduced plasticity in the adult stage possibly due to repetitive exposure to infectious agents and active removal of cell debris [53, 55].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [55]
In the citing paper
“Microglia represent a heterogeneous cell population accounting for approximately 5–12% of total brain cells. They are distributed unevenly throughout the CNS, as grey matter and specific structures such as the hippocampus, basal ganglia, and substantia nigra typically all exhibit greater densities than the white matter (58–60).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [59]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Self-citationHeterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
A new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858
Flagged first, then by citations
2 of the 83 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 361
Shiao, M. L., Yuan, C., Crane, A. T., Voth, J. P., Juliano, M., Stone, L. H., Nan, Z., Zhang, Y., Kuzmin‐Nichols, N., Sanberg, P. R., et al. (2019) · Cell Transplantation · doi:10.1177/0963689719836763 · Cited by 23
Gao, S., Cheng, Q., Hu, Y., Tan, Z., Chen, L., Liu, S., Kang, Q., & Wei, T. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118863 · Cited by 22
Ślusarczyk, J., Trojan, E., Głombik, K., Piotrowska, A., Budziszewska, B., Kubera, M., Popiołek-Barczyk, K., Lasoń, W., Mika, J., & Basta‐Kaim, A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13452 · Cited by 23
RetractedXu, Y., Diaz, V., & Hu, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314664 · Cited by 23
Vanherle, L., Lidington, D., Uhl, F. E., Steiner, S., Vassallo, S., Skoug, C., Duarte, J. M. N., Ramu, S., Uller, L., Desjardins, J., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104384 · Cited by 20
Sanford, L. D., Wellman, L. L., Adkins, A. M., Guo, M., Zhang, Y., Ren, R., Yang, L., & Tang, X. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100517 · Cited by 24
Bénardais, K., Gudi, V., Gai, L., Nessler, J. N., Singh, V., Prajeeth, C. K., Skripuletz, T., & Stangel, M. (2014) · Glia · doi:10.1002/glia.22706 · Cited by 19
Bortell, N., Basova, L., Najera, J. A., Morsey, B., Fox, H. S., & Marcondes, M. C. G. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9772-3 · Cited by 20
A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration
Maksoud, É., Liao, E. H., & Haghighi, A. P. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.077 · Cited by 19
Microglia of the Brain: Origin, Structure, Functions
Alekseeva, O. S., Kirik, O. V., Gilerovich, E. G., & Korzhevsky, D. E. (2019) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s002209301904001x · Cited by 18
Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era
Borst, K., & Prinz, M. (2020) · Brain Pathology · doi:10.1111/bpa.12910 · Cited by 17
Self-citationRabaneda‐Lombarte, N., Blasco-Agell, L., Serratosa, J., Ferigle, L., Saura, J., & Solà, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-67649-4 · Cited by 18
Glial cells as therapeutic targets in progressive multiple sclerosis
Wilbanks, B., Maher, L., & Rodriguez, M. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1614443 · Cited by 17
Fractalkine Attenuates Microglial Cell Activation Induced by Prenatal Stress
Ślusarczyk, J., Trojan, E., Głombik, K., Chamera, K., Roman, A., Budziszewska, B., & Basta‐Kaim, A. (2016) · Neural Plasticity · doi:10.1155/2016/7258201 · Cited by 17
RetractedPlasticity of microglia in remote regions after focal brain injury
Bisicchia, E., Sasso, V., Molinari, M., & Viscomi, M. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.011 · Cited by 17
Mignogna, M. L., Musardo, S., Ranieri, G., Gelmini, S., Espinosa, P., Marra, P., Belloli, S., Murtaj, V., Moresco, R. M., Bellone, C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01155-5 · Cited by 19
Various Energetic Metabolism of Microglia in Response to Different Stimulations
Liu, X., Jiang, N., & Zhou, W. (2023) · Molecules · doi:10.3390/molecules28114501 · Cited by 16
Quantitative modeling of regular retinal microglia distribution
Endo, Y., Asanuma, D., Namiki, S., Sugihara, K., Hirose, K., Uemura, A., Kubota, Y., & Miura, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-01820-3 · Cited by 16
Differential usage of DNA modifications in neurons, astrocytes, and microglia
Tooley, K. B., Chucair‐Elliott, A. J., Ocañas, S. R., Machalinski, A. H., Pham, K. D., Hoolehan, W., Kulpa, A. M., Stanford, D. R., & Freeman, W. M. (2023) · Epigenetics & Chromatin · doi:10.1186/s13072-023-00522-6 · Cited by 13
Craddock, T. J. A., Michalovicz, L. T., Kelly, K. A., Rice, M. A., Miller, D. B., Klimas, N. G., Morris, M., O'Callaghan, J. P., & Broderick, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00336 · Cited by 15
A role for macrophages in hematopoiesis in the embryonic head
Li, Z., Mariani, S. A., Rodríguez‐Seoane, C., He, W., Ning, X., Liu, B., Vink, C. S., & Dzierzak, E. A. (2019) · Blood · doi:10.1182/blood.2018881243 · Cited by 14
Molecular Biological Aspects of Depressive Disorders: A Modern View
Ushakova, V. M., Morozova, A. Y., Reznik, A. M., Kostyuk, G. P., & Chekhonin, V. P. (2020) · Molecular Biology · doi:10.1134/s0026893320050118 · Cited by 16
Wang, L., Gong, X., Liu, Y., Du, T., Zhang, Z., Zhang, T., & Wang, X. (2020) · Glia · doi:10.1002/glia.23811 · Cited by 15
Katoh, Y., Iriyama, T., Yano, E., Sayama, S., Seyama, T., Kotajima‐Murakami, H., Sato, A., Sakuma, H., Iguchi, Y., Yoshikawa, M., et al. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103752 · Cited by 14
Barreto‐Núñez, R., Béland, L., Boutej, H., Picher‐Martel, V., Dupré, N., Barbeito, L., & Križ, J. (2024) · Glia · doi:10.1002/glia.24531 · Cited by 17
WKYMVm/FPR2 Alleviates Spinal Cord Injury by Attenuating the Inflammatory Response of Microglia
Zhang, W., Chen, J., Guo, W., Kong, G., Wang, L., Cheng, X., Zeng, X., Wan, Y., & Li, X. (2022) · Mediators of Inflammation · doi:10.1155/2022/4408099 · Cited by 14
Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia
Claes, C., Daele, J. V. D., & Verfaillie, C. M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.019 · Cited by 13
Mechanisms and routes of G-protein coupled receptor-mediated Tau degradation in Alzheimer’s disease
Ananthanarayana, V., Chidambaram, H., Govindaraj, P., Vijayalakshmi, K., & Chinnathambi, S. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.07.003 · Cited by 14
Schnöder, L., Quan, W., Yu, Y., Tomic, I., Luo, Q., Hao, W., Peng, G., Li, D., Fassbender, K. C., & Liu, Y. (2023) · The FASEB Journal · doi:10.1096/fj.202201512r · Cited by 12
Rahimian, R., Guruswamy, R., Boutej, H., Cordeau, P., Weng, Y. C., & Križ, J. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.004 · Cited by 13
Joseph, A. T., Bhardwaj, S. K., & Srivastava, L. K. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00244 · Cited by 16
CD200‐CD200R1 signaling pathway regulates neuroinflammation after stroke
Zhao, S., Xu, H., Ya‐ping, W., Di, L., Wen‐qian, W., Ling‐song, M., Chu, Z., & Xu, Y. (2020) · Brain and Behavior · doi:10.1002/brb3.1882 · Cited by 13
Shermon, S., Goldfinger, M. S., Morris, A. J., Harper, B. D., Leder, A. N., Santella, A. J., & Krishnamachari, B. (2021) · Chronic Illness · doi:10.1177/17423953211039789 · Cited by 12
Han, T., Xu, Y., Liu, H., Sun, L., Cheng, X., Shen, Y., & Wei, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094920 · Cited by 14
Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging
Carrera, J., Tomberlin, J., Kurtz, J., Karakaya, E., Bostancıklıoğlu, M., & Albayram, Ö. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.606808 · Cited by 12
Frieß, L., Cheray, M., Keane, L., Grabert, K., & Joseph, B. (2021) · Molecular Brain · doi:10.1186/s13041-021-00794-7 · Cited by 11
Microglia and status epilepticus in the immature brain
López‐Meraz, M. L., & Álvarez‐Croda, D. (2022) · Epilepsia Open · doi:10.1002/epi4.12610 · Cited by 10
Changes in neocortical and hippocampal microglial cells during hibernation
León‐Espinosa, G., Regalado-Reyes, M., DeFelipe, J., & Muñoz, A. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1596-7 · Cited by 14
Shikha, D., Mahish, C., Sing, R., Chattopadhyay, S., & Goswami, C. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.09.078 · Cited by 11
Wang, F., Li, M., Lin, C., Jin, S., Li, H., Lu, Y., Wang, H., Wang, H., & Wang, X. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116131 · Cited by 12
Parkinson’s Disease: A Tale of Many Players
Pauwels, E. K. J., & Boer, G. J. (2023) · Medical Principles and Practice · doi:10.1159/000531422 · Cited by 14
Kumar, P., Mathew, S., Gamage, R. V., Bodkin, F., Doyle, K., Rosetti, I., Wagnon, I. M., Zhou, X., Raju, R., Gyengési, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311086 · Cited by 12
Behensky, A. A., Katnik, C. P., Yin, H., & Cuevas, J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00414 · Cited by 11
Tsui, C. T., MacGillivray, S. R., Weber, S. M., McAllister, L., Churchward, M. A., Dennison, C. R., & Todd, K. G. (2020) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2020.104176 · Cited by 11
Xu, M., Lantz, M. J., Nichols, R. A., & Li, Q. X. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00537 · Cited by 10
Vadišiūtė, A., Meijer, E. J., Therpurakal, R. N., Mueller, M., Szabó, F., Messore, F., Juršėnas, A., Bredemeyer, O., Krone, L. B., Mann, E. O., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06994-w · Cited by 10
Glia–glia crosstalk via semaphorins: Emerging implications in neurodegeneration
Palazzo, C., Nutarelli, S., Mastrantonio, R., Tamagnone, L., & Viscomi, M. T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102618 · Cited by 12
Wang, X., Sun, L., Guan, S., Hong, Y., Huang, X., Liang, M., Zhang, R., & Luo, T. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175118 · Cited by 9
Capriotti, Z., & Klase, Z. A. (2024) · Journal of NeuroVirology · doi:10.1007/s13365-024-01239-2 · Cited by 11
Senescent microglia: The hidden culprits accelerating Alzheimer’s disease
Li, W., Xie, Y., Jia-Xin, M., Shu-Chao, G., & Li-Ping, H. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149480 · Cited by 11
Inflammation as a mediator of stress-related psychiatric disorders
Flux, M. C., & Lowry, C. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00052-6 · Cited by 10
Association between human cytomegalovirus and onset of epilepsy.
Lei, H., Yang, D.-Q., Li, Y., Wang, L., & Zheng, M. (2015) · PubMed Central · Cited by 8
Qi, Y., Liu, L., Liang, D., Tang, S., Yu, X., Ye, H., & Chen, N. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154828 · Cited by 7
Anwer, D., Gubinelli, F., Kurt, Y. A., Sarauskyte, L., Jacobs, F., Venuti, C., Sandoval, I. M., Yang, Y., Stancati, J. A., Mazzocchi, M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284480 · Cited by 7
Liddie, J. M., Vieira, C. L. Z., Coull, B. A., Sparrow, D., Koutrakis, P., & Weisskopf, M. G. (2024) · Environment International · doi:10.1016/j.envint.2024.108666 · Cited by 8
Association of mycophenolate and azathioprine use with cognitive function in systemic lupus
Dobrowolski, C., McGinley, J., Fazzari, M. J., Su, J., Bingham, K. S., Anderson, N. M., Ruttan, L., Beaton, D., Wither, J., Tartaglia, M. C., et al. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac540 · Cited by 7
Hisada, C., Kajimoto, K., Tsugane, H., Iinuma, M., Azuma, K., & Kubo, K. (2023) · Journal of Prosthodontic Research · doi:10.2186/jpr.jpr_d_22_00255 · Cited by 7
Research Progress on the Immune-Inflammatory Mechanisms of Posttraumatic Epilepsy
Dang, Y., & Wang, T. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01429-2 · Cited by 7
Hodgson, L. M., Li, Y., Iturria‐Medina, Y., Stratton, J. A., Wolf, G., Krishnaswamy, S., Bennett, D. A., & Bzdok, D. (2024) · Communications Biology · doi:10.1038/s42003-024-06273-8 · Cited by 7
Microglia in Experimental Brain Injury: Implications on Neuronal Injury and Circuit Remodeling
Evilsizor, M. N., Ray-Jones, H. F., Ellis, T. W., Lifshitz, J., & Ziebell, J. M. (2015) · eCite Digital Repository (University of Tasmania) · Cited by 7
Молекулярно-биологические аспекты депрессивных состояний: современный взгляд на проблему
Ushakova, V. M., Морозова, А. Ю., Reznik, A. M., Kostyuk, G. P., & Chekhonin, V. P. (2020) · Molecular Biology · doi:10.31857/s0026898420050110 · Cited by 8
Delage, C. I., & Cornil, C. A. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22781 · Cited by 6
Systemic changes in neovascular age-related macular degeneration.
Singh, A. (2014) · PubMed · Cited by 7
Bechmann, I., & Woodroofe, M. N. (2014) · doi:10.1002/9781118406557.ch1 · Cited by 7
Latini, L., de Araújo, D. S. M., Amato, R., Canovai, A., Buccarello, L., Logu, F. D., Novelli, E., Vlasiuk, A., Malerba, F., Arisi, I., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17316 · Cited by 7
Cancela, L. M., Mongi‐Bragato, B., Avalos, M. P., & Bollati, F. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010385 · Cited by 9
Microglia in Gliomas: Friend or Foe?
Kaminska, B. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1431-5_9 · Cited by 6
Tsukahara, T., Sahara, Y., Ribeiro, N., Tsukahara, R., Gotoh, M., Sakamoto, S., Handa, H., & Murakami‐Murofushi, K. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109951 · Cited by 8
The therapeutic effect of controlled reoxygenation on chronic hypoxia-associated brain injury
Tu, Z., Tan, X., Li, S., Cui, J., Tu, S., & Jiang, L. (2019) · Biology Open · doi:10.1242/bio.039370 · Cited by 6
Cellular and molecular phenotypes of C9orf72 ALS/FTD patient derived iPSC-microglia mono-culturesPreprint
Lorenzini, I., Alsop, E. B., Levy, J., Gittings, L. M., Lall, D., Rabichow, B. E., Moore, S. R., Pevey, R. S., Bustos, L. M., Burciu, C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.03.277459 · Cited by 6
Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
Park, Y., Yu, S., Hwang, S. Y., & Seo, H. (2024) · Molecular & Cellular Toxicology · doi:10.1007/s13273-024-00441-x · Cited by 5
Rationale and emerging evidence for microglial replacement in Alzheimer’s disease
Bang, J. Y., & Yoo, Y. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100265 · Cited by 6
Unraveling Alzheimer’s: Exploring the Gut Microbiota–Brain Axis as a New Frontier in Understanding
Rashid, S. M., Razak, R., Tantray, A. K., James, A. W., Showkat, N., Shehjar, F., Jan, F., Ahmad, S. B., Khan, A., & Shah, Z. A. (2024) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad1010003 · Cited by 5
Huang, M., Yang, Y., Tang, Y., Li, Y., Wang, X., & Zhou, M. (2025) · Inflammation · doi:10.1007/s10753-025-02336-y · Cited by 5
Shen, H., Zhang, Q., Lv, Q., Liu, H., Wang, C., Meng, F., Guo, Y., Pei, J., Yu, C., Tie, J., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106081 · Cited by 4
Neuro-Immune Interactions in Depression: Mechanisms and Translational Implications
Abelaira, H. M., da Silva, R. H., Carlessi, A. S., Quevedo, J., & Réus, G. Z. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00008-1 · Cited by 5
Never-resting microglia: physiological roles in the healthy brain and pathological implications
(2015) · Frontiers research topics · doi:10.3389/978-2-88919-369-1 · Cited by 4
Recent progress in omics-driven analysis of MS to unravel pathological mechanisms
Malekzadeh, A., & Teunissen, C. E. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.835602 · Cited by 4
Zhou, Z., Deng, Z., Huang, Y., Chen, J., Yang, J. H., & Cao, Y. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116636 · Cited by 4
MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration
Huang, Y., Deng, Z., Zhou, Z., Fu, K., Liu, F., Zhang, H., Chen, J., Yang, J. H., & Cao, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-69189-3 · Cited by 4
An introduction to innate immunity in the central nervous system
Harry, G. J., Childers, G. M., & McPherson, C. A. (2018) · Advances in neurotoxicology · doi:10.1016/bs.ant.2018.10.002 · Cited by 3
Neuroprotection Versus Neurotoxicity
Biber, K. P. H., & Block, M. L. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_6 · Cited by 3
A mathematical model of microglia glucose metabolism and lactylation with positive feedback
Larripa, K., & Rǎdulescu, A. (2025) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2025.112049 · Cited by 2
Matthew, Y., Foley, N., Claiborne, D. T., Klase, Z. A., & Dick, A. (2026) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5c01103 · Cited by 2
Hao, N., Lü, G., Liu, X., Yu, B., Wu, H., Ji, D., Li, Y., & Han, X. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.050 · Cited by 2
Zhu, N., Zhang, C., Li, Z., Meng, Y., Feng, B., Wang, X., Yang, M., Wan, L., Ning, B., & Li, S. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0056-y · Cited by 2
Role of Microglia in Adult Neurogenesis
Ghosh, P., & Ghosh, A. (2016) · Springer eBooks · doi:10.1007/978-981-10-1711-7_13 · Cited by 2
Gushchina, S. V., Bo, K., Балашов, В. П., Pankov, V. G., & Balashov, A. V. (2018) · MORPHOLOGICAL NEWSLETTER · doi:10.20340/mv-mn.18(26).02.8-11 · Cited by 2
Timmerman, R., Zuiderwijk-Sick, E. A., Baron, W., & Bajramovic, J. J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1178504 · Cited by 2
Microglia and Psychiatric Disorders
Couch, A. C. M., & Vernon, A. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-71229-7_8 · Cited by 2
Central Nervous System Neoplasia in the Dog and Cat
Schwartz, D., Vernau, W., & Vernau, K. M. (2020) · Wiley eBooks · doi:10.1002/9781119380559.ch47 · Cited by 2
An Agent-Based Model of Microglia and Neuron Interaction: Implications in Neurodegenerative Disease
Ty, C., Case, A., Mezzulo, E., Penland, A., & Larripa, K. (2025) · Spora A Journal of Biomathematics · doi:10.61403/2473-5493.1097 · Cited by 1
Chen, C., Feng, L., Shi, P., Liu, Q., Zhang, L.-W., Wang, Q., Hua, R., Su, X., & Li, W. (2025) · Behavioral and Brain Functions · doi:10.1186/s12993-025-00305-x · Cited by 1
Zhang, K., Ding, S., Li, T., Yuan, T., & Cai, X. T. (2025) · Cytotechnology · doi:10.1007/s10616-025-00878-5 · Cited by 1
Balashov, A. V., Balashov, V. P., Шиханов, Н. П., Bystrova, E. V., & Gushchina, S. V. (2025) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-026-06548-6 · Cited by 1
Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents
Leduc‐Pessah, H., McAllister, B. B., Sinha, S., Stokes-Heck, S., Nishizawa, D., Fan, C. Y., St‐Pierre, M., Bradaïa, A., Defaye, M., Burma, N. E., et al. (2026) · Neuron · doi:10.1016/j.neuron.2025.11.018 · Cited by 1
Lei, K., Yang, S., Chen, H., Dai, J., Tan, Q., Wang, H., Du, E., Min, J., Lei, J., Luo, Y., et al. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115886 · Cited by 2
What are the Recurring Theories Regarding the Pathogenesis of Major Depressive Disorder?
Alawie, H., Hu, J.-C., & McLeod, A. (2021) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.215 · Cited by 2
Glia-Neuron Communication: Not a One-Way Street
Tran, A., Chen, J. T. C., & Belsham, D. D. (2021) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-62383-8_7 · Cited by 1
Microglial Cells Function in the Central Nervous System
El‐Mansoury, B., Smimih, K., Hamdan, Y. A., Draoui, A., Boulbaroud, S., & Jayakumar, A. R. (2023) · Advances in bioinformatics and biomedical engineering book series · doi:10.4018/978-1-6684-9675-6.ch004 · Cited by 1
Metadata
- Authors
- Kierdorf, K., & Prinz, M.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Prinz, Marco
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 44-44
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3632747
- OpenAlex
- W2149538964
- Cited by
- 360
- References
- 83
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 21 · 2023: 22 · 2022: 22 · 2021: 43 · 2020: 40 · 2019: 30 · 2018: 30 · 2017: 28 · 2016: 23 · 2015: 31 · 2014: 31 · 2013: 7
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (PR 577/8-2)
- Bundesministerium für Bildung und Forschung (PR 577/8-2)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- microglial activation, microglial homeostasis, central nervous system, IRF8, PU.1, CD200, CX3CR1, TREM2, neuroinflammation, CNS pathology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review