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Cited by 92Advanced MRI Techniques and ApplicationsFunctional Brain Connectivity StudiesNeural dynamics and brain function

Relation between functional magnetic resonance imaging (fMRI) and single neuron, local field potential (LFP) and electrocorticography (ECoG) activity in human cortex

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Ojemann, George A., Ojemann, Jeffrey, Ramsey, Nick F.·2013·Frontiers in Human Neuroscience
DOI 10.3389/fnhum.2013.00034PMC PMC3576621
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Abstract

The relation between changes in the blood oxygen dependent metabolic changes imaged by functional magnetic resonance imaging (fMRI) and neural events directly recorded from human cortex from single neurons, local field potentials (LFPs) and electrocorticogram (ECoG) is critically reviewed, based on the published literature including findings from the authors' laboratories. All these data are from special populations, usually patients with medically refractory epilepsy, as this provides the major opportunity for direct cortical neuronal recording in humans. For LFP and ECoG changes are often sought in different frequency bands, for single neurons in frequency of action potentials. Most fMRI studies address issues of functional localization. The relation of those findings to localized changes in neuronal recordings in humans has been established in several ways. Only a few studies have directly compared changes in activity from the same sites in the same individual, using the same behavioral measure. More often the comparison has been between fMRI and electrophysiologic changes in populations recorded from the same functional anatomic system as defined by lesion effects; in a few studies those systems have been defined by fMRI changes such as the "default" network. The fMRI-electrophysiologic relationships have been evaluated empirically by colocalization of significant changes, and by quantitative analyses, often multiple linear regression. There is some evidence that the fMRI-electrophysiology relationships differ in different cortical areas, particularly primary motor and sensory cortices compared to association cortex, but also within areas of association cortex. Although crucial for interpretation of fMRI changes as reflecting neural activity in human cortex, controversy remains as to these relationships. Supported by: Dutch Technology Foundation and University of Utrecht Grant UGT7685, ERC-Advanced grant 320708 (NR) and NIH grant NS065186 (JO).

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  • Gamma activity has been shown to correlate with brain activation and fMRI both in primary sensory motor cortices and in association cortex.

    “Nevertheless, gamma activity has been shown to correlate with brain activation and fMRI both in primary sensory motor cortices and in association cortex (see recent review by Ojemann and cooleague; Ojemann, Ojemann, & Ramsey, 2013).”

    From Brain oscillations, hypnosis, and hypnotizability (2015) · cites this paper as Ojemann, Ojemann, & Ramsey, 2013

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Cited by

Sorted by citations

Authors
Ojemann, G. A., Ojemann, J., & Ramsey, N. F.
Affiliations
  • University of Washington (US)
  • Seattle Children's Hospital (US)
  • University Medical Center Utrecht (NL)
Corresponding author
Ojemann, George A.
ORCID
Venue
Frontiers in Human Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
7
Pages
34-34
ISSN
1662-5161 (ISSN-L)
DOI
10.3389/fnhum.2013.00034
PMC
PMC3576621
OpenAlex
W2160722627
Cited by
92
References
3
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 12 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 4
FWCI
7.59
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Human Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • Stichting voor de Technische Wetenschappen (UGT7685)
  • National Institute of Neurological Disorders and Stroke (R01NS065186)
  • FP7 Ideas: European Research Council (320708)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
blood oxygenation level-dependent signal, local field potentials, electrocorticography, single-unit recording, human cortex, drug-resistant epilepsy, functional localization, association cortex, default mode network

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