Cited by 140Memory and Neural MechanismsCoffee research and impactsSleep and Wakefulness Research

Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice

Botton, Paulo Henrique, Costa, Marcelo S., Ardais, Ana Paula, Mioranzza, Sabrina, Souza, Diogo O., da Rocha, João Batista Teixeira, Porciúncula, Lisiane O.·2010·Behavioural Brain Research

Abstract

Caffeine is a psychostimulant with positive effects on cognition. Recent studies have suggested the participation of the cholinergic system in the effects of caffeine on wakefulness. However, there are few studies assessing the contribution of cholinergic system in the cognitive enhancer properties of caffeine. In the present study, the effects of a dose and schedule of administration of caffeine that improved memory recognition were investigated on scopolamine-induced impairment of memory in adult mice. Inhibitory avoidance and novel object recognition tasks were used to assess learning and memory. Caffeine (10mg/kg, i.p.) was administered during 4 consecutive days, and the treatment was interrupted 24h before scopolamine administration (2mg/kg, i.p.). Scopolamine was administered prior to or immediately after training. Short-term and long-term memory was evaluated in both tasks. In the novel object recognition task, pre treatment with caffeine prevented the disruption of short- and long-term memory by scopolamine. In the inhibitory avoidance task, caffeine prevented short- but not long-term memory disruption by pre training administration of scopolamine. Caffeine prevented short- and long-term memory disruption by post training administration of scopolamine. Both treatments did not affect locomotor activity of the animals. These findings suggest that acute treatment with caffeine followed by its withdrawal may be effective against cholinergic-induced disruption of memory assessed in an aversive and non-aversive task. Finally, our results revealed that the cholinergic system is involved in the positive effects of caffeine on cognitive functions.

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Crossref · 10.1016/j.bbr.2010.05.034

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  • Caffeine is effective in counteracting scopolamine-induced memory impairment in humans and animals.

    “Caffeine, a much more commonly used psychostimulant, was found to be effective in counteracting scopolamine-induced memory impairment in humans and animals [112,113], while no study has been performed to evaluate efficacy of caffeine in the management of MS alone or in combination with scopolamine and antihistamines.”

    From Motion Sickness: Current Knowledge and Recent Advance. (2016) · cites this paper as [112]

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Authors
Botton, P. H., Costa, M. S., Ardais, A. P., Mioranzza, S., Souza, D. O., da Rocha, J. B. T., & Porciúncula, L. O.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Porciúncula, Lisiane O.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2010-12
Volume
214
Issue
2
Pages
254-259
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2004980098
Cited by
140
References
48
Citations by year
2026: 7 · 2025: 11 · 2024: 10 · 2023: 16 · 2022: 8 · 2021: 5 · 2020: 15 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 15
FWCI
6.40
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
caffeine, scopolamine, memory consolidation, cholinergic system, passive avoidance, novel object recognition, short-term memory, long-term memory, cognitive enhancement, memory impairment, locomotor activity, mice
MeSH terms
Animals, Avoidance Learning, Caffeine, Drug Administration Schedule, Drug Interactions, Male, Memory, Mice, Inbred Strains, Motor Activity, Scopolamine, Recognition, Psychology, Mice

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