Pathological overeating: emerging evidence for a compulsivity construct

Moore, Catherine F; Sabino, Valentina; Koob, George F; Cottone, Pietro

doi:10.1038/npp.2016.269

Cited by 126Eating Disorders and BehaviorsNutrition, Health and Food BehaviorRegulation of Appetite and Obesity

Pathological overeating: emerging evidence for a compulsivity construct

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Moore, Catherine F, Sabino, Valentina, Koob, George F, Cottone, Pietro·2017·Neuropsychopharmacology

DOI 10.1038/npp.2016.269PMC PMC5436113

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Abstract

Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical and psychiatric conditions such as forms of obesity and eating disorders. Although feeding research is moving toward a better understanding of the proposed addictive properties of food, the components and the mechanisms contributing to compulsive eating are not yet clearly defined or understood. Current understanding highlights three elements of compulsive behavior as it applies to pathological overeating: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating despite aversive consequences. These elements emerge through mechanisms involving pathological habit formation through an aberrant learning process, the emergence of a negative emotional state, and dysfunctions in behavioral control. Dysfunctions in systems within neurocircuitries that comprise the basal ganglia, the extended amygdala, and the prefrontal cortex result in compulsive eating behaviors. Here, we present evidence to relate compulsive eating behavior and addiction and to characterize their underlying neurobiological mechanisms. A major need to improve understanding of compulsive eating through the integration of complex motivational, emotional, and cognitive constructs is warranted.

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A similar theoretical framework has been proposed for compulsive eating, in which habitual overeating, overeating to relieve a negative emotional state, and overeating despite aversive consequences reflect the three functional domains outlined in drug addiction.
“Note that a similar theoretical framework has been proposed for compulsive eating, in which habitual overeating, overeating to relieve a negative emotional state, and overeating despite aversive consequences reflect the three functional domains that are outlined in drug addiction (Moore et al., 2017(Moore et al., , 2019)).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Moore et al., 2017

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Authors: Moore, C. F., Sabino, V., Koob, G. F., & Cottone, P.
Affiliations: Boston University (US)
National Institutes of Health (US)
Corresponding author: Cottone, Pietro
ORCID: Moore, Catherine F
Sabino, Valentina
Koob, George F
Cottone, Pietro
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2016-12-06
Volume: 42
Issue: 7
Pages: 1375-1389
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2016.269
PMC: PMC5436113
OpenAlex: W2560447148
Cited by: 126
References: 218
Citations by year: 2026: 11 · 2025: 15 · 2024: 5 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 8 · 2017: 9
FWCI: 1.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund
National Institute on Alcohol Abuse and Alcoholism (AA024439)
National Institute of Mental Health (MH091945, DA030425, MH093650)
National Institute on Drug Abuse (DA030425)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: compulsive eating, compulsivity, food addiction, transdiagnostic constructs, emotional overeating, aversive consequences, habit formation, basal ganglia, extended amygdala, prefrontal cortex, obesity, eating disorders
MeSH terms: Amygdala, Compulsive Behavior, Humans, Hyperphagia, Nerve Net, Behavior, Addictive, Prefrontal Cortex

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Pathological overeating: emerging evidence for a compulsivity construct

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