The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis
Open accessAbstract
Adult hippocampal neurogenesis is a highly plastic process that responds swiftly to neuronal activity. Adult hippocampal neurogenesis can be regulated at the level of neural stem cell recruitment and activation, progenitor proliferation, as well as newborn cell survival and differentiation. An "excitation-neurogenesis" rule was proposed after the demonstration of the capability of cultured neural stem and progenitor cells to intrinsically sense neuronal excitatory activity. In vivo, this property has remained elusive although recently the direct response of neural stem cells to GABA in the hippocampus via GABAA receptors has evidenced a mechanism for a direct talk between neurons and neural stem cells. As it is pro-neurogenic, the effect of excitatory neuronal activity has been generally considered beneficial. But what happens in situations of neuronal hyperactivity in which neurogenesis can be dramatically boosted? In animal models, electroconvulsive shock markedly increases neurogenesis. On the contrary, in epilepsy rodent models, seizures induce the generation of misplaced neurons with abnormal morphological and electrophysiological properties, namely aberrant neurogenesis. We will herein discuss what is known about the mechanisms of influence of neurons on neural stem cells, as well as the severe effects of neuronal hyperexcitation on hippocampal neurogenesis.
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Neurogenesis is known to be elevated following hyperexcitability.
“Among the downregulated pathways in E3S/S/P301S hippocampus, neurogenesis is known to be elevated following hyperexcitability58,59, observed in E3/P301S mice using cFOS activity mapping.”
From The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway (2025) · cites this paper as [59]
The Introduction (page not provided) reports an early increase in cell proliferation after seizures and increased stem-cell activation after electroconvulsive shock. But “Activation and exhaustion of NSCs” says that, in the following weeks after seizures, neurogenesis diminishes to a minimum. The unqualified claim that neurogenesis is elevated following hyperexcitability omits this time-dependent reversal. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNeurogenesis is elevated in response to hyperexcitability.
“Neurogenesis is known to be elevated in response to hyperexcitability53,54”
From <i>APOE3</i> - <i>R136S</i> mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition (2024) · cites this paper as [54]
The Abstract says electroconvulsive shock markedly increases adult hippocampal neurogenesis, supporting an elevation in one model of hyperexcitation. But “Activation and exhaustion of NSCs” says seizures produce an initial boost in cell proliferation followed by a decline in neurogenesis to a minimum over the following weeks. The unqualified claim omits that time-dependent, contradictory response. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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- Authors
- Pineda, J. R., & Encinas, J. M.
- Affiliations
- Achucarro Basque Center for Neuroscience (ES)
- Ikerbasque (ES)
- Corresponding author
- Encinas, Juan M.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2016-03-03
- Volume
- 10
- Pages
- 74-74
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4776215
- OpenAlex
- W2297003971
- Cited by
- 29
- References
- 97
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministerio de Economía y Competitividad (RyC-2013-13450, RyC-2012-11137, SAF 2012-40085)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult hippocampal neurogenesis, neuronal hyperexcitation, neural stem cells, GABAA receptor, GABA signaling, electroconvulsive shock, epilepsy, neuronal activity regulation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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