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pH sensing and regulation in cancer
Open accessAbstract
Cells maintain intracellular pH (pHi) within a narrow range (7.1-7.2) by controlling membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH sensors. These sensors have the ability to recognize and induce cellular responses to maintain the pHi, often at the expense of acidifying the extracellular pH. In turn, extracellular acidification impacts cells via specific acid-sensing ion channels (ASICs) and proton-sensing G-protein coupled receptors (GPCRs). In this review, we will discuss some of the major players in proton sensing at the plasma membrane and their downstream consequences in cancer cells and how these pH-mediated changes affect processes such as migration and metastasis. The complex mechanisms by which they transduce acid pH signals to the cytoplasm and nucleus are not well understood. However, there is evidence that expression of proton-sensing GPCRs such as GPR4, TDAG8, and OGR1 can regulate aspects of tumorigenesis and invasion, including cofilin and talin regulated actin (de-)polymerization. Major mechanisms for maintenance of pHi homeostasis include monocarboxylate, bicarbonate, and proton transporters. Notably, there is little evidence suggesting a link between their activities and those of the extracellular H(+)-sensors, suggesting a mechanistic disconnect between intra- and extracellular pH. Understanding the mechanisms of pH sensing and regulation may lead to novel and informed therapeutic strategies that can target acidosis, a common physical hallmark of solid tumors.
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Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
Self-citationRubin, M., & Stephen, C. D. (1993) · Cited by 3,149
Dysregulated pH: a perfect storm for cancer progression
Webb, B. A., Chimenti, M., Jacobson, M. P., & Barber, D. L. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3110 · Cited by 2,237
Hypoxia signalling in cancer and approaches to enforce tumour regression
Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Sonveaux, P., Végran, F., Schroeder, T., Wergin, M. C., Verrax, J., Rabbani, Z. N., De Saedeleer, C. J., Kennedy, K. M., Diepart, C., Jordan, B. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36843 · Cited by 1,624
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
Jasti, J., Furukawa, H., Gonzales, E. B., & Gouaux, E. (2007) · Nature · doi:10.1038/nature06163 · Cited by 1,043
Diverse somatic mutation patterns and pathway alterations in human cancers
Kan, Z., Jaiswal, B. S., Stinson, J., Janakiraman, V., Bhatt, D., Stern, H. M., Yue, P., Haverty, P. M., Bourgon, R., Zheng, J., et al. (2010) · Nature · doi:10.1038/nature09208 · Cited by 1,027
ARF family G proteins and their regulators: roles in membrane transport, development and disease
Donaldson, J. G., & Jackson, C. L. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3117 · Cited by 934
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
Gallagher, F. A., Kettunen, M. I., Day, S. E., Hu, D.-E., Ardenkjær-Larsen, J. H., Zandt, R. I. ‘., Jensen, P. R., Karlsson, M., Golman, K., Lerche, M. H., et al. (2008) · Nature · doi:10.1038/nature07017 · Cited by 849
Proton-sensing G-protein-coupled receptors
Ludwig, M.-G., Vanek, M., Guerini, D., Gasser, J. A., Jones, C. E., Junker, U., Hofstetter, H., Wolf, R. M., & Seuwen, K. (2003) · Nature · doi:10.1038/nature01905 · Cited by 742
The monocarboxylate transporter family—Role and regulation
Halestrap, A. P., & Wilson, M. C. (2012) · IUBMB Life · doi:10.1002/iub.572 · Cited by 741
A microenvironmental model of carcinogenesis
Gatenby, R. A., & Gillies, R. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2255 · Cited by 721
Self-citationThe monocarboxylate transporter family—Structure and functional characterization
Halestrap, A. P. (2012) · IUBMB Life · doi:10.1002/iub.573 · Cited by 710
ADF/Cofilin: a functional node in cell biology
Bernstein, B. W., & Bamburg, J. R. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.001 · Cited by 704
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
Robey, I. F., Baggett, B. K., Kirkpatrick, N. D., Roe, D. J., Dosescu, J., Sloane, B. F., Hashim, A. I., Morse, D. L., Raghunand, N., Gatenby, R. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-07-5575 · Cited by 661
Self-citationAcid-sensing ion channels in pain and disease
Wemmie, J. A., Taugher, R. J., & Kreple, C. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3529 · Cited by 606
Alterations of intracellular pH homeostasis in apoptosis: origins and roles
Lagadic-Gossmann, D., Huc, L., & Lecureur, V (2004) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401466 · Cited by 522
Quantitative Imaging in Cancer Evolution and Ecology
Gatenby, R. A., Grove, O., & Gillies, R. J. (2013) · Radiology · doi:10.1148/radiol.13122697 · Cited by 515
Self-citationApoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.
Gottlieb, R. A., Nordberg, J., Skowronski, E., & Babior, B. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.654 · Cited by 494
Functions of cofilin in cell locomotion and invasion
Bravo-Cordero, J. J., Magalhaes, M. A. O., Eddy, R. J., Hodgson, L., & Condeelis, J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3609 · Cited by 461
Koukourakis, M. I., Giatromanolaki, A., Harris, A. L., & Sivridis, E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3260 · Cited by 440
Bourguignon, L. Y. W., Singleton, P. A., Diedrich, F., Stern, R., & Gilad, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311838200 · Cited by 422
Mitochondria-dependent apoptosis and cellular pH regulation
Matsuyama, S., & Reed, J. C. (2000) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400779 · Cited by 343
Extracellular Acidification Alters Lysosomal Trafficking in Human Breast Cancer Cells
Glunde, K., Guggino, S. E., Solaiyappan, M., Pathak, A. P., Ichikawa, Y., & Bhujwalla, Z. M. (2003) · Neoplasia · doi:10.1016/s1476-5586(03)80037-4 · Cited by 285
Acid-Sensitive Ion Channels and Receptors
Holzer, P. (2009) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-79090-7_9 · Cited by 282
Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin
Critchley, D. R. (2009) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.050708.133744 · Cited by 278
Hashim, A. I., Zhang, X., Wojtkowiak, J. W., Martinez, G. V., & Gillies, R. J. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1644 · Cited by 265
Self-citationBourguignon, L. W., Zhu, H., Shao, L., & Chen, Y.-W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006498200 · Cited by 262
Contributions of Cell Metabolism and H+ Diffusion to the Acidic pH of Tumors
Schornack, P. A., & Gillies, R. J. (2003) · Neoplasia · doi:10.1016/s1476-5586(03)80005-2 · Cited by 261
Self-citationWitkiewicz, A. K., Whitaker-Menezes, D., Dasgupta, A., Philp, N. J., Lin, Z., Gandara, R., Sneddon, S., Martinez-Outschoorn, U. E., Sotgia, F., & Lisanti, M. P. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19530 · Cited by 239
McIntyre, A., Patiar, S., Wigfield, S., Li, J.-L., Ledaki, I., Turley, H., Leek, R., Snell, C., Gatter, K., Sly, W. S., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1877 · Cited by 239
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
Swietach, P., Hulikova, A., Vaughan-Jones, R. D., & Harris, A. L. (2010) · Oncogene · doi:10.1038/onc.2010.455 · Cited by 233
NHE1 promotes invadopodial ECM proteolysis through acidification of the peri‐invadopodial space
Busco, G., Cardone, R. A., Greco, M. R., Bellizzi, A., Colella, M., Antelmi, E., Mancini, M. T., Dell'Aquila, M. E., Casavola, V., Paradiso, A., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-149518 · Cited by 229
Protons make tumor cells move like clockwork
Stock, C., & Schwab, A. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0677-8 · Cited by 228
Enerson, B. E., & Drewes, L. R. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10389 · Cited by 215
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway
Magalhaes, M. A. O., Larson, D. R., Mader, C. C., Bravo-Cordero, J. J., Gil-Henn, H., Oser, M., Chen, X., Koleske, A. J., & Condeelis, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201103045 · Cited by 215
Radu, C. G., Nijagal, A., McLaughlin, J., Wang, L., & Witte, O. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409415102 · Cited by 211
Carlier, M.-F. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80085-9 · Cited by 208
Hinton, A., Sennoune, S. R., Bond, S., Fang, M., Reuveni, M., Sahagian, G. G., Jay, D., Martinez-Zaguilan, R., & Forgac, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901201200 · Cited by 206
V-ATPase inhibitors and implication in cancer treatment
Pérez-Sayáns, M., Somoza-Martín, J. M., Barros-Angueira, F., Rey, J. M. G., & García-García, A. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.08.003 · Cited by 198
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding
Frantz, C., Barreiro, G., Dominguez, L., Chen, X., Eddy, R., Condeelis, J., Kelly, M. J. S., Jacobson, M. P., & Barber, D. L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804161 · Cited by 198
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
Sidani, M., Wessels, D., Mouneimne, G., Ghosh, M., Goswami, S., Sarmiento, C., Wang, W., Kuhl, S., El-Sibai, M., Backer, J. M., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200707009 · Cited by 198
Ishii, S., Kihara, Y., & Shimizu, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407832200 · Cited by 193
Morris, M. E., & Felmlee, M. A. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9035-6 · Cited by 192
Monocarboxylate transporter 1 is up‐regulated in basal‐like breast carcinoma
Pinheiro, C., Albergaria, A., Paredes, J., Sousa, B., Dufloth, R., Vieira, D., Schmitt, F., & Baltazar, F. (2010) · Histopathology · doi:10.1111/j.1365-2559.2010.03560.x · Cited by 189
Cancer prevention research — then and now
Bode, A. M., & Dong, Z. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2646 · Cited by 188
Redox regulation of the hypoxia-inducible factor
Pouysségur, J., & Mechta-Grigoriou, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.167 · Cited by 186 · cited 1×
“…Anhydrases such as CA2, CA9, and CA12 (Barathova et al., 2008; Supuran et al., 2010); V-ATPase (Hinton et al., 2009); Na+/HCO−3 co-transporters (Pouyssegur and Mechta-Grigoriou, 2006); the Na+-driven Cl−/HCO−3 exchanger, SLC4A8 (Pouyssegur et al., 2006); the monocarboxylate transporters:…”
Nichols, J. W., & Deamer, D. W. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2038 · Cited by 181
Metabolic symbiosis in cancer: Refocusing the Warburg lens
Nakajima, E. C., & Van Houten, B. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.21863 · Cited by 176
Schönichen, A., Webb, B. A., Jacobson, M. P., & Barber, D. L. (2013) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-050511-102349 · Cited by 162
Structure and activity of the acid-sensing ion channels
Sherwood, T. W., Frey, E. N., & Askwith, C. C. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00188.2012 · Cited by 159
Intracellular pH gradients in migrating cells
Martin, C., Pedersen, S. F., Schwab, A., & Stock, C. M. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00280.2010 · Cited by 154
Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis
Amith, S. R., & Fliegel, L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4031 · Cited by 153
Martı́nez–Zaguilán, R., Raghunand, N., Lynch, R. M., Bellamy, W. T., Martı́nez, G. M., Rojas, B., Smith, D., Dalton, W. S., & Gillies, R. J. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00022-2 · Cited by 144
Self-citationAcidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization
Nagae, M., Hiraga, T., & Yoneda, T. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-006-0734-8 · Cited by 144
Acid-sensing Ion Channels in Malignant Gliomas
Berdiev, B. K., Xia, J., McLean, L. A., Markert, J. M., Gillespie, G. Y., Mapstone, T. B., Naren, A. P., Jovov, B., Bubien, J. K., Ji, H.-L., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300991200 · Cited by 139
Srivastava, J., Barreiro, G., Groscurth, S., Gingras, A. R., Goult, B. T., Critchley, D. R., Kelly, M. J. S., Jacobson, M. P., & Barber, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805163105 · Cited by 138
Intracellular ion channels and cancer
Leanza, L., Biasutto, L., Managò, A., Gulbins, E., Zoratti, M., & Szabó, I. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00227 · Cited by 136
Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice
Ibrahim‐Hashim, A., Cornnell, H. H., Abrahams, D. F., Lloyd, M. C., Bui, M. M., Gillies, R. J., & Gatenby, R. A. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.03.113 · Cited by 133
Self-citationMetabolic consequences of a reversed pH gradient in rat tumors.
Stubbs, M., Rodrigues, L. M., Howe, F. A., Wang, J., Jeong, K.-S., Veech, R. L., & Griffiths, J. R. (1994) · PubMed · Cited by 127
Acid-sensing ion channels: A new target for pain and CNS diseases.
Sluka, K. A., Winter, O. C., & Wemmie, J. A. (2009) · PubMed · Cited by 122
Frantz, C., Karydis, A., Nalbant, P., Hahn, K. M., & Barber, D. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704169 · Cited by 120
Boedtkjer, E., Moreira, J. M. A., Mele, M., Vahl, P., Wielenga, V. T., Christiansen, P., Jensen, V. E. D., Pedersen, S. F., & Aalkjær, C. (2012) · International Journal of Cancer · doi:10.1002/ijc.27782 · Cited by 119
Huber, V., Milito, A. D., Harguindey, S., Reshkin, S. J., Wahl, M., Rauch, C., Chiesi, A., Pouysségur, J., Gatenby, R. A., Rivoltini, L., et al. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-57 · Cited by 119
Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain
Yoneda, T., Hata, K., Nakanishi, M., Nagae, M., Nagayama, T., Wakabayashi, H., Nishisho, T., Sakurai, T., & Hiraga, T. (2010) · Bone · doi:10.1016/j.bone.2010.07.009 · Cited by 111
Steffan, J. J., Snider, J. L., Skalli, O., Welbourne, T., & Cardelli, J. A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00904.x · Cited by 108
Transport of volatile solutes through AQP1
Cooper, G. J., Zhou, Y., Bouyer, P., Grichtchenko, I. I., & Boron, W. F. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023218 · Cited by 107
G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers
Sin, W. C., Zhang, Y., Zhong, W., Adhikarakunnathu, S., Powers, S., Hoey, T., An, S. M., & Yang, J. (2004) · Oncogene · doi:10.1038/sj.onc.1207838 · Cited by 105
Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch
Lee, S. A., Eyeson, R., Cheever, M. L., Geng, J., Verkhusha, V. V., Burd, C. G., Overduin, M., & Kutateladze, T. G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503900102 · Cited by 104
Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor
Castellone, R. D., Leffler, N. R., Dong, L., & Yang, L. V. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.08.013 · Cited by 102
Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001165107 · Cited by 100
Surface Expression of ASIC2 Inhibits the Amiloride-sensitive Current and Migration of Glioma Cells
Vila‐Carriles, W. H., Kovacs, G. G., Jovov, B., Zhou, Z.-H., Pahwa, A. K., Colby, G., Esimai, O., Gillespie, G. Y., Mapstone, T. B., Markert, J. M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603100200 · Cited by 98
Duan, B., Liu, D.-S., Huang, Y., Zeng, W.-Z., Wang, X., Yu, H., Zhu, M. X., Chen, Z.-Y., & Xu, T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4479-11.2012 · Cited by 97
Ovarian Cancer G Protein Coupled Receptor 1, a New Metastasis Suppressor Gene in Prostate Cancer
Singh, L. S., Berk, M. P., Oates, R., Zhao, Z., Tan, H., Jiang, Y., Zhou, A., Kirmani, K., Steinmetz, R., Lindner, D. J., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm107 · Cited by 97
Pinheiro, C. M., Longatto‐Filho, A., Simões, K., Jacob, C. E., Bresciani, C. J. C., Zilberstein, B., Cecconello, I., Alves, V. A. F., Schmitt, F. C., & Baltazar, F. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.06.018 · Cited by 95
Chiang, Y., Chou, C., Hsu, K., Huang, Y., & Shen, M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21277 · Cited by 93
Chen, H., Wang, L., Beretov, J., Hao, J., Xiao, W., & Li, Y. (2010) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9345-9 · Cited by 92
Baráthová, M., Takáčová, M., Holotnakova, T., Gibadulinová, A., Ohradanova‐Repic, A., Zaťovičová, M., Hulíková, A., Kopáček, J., Parkkila, S., Supuran, C. T., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604111 · Cited by 92
Proton/hydroxide conductance through lipid bilayer membranes
Gutknecht, J. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01870737 · Cited by 91
Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor
Wyder, L., Suply, T., Ricoux, B., Billy, É., Schnell, C., Baumgarten, B. U., Maira, S.-M., Koelbing, C., Ferretti, M., Kinzel, B., et al. (2011) · Angiogenesis · doi:10.1007/s10456-011-9238-9 · Cited by 91
Tafreshi, N. K., Bui, M. M., Bishop, K., Lloyd, M. C., Enkemann, S. A., Lopez, A. S., Abrahams, D. F., Carter, B. W., Vágner, J., Grobmyer, S. R., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0238 · Cited by 91
Self-citationLiu, J.-P., Nakakura, T., Tomura, H., Tobo, M., Mogi, C., Wang, J.-Q., He, X., Takano, M., Damirin, A., Komachi, M., et al. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.02.013 · Cited by 89
He, J., Scott, J. L., Heroux, A., Roy, S., Lenoir, M., Overduin, M., Stahelin, R. V., & Kutateladze, T. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.233015 · Cited by 87
Extracellular Acidification Elicits Spatially and Temporally Distinct Ca2+ Signals
Huang, W., Swietach, P., Vaughan‐Jones, R. D., Ansorge, O., & Glitsch, M. D. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.049 · Cited by 85
Role of OGR1 in myeloid-derived cells in prostate cancer
Yan, L., Singh, L. S., Zhang, L. Z. J., & Xu, Y. (2012) · Oncogene · doi:10.1038/onc.2012.566 · Cited by 79
Ionic Signalling by Growth Factor Receptors
Moolenaar, W. H., Defize, L. H. K., & de Laat, S. W. (1986) · Journal of Experimental Biology · doi:10.1242/jeb.124.1.359 · Cited by 77
Monocarboxylate Transporters 1 and 4 Are Associated with CD147 in Cervical Carcinoma
Pinheiro, C. M., Longatto‐Filho, A., Pereira, S. M. M., Etlinger, D., Moreira, M. A. R., Jubé, L. F., Queiroz, G. S., Schmitt, F. C., & Baltazar, F. (2009) · Disease Markers · doi:10.1155/2009/169678 · Cited by 73
Sherwood, T. W., & Askwith, C. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705118200 · Cited by 70
Intracellular pH in the Resistance Vasculature: Regulation and Functional Implications
Boedtkjer, E., & Aalkjær, C. (2012) · Journal of Vascular Research · doi:10.1159/000341235 · Cited by 66
Gillies, R. J. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10450 · Cited by 65
Self-citationLee, W., Huang, S.-C., Hsu, K., Tzeng, C., & Shen, W.-L. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.10.034 · Cited by 61
The Na+/H+‐exchanger (NHE1) generates pH nanodomains at focal adhesions
Ludwig, F. T., Schwab, A., & Stock, C. M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24293 · Cited by 59
NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP
Lin, Y., Chang, G., Wang, J., Jin, W., Wang, L., Li, H., Ma, L., Li, Q., & Pang, T. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.05.026 · Cited by 57
Molecular mechanism of membrane targeting by the GRP1 PH domain*
He, J., Haney, R. M., Vora, M., Verkhusha, V. V., Stahelin, R. V., & Kutateladze, T. G. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800150-jlr200 · Cited by 57
Li, J., Guo, B., Wang, J., Cheng, X., Xu, Y., & Sang, J. (2013) · Journal of Molecular Signaling · doi:10.1186/1750-2187-8-6 · Cited by 52
Boedtkjer, E., Damkier, H. H., & Aalkjær, C. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.227132 · Cited by 52
Longitudinal diffusion tensor imaging in a rat brain glioma model
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Waterfield, M. D. (1989) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072341 · Cited by 50
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Supuran, C. T., Fiore, A. D., Alterio, V., Monti, S. M., & Simone, G. D. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793429841 · Cited by 40
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Metadata
- Authors
- Damaghi, M., Wojtkowiak, J. W., & Gillies, R. J.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 370-370
- ISSN
- 1664-042X (ISSN-L)
- OpenAlex
- W2149078229
- Cited by
- 536
- References
- 114
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
