The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
Polyamines and Gut Microbiota
Open accessAbstract
The microbiota of gut is the community of microbes living in an individual's gastrointestinal tract. Several bacterial genera and species act in a concerted manner to establish metabolic interactions with the host (1). Although there is a general high interest in the study of metabolite flow across the microbe-host, at present, only some studies are targeting specific metabolites produced by intestinal microbiota such as polyamines (PAs)
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“Polyamines exhibit numerous beneficial effects including increased longevity, recovery of injured mucosa, as well as favorable effects on cognitive function.122, 123, 124”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [122]
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“Gut microbes such as E. coli, Bacteroides spp. and Fusobacterium spp. can synthesize polyamines.122”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [122]
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A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699
Microbial culturomics: paradigm shift in the human gut microbiome study
Lagier, J., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12023 · Cited by 1,200
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971 · cited 1×
“In fact, there is an increasing interest in the use of gut commensal bacteria as potential probiotics, such as the genera Bacteroides, Clostridium, Bifidobacterium, and Faecalibacterium that predominate in the human gut microbiome (47).”
BackgroundA perspective of polyamine metabolism
WALLACE, H. M., Fraser, A. V., & Hughes, A. D. (2003) · Biochemical Journal · doi:10.1042/bj20031327 · Cited by 933
Modulation of cellular function by polyamines
Igarashi, K., & Kashiwagi, K. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.009 · Cited by 852
The Gastrointestinal Microbiome: A Review
Barko, P. C., McMichael, M. A., Swanson, K. S., & Williams, D. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14875 · Cited by 750
Remaining mysteries of molecular biology: the role of polyamines in the cell
Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658
Microbial Ecology along the Gastrointestinal Tract
Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 614
Flagged first, then by citations
2 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Linsalata, 2010, Lactobacillus rhamnosus GG influencespolyamine metabolismin HGG-27 gastric cancer cell lines: a strategy toward nutritional approach to chemoprevention of gastric cancer, 847
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Emerging Microbial Lipid Shifts in a Multistage Simulated Gut Inoculated with Human Fecal Microbiota
Tamanna, I., Salonen, K., Mannochio-Russo, H., Kråkström, M., Gomes, P. W. P., Charron‐Lamoureux, V., Mohanty, I., Forssten, S. D., Ouwehand, A. C., Hyötyläinen, T., et al. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6c00050 · Cited by 2
Xue, X., Tang, T., Zhang, H., Wei, L., Wang, F., Chao, Z., Liu, H., Ren, Y., Hu, C., & Sun, R. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1846859
Pianka, M.-L., Zhang, X., & Stein‐Thoeringer, C. K. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2718561
Bi, Y., Song, W., Glymenaki, M., Hu, J., Li, X., Huang, H., Peng, Y., Ni, S., Haonon, O., Liu, Z., et al. (2026) · iMeta · doi:10.1002/imt2.70144 · Cited by 1
Ravindran, D. R., Anand, S., Verma, A., Meena, J. K., Kumar, H., Hari, P., Aggarwal, S., & Ahuja, V. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1875579
Saxena, S., Ahmed, I., Jha, R. K., Kumar, N., Saxena, M., Chakrabarty, S., Choudhary, R. K., Ahuja, D., Kumar, M. V., & Bhattacharjee, A. (2026) · Obesity Medicine · doi:10.1016/j.obmed.2026.100745
Хамидов, Ф., Jalolov, O., Nematov, U., Ilmira, U., Mavlyuda, Q., Sayfullayevna, S. M., Alkhawaja, A. S., Gulkhayyo, J., & Siahmansouri, H. (2026) · Seminars in Oncology · doi:10.1016/j.seminoncol.2026.152564
Microbiome-based diagnostics and biomarkers: The search for mechanistic connections
Kumari, N., Allani, S. K., Knapinska, A., & Bommareddy, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33206-7.00004-2
Venugopal, G., Jacob, A. A., Varghese, J. E., & Mattethra, G. C. (2026) · Comprehensive physiology · doi:10.1002/cph4.70278
Gut microbial metabolism of amino acids and its impact on enteric infections
Jaswal, K., & Behnsen, J. (2026) · Infection and Immunity · doi:10.1128/iai.00298-26
Microbiome-directed therapies in oncology: from animal models to clinical implementation
Skonieczna‐Żydecka, K., Marlicz, M., Kaczmarczyk, M., Łoniewski, I., Boluk, P., Ekstedt, N., Kutrzuba, K., & Marlicz, W. M. (2026) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2026.102148
Polyamines and Epithelial Barrier Loss During HIV Infection
Mahalingam, S. S., Cameron, C. M., Richardson, B., Cameron, M. J., da Silva, A. P., Pinto, A., Tamilselvan, B., Jayaraman, S., Jacobson, J. M., Yendewa, G. A., et al. (2026) · Pathogens · doi:10.3390/pathogens15101069
Metadata
- Authors
- Tofalo, R., Cocchi, S., & Suzzi, G.
- Affiliations
- University of Teramo (IT)
- Corresponding author
- Tofalo, Rosanna
- ORCID
- Tofalo, Rosanna
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2019-02-25
- Volume
- 6
- Pages
- 16-16
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC6397830
- OpenAlex
- W2917494464
- Cited by
- 306
- References
- 58
- Citations by year
- 2026: 48 · 2025: 41 · 2024: 42 · 2023: 41 · 2022: 34 · 2021: 59 · 2020: 30 · 2019: 10
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- polyamines, gut microbiota, host-microbe metabolic interactions, microbial metabolites, polyamine metabolism
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