Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain

Pan, Weixing X.; Mao, Tianyi; Dudman, Joshua T.

doi:10.3389/fnana.2010.00147

Cited by 150Neurological disorders and treatmentsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain

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Pan, Weixing X., Mao, Tianyi, Dudman, Joshua T.·2010·Frontiers in Neuroanatomy

DOI 10.3389/fnana.2010.00147PMC PMC3014656

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Abstract

The basal ganglia play a critical role in the regulation of voluntary action in vertebrates. Our understanding of the function of the basal ganglia relies heavily upon anatomical information, but continued progress will require an understanding of the specific functional roles played by diverse cell types and their connectivity. An increasing number of mouse lines allow extensive identification, characterization, and manipulation of specified cell types in the basal ganglia. Despite the promise of genetically modified mice for elucidating the functional roles of diverse cell types, there is relatively little anatomical data obtained directly in the mouse. Here we have characterized the retrograde labeling obtained from a series of tracer injections throughout the dorsal striatum of adult mice. We found systematic variations in input along both the medial-lateral and anterior-posterior neuraxes in close agreement with canonical features of basal ganglia anatomy in the rat. In addition to the canonical features we have provided experimental support for the importance of non-canonical inputs to the striatum from the raphe nuclei and the amygdala. To look for organization at a finer scale we have analyzed the correlation structure of labeling intensity across our entire dataset. Using this analysis we found substantial local heterogeneity within the large-scale order. From this analysis we conclude that individual striatal sites receive varied combinations of cortical and thalamic input from multiple functional areas, consistent with some earlier studies in the rat that have suggested the presence of a combinatorial map.

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The BLA sends a direct excitatory projection to the DMS.
“It sends a direct excitatory projection to the DMS30,31.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [30]
The CeA sends a direct, likely inhibitory projection to the striatum.
“It sends a direct, likely inhibitory33, projection to the striatum30,34,35 and is, thus, poised to oppose striatal activity.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [30]
DMS D1 and A2A neurons receive projections from BLA and CeA.
“rabies-labeled, DMS D1-projecting cell bodies in the BLA and CeA (right), consistent with prior reports30,34.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [30]

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Neuroanatomical And Neurochemical Organization Of Compartments In The Basal Ganglia Of The Rat
Rajakumar, N. (1993) · Scholarship@Western (Western University)
Reviewed by:
Pan, W. X., Mao, T., Dudman, J. T., Lanciego, J. L., Elena, M., Aguirre, E., & Salud, N. D. (2010)
Self-citation
The functional organisation of basal ganglia inputs
Johansson, Y. (2020) · Figshare
Limbic-Basal Ganglia Circuits Parallel and Integrative Aspects
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Authors: Pan, W. X., Mao, T., & Dudman, J. T.
Affiliations: Howard Hughes Medical Institute (US)
Oregon Health & Science University (US)
Corresponding author: Dudman, Joshua T.
ORCID: Mao, Tianyi
Dudman, Joshua T.
Venue: Frontiers in Neuroanatomy
Publisher: Frontiers Media SA
Published: 2010
Volume: 4
Pages: 147-147
ISSN: 1662-5129 (ISSN-L)
DOI: 10.3389/fnana.2010.00147
PMC: PMC3014656
OpenAlex: W2128290890
Cited by: 150
References: 84
Citations by year: 2026: 5 · 2025: 16 · 2024: 8 · 2023: 18 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 12 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 4
FWCI: 3.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroanatomy (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dorsal striatum, basal ganglia, retrograde tracing, parallel circuits, raphe nuclei, amygdala, cortical input, thalamic input, mice

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Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain

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