Cited by 160Neuroscience and Neural EngineeringEEG and Brain-Computer InterfacesUndergraduate Neuroscience Education and Research

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Biocompatibility of intracortical microelectrodes: current status and future prospects

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Marin, Cristina·2010·Frontier in Neuroengineering

DOI 10.3389/fneng.2010.00008PMC PMC2889721

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Abstract

Rehabilitation of sensory and/or motor functions in patients with neurological diseases is more and more dealing with artificial electrical stimulation and recording from populations of neurons using biocompatible chronic implants. As more and more patients have benefited from these approaches, the interest in neural interfaces has grown significantly. However an important problem reported with all available microelectrodes to date is long-term viability and biocompatibility. Therefore it is essential to understand the signals that lead to neuroglial activation and create a targeted intervention to control the response, reduce the adverse nature of the reactions and maintain an ideal environment for the brain-electrode interface. We discuss some of the exciting opportunities and challenges that lie in this intersection of neuroscience research, bioengineering, neurology and biomaterials.

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Authors: Marin, C.
Affiliations: Universitat de Miguel Hernández d'Elx (ES)
Corresponding author: Marin, Cristina
Venue: Frontier in Neuroengineering
Publisher: Frontiers Media SA
Published: 2010
Volume: 3
Pages: 8-8
ISSN: 1662-6443 (ISSN-L)
DOI: 10.3389/fneng.2010.00008
PMC: PMC2889721
OpenAlex: W2071949955
Cited by: 160
References: 62
Citations by year: 2026: 5 · 2025: 13 · 2024: 3 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 11 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 8
FWCI: 4.27
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Frontiers in Neuroengineering (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Social Sciences › Education › Undergraduate Neuroscience Education and Research
Keywords: intracortical microelectrodes, biocompatibility, neural interfaces, neural recording, electrical stimulation, biomaterials

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Biocompatibility of intracortical microelectrodes: current status and future prospects

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