The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
Polyamines and Gut Microbiota
Open accessAbstract
The microbiota of gut is the community of microbes living in an individual's gastrointestinal tract. Several bacterial genera and species act in a concerted manner to establish metabolic interactions with the host (1). Although there is a general high interest in the study of metabolite flow across the microbe-host, at present, only some studies are targeting specific metabolites produced by intestinal microbiota such as polyamines (PAs)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Polyamines exhibit numerous beneficial effects including increased longevity, recovery of injured mucosa, as well as favorable effects on cognitive function.122, 123, 124”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [122]
In the citing paper
“Gut microbes such as E. coli, Bacteroides spp. and Fusobacterium spp. can synthesize polyamines.122”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699
Microbial culturomics: paradigm shift in the human gut microbiome study
Lagier, J., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12023 · Cited by 1,200
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971 · cited 1×
“In fact, there is an increasing interest in the use of gut commensal bacteria as potential probiotics, such as the genera Bacteroides, Clostridium, Bifidobacterium, and Faecalibacterium that predominate in the human gut microbiome (47).”
BackgroundA perspective of polyamine metabolism
WALLACE, H. M., Fraser, A. V., & Hughes, A. D. (2003) · Biochemical Journal · doi:10.1042/bj20031327 · Cited by 933
Modulation of cellular function by polyamines
Igarashi, K., & Kashiwagi, K. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.009 · Cited by 852
The Gastrointestinal Microbiome: A Review
Barko, P. C., McMichael, M. A., Swanson, K. S., & Williams, D. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14875 · Cited by 750
Remaining mysteries of molecular biology: the role of polyamines in the cell
Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658
Microbial Ecology along the Gastrointestinal Tract
Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 614
Major New Microbial Groups Expand Diversity and Alter our Understanding of the Tree of Life
Castelle, C. J., & Banfield, J. F. (2018) · Cell · doi:10.1016/j.cell.2018.02.016 · Cited by 595
The probiotic paradox: live and dead cells are biological response modifiers
Adams, C. A. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000090 · Cited by 521
Short-Chain Fatty Acids in the Human Colon: Relation to Gastrointestinal Health and Disease
Mortensen, P. B., & Clausen, M. R. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094568 · Cited by 513
Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes
Li, W., & Duffy, A. J. (2017) · Journal of Nutrition · doi:10.3945/jn.116.240754 · Cited by 433
Richard, H., & Foster, J. W. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.18.6032-6041.2004 · Cited by 388
The mechanism of action of probiotics
Boirivant, M., & Strober, W. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f0cffc · Cited by 379
Impact of intestinal microbiota on intestinal luminal metabolome
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334
Polyamines and cancer: implications for chemotherapy and chemoprevention
Nowotarski, S. L., Woster, P. M., & Casero, R. A. (2013) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2013.3 · Cited by 306
Matsumoto, M., Kurihara, S., Kibe, R., Ashida, H., & Benno, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023652 · Cited by 290 · cited 1×
“The produced PAs induce maintenance and/or recovery of intestinal barrier function and other beneficial activities such as longevity (53).”
BackgroundKibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep04548 · Cited by 273
Polyamines in food—implications for growth and health
Bardócz, S., Grant, G., Brown, D. S., Ralph, A., & Pusztai, A. J. (1993) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(93)90001-d · Cited by 234
Vandenplas, Y., Huys, G. R. B., & Daube, G. (2014) · Jornal de Pediatria · doi:10.1016/j.jped.2014.08.005 · Cited by 218
A wide diversity of bacteria from the human gut produces and degrades biogenic amines
Pugin, B., Barcik, W., Westermann, P., Heider, A., Wawrzyniak, M., Hellings, P., Akdis, C. A., & O’Mahony, L. (2017) · Microbial Ecology in Health and Disease · doi:10.1080/16512235.2017.1353881 · Cited by 198
Targeting polyamine metabolism for cancer therapy and prevention
Stewart, T. M., Woster, P. M., & Casero, R. A. (2016) · Biochemical Journal · doi:10.1042/bcj20160383 · Cited by 190
Polyamine function in archaea and bacteria
Michael, A. J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.005670 · Cited by 190
Characteristics of cellular polyamine transport in prokaryotes and eukaryotes
Igarashi, K., & Kashiwagi, K. (2010) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2010.01.017 · Cited by 183
Biosynthesis of polyamines and polyamine-containing molecules
Michael, A. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160185 · Cited by 180
Polyamines: Emerging players in bacteria–host interactions
Martino, M. L. D., Campilongo, R., Casalino, M., Micheli, G., Colonna, B., & Prosseda, G. (2013) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2013.06.008 · Cited by 175
Polyamines in foods: development of a food database
Ali, M. A., Poortvliet, E., Strömberg, R., & Yngve, A. (2011) · Food & Nutrition Research · doi:10.3402/fnr.v55i0.5572 · Cited by 163
Polyamines in the gut lumen: bioavailability and biodistribution
Milović, V. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200109000-00004 · Cited by 159
New perspectives on probiotics in health and disease
Daliri, E. B., & Lee, B. H. (2015) · Food Science and Human Wellness · doi:10.1016/j.fshw.2015.06.002 · Cited by 158
Polyamines As A Chemotaxonomic Marker in Bacterial Systematics
Hamana, K., & Matsuzaki, S. (1992) · Critical Reviews in Microbiology · doi:10.3109/10408419209113518 · Cited by 156
Gong, S., Richard, H., & Foster, J. W. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.15.4402-4409.2003 · Cited by 142
Burrell, M. R., Hanfrey, C. C., Murray, E. J., Stanley‐Wall, N. R., & Michael, A. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.163154 · Cited by 135
Hanfrey, C. C., Pearson, B. M., Hazeldine, S. T., Lee, J., Gaskin, D. J. H., Woster, P. M., Phillips, M. A., & Michael, A. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307835 · Cited by 132
Matsumoto, M., & Benno, Y. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb03887.x · Cited by 129
Repertoire of human gut microbes
Hugon, P., Lagier, J., Colson, P., Bittar, F., & Raoult, D. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.06.020 · Cited by 105
Dietary Guar Gum and Pectin Stimulate Intestinal Microbial Polyamine Synthesis in Rats
Noack, J., Kleessen, B., Proll, J., Dongowski, G., & Blaut, M. (1998) · Journal of Nutrition · doi:10.1093/jn/128.8.1385 · Cited by 104
Noack, J., Dongowski, G., Hartmann, L., & Blaut, M. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1225 · Cited by 101
Nakamura, A., Ooga, T., & Matsumoto, M. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1494466 · Cited by 100
Matsumoto, M., Aranami, A., Ishige, A., Watanabe, K., & Benno, Y. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02642.x · Cited by 98
Kitada, Y., Muramatsu, K., Toju, H., Kibe, R., Benno, Y., Kurihara, S., & Matsumoto, M. (2018) · Science Advances · doi:10.1126/sciadv.aat0062 · Cited by 98
Polyamines and Gut Mucosal Homeostasis.
Timmons, J. A., Chang, E. T., Wang, J., & Rao, J. N. (2012) · PubMed · Cited by 97
Targeting Polyamines and Inflammation for Cancer Prevention
Babbar, N., & Gerner, E. W. (2010) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-10858-7_4 · Cited by 82
Matsumoto, M., & Benno, Y. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.07.016 · Cited by 75
Orlando, A., Messa, C., Linsalata, M., Cavallini, A., & Russo, F. (2009) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970802443631 · Cited by 72
Impact of LKM512 yogurt on improvement of intestinal environment of the elderly
Matsumoto, M., Ohishi, H., & Benno, Y. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00518.x · Cited by 66
Sugiyama, Y., Nara, M., Sakanaka, M., Gotoh, A., Kitakata, A., Okuda, S., & Kurihara, S. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.10.015 · Cited by 64
Shigellosis: An Old Disease in New Clothes?
Sansonetti, P. J. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030354 · Cited by 60
Spermine Metabolism and Anticancer Therapy
Amendola, R., Cervelli, M., Fratini, E., Polticelli, F., SALLUSTIO, D. E., & Mariottini, P. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787580935 · Cited by 57
Suárez, C. A., Espariz, M., Blancato, V. S., & Magni, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076170 · Cited by 48
Matsumoto, M., Kitada, Y., Shimomura, Y., & Naito, Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.032 · Cited by 38
Rossi, G., Cerquetella, M., Scarpona, S., Pengo, G., Fettucciari, K., Bassotti, G., Jergens, A. E., & Suchodolski, J. S. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0024 · Cited by 37
Sakanaka, M., Sugiyama, Y., Kitakata, A., Katayama, T., & Kurihara, S. (2016) · Amino Acids · doi:10.1007/s00726-016-2233-0 · Cited by 35
Linsalata, M., Cavallini, A., Messa, C., Orlando, A., Refolo, M. G., & Russo, F. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883598 · Cited by 34
Linsalata, M., Orlando, A., & Russo, F. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2597 · Cited by 31
Research works printed but not linked: 1
- Linsalata, 2010, Lactobacillus rhamnosus GG influencespolyamine metabolismin HGG-27 gastric cancer cell lines: a strategy toward nutritional approach to chemoprevention of gastric cancer, 847
Cited by
Sorted by citations
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835
Human gut microbiota in health and disease: Unveiling the relationship
Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.999001 · Cited by 762
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome
Han, S., Treuren, W. V., Fischer, C. R., Merrill, B. D., DeFelice, B. C., Sánchez, J. M., Higginbottom, S. K., Guthrie, L., Fall, L. A., Dodd, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03707-9 · Cited by 413
The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response
Sánchez‐Alcoholado, L., Ramos‐Molina, B., Otero, A. P., Laborda-Illanes, A., Ordóñez, R., Medina, J. A., Gómez‐Millán, J., & Queipo‐Ortuño, M. I. (2020) · Cancers · doi:10.3390/cancers12061406 · Cited by 346
Muñoz‐Esparza, N., Latorre‐Moratalla, M. L., Comas-Basté, O., Toro-Funes, N., Veciana-Nogués, M. T., & Vidal‐Carou, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00108 · Cited by 275
Metadata
- Authors
- Tofalo, R., Cocchi, S., & Suzzi, G.
- Affiliations
- University of Teramo (IT)
- Corresponding author
- Tofalo, Rosanna
- ORCID
- Tofalo, Rosanna
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2019-02-25
- Volume
- 6
- Pages
- 16-16
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC6397830
- OpenAlex
- W2917494464
- Cited by
- 306
- References
- 58
- Citations by year
- 2026: 48 · 2025: 41 · 2024: 42 · 2023: 41 · 2022: 34 · 2021: 59 · 2020: 30 · 2019: 10
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- polyamines, gut microbiota, host-microbe metabolic interactions, microbial metabolites, polyamine metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
