Premotor cortex is critical for goal-directed actions
Open accessAbstract
Shifting between motor plans is often necessary for adaptive behavior. When faced with changing consequences of one's actions, it is often imperative to switch from automatic actions to deliberative and controlled actions. The pre-supplementary motor area (pre-SMA) in primates, akin to the premotor cortex (M2) in mice, has been implicated in motor learning and planning, and action switching. We hypothesized that M2 would be differentially involved in goal-directed actions, which are controlled by their consequences vs. habits, which are more dependent on their past reinforcement history and less on their consequences. To investigate this, we performed M2 lesions in mice and then concurrently trained them to press the same lever for the same food reward using two different schedules of reinforcement that differentially bias towards the use of goal-directed versus habitual action strategies. We then probed whether actions were dependent on their expected consequence through outcome revaluation testing. We uncovered that M2 lesions did not affect the acquisition of lever-pressing. However, in mice with M2 lesions, lever-pressing was insensitive to changes in expected outcome value following goal-directed training. However, habitual actions were intact. We confirmed a role for M2 in goal-directed but not habitual actions in separate groups of mice trained on the individual schedules biasing towards goal-directed versus habitual actions. These data indicate that M2 is critical for actions to be updated based on their consequences, and suggest that habitual action strategies may not require processing by M2 and the updating of motor plans.
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Altered synaptic properties at the Cg1/M2-to-DMS input could underlie OCD-like behavioral inflexibility leading to aberrant habit formation.
“Altered synaptic properties at this input could underlie OCD-like behavioral inflexibility leading to aberrant habit formation [15] since lesioning the M2 impairs goal-directed behavior [46].”
From Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice (2020) · cites this paper as [46]
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Severino, F. P. U., Lawal, O. O., Sakers, K., Wang, S., Kim, N., Friedman, A., Johnson, S. A., Sriworarat, C., Hughes, R. N., Soderling, S. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.20.440613
Nautilus: los secretos de una antigua criatura
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Modulation of perception by visual, auditory, and audiovisual reward predicting cuesPreprint
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Self-citationChronic alcohol disrupts premotor cortex intrinsic excitability and transmission
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- Authors
- Gremel, C. M., & Costa, R. M.
- Affiliations
- National Institutes of Health (US)
- Champalimaud Foundation (PT)
- Corresponding author
- Costa, Rui M.
- Venue
- Frontiers in Computational Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 110-110
- ISSN
- 1662-5188 (ISSN-L)
- PMC
- PMC3740264
- OpenAlex
- W2095109706
- Cited by
- 75
- References
- 41
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Computational Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- National Institute on Alcohol Abuse and Alcoholism
- FP7 Ideas: European Research Council (243393)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- premotor cortex, M2, goal-directed action, habitual behavior, action switching, motor planning, reinforcement schedules, motor learning, lesion studies, mice
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