The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Advances in Oral Drug Delivery
Open accessAbstract
The oral route is the most common route for drug administration. It is the most preferred route, due to its advantages, such as non-invasiveness, patient compliance and convenience of drug administration. Various factors govern oral drug absorption including drug solubility, mucosal permeability, and stability in the gastrointestinal tract environment. Attempts to overcome these factors have focused on understanding the physicochemical, biochemical, metabolic and biological barriers which limit the overall drug bioavailability. Different pharmaceutical technologies and drug delivery systems including nanocarriers, micelles, cyclodextrins and lipid-based carriers have been explored to enhance oral drug absorption. To this end, this review will discuss the physiological, and pharmaceutical barriers influencing drug bioavailability for the oral route of administration, as well as the conventional and novel drug delivery strategies. The challenges and development aspects of pediatric formulations will also be addressed.
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Cites
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Membrane transporters in drug development
The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3028 · Cited by 3,340
Block copolymer micelles: preparation, characterization and application in drug delivery
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Review and analysis of FDA approved drugs using lipid-based formulations
Savla, R., Browne, J., Plassat, V., Wasan, K. M., & Wasan, E. K. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1342654 · Cited by 225
Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting
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Advances in drug delivery systems, challenges and future directions
Ezike, T. C., Okpala, U. S., Onoja, U. L., Nwike, C. P., Ezeako, E. C., Okpara, O. J., Okoroafor, C. C., Eze, S. C., Kalu, O. L., Odoh, E. C., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17488 · Cited by 1,040
The Bioavailability of Drugs—The Current State of Knowledge
Stielow, M., Witczyńska, A., Kubryń, N., Fijałkowski, Ł., Nowaczyk, J., & Nowaczyk, A. (2023) · Molecules · doi:10.3390/molecules28248038 · Cited by 391
Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy
Kim, H., Jang, H., Cho, H., Choi, J., Hwang, K. Y., Choi, Y., Kim, S. H., & Yang, Y. (2021) · Cancers · doi:10.3390/cancers13174435 · Cited by 152
Ghosh, S., Basu, S., Anbarasu, A., & Ramaiah, S. (2025) · Phytotherapy Research · doi:10.1002/ptr.8365 · Cited by 33
Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15
Metadata
- Authors
- Alqahtani, M. S., Kazi, M., Alsenaidy, M. A., & Ahmad, M. Z.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2021-02-19
- Volume
- 12
- Pages
- 618411-618411
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W3131769770
- Cited by
- 876
- References
- 8
- FWCI
- 43.44
- Type
- journal article
- Language
- en
- Open access
- gold
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- Alqahtani, M. S., Kazi, M., Alsenaidy, M. A., & Ahmad, M. Z. (2021). Advances in Oral Drug Delivery. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2021.618411
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
