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Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
Open accessAbstract
For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of clinical trials. The successful advantages of polymeric micelles from bench to bedside are due to their special core/shell structures, which can carry specific drugs in certain disease conditions. Particularly, poly(ethylene glycol)-polylactide (PEG-PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period. Meanwhile, the hydrophobic PLA core can effectively encapsulate many therapeutic agents. This review summarizes recent advances in PEG-PLA micelles for the treatment of malignancy. In addition, future perspectives for the development of PEG-PLA micelles as drug delivery systems are also presented.
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“The polymeric nanomicelles possess the merit of the EPR effect due to their small size [92] where they passively diffuse through the endothelial lining and remain at the site of inflammation owing to poor lymphatic drainage, thus releasing their payload at the specific site.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [92]
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Cites
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Targeting multidrug resistance in cancer
Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
Magnetic nanoparticles in MR imaging and drug delivery
Sun, C., Lee, J. S. H., & Zhang, M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.018 · Cited by 2,642
Progress and problems with the use of viral vectors for gene therapy
Thomas, C. E., Ehrhardt, A., & Kay, M. A. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1066 · Cited by 2,501
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438
Nanoparticle and targeted systems for cancer therapy
Brannon‐Peppas, L., & Blanchette, J. O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.014 · Cited by 2,335
Scott, A. M., Wolchok, J. D., & Old, L. J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3236 · Cited by 2,244
Chemotherapy and the war on cancer
Chabner, B. A., & Roberts, T. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1529 · Cited by 2,231
Flagged first, then by citations
Research works printed but not linked: 2
- Das, 2016, Silencing the disease messengers: progress and prospects in developing nucleic acid based therapeutics, RNAi Technol., 5, 85
- Huang, 2011, Vaccine Delivery Systems Based on Amphiphilic Bioresorbable Polymers and Their Role in Vaccine Immunogenicity
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Jurczyk, M., Musiał‐Kulik, M., Foryś, A., Godzierz, M., Kaczmarczyk, B., Kasperczyk, J., Wrześniok, D. M., Beberok, A., & Jelonek, K. (2023) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35318 · Cited by 5
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PEREIRA, L. F. T., Tredus, J. G. R., Corá, L. O., Novacki, L. L., Oliveira, G. E. D., Vodiani, M., Dias, I. P., Filho, R. X. V., & Picheth, G. F. (2024) · Nanomedicine · doi:10.1080/17435889.2024.2382077 · Cited by 5
Xu, C., Jiang, X., Yin, W., Lyu, L., Tan, H., He, W., Wang, W., Zhou, Z., Zhou, H., Xu, B., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb02080d · Cited by 5
Min, Y., Zhang, H., Wang, H., & Song, Y. (2020) · Designed Monomers & Polymers · doi:10.1080/15685551.2020.1845428 · Cited by 5
Ding, J., Su, J., Luo, B., & Ding, L. (2024) · Molecules · doi:10.3390/molecules29051081 · Cited by 5
Khong, M.-T., Darcos, V., Vialaret, J., Ng, F., Couture, G., Cagnon, M.-E., Noriega, A. L., Kindermans, J., Garric, X., Hirtz, C., et al. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c01169 · Cited by 4
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Liang, Z.-J., Li, J., Huang, H., Jiang, H., Luo, L., Li, S., Huang, H., & Hu, F. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107073 · Cited by 4
Self-citationQu, H., Wang, K., Lin, Z., Li, S., Tang, C., & Yin, C. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124337 · Cited by 4
Self-citationDrug delivery and functional nanoparticles
Roy, D., Modi, A., Ghosh, R., & Benito‐León, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91783-4.00018-8 · Cited by 4
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Xian, X., Gong, F., Chen, M., Zheng, J., Tian, J. H., Fu, S., Zhou, G., & Zhang, W. (2023) · European Polymer Journal · doi:10.1016/j.eurpolymj.2023.112328 · Cited by 4
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Pandey, P., Patel, J. K., & Kumar, S. (2022) · Wiley eBooks · doi:10.1002/9781119650294.ch6 · Cited by 4
Malkawi, A. S., Airemwen, C. O., & Malkawi, A. (2025) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-10041-4 · Cited by 4
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Ibharm, S. F., Ismail, N. I., & Jusoh, N. (2021) · IEEE International Biomedical Instrumentation and Technology Conference (IBITeC) · doi:10.1109/ibitec53045.2021.9649094 · Cited by 2
Polymeric micelles–mediated photodynamic therapy
de Santana, W. M. O. S., Pochapski, D. J., Pulcinelli, S. H., Fontana, C. R., & Santilli, C. V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85595-2.00003-7 · Cited by 2
Kang, M.-S., Lee, G., Yang, M., Sung, M., Han, H., Lee, B., Baek, B., Kim, D., & Park, E. (2022) · Nanotoxicology · doi:10.1080/17435390.2023.2177205 · Cited by 2
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Singh, A., Pal, V., Aggarwal, S., & Pant, M. (2023) · Springer eBooks · doi:10.1007/978-981-99-0927-8_9 · Cited by 1
El‐Nahass, E., Eldahab, S. I. A., & Salim, E. I. (2025) · Toxicology Research · doi:10.1093/toxres/tfaf057 · Cited by 1
Mandal, S. K. (2025) · Current Cancer Drug Targets · doi:10.2174/0115680096351325250412164059 · Cited by 1
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Sudhina, S., Heera, S., Abhirami, Mohan, A., Deepa, K., & Janeesh, P. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-90838-2.00001-1
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Liu, H., & Birch, C. (2024) · Journal of Student Research · doi:10.47611/jsrhs.v13i1.6259
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Metadata
- Authors
- Wang, J., Li, S., Han, Y., Guan, J., Chung, S., Wang, C., & Li, D.
- Affiliations
- Chinese Academy of Sciences (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- University of Waterloo (CA)
- Corresponding author
- Han, Yuping
- Guan, Jingjing
- Li, Di
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2018-03-08
- Volume
- 9
- Pages
- 202-202
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC5890116
- OpenAlex
- W2792803144
- Cited by
- 155
- References
- 115
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 26 · 2023: 21 · 2022: 22 · 2021: 20 · 2020: 24 · 2019: 16 · 2018: 5
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (51673190, 51603204, 51303174, 51473165, 51390484, 51520105004)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, cancer therapy, drug delivery systems, nanocarriers, core-shell structure, PEGylation, blood circulation, protein adsorption resistance, photosensitizers, gene delivery, clinical translation
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