Exosomes: Potential Biomarkers and Functions in Head and Neck Squamous Cell Carcinoma
Open accessAbstract
Head and neck squamous cell carcinoma (HNSCC), originating from the mucosal epithelial cells of the oral cavity, pharynx, and larynx, is a lethal malignancy of the head and neck. Patients with advanced and recurrent HNSCC have poor outcomes due to limited therapeutic options. Exosomes have active roles in the pathophysiology of tumors and are suggested as a potential therapeutic target of HNSCC. Exosomes in HNSCC have been intensively studied for disease activity, tumor staging, immunosuppression, and therapeutic monitoring. In this review, the biological mechanisms and the recent clinical application of exosomes are highlighted to reveal the potential of exosomes as biomarkers and therapeutic targets for HNSCC.
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ESCRT is accepted as molecular media by which exosomes have specific cargo sorting functions.
“The endosomal sorting complex required for transport (ESCRT) is accepted as molecular media by which exosomes have specific cargo sorting functions [12].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [12]
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- Authors
- Li, T., Li, J., Wang, H., Zhao, J., Yan, M., He, H., & Yu, S.
- Affiliations
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- National Institutes of Health (US)
- Corresponding author
- Yu, Shan
- Venue
- Frontiers in Molecular Biosciences
- Publisher
- Frontiers Media SA
- Published
- 2022-06-14
- Volume
- 9
- Pages
- 881794-881794
- ISSN
- 2296-889X (ISSN-L)
- PMC
- PMC9237451
- OpenAlex
- W4282832296
- Cited by
- 18
- References
- 135
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Update notices
- corrigendum (2022-11-03)
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Molecular Biosciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Harbin Medical University
- Universidade de Macau
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- exosomes, head and neck squamous cell carcinoma, biomarkers, therapeutic target, tumor immunosuppression, tumor staging, therapeutic monitoring, extracellular vesicles
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