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Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain
Open accessAbstract
Growing evidence suggests that synaptic signaling is compromised in the aging brain and in Alzheimer's disease (AD), contributing to synaptic decline. Wnt signaling is a prominent pathway at the synapse and is required for synaptic plasticity and maintenance in the adult brain. In this review, we summarize the current knowledge on deregulation of Wnt signaling in the context of aging and AD. Emerging studies suggest that enhancing Wnt signaling could boost synaptic function during aging, and ameliorate synaptic pathology in AD. Although further research is needed to determine the precise contribution of deficient Wnt signaling to AD pathogenesis, targeting Wnt signaling components may provide novel therapeutic avenues for synapse protection or restoration in the brain.
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“Wnt signaling has also been implicated in neurological aging (Inestrosa et al., 2020) and neurological aging disorders such as AD (Palomer et al., 2019).”
From APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases (2024) · cites this paper as Palomer et al., 2019
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Metadata
- Authors
- Palomer, E., Buechler, J., & Salinas, P. C.
- Affiliations
- University College London (GB)
- Corresponding author
- Palomer, Ernest
- Salinas, Patricia C.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-05-22
- Volume
- 13
- Pages
- 227-227
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC6538920
- OpenAlex
- W2945124452
- Cited by
- 237
- References
- 63
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 46 · 2023: 35 · 2022: 42 · 2021: 35 · 2020: 23 · 2019: 2
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (102267/Z/13/Z, 102267)
- European Commission (HORIZON2020, H2020, 749209)
- Horizon 2020 Framework Programme (MSCA-IF 749209)
- Medical Research Council (MR/M024083, MR/M024083/1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Wnt signaling, Alzheimer's disease, brain aging, synaptic plasticity, synaptic dysfunction, therapeutic target
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