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Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting

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Hare, Todd A., Hakimi, Shabnam, Rangel, Antonio·2014·Frontiers in Neuroscience
DOI 10.3389/fnins.2014.00050
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Abstract

There is widespread interest in identifying computational and neurobiological mechanisms that influence the ability to choose long-term benefits over more proximal and readily available rewards in domains such as dietary and economic choice. We present the results of a human fMRI study that examines how neural activity relates to observed individual differences in the discounting of future rewards during an intertemporal monetary choice task. We found that a region of left dorsolateral prefrontal cortex (dlPFC) BA-46 was more active in trials where subjects chose delayed rewards, after controlling for the subjective value of those rewards. We also found that the connectivity from dlPFC BA-46 to a region of ventromedial prefrontal cortex (vmPFC) widely associated with the computation of stimulus values, increased at the time of choice, and especially during trials in which subjects chose delayed rewards. Finally, we found that estimates of effective connectivity between these two regions played a critical role in predicting out-of-sample, between-subject differences in discount rates. Together with previous findings in dietary choice, these results suggest that a common set of computational and neurobiological mechanisms facilitate choices in favor of long-term reward in both settings.

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Metadata

Authors
Hare, T. A., Hakimi, S., & Rangel, A.
Venue
Frontiers in Neuroscience
Publisher
Frontiers Media SA
Published
2014-03-18
Volume
8
Pages
50-50
ISSN
1662-453X (ISSN-L)
DOI
10.3389/fnins.2014.00050
OpenAlex
W2100327536
Cited by
206
References
23
FWCI
11.07
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting. https://app.cochat.ai/papers/10.3389/fnins.2014.00050
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Hare, T. A., Hakimi, S., & Rangel, A. (2014). Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting. Frontiers in Neuroscience. https://doi.org/10.3389/fnins.2014.00050

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