Moringa oleifera Seed Extract Alleviates Scopolamine-Induced Learning and Memory Impairment in Mice
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seed extract (MSE) on cognitive impairment caused by scopolamine injection in mice using the passive avoidance and Morris water maze (MWM) tests. MSE (250 or 500 mg/kg) was administered to mice by oral gavage for 7 or 14 days, and cognitive impairment was induced by intraperitoneal injection of scopolamine (4 mg/kg) for 1 or 6 days. Mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity and neurogenesis in the hippocampus. MSE pretreatment significantly ameliorated scopolamine-induced cognitive impairment and enhanced cholinergic system reactivity and neurogenesis in the hippocampus. Additionally, the protein expressions of phosphorylated Akt, ERK1/2, and CREB in the hippocampus were significantly decreased by scopolamine, but these decreases were reversed by MSE treatment. These results suggest that MSE-induced ameliorative cognitive effects are mediated by enhancement of the cholinergic neurotransmission system and neurogenesis via activation of the Akt, ERK1/2, and CREB signaling pathways. These findings suggest that MSE could be a potent neuropharmacological drug against amnesia, and its mechanism might be modulation of cholinergic activity via the Akt, ERK1/2, and CREB signaling pathways.
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Other studies demonstrated the protective effect of M. oleifera against memory impairment in experimental models of dementia.
“Other studies also demonstrated the protective effect of M. oleifera against memory impairment in experimental models of dementia [225,226].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [226]
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- Authors
- Zhou, J., Yang, W.-S., Suo, D.-Q., Li, Y., Peng, L., Xu, L.-X., Zeng, K.-Y., Ren, T., Wang, Y., Zhou, Y., Zhao, Y., Yang, L.-C., & Jin, X.
- Affiliations
- Xiamen University (CN)
- Xiamen Medical College (CN)
- Corresponding author
- Jin, Xin
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2018-04-24
- Volume
- 9
- Pages
- 389-389
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC5928465
- OpenAlex
- W2801790366
- Cited by
- 53
- References
- 40
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- 2026: 5 · 2025: 2 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 7 · 2020: 5 · 2019: 2 · 2012: 1
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- 3.10
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- journal article
- Language
- en
- Open access
- gold
- doi.org
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- Europe PMC (PubMed Central) (publishedVersion, cc-by)
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- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Moringa oleifera research and applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Moringa oleifera, seed extract, scopolamine, cognitive impairment, learning and memory, cholinergic neurotransmission, hippocampal neurogenesis, Akt signaling, ERK signaling, CREB signaling, amnesia, neuroprotection
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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