The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Dying cell clearance and its impact on the outcome of tumor radiotherapy
Open accessAbstract
The induction of tumor cell death is one of the major goals of radiotherapy and has been considered to be the central determinant of its therapeutic outcome for a long time. However, accumulating evidence suggests that the success of radiotherapy does not only derive from direct cytotoxic effects on the tumor cells alone, but instead might also depend - at least in part - on innate as well as adaptive immune responses, which can particularly target tumor cells that survive local irradiation. The clearance of dying tumor cells by phagocytic cells of the innate immune system represents a crucial step in this scenario. Dendritic cells and macrophages, which engulf, process and present dying tumor cell material to adaptive immune cells, can trigger, skew, or inhibit adaptive immune responses, respectively. In this review we summarize the current knowledge of different forms of cell death induced by ionizing radiation, the multi-step process of dying cell clearance, and its immunological consequences with special regard toward the potential exploitation of these mechanisms for the improvement of tumor radiotherapy.
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Cites
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Cited by
Consensus guidelines for the detection of immunogenic cell death
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Self-citationThe complex roles of efferocytosis in cancer development, metastasis, and treatment
Tajbakhsh, A., Gheibi hayat, S. M., Movahedpour, A., Savardashtaki, A., Loveless, R., Barreto, G. E., Teng, Y., & Sahebkar, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111776 · Cited by 64
Metadata
- Authors
- Lauber, K., Ernst, A., Orth, M., Herrmann, M., & Belka, C.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 2
- Pages
- 116-116
- ISSN
- 2234-943X (ISSN-L)
- OpenAlex
- W2108387330
- Cited by
- 187
- References
- 34
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- gold
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