Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia
Open accessAbstract
Vascular dementia (VaD), the second most common cause of cognitive impairment in the population, is a disease that results from reduction in regional cerebral blood flow and involves oxidative stress and inflammation. Co-ultramicronized PEALut (co-ultra PEALut) is a new compound with beneficial effects, which include anti-inflammatory and anti-oxidant properties. Recently, co-ultraPEALut has been shown to exhibit neuroprotective effects in models of Parkinson's disease, cerebral ischemia and Alzheimer's disease. However, its effects on VaD remain unknown. Therefore, the purpose of the present study was to highlight the potential neuroprotective actions of co-ultraPEALut containing N-Palmitoylethanolamine (PEA) and the anti-oxidant flavonoid luteolin (Lut) (10:1 by mass) in a mouse model of VaD induced by bilateral carotid arteries occlusion. At 24 hours after VaD induction, mice were orally treated with 1 mg/kg co-ultraPEALut daily for 15 days. On the 15th day, brain tissues were processed for histological, immunohistochemical, western blot and immunofluorescent analysis. Our results clearly demonstrate that co-ultraPEALut improved learning, memory ability, locomotor activity and the reciprocal social interaction. In addition, the mice subjected to VaD and treated with the co-ultraPEALut showed a reorganization of CA1 and CA3 regions of the hippocampus and restored the number of hippocampal neurons as evidenced by NeuN expression, a specific marker of neurons. Furthermore following carotid arteries ligation, mice treated with co-ultraPEALut, showed a modification of pro-inflammatory, pro-apoptotic proteins and of oxidative stress as evidenced by the expression of IκB-α, NF-κB p65, Bax , Bcl-2, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). In order, co-ultraPEALut treatment restored VaD-induced loss of brain-derived neurotrophic factor (BDNF) and neurotrophins 3 (NT-3) expression in mice. These results confirmed that the neuroprotective effects of co-ultraPEALut were associated with its anti-inflammatory and anti-oxidant properties.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Luteolin improves cognitive abilities in a mouse model of vascular dementia by modulating pro-inflammatory and pro-apoptotic proteins and stimulating neurogenesis.
“luteolin has been demonstrated to improve cognitive abilities in a mouse model of vascular dementia by modulating the expression of pro-inflammatory and pro-apoptotic proteins and by stimulating neurogenesis (Siracusa et al., 2017; Cordaro et al., 2020)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Siracusa et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Daulatzai, M. A. (2016) · Europe PMC (PubMed Central) · Cited by 60 · see citing works
RetractedSiracusa, R., Paterniti, I., Bruschetta, G., Cordaro, M., Impellizzeri, D., Crupi, R., Cuzzocrea, S., & Esposito, E. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9328-6 · Cited by 33 · see citing works
Self-citationRetractedFree Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956 · see citing works
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain
Chan, P. H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200101000-00002 · Cited by 1,589 · see citing works
The orphan receptor GPR55 is a novel cannabinoid receptor
Ryberg, E., Larsson, N., Sjögren, S., Hjorth, S., Hermansson, N., Leonova, J., Elebring, T., Nilsson, K., Drmota, T., & Greasley, P. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707460 · Cited by 1,568 · see citing works
Leptin-regulated endocannabinoids are involved in maintaining food intake
Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559 · see citing works
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Dietary agents in cancer prevention: flavonoids and isoflavonoids
Birt, D. F., Hendrich, S., & Wang, W. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00137-1 · Cited by 1,172 · see citing works
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
Gu, Z., Kaul, M., Yan, B., Kridel, S. J., Cui, J., Strongin, A., Smith, J. W., Liddington, R. C., & Lipton, S. A. (2002) · Science · doi:10.1126/science.1073634 · Cited by 950 · see citing works
Emerging roles of PPARS in inflammation and immunity
Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 922 · see citing works
Lo Verme, J., Fu, J., Astarita, G., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006353 · Cited by 882 · see citing works
Finucane, D., Bossy‐Wetzel, E., Waterhouse, N. J., Cotter, T. G., & Green, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2225 · Cited by 714 · see citing works
Nerve growth factor: from neurotrophin to neurokine
Levi‐Montalcini, R., Skaper, S. D., Toso, R. D., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 684 · see citing works
Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin
Seelinger, G., Merfort, I., & Schempp, C. M. (2008) · Planta Medica · doi:10.1055/s-0028-1088314 · Cited by 562 · see citing works
The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia: Two Roads Converged
Craft, S. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.27 · Cited by 547 · see citing works
Incidence of dementia: does gender make a difference?
Ruitenberg, A., Ott, A., van Swieten, J. C., Hofman, A., & Breteler, M. M. B. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00231-7 · Cited by 467 · see citing works
Iannotti, F. A., Marzo, V. D., & Petrosino, S. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.02.002 · Cited by 357 · see citing works
Self-citationXagorari, A., Papapetropoulos, A., Mauromatis, A., Economou, M., Fotsis, T., & Roussos, C. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29679-8 · Cited by 294 · see citing works
Bisogno, T., Sepe, N., Melck, D. J., Maurelli, S., PETROCELLIS, L. D., & Marzo, V. D. (1997) · Biochemical Journal · doi:10.1042/bj3220671 · Cited by 273 · see citing works
The role of microglia and myeloid immune cells in acute cerebral ischemia
Benakis, C., García‐Bonilla, L., Iadecola, C., & Anrather, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00461 · Cited by 249 · see citing works
Fujii, M., Hara, H., Meng, W., Vonsattel, J. P., Huang, Z., & Moskowitz, M. A. (1997) · Stroke · doi:10.1161/01.str.28.9.1805 · Cited by 243 · see citing works
Angiotensin-Converting Enzyme and Vascular Remodeling
Heeneman, S., Sluimer, J. C., & Daemen, M. J. A. P. (2007) · Circulation Research · doi:10.1161/circresaha.107.148338 · Cited by 223 · see citing works
N-Acylethanolamines and precursor phospholipids — relation to cell injury
Hansen, H. S., Moesgaard, B., Hansen, H. H., & Petersen, G. L. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00192-4 · Cited by 222 · see citing works
Vascular Dementia: Distinguishing Characteristics, Treatment, and Prevention
Román, G. C. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.5155.x · Cited by 219 · see citing works
A proposed autacoid mechanism controlling mastocyte behaviour
Aloe, L., Leon, A., & Levi‐Montalcini, R. (1993) · Inflammation Research · doi:10.1007/bf01972748 · Cited by 209 · see citing works
Cardiovascular Risk Factors and Incident Alzheimer Disease: A Systematic Review of the Literature
Purnell, C., Gao, S., Callahan, C. M., & Hendrie, H. C. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318187541c · Cited by 189 · see citing works
Astrocytes in Culture Produce Anandamide and Other Acylethanolamides
Walter, L. M., Franklin, A. A., Witting, A., Möller, T., & Stella, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110813200 · Cited by 186 · see citing works
Inflammasomes link vascular disease with neuroinflammation and brain disorders
Lénárt, N., Brough, D., & Dénes, Á. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16662043 · Cited by 169 · see citing works
Palmitoylethanolamide in CNS health and disease
Raso, G. M., Russo, R., Calignano, A., & Meli, R. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.05.006 · Cited by 148 · see citing works
Kumazawa, Y., Kawaguchi, K., & Takimoto, H. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778743565 · Cited by 146 · see citing works
Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease
Esposito, E., Impellizzeri, D., Mazzon, E., Paterniti, I., & Cuzzocrea, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041880 · Cited by 144 · see citing works
Self-citationBotton, P. H., Costa, M. S., Ardais, A. P., Mioranzza, S., Souza, D. O., da Rocha, J. B. T., & Porciúncula, L. O. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.034 · Cited by 140 · see citing works
Vascular Cognitive Impairment: Disease Mechanisms and Therapeutic Implications
Levine, D. A., & Langa, K. M. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0047-z · Cited by 130 · see citing works
Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment
Wang, J., Zhang, H., & Tang, X.-C. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.82 · Cited by 124 · see citing works
Paterniti, I., Impellizzeri, D., Crupi, R., Morabito, R., Campolo, M., Esposito, E., & Cuzzocrea, S. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-20 · Cited by 113 · see citing works
Self-citationEnhanced Poly(ADP-ribosyl)ation after Focal Ischemia in Rat Brain
Tokime, T., Nozaki, K., Sugino, T., Kikuchi, H., Hashimoto, N., & Ueda, K. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199809000-00008 · Cited by 111 · see citing works
N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution
Skaper, S. D., Facci, L., Barbierato, M., Zusso, M., Bruschetta, G., Impellizzeri, D., Cuzzocrea, S., & Giusti, P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9253-8 · Cited by 110 · see citing works
Self-citationStroke Study Group, Caltagirone, C., Cisari, C., Schievano, C., Paola, R. D., Cordaro, M., Bruschetta, G., Esposito, E., & Cuzzocrea, S. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0440-8 · Cited by 98 · see citing works
Self-citationPaterniti, I., Impellizzeri, D., Paola, R. D., Navarra, M., Cuzzocrea, S., & Esposito, E. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-91 · Cited by 93 · see citing works
Self-citationLerouet, D., Beray‐Berthat, V., Palmier, B., Plotkine, M., & Margaill, I. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03685-5 · Cited by 92 · see citing works
Palmitoylethanolamide in Homeostatic and Traumatic Central Nervous System Injuries
Esposito, E., & Cuzzocrea, S. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312010010 · Cited by 92 · see citing works
Self-citationMannelli, L. D. C., Pacini, A., Corti, F., Boccella, S., Luongo, L., Esposito, E., Cuzzocrea, S., Maione, S., Calignano, A., & Ghelardini, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128080 · Cited by 91 · see citing works
Self-citationPaterniti, I., Cordaro, M., Campolo, M., Siracusa, R., Cornelius, C., Navarra, M., Cuzzocrea, S., & Esposito, E. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140806124322 · Cited by 90 · cited 5× · see citing works
“Esposito E, Impellizzeri D, Mazzon E, Paterniti I, Cuzzocrea S. Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson’s disease.”
BackgroundInfluentialSelf-citationAhmad, A., Crupi, R., Impellizzeri, D., Campolo, M., Marino, A., Esposito, E., & Cuzzocrea, S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.021 · Cited by 87 · see citing works
Self-citationVascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions
Villeneuve, S., Reed, B., Madison, C. M., Wirth, M., Marchant, N. L., Kriger, S., Mack, W. J., Sanossian, N., DeCarli, C. S., Chui, H. C., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000550 · Cited by 87 · see citing works
Liu, H., Yang, X., Tang, R., Liu, J., & Xu, H. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2004.09.001 · Cited by 85 · see citing works
Microglia produce and hydrolyze palmitoylethanolamide
Muccioli, G. G., & Stella, N. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.015 · Cited by 82 · see citing works
Siracusa, R., Paterniti, I., Impellizzeri, D., Cordaro, M., Crupi, R., Navarra, M., Cuzzocrea, S., & Esposito, E. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150821102823 · Cited by 78 · see citing works
Self-citationKowaltowski, A. J., Fenton, R. G., & Fiskum, G. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.005 · Cited by 78 · see citing works
Cordaro, M., Impellizzeri, D., Paterniti, I., Bruschetta, G., Siracusa, R., Stefano, D. D., Cuzzocrea, S., & Esposito, E. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3460 · Cited by 74 · see citing works
Self-citationYuan, Y., Fang, M., Wu, C., & Ling, E. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8394-x · Cited by 55 · see citing works
Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo
Helman, A. M., & Murphy, M. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.009 · Cited by 54 · see citing works
Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential
Nestmann, E. R. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.392 · Cited by 54 · see citing works
Akanuma, K., Meguro, K., Meguro, M., Sasaki, E., Chiba, K., Ishii, H., & Tanaka, N. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.11.012 · Cited by 52 · see citing works
Moss, M. A., Varvel, N. H., Nichols, M. R., Reed, D. K., & Rosenberry, T. L. (2004) · PubMed · doi:10.1124/mol.66.3 · Cited by 37 · see citing works
Establishment of an animal model of vascular dementia
Wang, H. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1926 · Cited by 19 · see citing works
Cognitive Decline and Dementia
Claassen, J. A. H. R. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04706 · Cited by 14 · see citing works
[Demographic evolution, aging and frailty].
Cicconetti, P., Riolo, N., Ettorre, E., Costarella, M., Priami, C., & Marigliano, V. (2003) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?
Stuckey, S. M., Ong, L. K., Collins‐Praino, L. E., & Turner, R. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313101 · Cited by 157 · see citing works
早坂夏実, Shimizu, N., Komoda, T., Mohri, S., Tsushida, T., Eitsuka, T., Miyazawa, T., & Nakagawa, K. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03273 · Cited by 107 · see citing works
Vascular dementia: A microglia's perspective
Yang, Y. R., Zhao, X., Zhu, Z., & Zhang, L. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101734 · Cited by 103 · see citing works
Management of Traumatic Brain Injury: From Present to Future
Crupi, R., Cordaro, M., Cuzzocrea, S., & Impellizzeri, D. (2020) · Antioxidants · doi:10.3390/antiox9040297 · Cited by 91 · see citing works
Self-citationPetrosino, S., Cordaro, M., Verde, R., Moriello, A. S., Marcolongo, G., Schievano, C., Siracusa, R., Piscitelli, F., Peritore, A. F., Crupi, R., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00249 · Cited by 89 · see citing works
Self-citationImpellizzeri, D., Siracusa, R., Cordaro, M., Crupi, R., Peritore, A. F., Gugliandolo, E., D’Amico, R., Petrosino, S., Evangelista, M., Paola, R. D., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.007 · Cited by 83 · see citing works
Self-citationEvaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice
Gugliandolo, E., Peritore, A. F., D’Amico, R., Licata, P., & Crupi, R. (2020) · Animals · doi:10.3390/ani10050898 · Cited by 80 · see citing works
Self-citationPiccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
Gugliandolo, E., Fusco, R., D’Amico, R., Militi, A., Oteri, G., Wallace, J. L., Paola, R. D., & Cuzzocrea, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.022 · Cited by 70 · see citing works
Self-citationImpellizzeri, D., Peritore, A. F., Cordaro, M., Gugliandolo, E., Siracusa, R., Crupi, R., D’Amico, R., Fusco, R., Evangelista, M., Cuzzocrea, S., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900538r · Cited by 69 · see citing works
Self-citationHidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model
Fusco, R., Salinaro, A. T., Siracusa, R., D’Amico, R., Impellizzeri, D., Scuto, M. C., Ontario, M. L., Crea, R., Cordaro, M., Cuzzocrea, S., et al. (2021) · Antioxidants · doi:10.3390/antiox10050778 · Cited by 68 · see citing works
Self-citationSinha, K., Sun, C. E., Kamari, R., & Bettermann, K. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.01.003 · Cited by 63 · see citing works
Fusco, R., Gugliandolo, E., Siracusa, R., Scuto, M. C., Cordaro, M., D’Amico, R., Evangelista, M., Peli, A., Peritore, A. F., Impellizzeri, D., et al. (2020) · Biology · doi:10.3390/biology9090238 · Cited by 63 · see citing works
Self-citationRetractedD’Amico, R., Impellizzeri, D., Cuzzocrea, S., & Paola, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155330 · Cited by 62 · see citing works
Self-citationInfantino, R., Schiano, C., Luongo, L., Paino, S., Mansueto, G., Boccella, S., Guida, F., Ricciardi, F., Iannotta, M., Belardo, C., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105611 · Cited by 61 · see citing works
Peritore, A. F., Crupi, R., Scuto, M. C., Gugliandolo, E., Siracusa, R., Impellizzeri, D., Cordaro, M., D’Amico, R., Fusco, R., Paola, R. D., et al. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200107094732 · Cited by 58 · see citing works
Self-citationMa, X., Wang, Y., Shi, Y., Li, S., Liu, J., Li, X., Zhong, W., & Pan, Q. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02995-w · Cited by 59 · see citing works
Clinical Trials of New Drugs for Vascular Cognitive Impairment and Vascular Dementia
Linh, T. T. D., Hsieh, Y., Huang, L., & Hu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911067 · Cited by 56 · see citing works
D’Amico, R., Fusco, R., Siracusa, R., Impellizzeri, D., Peritore, A. F., Gugliandolo, E., Interdonato, L., Sforza, A. M., Crupi, R., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126471 · Cited by 51 · see citing works
Self-citationTREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia
Wang, Q., Yang, W., Zhang, J., Zhao, Y., & Xu, Y. (2020) · Neural Plasticity · doi:10.1155/2020/8834275 · Cited by 51 · see citing works
Atrazine Inhalation Causes Neuroinflammation, Apoptosis and Accelerating Brain Aging
Genovese, T., Siracusa, R., Fusco, R., D’Amico, R., Impellizzeri, D., Peritore, A. F., Crupi, R., Gugliandolo, E., Morabito, R., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157938 · Cited by 49 · see citing works
Self-citationCordaro, M., D’Amico, R., Fusco, R., Peritore, A. F., Genovese, T., Interdonato, L., Franco, G. A., Arangia, A., Gugliandolo, E., Crupi, R., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10061448 · Cited by 48 · see citing works
Self-citationSiracusa, R., Impellizzeri, D., Cordaro, M., Gugliandolo, E., Peritore, A. F., Paola, R. D., & Cuzzocrea, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00871 · Cited by 43 · see citing works
Self-citationThe Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia
Altahrawi, A. Y., James, A. W., & Shah, Z. A. (2025) · Cells · doi:10.3390/cells14080609 · Cited by 41 · see citing works
Contarini, G., Franceschini, D., Facci, L., Barbierato, M., Giusti, P., & Zusso, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1514-4 · Cited by 38 · see citing works
Facchinetti, R., Valenza, M., Bronzuoli, M. R., Menegoni, G., Ratano, P., Steardo, L., Campolongo, P., & Scuderi, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113802 · Cited by 38 · see citing works
Colizzi, M., Bortoletto, R., Colli, C., Bonomo, E., Pagliaro, D., Maso, E., Gennaro, G. D., & Balestrieri, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1038122 · Cited by 35 · see citing works
N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice
Crupi, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Casili, G., Evangelista, M., & Cuzzocrea, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0959-2 · Cited by 34 · see citing works
Self-citationImpellizzeri, D., D’Amico, R., Fusco, R., Genovese, T., Peritore, A. F., Gugliandolo, E., Crupi, R., Interdonato, L., Paola, D. D., Paola, R. D., et al. (2022) · Cells · doi:10.3390/cells11162616 · Cited by 31 · see citing works
Self-citationWound healing effects of methanol extract ofLaurocerasus officinalisroem
Ayla, Ş., Okur, M. E., Günal, M. Y., Özdemir, E. M., Polat, D. Ç., Yoltaş, A., Biçeroğlu, Ö., & Karahüseyinoğlu, S. (2018) · Biotechnic & Histochemistry · doi:10.1080/10520295.2018.1539242 · Cited by 29 · see citing works
Hohmann, U., Pelzer, M., Kleine, J., Hohmann, T., Ghadban, C., & Dehghani, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01180 · Cited by 29 · see citing works
Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury
Campolo, M., Crupi, R., Cordaro, M., Cardali, S., Ardizzone, A., Casili, G., Scuderi, S., Siracusa, R., Esposito, E., Conti, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168717 · Cited by 28 · see citing works
Self-citationD’Amico, R., Impellizzeri, D., Genovese, T., Fusco, R., Peritore, A. F., Crupi, R., Interdonato, L., Franco, G. A., Marino, Y., Arangia, A., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02982-5 · Cited by 28 · see citing works
Self-citationSiracusa, R., Monaco, F. L., D’Amico, R., Genovese, T., Cordaro, M., Interdonato, L., Gugliandolo, E., Peritore, A. F., Crupi, R., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136879 · Cited by 27 · see citing works
Self-citationPark, S., Kang, J., Kim, J. M., Kim, H.-J., & Heo, H. (2021) · Marine Drugs · doi:10.3390/md19030131 · Cited by 22 · see citing works
Wang, D., Yin, H., Kang, K., Lin, Q. D., Su, S., & Hai, J. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.06.012 · Cited by 27 · see citing works
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
Nobili, S., Micheli, L., Lucarini, E., Toti, A., Ghelardini, C., & Mannelli, L. D. C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108649 · Cited by 22 · see citing works
Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury
Genovese, T., Duranti, A., D’Amico, R., Fusco, R., Impellizzeri, D., Peritore, A. F., Crupi, R., Gugliandolo, E., Cuzzocrea, S., Paola, R. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052781 · Cited by 18 · see citing works
Self-citationGenovese, T., Siracusa, R., D’Amico, R., Cordaro, M., Peritore, A. F., Gugliandolo, E., Crupi, R., Salinaro, A. T., Raffone, E., Impellizzeri, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115998 · Cited by 17 · see citing works
Self-citationD’Amico, R., Fusco, R., Cordaro, M., Interdonato, L., Crupi, R., Gugliandolo, E., Paola, D. D., Peritore, A. F., Siracusa, R., Impellizzeri, D., et al. (2022) · Antioxidants · doi:10.3390/antiox11112129 · Cited by 18 · see citing works
Self-citationZhang, M., Huang, S., He, W.-Y., Cao, W., Sun, M.-Y., & Zhu, N.-W. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s452045 · Cited by 17 · see citing works
Wu, X., Liu, Y., Zhu, L., Wang, Y., Ren, Y., Cheng, B., Ren, L., Ge, K., & Li, H. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s311760 · Cited by 16 · see citing works
Liao, Y., Chen, J., Long, J.-Y., Zhou, Y., Liang, B., & Zhou, Y. (2020) · BioMed Research International · doi:10.1155/2020/2702175 · Cited by 15 · see citing works
Therapeutic Expedition of Luteolin against Brain-related Disorders: An Updated Review
Singh, N. K., Bhushan, B., Singh, P., & Sahu, K. K. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073303342240409060918 · Cited by 14 · see citing works
Facci, L., Barbierato, M., Fusco, M., Giusti, P., & Zusso, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.698133 · Cited by 11 · see citing works
Pan, Q., Wang, Y., Xiang, Z., Yin, Y., Deng, Y., Xiao, K., Xu, X., Wang, Y., Deng, G., Wang, X., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02073-1 · Cited by 10 · see citing works
Inflammatory pathways in patients with post-acute sequelae of COVID-19
Elliott, M., O'Connor, A. E., & Marshall, G. D. (2024) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2024.08.021 · Cited by 10 · see citing works
Aberrant Distributions of Collagen I, III, and IV in Hirschsprung Disease
Gao, N., Wang, J., Zhang, Q., Zhou, T., Mu, W., Hou, P., Wang, D., Lv, X., & Li, A. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002627 · Cited by 10 · see citing works
Siracusa, R., D’Amico, R., Fusco, R., Impellizzeri, D., Peritore, A. F., Gugliandolo, E., Crupi, R., Interdonato, L., Cordaro, M., Cuzzocrea, S., et al. (2022) · Antioxidants · doi:10.3390/antiox11122355 · Cited by 9 · see citing works
Self-citationGenovese, T., Duranti, A., Monaco, F. L., Siracusa, R., Fusco, R., Impellizzeri, D., D’Amico, R., Cordaro, M., Cuzzocrea, S., & Paola, R. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210125 · Cited by 8 · see citing works
Self-citationInterdonato, L., Marino, Y., Impellizzeri, D., D’Amico, R., Siracusa, R., Fusco, R., Cammilleri, G., Pantano, L., Modafferi, S., Abdelhameed, A. S., et al. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1320960 · Cited by 8 · see citing works
Self-citationPirro, M., Ferri, L. F., Piccioni, L., Bellucci, A. M., Bartolucci, F., Russo, A., Piga, A., Ciaramaglia, P. L., Lucangeli, M., Russo, A. M., et al. (2023) · Nutrients · doi:10.3390/nu15173701 · Cited by 13 · see citing works
Self-citationYuan, P., Chen, W., Wang, X., Li, L., Peng, Z., Mu, S., You, M., & Xu, H. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2259480 · Cited by 7 · see citing works
Cenacchi, V., Furlanis, G., Menichelli, A., Lunardelli, A., Pesavento, V., & Manganotti, P. (2024) · Brain Sciences · doi:10.3390/brainsci14030293 · Cited by 7 · see citing works
Increased Fibronectin Impairs the Function of Excitatory/Inhibitory Synapses in Hirschsprung Disease
Gao, N., Hou, P., Wang, J., Zhou, T., Wang, D., Zhang, Q., Mu, W., Lv, X., & Li, A. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00759-4 · Cited by 7 · see citing works
LncRNA MALAT1 Targets miR-9-3p to Upregulate SAP97 in the Hippocampus of Mice with Vascular Dementia
Wang, P., Mao, S., Yi, T., & Wang, L. (2022) · Biochemical Genetics · doi:10.1007/s10528-022-10289-2 · Cited by 8 · see citing works
Koriem, K. M. M., & El-Soury, N. H. T. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137652 · Cited by 6 · see citing works
Wang, Y., Zhao, J., Guo, Q., Yin, Y., Tian, W., Wang, X., Deng, G., Pan, Q., & Ma, X. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115224 · Cited by 7 · see citing works
Du, M., Wang, X., Ma, F., Li, F., Li, H., Li, F., Zhang, A., & Gao, Y. (2022) · Journal of Cardiac Surgery · doi:10.1111/jocs.16248 · Cited by 6 · see citing works
Wang, Y., Wu, Z., He, Y., Zeng, X., Gu, Z., Zhou, X., Si, W., & Chen, D. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102428 · Cited by 4 · see citing works
Keskin, A., Acar, G., Aladag, T., Onal, U., Baltacı, S. B., Moğulkoç, R., & Baltacı, A. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05050-w · Cited by 4 · see citing works
Meenu, M., Virmani, T., Singh, L., & Kaushik, R. (2023) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.13.3.18 · Cited by 2 · see citing works
Melik-Kasumov, T. B., Korneeva, M. A., Chuprina, A. V., Zhabinskaya, A. A., & Rozhko, A. A. (2022) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093022020132 · Cited by 1 · see citing works
Ma, X., Wang, Y., Shi, Y., Li, S., Liu, J., Li, X., Zhong, W., & Pan, Q. (2022) · Figshare · doi:10.6084/m9.figshare.20324758
The Prospects of Palmitylethanolamide in Tumor Prevention and Treatment
Pan, Y., Wei, P., Li, Z., Wang, J., & Wang, X. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s549752
- Authors
- Siracusa, R., Impellizzeri, D., Cordaro, M., Crupi, R., Esposito, E., Petrosino, S., & Cuzzocrea, S.
- Affiliations
- University of Messina (IT)
- Istituto di Chimica Biomolecolare (IT)
- Corresponding author
- Cuzzocrea, Salvatore
- ORCID
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2017-06-06
- Volume
- 8
- Pages
- 233-233
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC5460147
- OpenAlex
- W2623874973
- Cited by
- 65
- References
- 65
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 16 · 2021: 10 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 1
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università degli Studi di Messina
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- vascular dementia, N-palmitoylethanolamine, luteolin, neuroprotection, anti-inflammatory activity, oxidative stress, bilateral common carotid artery occlusion, hippocampal neuroprotection, brain-derived neurotrophic factor, neurotrophin-3, NF-κB signaling, apoptosis, learning and memory, social interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review