The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes
Open accessAbstract
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ plays key role in pathogenesis of vascular complications of diabetes. Persistent hyperglycemia activates NF-κβ that triggers expression of various cytokines, chemokines and cell adhesion molecules. Over-expression of TNF-α, interleukins, TGF-β, Bcl2 and other pro-inflammatory proteins and pro-apoptotic genes by NF-κβ is key risk factor in vascular dysfunction. NF-κβ over-expression also triggers calcification of endothelial cells leading to endothelial dysfunction and further vascular complications. Inhibition of NF-κβ pro-inflammatory pathway is upcoming novel target for management of vascular complications of diabetes. Various natural and synthetic inhibitors of NF-κβ have been studied in management of diabetic complications. Recent preclinical and clinical studies validate NF-κβ as promising target in the management of vascular complications of diabetes.
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Citations
Cites
Biochemistry and molecular cell biology of diabetic complications
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The Nuclear Factor NF- B Pathway in Inflammation
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Phosphorylation meets ubiquitination: the control of NF-κB activity
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“In canonical pathway when signal is transduced, NEMO-containing IKK complexes are activated and induce phosphorylation of IKK complex via ubiquitination leading to release of NF-κβ dimers (Karin and Ben-Neriah, 2000).”
BackgroundNF-κB regulation in the immune system
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Missing Pieces in the NF-κB Puzzle
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“These transcription proteins possess dimerization domain to which DNA binds; Rel homology domain (RHD) at N-terminal facilitates site for dimerization through which they forms homo or hetero–dimers (Ghosh and Karin, 2002; Hayden and Ghosh, 2011).”
BackgroundDanaei, G., Finucane, M. M., Lu, Y., Singh, G. M., Cowan, M. J., Paciorek, C. J., Lin, J. K., Farzadfar, F., Khang, Y.-H., Stevens, G. A., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60679-x · Cited by 3,568
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Cited by
Scioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281
Przeor, M. (2022) · Pharmaceuticals · doi:10.3390/ph15010065 · Cited by 93
Pharmacological features, health benefits and clinical implications of honokiol
Khatoon, F., Ali, S., Kumar, V., Elasbali, A. M., Alhassan, H. H., Alharethi, S. H., Islam, A., & Hassan, M. I. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2120541 · Cited by 50
The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy
Oezer, K., Kolibabka, M., Gassenhuber, J., Dietrich, N., Fleming, T., Schlotterer, A., Morcos, M., Wohlfart, P., & Hammes, H.-P. (2023) · Acta Diabetologica · doi:10.1007/s00592-023-02135-7 · Cited by 22
Metadata
- Authors
- Suryavanshi, S. V., & Kulkarni, Y. A.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2017-11-07
- Volume
- 8
- Pages
- 798-798
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2767589056
- Cited by
- 348
- References
- 148
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Suryavanshi, S. V., & Kulkarni, Y. A. (2017). NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2017.00798
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
