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Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Beccano-Kelly, Dayne A., Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N., Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J., Milnerwood, Austen J.·2014·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2014.00301PMC PMC4176085
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  • Multiple studies point to a role for LRRK2 at the presynaptic terminal where it plays a role in release of dopamine from striato-nigral neurons, and glutamate from corticostriatal neurons.

    “Multiple studies point to a role for LRRK2 at the presynaptic terminal where it plays a role in release of dopamine from striato-nigral neurons, and glutamate from corticostriatal neurons [5, 6, 11, 50, 86, 92, 95].”

    From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [5]

    The Introduction and Discussion (pages not supplied) report that LRRK2 affects presynaptic machinery and glutamate release in cultured cortical neurons. The paper does not establish that the measured release was specifically from corticostriatal neurons, or report LRRK2-dependent dopamine release from striato-nigral neurons. (LLM, conf=0.86)

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Research works printed but not linked: 53

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Metadata

Authors
Beccano-Kelly, D. A., Kuhlmann, N., Tatarnikov, I., Volta, M., Munsie, L. N., Chou, P., Cao, L.-P., Han, H., Tapia, L., Farrer, M. J., & Milnerwood, A. J.
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2014-09-26
Volume
8
ISSN
1662-5102
DOI
10.3389/fncel.2014.00301
PMC
PMC4176085
Cited by
97
References
1

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