Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

Klein, R., Nanduri, V., Jing, S., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F., & Barbacid, M. (1991) · Cell · doi:10.1016/0092-8674(91)90628-c · Cited by 958 · see citing works

Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons.

Lu, B., Yokoyama, M., Dreyfus, C. F., & Black, I. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6289 · Cited by 109 · see citing works

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works

Neurotrophins and their receptors: A convergence point for many signalling pathways

Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works

A molecular and cellular theory of depression

Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works

Neurotrophin regulation of neural circuit development and function

Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works

The induction of pain: an integrative review

Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774 · see citing works

Neurotrophins as synaptic modulators

Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works

NEUROTROPHINS AND SYNAPTIC PLASTICITY

McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337 · see citing works

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works

BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106 · see citing works

TrkB signalling pathways in LTP and learning

Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works

BDNF - a key transducer of antidepressant effects

Björkholm, C., & Monteggia, L. M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.034 · Cited by 958 · see citing works

Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery

Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21393 · Cited by 875 · see citing works

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works

The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function.

FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799 · see citing works

Essential role of brain-derived neurotrophic factor in adult hippocampal function

Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works

Dynamic visualization of local protein synthesis in hippocampal neurons

Aakalu, G., Smith, W. B., Nguyen, N., Jiang, C., & Schuman, E. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00295-1 · Cited by 611 · see citing works

5-HT_2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex

Vaidya, V. A., Marek, G. J., Aghajanian, G. K., & Duman, R. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02785.1997 · Cited by 479 · see citing works

Learning deficit in BDNF mutant mice.

Linnarsson, S., Björklund, A., & Ernfors, P. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01687.x · Cited by 471 · see citing works

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

Berchtold, N. C., Chinn, G., Chou, M., Kesslak, J. P., & Cotman, C. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.026 · Cited by 471 · see citing works

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

Lee, J., Seroogy, K. B., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00747.x · Cited by 455 · see citing works

Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing <i>N</i> -methyl- <scp>d</scp> -aspartic acid receptor activity

Levine, E. S., Crozier, R. A., Black, I. B., & Plummer, M. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10235 · Cited by 412 · see citing works

Inhibition of GABA_ASynaptic Responses by Brain-Derived Neurotrophic Factor (BDNF) in Rat Hippocampus

Tanaka, T., Saito, H., & Matsuki, N. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-09-02959.1997 · Cited by 385 · see citing works

Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V, Thoenen, H., & Bonhoeffer, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12547 · Cited by 351 · see citing works

Physical activity–antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model

Russo-Neustadt, A., Ha, T., Ramirez, R., & Kesslak, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00364-8 · Cited by 346 · see citing works

Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation

Schaaf, M. J. M., De Kloet, E. R., & Vreugdenhil, E. (2000) · Stress · doi:10.3109/10253890009001124 · Cited by 270 · see citing works

Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats

Marmigère, F., Givalois, L., Rage, F., Arancibia, S., & Tapia‐Arancibia, L. (2003) · Hippocampus · doi:10.1002/hipo.10109 · Cited by 253 · see citing works

BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA_A receptor surface expression

Brünig, I., Penschuck, S., Berninger, B., Benson, J., & Fritschy, J. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01506.x · Cited by 247 · see citing works

Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.

Edelmann, E., Leßmann, V., & Brigadski, T. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.043 · Cited by 248 · see citing works

Form follows function: BDNF and its involvement in sculpting the function and structure of synapses

Zagrebelsky, M., & Korte, M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.029 · Cited by 241 · see citing works

Acute Intrahippocampal Infusion of BDNF Induces Lasting Potentiation of Synaptic Transmission in the Rat Dentate Gyrus

Messaoudi, E., Bårdsen, K., Srebro, B., & Bramham, C. R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.496 · Cited by 208 · see citing works

Brain-Derived Neurotrophic Factor Differentially Regulates Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures

Bolton, M. M., Pittman, A. J., & Lo, D. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03221.2000 · Cited by 201 · see citing works

Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

Duan, W., Lee, J., Guo, Z., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:1:1 · Cited by 183 · see citing works

Activity- and Ca2+-Dependent Modulation of Surface Expression of Brain-Derived Neurotrophic Factor Receptors in Hippocampal Neurons

Du, J., Feng, L., Yang, F., & Lu, B. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1423 · Cited by 178 · see citing works

Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.081 · Cited by 129 · see citing works

BDNF-Promoted Increases in Proximal Dendrites Occur via CREB-Dependent Transcriptional Regulation of Cypin

Kwon, M., Fernandez, J. R., Zegarek, G. F., Lo, S. B., & Firestein, B. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6785-10.2011 · Cited by 115 · see citing works

Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

Gibon, J., & Barker, P. A. (2017) · The Neuroscientist · doi:10.1177/1073858417697037 · Cited by 115 · see citing works

Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression

Wang, G., An, T., Lei, C., Zhu, X., Yang, L., Zhang, L., & Zhang, R. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.03.005 · Cited by 101 · see citing works

BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses

Rauti, R., Cellot, G., D’Andrea, P., Colliva, A., Scaini, D., Tongiorgi, E., & Ballerini, L. (2020) · Molecular Brain · doi:10.1186/s13041-020-00582-9 · Cited by 78 · see citing works

Short-term sleep disturbance enhances brain-derived neurotrophic factor gene expression in rat hippocampus by acting as internal stressor

Fujihara, H., Sei, H., Morita, Y., Ueta, Y., & Morita, K. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:21:3:223 · Cited by 57 · see citing works

Pharmacological and optical activation of TrkB in Parvalbumin interneurons regulate intrinsic states to orchestrate cortical plasticity

Winkel, F., Ryazantseva, M., Voigt, M. B., Didio, G., Lilja, A., Llach Pou, M., Steinzeig, A., Harkki, J., Englund, J., Khirug, S., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01211-0 · Cited by 50 · see citing works

Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture

Gao, Y., Hu, Y., Wang, J., Liu, C., Im, H., Jin, W., Zhu, W., Ge, W., Zhao, G., Yao, Q., et al. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121029 · Cited by 43 · see citing works

Differential effects of neurotrophins on ocular dominance plasticity in developing and adult cat visual cortex

Galuske, R. A. W., Kim, D., Castrén, E., & Singer, W. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00213.x · Cited by 38 · see citing works