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Biocompatibility of intracortical microelectrodes: current status and future prospects
Open accessAbstract
Rehabilitation of sensory and/or motor functions in patients with neurological diseases is more and more dealing with artificial electrical stimulation and recording from populations of neurons using biocompatible chronic implants. As more and more patients have benefited from these approaches, the interest in neural interfaces has grown significantly. However an important problem reported with all available microelectrodes to date is long-term viability and biocompatibility. Therefore it is essential to understand the signals that lead to neuroglial activation and create a targeted intervention to control the response, reduce the adverse nature of the reactions and maintain an ideal environment for the brain-electrode interface. We discuss some of the exciting opportunities and challenges that lie in this intersection of neuroscience research, bioengineering, neurology and biomaterials.
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“The results therefore suggest that silicon-based, penetrating microelectrode arrays could provide the stability required in a clinical device (11, 32-34) but further investigations in more subjects and over a longer period of time are needed.”
From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [32]
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Metadata
- Authors
- Marin, C.
- Affiliations
- Universitat de Miguel Hernández d'Elx (ES)
- Corresponding author
- Marin, Cristina
- Venue
- Frontier in Neuroengineering
- Publisher
- Frontiers Media SA
- Published
- 2010
- Volume
- 3
- Pages
- 8-8
- ISSN
- 1662-6443 (ISSN-L)
- PMC
- PMC2889721
- OpenAlex
- W2071949955
- Cited by
- 160
- References
- 62
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 3 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 11 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 8
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroengineering (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Social Sciences › Education › Undergraduate Neuroscience Education and Research
- Keywords
- intracortical microelectrodes, biocompatibility, neural interfaces, neural recording, electrical stimulation, biomaterials
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