Cited by 312Polyamine Metabolism and ApplicationsGut microbiota and healthAnimal Nutrition and Physiology

The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.

Polyamines and Gut Microbiota

Open access

Tofalo, Rosanna, Cocchi, Simone, Suzzi, Giovanna·2019·Frontiers in Nutrition

DOI 10.3389/fnut.2019.00016PMC PMC6397830

Open this paper in CoChat — free account Open PDF

Abstract

The microbiota of gut is the community of microbes living in an individual's gastrointestinal tract. Several bacterial genera and species act in a concerted manner to establish metabolic interactions with the host (1). Although there is a general high interest in the study of metabolite flow across the microbe-host, at present, only some studies are targeting specific metabolites produced by intestinal microbiota such as polyamines (PAs)

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fnut.2019.00016

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Main polyamine metabolic pathways modified from Linsalata et al. (27). The abbreviations used are as follows: ODC, ornithine decarboxylase; SAMDC, S-adenosylmethionine decarboxylase; SSAT, spermidine-spermine-N-acetyl transferase; PAO, polyamine oxidase; AZ, antizyme; SMO, spermine oxidase. AZ inactivates ODC, increases polyamine efflux and decreases polyamine uptake.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699
Microbial culturomics: paradigm shift in the human gut microbiome study
Lagier, J., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12023 · Cited by 1,200
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971 · cited 1×
“In fact, there is an increasing interest in the use of gut commensal bacteria as potential probiotics, such as the genera Bacteroides, Clostridium, Bifidobacterium, and Faecalibacterium that predominate in the human gut microbiome (47).”
Background
A perspective of polyamine metabolism
WALLACE, H. M., Fraser, A. V., & Hughes, A. D. (2003) · Biochemical Journal · doi:10.1042/bj20031327 · Cited by 933
Modulation of cellular function by polyamines
Igarashi, K., & Kashiwagi, K. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.009 · Cited by 852
The Gastrointestinal Microbiome: A Review
Barko, P. C., McMichael, M. A., Swanson, K. S., & Williams, D. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14875 · Cited by 750
Remaining mysteries of molecular biology: the role of polyamines in the cell
Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658
Microbial Ecology along the Gastrointestinal Tract
Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 614

Show all 58 references

Research works printed but not linked: 1

Linsalata, 2010, Lactobacillus rhamnosus GG influencespolyamine metabolismin HGG-27 gastric cancer cell lines: a strategy toward nutritional approach to chemoprevention of gastric cancer, 847

Sorted by citations

Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835
Human gut microbiota in health and disease: Unveiling the relationship
Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.999001 · Cited by 762
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome
Han, S., Treuren, W. V., Fischer, C. R., Merrill, B. D., DeFelice, B. C., Sánchez, J. M., Higginbottom, S. K., Guthrie, L., Fall, L. A., Dodd, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03707-9 · Cited by 413
The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response
Sánchez‐Alcoholado, L., Ramos‐Molina, B., Otero, A. P., Laborda-Illanes, A., Ordóñez, R., Medina, J. A., Gómez‐Millán, J., & Queipo‐Ortuño, M. I. (2020) · Cancers · doi:10.3390/cancers12061406 · Cited by 346
Polyamines in Food
Muñoz‐Esparza, N., Latorre‐Moratalla, M. L., Comas-Basté, O., Toro-Funes, N., Veciana-Nogués, M. T., & Vidal‐Carou, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00108 · Cited by 275
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
Modulation of bone remodeling by the gut microbiota: A new therapy for osteoporosis
Lyu, Z., Hu, Y., Guo, Y., & Liu, D. (2023) · Bone Research · doi:10.1038/s41413-023-00264-x · Cited by 207
Metabolite interactions between host and microbiota during health and disease: Which feeds the other?
Zhang, Y., Chen, R., Zhang, D., Qi, S., & Liu, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114295 · Cited by 224
Warmth Prevents Bone Loss Through the Gut Microbiota
Chevalier, C., Kieser, S., Çolakoğlu, M., Hadadi, N., Brun, J., Rigo, D., Suárez-Zamorano, N., Spiljar, M., Fabbiano, S., Busse, B., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.012 · Cited by 183
Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere
Baquero, F., Lanza, V. F., Baquero, M.-R., del Campo, R., & Bravo-Vázquez, D. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02261 · Cited by 174
Microbiota-Derived Metabolites in Tumor Progression and Metastasis
Rossi, T., Vergara, D., Fanini, F., Maffia, M., Bravaccini, S., & Pirini, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165786 · Cited by 165
Structural diversity, functional aspects and future therapeutic applications of human gut microbiome
Ghosh, S., & Pramanik, S. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02516-y · Cited by 158
The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling
Sipos, A., Ujlaki, G., Mikó, E., Maka, E., Szabó, J., Uray, K., Krasznai, Z. T., & Bai, P. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00295-2 · Cited by 153
Microbial Metabolites Determine Host Health and the Status of Some Diseases
Sittipo, P., Shim, J., & Lee, Y. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215296 · Cited by 146
Gut-Derived Protein-Bound Uremic Toxins
Graboski, A. L., & Redinbo, M. R. (2020) · Toxins · doi:10.3390/toxins12090590 · Cited by 137
Gut–X axis
Xu, L., Zhang, Y., Li, X., Li, C., Hu, H., Hu, J., Liu, M., Yang, Q. Z., Gu, P., Li, J., et al. (2025) · iMeta · doi:10.1002/imt2.270 · Cited by 143
Gut microbiome-produced metabolites in pigs: a review on their biological functions and the influence of probiotics
Vasquez, R., Oh, J. K., Song, J. H., & Kang, D. (2022) · Journal of Animal Science and Technology · doi:10.5187/jast.2022.e58 · Cited by 131
Microbiota and cancer: host cellular mechanisms activated by gut microbial metabolites
Tsvetikova, S. A., & Koshel, E. I. (2020) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2020.151425 · Cited by 112
Nutritional Aspects of Spermidine
Madeo, F., Hofer, S. J., Pendl, T., Bauer, M. A., Eisenberg, T., Carmona‐Gutiérrez, D., & Kroemer, G. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120419-015419 · Cited by 116
Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model
Farag, M. A., Abdelwareth, A., Sallam, I. E., Shorbagi, M., Jehmlich, N., Fritz‐Wallace, K., Schäpe, S. S., Rolle-Kampczyk, U. E., Ehrlich, A., Wessjohann, L. A., et al. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.01.001 · Cited by 116
Gut commensals and their metabolites in health and disease
Krishnamurthy, H. K., Pereira, M., Bosco, J., George, J., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1244293 · Cited by 112
Polyamine metabolism links gut microbiota and testicular dysfunction
Zhao, Q., Huang, J., Cheng, Y., Dai, M., Zhu, W., Yang, X., Gonzalez, F. J., & Li, F. (2021) · Microbiome · doi:10.1186/s40168-021-01157-z · Cited by 106
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome
Diener, C., Dai, C. L., Wilmanski, T., Baloni, P., Smith, B., Rappaport, N., Hood, L., Magis, A. T., & Gibbons, S. M. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00670-1 · Cited by 102
Maternal and Perinatal Factors Associated with the Human Milk Microbiome
Demmelmair, H., Jiménez, E., Collado, M. C., Salminen, S., & McGuire, M. K. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa027 · Cited by 100
A conserved interdomain microbial network underpins cadaver decomposition despite environmental variables
Burcham, Z. M., Belk, A. D., McGivern, B. B., Bouslimani, A., Ghadermazi, P., Martino, C., Shenhav, L., Zhang, A. R., Shi, P., Emmons, A. L., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01580-y · Cited by 99
Polyamines in Parkinson's Disease: Balancing Between Neurotoxicity and Neuroprotection
Vrijsen, S., Houdou, M., Cascalho, A. C. C., Eggermont, J., & Vangheluwe, P. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-071322-021330 · Cited by 100
Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies
Kitada, Y., Muramatsu, K., Toju, H., Kibe, R., Benno, Y., Kurihara, S., & Matsumoto, M. (2018) · Science Advances · doi:10.1126/sciadv.aat0062 · Cited by 98
Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression
Zhou, J., Pang, J., Tripathi, M., Ho, J. P., Widjaja, A. A., Shekeran, S. G., Cook, S. A., Suzuki, A., Diehl, A. M., Petretto, E. G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32788-x · Cited by 95
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity
Guerbette, T., Boudry, G., & Lan, A. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101546 · Cited by 100
Dissecting the Interplay Mechanism between Epigenetics and Gut Microbiota: Health Maintenance and Disease Prevention
Wu, Y., Wang, C., Wan, J., Yao, H., & Yuan, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136933 · Cited by 88
Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives
Li, M., Yang, L., Mu, C., Sun, Y., Gu, Y., Chen, D., Liu, T., & Cao, H. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.038 · Cited by 89
Are mitophagy enhancers therapeutic targets for Alzheimer’s disease?
Pradeepkiran, J. A., Hindle, A., Kshirsagar, S., & Reddy, P. H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112918 · Cited by 83
Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis
Li, X., Shang, S., Wu, M., Song, Q., & Chen, D. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217096 · Cited by 87
Immunomodulatory role of gut microbial metabolites: mechanistic insights and therapeutic frontiers
Zeng, L., Qian, Y., Cui, X., Zhao, J., Ning, Z., Cha, J., Wang, K., Ge, C., Jia, J., Dou, T., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1675065 · Cited by 102
Does diet play a role in reducing nociception related to inflammation and chronic pain?
Bjørklund, G., Aaseth, J., Doşa, M. D., Pivina, L. M., Dadar, M., Pen, J. J., & Chirumbolo, S. (2019) · Nutrition · doi:10.1016/j.nut.2019.04.007 · Cited by 81
Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host
D’Aquila, P., Carelli, L. L., Rango, F. D., Passarino, G., & Bellizzi, D. (2020) · Nutrients · doi:10.3390/nu12030597 · Cited by 80
Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index
Laforest‐Lapointe, I., Becker, A. B., Mandhane, P. J., Turvey, S. E., Moraes, T. J., Sears, M. R., Subbarao, P., Sycuro, L. K., Azad, M. B., & Arrieta, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1857513 · Cited by 77
Unraveling the Role of the Human Gut Microbiome in Health and Diseases
Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 100
The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment
Lian, J., Liang, Y., Zhang, H., Lan, M., Ye, Z., Lin, B., Qiu, X., & Zeng, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.912279 · Cited by 75
Artificial intelligence and synthetic biology approaches for human gut microbiome
Kumar, P., Sinha, R., & Shukla, P. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1850415 · Cited by 78
A meta-analysis study of the robustness and universality of gut microbiome-metabolome associations
Muller, E., Algavi, Y. M., & Borenstein, E. (2021) · Microbiome · doi:10.1186/s40168-021-01149-z · Cited by 76
The Role of the Microbiome in Food Allergy: A Review
Nance, C. L., Deniskin, R., Diaz, V. C., Paul, M., Anvari, S., & Anagnostou, A. (2020) · Children · doi:10.3390/children7060050 · Cited by 75
Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk
Fellows, R., & Varga‐Weisz, P. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.005 · Cited by 77
Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”
Hu, X., He, Z., Zhao, C., He, Y., Qiu, M., Xiang, K., Zhang, N., & Fu, Y. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.02.009 · Cited by 72
Role of the microbiome and its metabolites in ankylosing spondylitis
Song, Z., Yuan, D., & Zhang, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010572 · Cited by 72
Phylogeny resolved, metabolism revealed: functional radiation within a widespread and divergent clade of sponge symbionts
Taylor, J. A., Palladino, G., Wemheuer, B., Steinert, G., Sipkema, D., Williams, T. J., & Thomas, T. (2020) · The ISME Journal · doi:10.1038/s41396-020-00791-z · Cited by 63
Gut microbiota and anti-aging: Focusing on spermidine
Yu, L., Pan, J., Guo, M., Duan, H., Zhang, H., Narbad, A., Zhai, Q., Tian, F., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2224867 · Cited by 63
Malodorous biogenic amines in Escherichia coli-caused urinary tract infections in women—a metabolomics approach
Puebla-Barragan, S., Renaud, J. B., Sumarah, M. W., & Reid, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-66662-x · Cited by 60
Putrescine mitigates intestinal atrophy through suppressing inflammatory response in weanling piglets
Liu, B., Jiang, X., Cai, L., Zhao, X., Dai, Z., Wu, G., & Li, X. (2019) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-019-0379-9 · Cited by 60
Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells
Calvo‐Barreiro, L., Zhang, L., Abdel‐Rahman, S. A., Naik, S. P., & Gabr, M. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021806 · Cited by 62
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
Chagneau, C. V., Garcie, C., Bossuet‐Greif, N., Tronnet, S., Brachmann, A. O., Piel, J., Nougayrède, J., Martín, P., & Oswald, É. (2019) · mSphere · doi:10.1128/msphere.00414-19 · Cited by 65
Gut Microbial Metabolites on Host Immune Responses in Health and Disease
Yoon, J.-H., Do, J.-S., Velankanni, P., Lee, C., & Kwon, H. (2023) · Immune Network · doi:10.4110/in.2023.23.e6 · Cited by 64
Occurrence of Polyamines in Foods and the Influence of Cooking Processes
Muñoz‐Esparza, N., Costa-Catala, J., Comas-Basté, O., Toro-Funes, N., Latorre‐Moratalla, M. L., Veciana-Nogués, M. T., & Vidal‐Carou, M. C. (2021) · Foods · doi:10.3390/foods10081752 · Cited by 57
Roles of microbiota in pancreatic cancer development and treatment
Cruz, M. S., Tintelnot, J., & Gagliani, N. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2320280 · Cited by 64
Gut Microbiota-Derived Metabolite Signature in Suckling and Weaned Piglets
Beaumont, M., Cauquil, L., Bertide, A., Ahn, I., Barilly, C., Gil, L., Canlet, C., Zemb, O., Pascal, G., Samson, A., et al. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00745 · Cited by 56
Microbial Metabolite Dysbiosis and Colorectal Cancer
Niekamp, P., & Kim, C. H. (2023) · Gut and Liver · doi:10.5009/gnl220260 · Cited by 60
Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis
Xing, P. Y., Pettersson, S., & Kundu, P. (2020) · PROTEOMICS · doi:10.1002/pmic.201800419 · Cited by 55
Anti-Inflammatory Potential of Cow, Donkey and Goat Milk Extracellular Vesicles as Revealed by Metabolomic Profile
Mecocci, S., Gevi, F., Pietrucci, D., Cavinato, L., Luly, F. R., Pascucci, L., Petrini, S., Ascenzioni, F., Zolla, L., Chillemi, G., et al. (2020) · Nutrients · doi:10.3390/nu12102908 · Cited by 53
Metabolome Changes With Diet-Induced Remission in Pediatric Crohn’s Disease
Ghiboub, M., Penny, S. L., Verburgt, C. M., Boneh, R. S., Wine, E., Cohen, A., Dunn, K. A., Pinto, D. M., Benninga, M. A., de Jonge, W. J., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.05.050 · Cited by 54
The gut microbiota in retinal diseases
Bringer, M.-A., Gabrielle, P., Bron, A. M., Creuzot-Garcher, C. P., & Acar, N. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108867 · Cited by 52
Microbiota of the gastrointestinal tract: Friend or foe?
Senchukova, M. A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.19 · Cited by 56
Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings
Krzystek‐Korpacka, M., Fleszar, M. G., Bednarz-Misa, I. S., Lewandowski, Ł., Szczuka, I., Kempiński, R., & Neubauer, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051641 · Cited by 51
Effects of aging on the skin and gill microbiota of farmed seabass and seabream
Rosado, D., Pérez‐Losada, M., Pereira, A., Severino, R., & Xavier, R. (2021) · Animal Microbiome · doi:10.1186/s42523-020-00072-2 · Cited by 50
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, I., Koistinen, V., Kokla, M., Klåvus, A., Babu, A. F., Lehtonen, M., Auriola, S. O. K., & Hanhineva, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-19327-w · Cited by 49
Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach
Barker‐Tejeda, T. C., Zubeldia‐Varela, E., Macías‐Camero, A., Alonso, L., Martín‐Antoniano, I. A., Rey-Stolle, F., Mera‐Berriatua, L., Bazire, R., Cabrera‐Freitag, P., Shanmuganathan, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47182-y · Cited by 55
Supplemental selenium source on gut health: insights on fecal microbiome and fermentation products of growing puppies
Pereira, A. M., Pinna, C., Biagi, G., Stefanelli, C., Maia, M. R. G., Matos, E., Segundo, M. A., Fonseca, A. J. M., & Cabrita, A. R. J. (2020) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiaa212 · Cited by 51
Polyamine biomarkers as indicators of human disease
Amin, M., Tang, S., Shalamanova, L., Taylor, R. L., Wylie, S. R., Abdullah, B. M., & Whitehead, K. A. (2021) · Biomarkers · doi:10.1080/1354750x.2021.1875506 · Cited by 51
The role of the microbiota in glaucoma
Huang, L., Hong, Y., Fu, X., Tan, H., Chen, Y., Wang, Y., & Chen, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101221 · Cited by 49
Mammalian gut metabolomes mirror microbiome composition and host phylogeny
Gregor, R., Probst, M., Eyal, S., Aksenov, A. A., Sasson, G., Horovitz, I., Dorrestein, P. C., Meijler, M. M., & Mizrahi, I. (2021) · The ISME Journal · doi:10.1038/s41396-021-01152-0 · Cited by 47
Accumulation γ-Aminobutyric Acid and Biogenic Amines in a Traditional Raw Milk Ewe’s Cheese
Tofalo, R., Perpetuini, G., Battistelli, N., Pepe, A., Ianni, A., Martino, G., & Suzzi, G. (2019) · Foods · doi:10.3390/foods8090401 · Cited by 45
Self-citation
De-coding the complex role of microbial metabolites in cancer
Escriva, P. P., Bernardino, C. C. T., & Letellier, E. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115358 · Cited by 48
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription
Peng, V., Cao, S. “., Tršan, T., Bando, J. K., Ávila-Pacheco, J., Cleveland, J. L., Clish, C. B., Xavier, R. J., & Colonna, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214900119 · Cited by 41
Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis
Kulkarni, A., Anderson, C. M., Mirmira, R. G., & Tersey, S. A. (2022) · Metabolites · doi:10.3390/metabo12040344 · Cited by 40
The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story
Skoufou, M., Tsigalou, C., Vradelis, S., & Bezirtzoglou, E. (2024) · Microorganisms · doi:10.3390/microorganisms12010194 · Cited by 41
Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients
Sammallahti, H., Kokkola, A., Rezasoltani, S., Ghanbari, R., Aghdaei, H. A., Knuutila, S., Puolakkainen, P. A., & Sarhadi, V. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312978 · Cited by 40
Modulation of Anti-Tumour Immune Responses by Probiotic Bacteria
Aindelis, G., & Chlichlia, K. (2020) · Vaccines · doi:10.3390/vaccines8020329 · Cited by 39
Neuroprotection by agmatine: Possible involvement of the gut microbiome?
Saha, P., Panda, S., Holkar, A., Vashishth, R., Rana, S. S., Arumugam, M., Ashraf, G. M., Haque, S., & Ahmad, F. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102056 · Cited by 35
Postbiotics as Antiinflammatory and Immune‐Modulating Bioactive Compounds in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Yilmaz, Y. N. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400754 · Cited by 34
Potential Probiotic Bacillus subtilis Isolated from a Novel Niche Exhibits Broad Range Antibacterial Activity and Causes Virulence and Metabolic Dysregulation in Enterotoxic E. coli
Sudan, S., Flick, R., Nong, L., & Li, J. (2021) · Microorganisms · doi:10.3390/microorganisms9071483 · Cited by 39
Fecal microbiota transplantation, a tool to transfer healthy longevity
Novelle, M. G., Naranjo-Martínez, B., Lopez-Canovas, J. L., & Díaz‐Ruiz, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102585 · Cited by 35
Therapeutic potential of microbial modulation in pancreatic cancer
Chandra, V., & McAllister, F. M. (2021) · Gut · doi:10.1136/gutjnl-2019-319807 · Cited by 35
Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice
Forgie, A. J., Pepin, D. M., Ju, T., Tollenaar, S. L., Sergi, C. M., Gruenheid, S., & Willing, B. P. (2023) · Microbiome · doi:10.1186/s40168-023-01461-w · Cited by 36
Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV
Mahalingam, S. S., Jayaraman, S., Bhaskaran, N., Schneider, E., Faddoul, F., da Silva, A. P., Lederman, M. M., Asaad, R. J., Adkins-Travis, K., Shriver, L. P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36163-2 · Cited by 32
Synbiotic supplementation with prebiotic Schizophyllum commune derived β-(1,3/1,6)-glucan and probiotic concoction benefits gut microbiota and its associated metabolic activities
Singh, V., Muthuramalingam, K., Kim, Y., Park, S., Kim, S. H., Lee, J., Hyun, C. L., Unno, T., & Cho, M. (2021) · Applied Biological Chemistry · doi:10.1186/s13765-020-00572-4 · Cited by 32
Microbiome-Derived Metabolites in Allogeneic Hematopoietic Stem Cell Transplantation
Masetti, R., Zama, D., Leardini, D., Muratore, E., Turroni, S., Brigidi, P., & Pession, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031197 · Cited by 30
The metabolic role of spermidine in obesity: Evidence from cells to community
Choksomngam, Y., Pattanakuhar, S., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2021.06.009 · Cited by 30
Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body
Rieck, J., Skatchkov, S. N., Derst, C., Eaton, M. J., & Veh, R. W. (2022) · Biomolecules · doi:10.3390/biom12040501 · Cited by 28
Plasma high-resolution metabolomics identifies linoleic acid and linked metabolic pathways associated with bone mineral density
Bellissimo, M. P., Ziegler, T. R., Jones, D. P., Liu, K., Fernandes, J., Roberts, J. L., Weitzmann, M. N., Pacifici, R., & Alvarez, J. A. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.041 · Cited by 29
Bacterial cross talk with gut microbiome and its implications: a short review
Shastry, R. P., & Rekha, P. D. (2020) · Folia Microbiologica · doi:10.1007/s12223-020-00821-5 · Cited by 29
The infant gut microbiota: in pursuit of non-protein nitrogen
Schimmel, P., Stahl, B., Knol, J., & Belzer, C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2211917 · Cited by 28
Genomic and functional characterization of the Atlantic salmon gut microbiome in relation to nutrition and health
de León, A. V.-P., Hensen, T., Hoetzinger, M., Gupta, S., Weston, B. R., Johnsen, S. M., Rasmussen, J. A., Clausen, C. G., Pless, L., Verissimo, A. R., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01830-7 · Cited by 27
Probiotics or synbiotics addition to sows’ diets alters colonic microbiome composition and metabolome profiles of offspring pigs
Zhu, Q., Song, M., Azad, M. A. K., Cheng, Y., Liu, Y., Liu, Y., Blachier, F., Yin, Y., & Kong, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.934890 · Cited by 34
The Molecular Role of Polyamines in Age-Related Diseases: An Update
Jiménez-Gutiérrez, G. E., Jiménez, F. V. B., Muñoz, L. G., Tapia-Guerrero, Y. S., Murillo-Melo, N. M., Cristóbal-Luna, J. M., Leyva‐García, N., Cordero‐Martínez, J., & Magaña, J. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216469 · Cited by 34
A comprehensive review for gut microbes: technologies, interventions, metabolites and diseases
Qi, C., Wang, P., Fu, T., Lu, M., Cai, Y., Chen, X., & Cheng, L. (2020) · Briefings in Functional Genomics · doi:10.1093/bfgp/elaa029 · Cited by 28
Cage bedding modifies metabolic and gut microbiota profiles in mouse studies applying dietary restriction
Gregor, A., Fragner, L., Trajanoski, S., Li, W., Sun, X., Weckwerth, W., König, J. S., & Duszka, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-77831-3 · Cited by 29
Understanding and harnessing triple-negative breast cancer-related microbiota in oncology
Devoy, C., Bueso, Y. F., & Tangney, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1020121 · Cited by 29
Current understandings of colibactin regulation
Addington, E., Sandalli, S., & Roe, A. J. (2024) · Microbiology · doi:10.1099/mic.0.001427 · Cited by 27
Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis”
Yadav, S., Sapra, L., & Srivastava, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134655 · Cited by 29
Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
Sieckmann, T., Schley, G., Ögel, N., Kelterborn, S., Boivin, F. J., Fähling, M., Ashraf, M., Reichel, M., Vigolo, E., Hartner, A., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.04.005 · Cited by 26
Implication of gut microbes and its metabolites in colorectal cancer
Kumar, A., Ali, A., Kapardar, R. K., Dar, G. M., Nimisha, Apurva, A., Sharma, A. K., Verma, R., Sattar, R. S. A., Ahmad, E., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04422-2 · Cited by 26

Authors: Tofalo, R., Cocchi, S., & Suzzi, G.
Affiliations: University of Teramo (IT)
Corresponding author: Tofalo, Rosanna
ORCID: Tofalo, Rosanna
Venue: Frontiers in Nutrition
Publisher: Frontiers Media SA
Published: 2019-02-25
Volume: 6
Pages: 16-16
ISSN: 2296-861X (ISSN-L)
DOI: 10.3389/fnut.2019.00016
PMC: PMC6397830
OpenAlex: W2917494464
Cited by: 306
References: 58
Citations by year: 2026: 48 · 2025: 41 · 2024: 42 · 2023: 41 · 2022: 34 · 2021: 59 · 2020: 30 · 2019: 10
FWCI: 11.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Nutrition (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: polyamines, gut microbiota, host-microbe metabolic interactions, microbial metabolites, polyamine metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polyamines and Gut Microbiota

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks