Cited by 174Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

Losing the rose tinted glasses: neural substrates of unbiased belief updating in depression

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Garrett, Neil, Sharot, Tali, Faulkner, Paul, Korn, Christoph W., Roiser, Jonathan P., Dolan, Raymond J.·2014·Frontiers in Human Neuroscience

Abstract

Recent evidence suggests that a state of good mental health is associated with biased processing of information that supports a positively skewed view of the future. Depression, on the other hand, is associated with unbiased processing of such information. Here, we use brain imaging in conjunction with a belief update task administered to clinically depressed patients and healthy controls to characterize brain activity that supports unbiased belief updating in clinically depressed individuals. Our results reveal that unbiased belief updating in depression is mediated by strong neural coding of estimation errors in response to both good news (in left inferior frontal gyrus and bilateral superior frontal gyrus) and bad news (in right inferior parietal lobule and right inferior frontal gyrus) regarding the future. In contrast, intact mental health was linked to a relatively attenuated neural coding of bad news about the future. These findings identify a neural substrate mediating the breakdown of biased updating in major depression disorder, which may be essential for mental health.

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  • Optimistic updating cannot be interpreted purely on the basis of selective attention, cognitive, or mnemonic abilities in processing desirable and undesirable feedback.

    “optimistic updating could not be interpreted purely on the basis of selective attention, cognitive, or mnemonic abilities in processing desirable and undesirable feedback (19, 20, 45)”

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  1. Allport G. W. (1955). Becoming; Basic Considerations for a Psychology ofPersonality, Vol. 20 New Haven, CT: Yale University Press

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Authors
Garrett, N., Sharot, T., Faulkner, P., Korn, C. W., Roiser, J. P., & Dolan, R. J.
Affiliations
  • University College London (GB)
  • University of Zurich (CH)
  • Wellcome Centre for Human Neuroimaging (GB)
Corresponding author
  • Garrett, Neil
  • Sharot, Tali
Venue
Frontiers in Human Neuroscience
Published
2014-08-28
Volume
8
Pages
639-639
ISSN
1662-5161 (ISSN-L)
OpenAlex
W2129972322
Cited by
174
References
48
Citations by year
2026: 7 · 2025: 20 · 2024: 14 · 2023: 13 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 8 · 2018: 32 · 2017: 10 · 2016: 13 · 2015: 7 · 2014: 1
FWCI
5.76
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Human Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Wellcome Trust (091593, 091593/Z/10/, 098362, 098362/Z/12/Z, 091593/Z/10/Z, 098362/Z/12/)
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
depression, belief updating, estimation error, neural coding, future expectations, positive skewness, inferior frontal gyrus, inferior parietal lobule, superior frontal gyrus, mental health, cognitive biases

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