The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
Open accessAbstract
YTH N6-methyladenosine(m6A) RNA binding protein 1 (YTHDF1) is a core factor in RNA methylation modification. Recent studies have shown that m6A is closely related to multiple tumors, thus YTHDF1 may also play a role in tumorigenesis. This study, aimed to explore the role of YTHDF1 in the colorectal cancer (CRC) . In this study, we identified YTHDF1 as being highly expressed at the mRNA and protein levels in TCGA, GEO CRC and primary CRC. Furthermore, the YTHDF1 gene copy number was positively correlated with YTHDF1 mRNA expression in CRC. Knocking down the expression of YTHDF1 significantly inhibited the CRC cell’s tumorigenicity in vitro and murine xenograft tumor growth in vivo. Furthermore, silencing of YTHDF1 inhibited the colonosphere formation ability in vitro. Mechanistically, we found that silencing YTHDF1 significantly inhibited Wnt/β-catenin pathway activity in CRC cells. Together, YTHDF1 is overexpressed in CRC and plays a vital oncogenic role in CRC, and this novel finding may provide a potential therapeutic target for CRC.
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Cited by
The potential role of RNA N6-methyladenosine in Cancer progression
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m6A-binding proteins: the emerging crucial performers in epigenetics
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Reading the m6A-encoded epitranscriptomic information in development and diseases
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Metadata
- Authors
- Bai, Y., Yang, C., Wu, R., Huang, L., Song, S., Li, W., Yan, P., Lin, C., Li, D., & Zhang, Y.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-03
- Volume
- 9
- Pages
- 332-332
- ISSN
- 2234-943X (ISSN-L)
- OpenAlex
- W2939559050
- Cited by
- 267
- References
- 48
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bai, Y., Yang, C., Wu, R., Huang, L., Song, S., Li, W., Yan, P., Lin, C., Li, D., & Zhang, Y. (2019). YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. Frontiers in Oncology. https://doi.org/10.3389/fonc.2019.00332
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