Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
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Homeostatic plasticity may compensate for Hebbian forms of synaptic plasticity, such as long-term potentiation (LTP) and depression (LTD), by scaling neuronal output without changing the relative strength of individual synapses. This delicate balance between neuronal output and distributed synaptic weight may be necessary for maintaining efficient encoding of information across neuronal networks. Here, we demonstrate that Arc/Arg3.1, an immediate-early gene (IEG) that is rapidly induced by neuronal activity associated with information encoding in the brain, mediates homeostatic synaptic scaling of AMPA type glutamate receptors (AMPARs) via its ability to activate a novel and selective AMPAR endocytic pathway. High levels of Arc/Arg3.1 block the homeostatic increases in AMPAR function induced by chronic neuronal inactivity. Conversely, loss of Arc/Arg3.1 results in increased AMPAR function and abolishes homeostatic scaling of AMPARs. These observations, together with evidence that Arc/Arg3.1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability.
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BDNF, Arc, TNFa, MHC1, b3 integrins, PICK1, and scaffold proteins PSD-95 and PSD-93 can all contribute to, or are essential for, synaptic scaling in dissociated cultures.
“Additionally, there is evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) (Rutherford et al. 1998), the immediate early gene Arc (Shepherd et al. 2006), the cytokine TNFa (Stellwagen and Malenka 2006;Steinmetz and Turrigiano, 2010), the immune molecule MHC1 (Goddard et al. 2007), b3 integrins (Cingolani et al. 2008), the AMPAR binding protein PICK1 (Anggono et al. 2011), and”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Shepherd et al. 2006
Synaptic scaling in vitro requires TNFa and Arc signaling.
“Interestingly, the delayed potentiation in visual cortex following lid suture requires TNFa and Arc signaling (Kaneko et al. 2008;McCurry et al. 2011) as does synaptic scaling in vitro (Shepherd et al. 2006;Stellwagen and Malenka 2006;Steinmetz and Turrigiano 2010); however, both these manipulations likely affect many forms of plasticity, so it still remains to be seen if synaptic scaling”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Shepherd et al. 2006
NPTXs may contribute to cognitive decline in neurodegeneration and other diseases of the CNS by modifying excitatory synaptic drive onto fast-spiking PV interneurons, leading to E/I imbalance.
“NPTXs may contribute to the cognitive decline in neurodegeneration and other diseases of the CNS by modifying the excitatory synaptic drive onto fast-spiking PV interneurons which leads to E/I imbalance.”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Shepherd et al. 2006
This E/I imbalance might promote or accelerate disease progression by increasing demand in other compensatory mechanisms.
“This might promote or accelerate disease progression by increasing the demand in other compensatory mechanisms (Hu et al. 2010; Shepherd et al. 2006; Xiao et al. 2017).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Shepherd et al. 2006
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Cites
1 retracted
Combinatorial Effects of Odorant Mixes in Olfactory Cortex
Zou, Z., & Buck, L. B. (2006) · Science · doi:10.1126/science.1124755 · Cited by 147 · see citing works
RetractedSynaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 9× · see citing works
“1’s effects on LTP/LTD are secondary to poor homeostatic scaling in neurons or that these two processes may be independent of each other.”
BackgroundInfluentialSynaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., & Worley, P. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90299-6 · Cited by 1,212 · see citing works
Self-citationVariability, compensation and homeostasis in neuron and network function
Marder, E., & Goaillard, J.-M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1949 · Cited by 1,212 · see citing works
Huttner, W. Β., SCHIEBLER, W., Greengard, P., & Camilli, P. V. D. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.5.1374 · Cited by 1,172 · see citing works
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110 · see citing works
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015 · see citing works
Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03993.2000 · Cited by 992 · see citing works
Self-citationLu, W.-Y., Man, H.-Y., Ju, W., Trimble, W., Macdonald, J., & Wang, Y.-T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00194-5 · Cited by 978 · see citing works
Steward, O., Wallace, C. S., Lyford, G., & Worley, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80591-7 · Cited by 845 · see citing works
Self-citationArc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works
Self-citationArc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Self-citationRegulation of AMPA receptors during synaptic plasticity
Song, I., & Huganir, R. L. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02270-1 · Cited by 777 · see citing works
Self-citationRecycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688 · see citing works
Self-citationZalfa, F., Giorgi, M., Primerano, B., Moro, A., Di Penta, A., Reis, S., Oostra, B., & Bagni, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00079-5 · Cited by 676 · see citing works
Inactivity produces increases in neurotransmitter release and synapse size
Murthy, V. N., Schikorski, T., Stevens, C. F., & Zhu, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00500-1 · Cited by 612 · see citing works
Impaired Spatial Learning after Saturation of Long-Term Potentiation
Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M. (1998) · Science · doi:10.1126/science.281.5385.2038 · Cited by 505 · see citing works
Adaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 482 · see citing works
Steward, O., & Worley, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00275-6 · Cited by 474 · see citing works
Self-citationMapping behaviorally relevant neural circuits with immediate-early gene expression
Guzowski, J. F., Timlin, J. A., Roysam, B., McNaughton, B. L., Worley, P. F., & Barnes, C. A. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.018 · Cited by 404 · see citing works
Self-citationVerde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works
Self-citationRamı́rez-Amaya, V., Vazdarjanova, A. I., Mikhael, D. M., Rosi, S., Worley, P. F., & Barnes, C. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4342-04.2005 · Cited by 364 · see citing works
Self-citationMaintaining the Stability of Neural Function: A Homeostatic Hypothesis
Davis, G. W., & Bezprozvanny, I. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.847 · Cited by 302 · see citing works
Thiagarajan, T. C., Piedras-Renterı́a, E. S., & Tsien, R. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)01049-8 · Cited by 288 · see citing works
Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors
Liao, D., Scannevin, R. H., & Huganir, R. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06008.2001 · Cited by 286 · see citing works
Self-citationNguyen, P., & Kandel, E. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03189.1996 · Cited by 275 · see citing works
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works
Self-citationDickey, C. A., Loring, J. F., Montgomery, J., Gordon, M. N., Eastman, P. S., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05219.2003 · Cited by 242 · see citing works
Wang, K. H., Majewska, A. K., Schummers, J., Farley, B. J., Hu, C., Sur, M., & Tonegawa, S. (2006) · Cell · doi:10.1016/j.cell.2006.06.038 · Cited by 242 · see citing works
Blackstone, C. D., Moss, S. J., Martin, L. J., Levey, A. I., Price, D. L., & Huganir, R. L. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09370.x · Cited by 240 · see citing works
Self-citationMultiple periods of functional ocular dominance plasticity in mouse visual cortex
Tagawa, Y., Kanold, P. O., Majdan, M., & Shatz, C. J. (2005) · Nature Neuroscience · doi:10.1038/nn1410 · Cited by 235 · see citing works
Rumbaugh, G., Sia, G., Garner, C., & Huganir, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04567.2003 · Cited by 197 · see citing works
Self-citationAMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc
Rao, V. R., Pintchovski, S. A., Chin, J., Peebles, C., Mitra, S. S., & Finkbeiner, S. M. (2006) · Nature Neuroscience · doi:10.1038/nn1708 · Cited by 188 · see citing works
Guzowski, J. F., Miyashita, T., Chawla, M. K., Sanderson, J. L., Maes, L. I., Houston, F. P., Lipa, P., McNaughton, B. L., Worley, P. F., & Barnes, C. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505519103 · Cited by 178 · see citing works
Self-citationA proportional but slower NMDA potentiation follows AMPA potentiation in LTP
Watt, A., Sjöström, P., Häusser, M., Nelson, S., & Turrigiano, G. (2004) · Nature Neuroscience · doi:10.1038/nn1220 · Cited by 176 · see citing works
Temporal Regulation of the Expression Locus of Homeostatic Plasticity
Wierenga, C. J., Walsh, M. F., & Turrigiano, G. G. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00107.2006 · Cited by 175 · see citing works
Ye, B., Liao, D., Zhang, X., Zhang, P., Dong, H., & Huganir, R. L. (2000) · Neuron · doi:10.1016/s0896-6273(00)81198-8 · Cited by 155 · see citing works
Self-citationPalop, J. J., Chin, J., Bien‐Ly, N., Massaro, C. M., Yeung, B. Z., Yu, G.-Q., & Mucke, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2829-05.2005 · Cited by 144 · see citing works
Synaptic homeostasis and input selectivity follow from a calcium-dependent plasticity model
Yeung, L. C., Shouval, H. Z., Blais, B. S., & Cooper, L. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405555101 · Cited by 101 · see citing works
Otani, S., & Abraham, W. C. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90222-x · Cited by 95 · see citing works
Burke, S. N., Chawla, M. K., Penner, M. R., Crowell, B. E., Worley, P. F., Barnes, C. A., & McNaughton, B. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.042 · Cited by 78 · see citing works
Self-citationChen, B., & Janes, H. W. (2002) · Humana Press eBooks · doi:10.1385/1592591779 · Cited by 35 · see citing works
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Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450 · see citing works
Self-citationThe self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533 · see citing works
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · see citing works
Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works
Self-citationArc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Self-citationThe role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement
Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671 · see citing works
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708 · see citing works
The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc
Greer, P. L., Hanayama, R., Bloodgood, B. L., Mardinly, A. R., Lipton, D. M., Flavell, S. W., Kim, T.-K., Griffith, E. C., Waldon, Z., Maehr, R., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.026 · Cited by 30 · see citing works
Self-citationLüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works
Unraveling mechanisms of homeostatic synaptic plasticity
Pozo, K., & Goda, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.028 · Cited by 565 · see citing works
Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516 · see citing works
Self-citationNeuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function
West, A. E., & Greenberg, M. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005744 · Cited by 532 · see citing works
Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., & Huber, K. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.014 · Cited by 474 · see citing works
Bramham, C. R., Alme, M. N., Bittins, M., Kuipers, S. D., Nair, R. R., Pai, B., Panja, D., Schubert, M., Soule, J., Tiron, A., et al. (2010) · Experimental Brain Research · doi:10.1007/s00221-009-1959-2 · Cited by 452 · see citing works
Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease
Cohen, S., & Greenberg, M. E. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175235 · Cited by 400 · see citing works
Arc in synaptic plasticity: from gene to behavior
Korb, E., & Finkbeiner, S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.007 · Cited by 388 · see citing works
Different Neuronal Activity Patterns Induce Different Gene Expression Programs
Tyssowski, K. M., DeStefino, N. R., Cho, J.-H., Dunn, C. J., Poston, R. G., Carty, C. E., Jones, R. D., Chang, S. M., Romeo, P., Wurzelmann, M. K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.001 · Cited by 390 · see citing works
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works
Self-citationInverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ
Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., Kawashima, T., Fujii, H., Takemoto-Kimura, S., Abe, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.062 · Cited by 310 · see citing works
Self-citationNPTX2 and cognitive dysfunction in Alzheimer’s Disease
Xiao, M.-F., Xu, D., Craig, M. T., Pelkey, K. A., Chien, C.-C., Shi, Y., Zhang, J., Resnick, S., Pletnikova, O., Salmon, D., et al. (2017) · eLife · doi:10.7554/elife.23798 · Cited by 316 · see citing works
Self-citationDendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease
Knobloch, M., & Mansuy, I. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8018-z · Cited by 296 · see citing works
Smith, S. E. P., Zhou, Y.-D., Zhang, G., Jin, Z., Stoppel, D. C., & Anderson, M. P. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002627 · Cited by 267 · see citing works
Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.041 · Cited by 273 · see citing works
Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes
Mabb, A. M., Judson, M. C., Zylka, M. J., & Philpot, B. D. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.04.001 · Cited by 263 · see citing works
Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms
Gladding, C. M., Fitzjohn, S. M., & Molnár, E. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001735 · Cited by 233 · see citing works
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
Hou, Q., Zhang, D., Jarzylo, L., Huganir, R. L., & Man, H.-Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706447105 · Cited by 179 · see citing works
Self-citationBeagan, J. A., Pastuzyn, E. D., Fernandez, L. R., Guo, M. H., Feng, K., Titus, K. R., Chandrashekar, H., Shepherd, J. D., & Phillips-Cremins, J. E. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0634-6 · Cited by 143 · see citing works
Self-citationGluA2-lacking, calcium-permeable AMPA receptors--inducers of plasticity?
Man, H.-Y. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.001 · Cited by 142 · see citing works
GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
Shin, S. M., Zhang, N., Hansen, J., Gerges, N. Z., Pak, D. T. S., Sheng, M., & Lee, S. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3259 · Cited by 126 · see citing works
Cho, R. W., Park, J. M., Wolff, S. B. E., Xu, D., Hopf, C., Kim, J.-A., Reddy, R. C., Petralia, R. S., Perin, M. S., Linden, D. J., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.010 · Cited by 125 · see citing works
Self-citationPlasticity of dendritic spines: subcompartmentalization of signaling
Colgan, L. A., & Yasuda, R. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170400 · Cited by 124 · see citing works
Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works
DNA methylation regulates neuronal glutamatergic synaptic scaling
Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D. (2015) · Science Signaling · doi:10.1126/scisignal.aab0715 · Cited by 111 · see citing works
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106 · see citing works
PICK1 loss of function occludes homeostatic synaptic scaling
Anggono, V., Clem, R. L., & Huganir, R. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5633-10.2011 · Cited by 111 · see citing works
Self-citationOrchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease
Rudinskiy, N., Hawkes, J. M., Betensky, R. A., Eguchi, M., Yamaguchi, S., Spires-Jones, T. L., & Hyman, B. T. (2012) · Nature Neuroscience · doi:10.1038/nn.3199 · Cited by 103 · see citing works
Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics
Wu, Y. K., Hengen, K. B., Turrigiano, G. G., & Gjorgjieva, J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918368117 · Cited by 86 · see citing works
Wang, Z.-J., Zhong, P., Ma, K., Seo, J.-S., Yang, F., Hu, Z., Zhang, F., Lin, L., Wang, J., Liu, T., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0351-2 · Cited by 82 · see citing works
The why and how of sleep-dependent synaptic down-selection
Cirelli, C., & Tononi, G. (2022) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2021.02.007 · Cited by 74 · see citing works
Synapse development organized by neuronal activity-regulated immediate-early genes
Kim, S., Kim, H., & Um, J. W. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0025-1 · Cited by 77 · see citing works
GRIP1 is required for homeostatic regulation of AMPAR trafficking
Tan, H. L., Queenan, B. N., & Huganir, R. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512786112 · Cited by 69 · see citing works
Self-citationCoppens, C. M., Siripornmongcolchai, T., Wibrand, K., Alme, M. N., Buwalda, B., de Boer, S. F., Koolhaas, J. M., & Bramham, C. R. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00072 · Cited by 61 · see citing works
Hyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works
How to scale down postsynaptic strength
Tatavarty, V., Sun, Q., & Turrigiano, G. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1676-13.2013 · Cited by 50 · see citing works
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses
Rudinskiy, N., Hawkes, J. M., Wegmann, S., Kuchibhotla, K. V., Muzikansky, A., Betensky, R. A., Spires-Jones, T. L., & Hyman, B. T. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-63 · Cited by 32 · see citing works
Karashima, A., Katayama, N., & Nakao, M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.060 · Cited by 20 · see citing works
BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Petrus, E., & Lee, H.-K. (2014) · Neural Plasticity · doi:10.1155/2014/128631 · Cited by 19 · see citing works
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2024) · The Neuroscientist · doi:10.1177/10738584221112336 · Cited by 17 · see citing works
Schochet, T. L., Bremer, Q. Z., Brownfield, M. S., Kelley, A. E., & Landry, C. F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06483.x · Cited by 14 · see citing works
- Authors
- Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F.
- Affiliations
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Freie Universität Berlin (DE)
- Corresponding author
- Worley, Paul F.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 52
- Issue
- 3
- Pages
- 475-484
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC1764219
- OpenAlex
- W2114559471
- Cited by
- 779
- References
- 49
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 35 · 2023: 32 · 2022: 34 · 2021: 34 · 2020: 31 · 2019: 34 · 2018: 37 · 2017: 52 · 2016: 37 · 2015: 38 · 2014: 40 · 2013: 43 · 2012: 59
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH053608, P50MH068830)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Arc/Arg3.1, homeostatic synaptic scaling, AMPA receptors, homeostatic plasticity, immediate early genes, memory consolidation, synaptic plasticity, neuronal excitability, synaptic homeostasis
- MeSH terms
- Anesthetics, Local, Animals, Bicuculline, Brain, Cells, Cultured, Cytoskeletal Proteins, Embryo, Mammalian, Endocytosis, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Neurons, Subcellular Fractions, Synapses, Tetrodotoxin, Transfection, Blotting, Western, Receptors, AMPA, Mice, Knockout, Patch-Clamp Techniques, GABA Antagonists, Biotinylation, Immunoprecipitation, Green Fluorescent Proteins, Mice, Rats
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