SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1
Open accessAbstract
The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation. Using a combination of spinning-disc confocal and total internal reflection fluorescence microscopy, we examined the uptake and transcytosis of HDL by human primary brain microvascular endothelial cell monolayers. Using these approaches, we report that HDL internalization requires dynamin but not clathrin heavy chain and that its internalization and transcytosis are saturable. Internalized HDL partially co-localized with the scavenger receptor BI (SR-BI) and knockdown of SR-BI significantly attenuated HDL internalization. However, we observed that the adaptor protein PDZK1-which is critical to HDL-SR-BI signaling in other tissues-is not required for HDL uptake in these cells. Additionally, while these cells express caveolin, the abundance of caveolae in this tissue is negligible and we find that SR-BI and caveolin do not co-fractionate. Furthermore, direct silencing of caveolin-1 had no impact on the uptake of HDL. Finally, inhibition of endothelial nitric oxide synthase increased HDL internalization while increasing nitric oxide levels had no impact. Together, these data indicate that SR-BI-mediated transcytosis in brain microvascular endothelial cells is distinct from uptake and signaling pathways described for this receptor in other cell types.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cholesterol does not cross from the periphery into the central nervous system, and small HDL particles possibly traverse by endocytosis to a small extent.
“Cholesterol does not cross from the periphery into the central nervous system (CNS) and small HDL particles possibly traverse by endocytosis to a small extent [15].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [15]
The Introduction (page unavailable) says HDL can cross the blood–brain barrier by transcytosis, which involves endothelial internalization, and the Conclusion reports HDL moving from the apical to the basolateral surface in a cell model. The paper does not specify that the particles are small or that only a small amount crosses. It also does not establish the categorical claim that peripheral cholesterol cannot enter the CNS. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,816 · see citing works
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629 · see citing works
Söllner, T. H., Bennett, M., Whiteheart, S., Scheller, R., & Rothman, J. (1993) · Cell · doi:10.1016/0092-8674(93)90376-2 · Cited by 1,922 · see citing works
Phenotypic Heterogeneity of the Endothelium
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255691.76142.4a · Cited by 1,744 · see citing works
Signaling Mechanisms Regulating Endothelial Permeability
Mehta, D., & Malik, A. B. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2005 · Cited by 1,711 · see citing works
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261 · see citing works
Phenotypic Heterogeneity of the Endothelium
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255690.03436.ae · Cited by 1,252 · see citing works
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-Zvi, A., Lacoste, B., Kur, E., Andreone, B. J., Mayshar, Y., Yan, H., & Gu, C. (2014) · Nature · doi:10.1038/nature13324 · Cited by 1,037 · see citing works
Endothelial Cell HeterogeneityPreprint
Aird, W. C. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006429 · Cited by 729 · see citing works
Oh, P., McIntosh, D. P., & Schnitzer, J. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.101 · Cited by 662 · see citing works
Andreone, B. J., Chow, B. W., Tata, A., Lacoste, B., Ben-Zvi, A., Bullock, K., Deik, A. A., Ginty, D. D., Clish, C. B., & Gu, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.043 · Cited by 636 · see citing works
A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier
Dehouck, B., Fénart, L., Dehouck, M., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 568 · see citing works
Molecular Mechanisms of Cellular Cholesterol Efflux
Phillips, M. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.583658 · Cited by 546 · see citing works
Transport, docking and exocytosis of single secretory granules in live chromaffin cells
Steyer, J. A., Horstmann, H., & Almers, W. (1997) · Nature · doi:10.1038/41329 · Cited by 443 · see citing works
Nakatsubo, N., Kojima, H., Kikuchi, K., Nagoshi, H., Hirata, Y., Maeda, D., Imai, Y., Irimura, T., & Nagano, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00440-2 · Cited by 394 · see citing works
Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
Calvo, D., Gómez‐Coronado, D., Suárez, Y., Lasunción, M. A., & Vega, M. A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32566-9 · Cited by 382 · see citing works
Blood Capillaries of the Heart and Other Organs
Kossmann, C. E., & Palade, G. E. (1961) · Circulation · doi:10.1161/01.cir.24.2.368 · Cited by 311 · see citing works
Uittenbogaard, A., Shaul, P. W., Yuhanna, I. S., Blair, A., & Smart, E. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11278 · Cited by 310 · see citing works
Characterization of four lipoprotein classes in human cerebrospinal fluid
Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., & Beisiegel, U. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31605-9 · Cited by 298 · see citing works
Bomsel, M., Parton, R. G., Kuznetsov, S. A., Schroer, T. A., & Gruenberg, J. E. (1990) · Cell · doi:10.1016/0092-8674(90)90117-w · Cited by 298 · see citing works
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36
Neculai, D., Schwake, M., Ravichandran, M., Zunke, F., Collins, R. F., Peters, J., Neculai, A. M., Plumb, J. D., Loppnau, P., Pizarro, J. C., et al. (2013) · Nature · doi:10.1038/nature12684 · Cited by 288 · see citing works
HDL and cholesterol handling in the brain
Vitali, C., Wellington, C. L., & Calabresi, L. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu148 · Cited by 254 · see citing works
Silver, D. L., Wang, N., Xiao, X., & Tall, A. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101726200 · Cited by 252 · see citing works
Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function
Jaqaman, K., Kuwata, H., Touret, N., Collins, R. F., Trimble, W. S., Danuser, G. M., & Grinstein, S. (2011) · Cell · doi:10.1016/j.cell.2011.06.049 · Cited by 244 · see citing works
Calvo, D., Gómez‐Coronado, D., Lasunción, M. A., & Vega, M. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2341 · Cited by 242 · see citing works
Balázs, Z., Panzenboeck, U., Hammer, A., Sovic, A., Quehenberger, O., Malle, E., & Sattler, W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02373.x · Cited by 239 · see citing works
Chadda, R., Howes, M. T., Plowman, S. J., Hancock, J. F., Parton, R. G., & Mayor, S. (2007) · Traffic : the International Journal of Intracellular Transport · doi:10.1111/j.1600-0854.2007.00565.x · Cited by 218 · see citing works
Rational Development of Addiction Pharmacotherapies: Successes, Failures, and ProspectsPreprint
Pierce, R. C., O'Brien, C. P., Kenny, P. J., & Vanderschuren, L. J. M. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012880 · Cited by 178 · see citing works
A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis
Armstrong, S. M., Sugiyama, M. G., Fung, K., Gao, Y. K., Wang, C., Levy, A. S., Azizi, P., Roufaiel, M., Zhu, S.-N., Neculai, D., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv218 · Cited by 172 · see citing works
Self-citationKocher, O. N., Yesilaltay, A., Cirovic, C., Pal, R., Rigotti, A., & Krieger, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310482200 · Cited by 172 · see citing works
Rohrer, L., Ohnsorg, P. M., Lehner, M., Landolt, F., Rinninger, F., & von Eckardstein, A. (2009) · Circulation Research · doi:10.1161/circresaha.108.190587 · Cited by 160 · see citing works
Catanese, M. T., Graziani, R., von Hahn, T., Moreau, M., Huby, T., Paonessa, G., Santini, C., Luzzago, A., Rice, C. M., Cortese, R., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00193-07 · Cited by 160 · see citing works
Into rather unexplored terrain—transcellular transport across the blood–brain barrier
Bock, M. D., Haver, V. V., Vandenbroucke, R. E., Decrock, E., Wang, N., & Leybaert, L. (2016) · Glia · doi:10.1002/glia.22960 · Cited by 154 · see citing works
Optimized bacterial expression of human apolipoprotein A-I
Ryan, R. O., Forte, T. M., & Oda, M. N. (2002) · Protein Expression and Purification · doi:10.1016/s1046-5928(02)00568-5 · Cited by 152 · see citing works
Koldamova, R. P., Lefterov, I. M., Lefterova, M. I., & Lazo, J. S. (2001) · Biochemistry · doi:10.1021/bi002186k · Cited by 131 · see citing works
Lefterov, I. M., Fitz, N. F., Cronican, A. A., Fogg, A., Lefterov, P., Kodali, R. B., Wetzel, R. B., & Koldamova, R. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.127738 · Cited by 129 · see citing works
Zhu, W., Saddar, S., Seetharam, D., Chambliss, K. L., Longoria, C., Silver, D. L., Yuhanna, I. S., Shaul, P. W., & Mineo, C. (2008) · Circulation Research · doi:10.1161/circresaha.107.159079 · Cited by 122 · see citing works
Nitric oxide directly promotes vascular endothelial insulin transport
Wang, H., Wang, A. X., Aylor, K., & Barrett, E. J. (2013) · Diabetes · doi:10.2337/db13-0627 · Cited by 117 · see citing works
Signaling by the High-Affinity HDL Receptor Scavenger Receptor B Type I
Saddar, S., Mineo, C., & Shaul, P. W. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.196170 · Cited by 95 · see citing works
Aït‐Slimane, T., Galmes, R., Trugnan, G., & Maurice, M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-04-0275 · Cited by 95 · see citing works
Cavelier, C., Ohnsorg, P. M., Rohrer, L., & von Eckardstein, A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.238063 · Cited by 92 · see citing works
Azizi, P., Zyla, R. E., Guan, S., Wang, C., Liu, J., Bolz, S., Heit, B., Klip, A., & Lee, W. L. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-08-1307 · Cited by 89 · see citing works
Self-citationArmstrong, S. M., Khajoee, V., Wang, C., Wang, T., Tigdi, J., Yin, J., Kuebler, W. M., Gillrie, M. R., Davis, S. P., Ho, M., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.12.002 · Cited by 67 · see citing works
Self-citationHigh-density lipoprotein endocytosis in endothelial cells
Fruhwürth, S., Pavelka, M., Bittman, R., Kovacs, W. J., Walter, K., Röhrl, C., & Stangl, H. (2013) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v4.i4.131 · Cited by 26 · see citing works
Kontush, A., & Chapman, M. J. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.169714 · Cited by 22 · see citing works
Lee, W. L., Armstrong, S. M., Khajoee, V., Wang, C., Wang, T., Tigdi, J., Yin, J., Kuebler, W. M., Gillrie, M. R., Davis, S. P., et al. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.862.1 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Xu, S., Ilyas, I., Little, P. J., Li, H., Kamato, D., Zheng, X., Luo, S., Li, Z., Liu, P., Han, J., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000096 · Cited by 1,167 · see citing works
Ahn, S. I., Sei, Y. J., Park, H., Kim, J., Ryu, Y., Choi, J. J., Sung, H., MacDonald, T. J., Levey, A. I., & Kim, Y. (2020) · Nature Communications · doi:10.1038/s41467-019-13896-7 · Cited by 409 · see citing works
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
Huang, L., Chambliss, K. L., Gao, X., Yuhanna, I. S., Behling‐Kelly, E. L., Bergaya, S., Ahmed, M. H., Michaely, P., Luby‐Phelps, K., Darehshouri, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1140-4 · Cited by 354 · see citing works
Emerging Roles of Vascular Endothelium in Metabolic Homeostasis
Pi, X., Xie, L., & Patterson, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.313237 · Cited by 299 · see citing works
Robichaud, S., Fairman, G., Vijithakumar, V., Mak, E., Cook, D. P., Pelletier, A. R., Huard, S., Vanderhyden, B. C., Figeys, D., Lavallée‐Adam, M., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1886839 · Cited by 228 · see citing works
Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier
Li, J., Zheng, M., Shimoni, O., Banks, W. A., Bush, A. I., Gamble, J. R., & Shi, B. (2021) · Advanced Science · doi:10.1002/advs.202101090 · Cited by 202 · see citing works
Hoscheidt, S. M., Sanderlin, A. H., Baker, L. D., Jung, Y., Lockhart, S. N., Kellar, D., Whitlow, C. T., Hanson, A. J., Friedman, S. D., Register, T. C., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12421 · Cited by 170 · see citing works
Ramírez, C. M., Zhang, X., Bandyopadhyay, C., Rotllán, N., Sugiyama, M. G., Aryal, B., Liu, X., He, S., Kraehling, J. R., Ulrich, V., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.038571 · Cited by 166 · see citing works
Self-citationRole of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases
Kim, S., Jung, U. J., & Kim, S. R. (2024) · Antioxidants · doi:10.3390/antiox13121462 · Cited by 173 · see citing works
Endothelial Transcytosis of Lipoproteins in Atherosclerosis
Zhang, X., Sessa, W. C., & Fernandez-Hernando, C. F. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00130 · Cited by 158 · see citing works
Pérez-López, A., Torres‐Suárez, A. I., Martín‐Sabroso, C., & Aparicio-Blanco, J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114816 · Cited by 121 · see citing works
Robichaud, S., Rasheed, A., Pietrangelo, A., Kim, A. D., Boucher, D. M., Emerton, C., Vijithakumar, V., Gharibeh, L., Fairman, G., Mak, E., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.320047 · Cited by 118 · see citing works
HDL from an Alzheimer's disease perspective
Button, E. B., Robert, J., Caffrey, T. M., Fan, J., Zhao, W., & Wellington, C. L. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000604 · Cited by 114 · see citing works
Interactions of Lipids, Lipoproteins, and Apolipoproteins with the Blood-Brain Barrier
Rhea, E. M., & Banks, W. A. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03098-6 · Cited by 97 · see citing works
In vitro blood brain barrier models: An overview
Jagtiani, E., Yeolekar, M., Naik, S. V., & Patravale, V. B. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.011 · Cited by 92 · see citing works
Georgakis, M. K., Malik, R., Anderson, C. D., Parhofer, K. G., Hopewell, J. C., & Dichgans, M. (2019) · Brain · doi:10.1093/brain/awz413 · Cited by 91 · see citing works
The Endothelium Is Both a Target and a Barrier of HDL’s Protective Functions
Robert, J., Osto, E., & von Eckardstein, A. (2021) · Cells · doi:10.3390/cells10051041 · Cited by 88 · see citing works
Mitochondrial therapeutic interventions in Alzheimer’s disease
Giau, V. V., An, S. S. A., & Hulme, J. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.09.033 · Cited by 87 · see citing works
Transendothelial transport of lipoproteins
Jang, E., Robert, J., Rohrer, L., von Eckardstein, A., & Lee, W. L. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.09.020 · Cited by 83 · see citing works
Self-citationKim, J., Ahn, S. I., & Kim, Y. (2019) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2019.01.021 · Cited by 76 · see citing works
Zhou, A. L., Swaminathan, S. K., Curran, G. L., Poduslo, J. F., Lowe, V. J., Li, L., & Kandimalla, K. K. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254201 · Cited by 63 · see citing works
Delivery of Nanoparticles and Macromolecules across the Blood–Brain Barrier
Nowak, M., Helgeson, M. E., & Mitragotri, S. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900073 · Cited by 60 · see citing works
Magro, R. D., Simonelli, S., Cox, A., Formicola, B., Corti, R., Cassina, V., Nardo, L., Mantegazza, F., Salerno, D., Grasso, G., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00419 · Cited by 58 · see citing works
Kim, J., Dey, A., Malhotra, A., Liu, J., Ahn, S. I., Sei, Y. J., Kenney, A. M., MacDonald, T. J., & Kim, Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911229117 · Cited by 59 · see citing works
HDL Proteome and Alzheimer’s Disease: Evidence of a Link
Marsillach, J., Adorni, M. P., Zimetti, F., Papotti, B., Zuliani, G., & Cervellati, C. (2020) · Antioxidants · doi:10.3390/antiox9121224 · Cited by 57 · see citing works
Ankul Singh, S., & Vellapandian, C. (2023) · Current Drug Metabolism · doi:10.2174/1389200224666230608110349 · Cited by 57 · see citing works
Vesicular Transport Machinery in Brain Endothelial Cells: What We Know and What We Do not
Tóth, A. E., Holst, M. R., & Nielsen, M. S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200212113421 · Cited by 52 · see citing works
Zimetti, F., Adorni, M. P., Marsillach, J., Marchi, C., Trentini, A., Valacchi, G., & Cervellati, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6695796 · Cited by 49 · see citing works
Lipid metabolism and retinal diseases
Gabrielle, P. (2022) · Acta Ophthalmologica · doi:10.1111/aos.15226 · Cited by 48 · see citing works
Zuin, M., Cervellati, C., Trentini, A., Passaro, A., Rosta, V., Zimetti, F., & Zuliani, G. (2021) · Diagnostics · doi:10.3390/diagnostics11060984 · Cited by 45 · see citing works
Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders
Turri, M., Marchi, C., Adorni, M. P., Calabresi, L., & Zimetti, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159123 · Cited by 54 · see citing works
Lipid efflux mechanisms, relation to disease and potential therapeutic aspects
Castaño, D., Rattanasopa, C., Monteiro-Cardoso, V. F., Corlianò, M., Liu, Y., Zhong, A., Rusu, M., Liehn, E. A., & Singaraja, R. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.013 · Cited by 37 · see citing works
Valkenburgh, J. S. V., Meuret, C. J., Martinez, A. E., Kodancha, V., Solomon, V. A., Chen, K., & Yassine, H. N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.700847 · Cited by 36 · see citing works
Raheel, H., Ghaffari, S., Khosraviani, N., Mintsopoulos, V., Auyeung, D., Wang, C., Kim, Y. H., Mullen, B. M., Sung, H., Ho, M., et al. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00127.2018 · Cited by 34 · see citing works
Self-citationWainwright, L., Hargreaves, I. P., Georgian, A. R., Turner, C., Dalton, R. N., Abbott, N. J., Heales, S., & Preston, J. E. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103236 · Cited by 35 · see citing works
Free Cholesterol Bioavailability and Atherosclerosis
Abe, R. J., Abe, J., Nguyen, M. T., Olmsted‐Davis, E. A., Mamun, A., Banerjee, P., Cooke, J. P., Fang, L., Pownall, H. J., & Le, N.-T. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01011-z · Cited by 33 · see citing works
Sergi, D., Zauli, E., Tisato, V., Secchiero, P., Zauli, G., & Cervellati, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054403 · Cited by 32 · see citing works
The SR-B1 Receptor as a Potential Target for Treating Glioblastoma
Berney, E., Sabnis, N. A., Panchoo, M., Raut, S., Dickerman, R. D., & Lacko, A. G. (2019) · Journal of Oncology · doi:10.1155/2019/1805841 · Cited by 30 · see citing works
Lu, L., Zi, H., Zhou, J., Huang, J., Deng, Z., Tang, Z., Li, L., Shi, X., Lo, P., Lovell, J. F., et al. (2023) · Advanced Science · doi:10.1002/advs.202206212 · Cited by 29 · see citing works
Approaches to Visualising Endocytosis of LDL-Related Lipoproteins
Siddiqui, H., Yevstigneyev, N. S., Madani, G., & McCormick, S. P. A. (2022) · Biomolecules · doi:10.3390/biom12020158 · Cited by 29 · see citing works
Tierney, E., Remaley, A. T., Thurm, A., Jager, L. R., Wassif, C. A., Kratz, L. E., Bailey-Wilson, J. E., Bukelis, I., Sarphare, G., Jung, E. S., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01580-8 · Cited by 26 · see citing works
Fung, K., Ho, T. W. W., Xu, Z., Neculai, D., Beauchemin, C. A. A., Lee, W. L., & Fairn, G. D. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100530 · Cited by 26 · see citing works
Self-citationCausal cardiovascular risk factors for dementia: insights from observational and genetic studies
Kjeldsen, E. W., & Frikke‐Schmidt, R. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae235 · Cited by 28 · see citing works
Salazar, J. G., Marsillach, J., Reverte, I., Mackness, B., Mackness, M., Joven, J., Camps, J., & Colomina, M. T. (2021) · Antioxidants · doi:10.3390/antiox10030339
Inherited Variants in SCARB1 Cause Severe Early-Onset Coronary Artery Disease
Koenig, S. N., Sucharski, H. C., Jose, E. M., Dudley, E. K., Madiai, F., Cavus, O., Argall, A. D., Williams, J. L., Murphy, N. P., Keith, C. B. R., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318793 · Cited by 26 · see citing works
Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses
Lam, S. M., Huang, X., & Shui, G. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.04.011 · Cited by 25 · see citing works
SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19
Al-Kuraishy, H. M., Hussein, N. R., Al‐Niemi, M. S., Fahad, E. H., Albuhadily, A. K., Al-Gareeb, A. I., Al-Hamash, S. M., Tsagkaris, C., Papadakis, M., Alexiou, A. T., et al. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.861 · Cited by 25 · see citing works
High-Density Lipoproteins in Kidney Disease
Kon, V., Yang, H., Smith, L. E., Vickers, K. C., & Linton, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158201 · Cited by 24 · see citing works
Jones, J. H., & Minshall, R. D. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190012 · Cited by 24 · see citing works
Caron, N. S., Aly, A. E.-E., Black, H. F., Martin, D. D. O., Schmidt, M. E., Ko, S., Anderson, C., Harvey, E. M., Casal, L. L., Anderson, L. M., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.011 · Cited by 23 · see citing works
Jebari‐Benslaiman, S., Uribe, K. B., Benito‐Vicente, A., Galicia-García, U., Larrea, A., Santín, I., Alloza, I., Vandenbroeck, K., Ostolaza, H., & Martı́n, C. (2022) · Small · doi:10.1002/smll.202105915 · Cited by 23 · see citing works
HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation
Radford‐Smith, D. E., Yates, A. G., Rizvi, L., Anthony, D. C., & Probert, F. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01817-z · Cited by 23 · see citing works
Swaminathan, S. K., Zhou, A. L., Ahlschwede, K. M., Curran, G. L., Lowe, V. J., Li, L., & Kandimalla, K. K. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.265876 · Cited by 22 · see citing works
Lipoprotein Particles in Cerebrospinal Fluid
Tsujita, M., Melchior, J., & Yokoyama, S. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318284 · Cited by 21 · see citing works
Ma, B., Jia, J., Wang, X., Zhang, R., Niu, S., Ni, L., Di, X., & Liu, C. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11383 · Cited by 21 · see citing works
Novel Functions of Endothelial Scavenger Receptor Class B Type I
Yu, L., Dai, Y., & Mineo, C. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00903-2 · Cited by 21 · see citing works
Deciphering the relationship between caveolae-mediated intracellular transport and signalling events
Popov, L. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110399 · Cited by 21 · see citing works
Tsujita, M., Vaisman, B. L., Liu, C., Vickers, K. C., Okuhira, K., Braesch‐Andersen, S., & Remaley, A. T. (2020) · FEBS Letters · doi:10.1002/1873-3468.13950 · Cited by 20 · see citing works
Velagapudi, S., Schraml, P., Yalçınkaya, M., Bolck, H. A., Rohrer, L., Moch, H., & von Eckardstein, A. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m083311 · Cited by 20 · see citing works
Hu, Y., Meuret, C. J., Martinez, A., Yassine, H. N., & Nedelkov, D. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000919 · Cited by 20 · see citing works
HDL and Scavenger Receptor Class B Type I (SRBI)
Yu, H. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-1592-5_6 · Cited by 19 · see citing works
D'Arrigo, J. S. (2020) · Biomimetics · doi:10.3390/biomimetics5010011 · Cited by 19 · see citing works
Sulliman, N. C., Ghaddar, B., Gence, L., Patché, J., Rastegar, S., Meilhac, O., & Diotel, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-85183-9 · Cited by 19 · see citing works
Kakava, S., Schlumpf, E., Panteloglou, G., Tellenbach, F. L., von Eckardstein, A., & Robert, J. (2022) · Cells · doi:10.3390/cells11193044 · Cited by 17 · see citing works
Development of Organs-on-Chips and Their Impact on Precision Medicine and Advanced System Simulation
Luo, Y., Li, X., Zhao, Y., Zhong, W., Xing, M. M. Q., & Lyu, G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082094 · Cited by 17 · see citing works
Nguyen, T. T., Vo, T. K., & Vo, G. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_13 · Cited by 17 · see citing works
Piao, J., Su, Z., He, J., Zhu, T., Fan, F., Wang, X., Yang, Z., Zhan, H., & Luo, D. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111252 · Cited by 16 · see citing works
The Cross-Talk Between the Peripheral and Brain Cholesterol Metabolisms
Săvulescu-Fiedler, I., Dorobantu-Lungu, L.-R., Dragosloveanu, Ş., Benea, S. N., Dragosloveanu, C. D. M., Căruntu, A., Scheau, A.-E., Căruntu, C., & Scheau, C. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47020115 · Cited by 16 · see citing works
Schnurr, M., Volk, I., Nikolenko, H., Winkler, L., Dathe, M., & Schröder, L. (2020) · Advanced Biosystems · doi:10.1002/adbi.201900251 · Cited by 16 · see citing works
Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia
D'Arrigo, J. S. (2020) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317520976761 · Cited by 16 · see citing works
Córdoba, K. M., Serrano-Mendioroz, I., Jericó, D., Merino, M., Jiang, L., Sampedro, A., Alegre, M., Corrales, F. J., Garrido, M. J., Martini, P. G. V., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abc0700 · Cited by 16 · see citing works
Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood–Brain Barrier
D'Arrigo, J. S. (2018) · Biomimetics · doi:10.3390/biomimetics3010004 · Cited by 15 · see citing works
Zhu, P., Xiao, L., & Wang, Y. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00721-1 · Cited by 15 · see citing works
Bosma, E. K., Darwesh, S., Habani, Y. I., Cammeraat, M., Martinez, P. S., Smallenburg, M. E. V. B., Zheng, J. Y., Vogels, I. M. C., Noorden, C. J. F. V., Schlingemann, R. O., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-46893-4 · Cited by 14 · see citing works
Choi, M., Kim, D., Youn, Y.-J., Ryu, J., & Jeong, Y. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012296 · Cited by 13 · see citing works
IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a
Jang, E., Ho, T. W. W., Brumell, J. H., Lefebvre, F., Wang, C., & Lee, W. L. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.320940 · Cited by 13 · see citing works
Self-citationOrtí, J. E. D. L. R., Armero, J. L. P., Cuerda‐Ballester, M., Sanchis-Sanchis, C. E., Navarro-Illana, E., Lajara-Romance, J. M., Benlloch, M., Cerón, J. M. C., Tvarijonaviciute, A., & Proaño, B. (2023) · Foods · doi:10.3390/foods12203730 · Cited by 12 · see citing works
Role of Scavenger Receptor B1 (SR-B1) in Improving Food Benefits for Human Health
Valacchi, G., & Pecorelli, A. (2025) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111523-121935 · Cited by 11 · see citing works
Lipoprotein modulation of proteinuric renal injury
Tsuchida, Y., Zhong, J., Otsuka, T., Dikalova, A., Pastan, I. H., Anantharamaiah, G. M., Linton, M. F., Yancey, P. G., Ikizler, T. A., Fogo, A. B., et al. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0253-6 · Cited by 11 · see citing works
Chen, X., Wang, X., Zhu, F., Qian, C., Xu, F., Huang, X., Zhang, W., & Sun, B. (2022) · Journal of Immunology Research · doi:10.1155/2022/8785567 · Cited by 11 · see citing works
Śmierciak, N., Krzyściak, W., Szwajca, M., Karcz, P., Bryll, A., Popiela, T. J., Donicz, P., Turek, A., Aleksandrovych, V., & Pilecki, M. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411375 · Cited by 11 · see citing works
Circulatory proteins shape microglia state and boost phagocytosisPreprint
Lu, N., Losada, P. M., Hahn, O., Saksena, A., Tapp, E., Chadarevian, J. P., Dong, W., Shi, S. M., Shuken, S. R., Guldner, I. H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615861 · Cited by 12 · see citing works
Zhang, Q., Wang, J., Chen, Z., Qin, H., Zhang, Q., Tian, B., & Li, X. (2025) · Biomedical Materials · doi:10.1088/1748-605x/ada85e · Cited by 10 · see citing works
Luquain‐Costaz, C., Kockx, M., Anastasius, M. O., Chow, V., Kontush, A., Jessup, W., & Kritharides, L. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314847 · Cited by 9 · see citing works
Xie, G., Jiang, G., Huang, L., Sun, S., Wan, Y., Li, F., Wu, B., Zhang, Y., Li, X., Xiong, B., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18060790 · Cited by 10 · see citing works
von Eckardstein, A., & Robert, J. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.321546 · Cited by 8 · see citing works
Delaying Dementia: Targeted Brain Delivery Using Lipid Cubic Phases
D'Arrigo, J. S. (2019) · OBM Neurobiology · doi:10.21926/obm.neurobiol.1903040 · Cited by 8 · see citing works
Quantifying Endothelial Transcytosis with Total Internal Reflection Fluorescence Microscopy (TIRF)
Jang, E., Ghaffari, S., & Lee, W. L. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2051-9_7 · Cited by 8 · see citing works
Self-citationApplication of In vitro transcytosis models to brain targeted biologics
Deng, K., Lu, Y., Finnema, S. J., Vangjeli, K., Huang, J., Huang, L., & Goodearl, A. D. J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289970 · Cited by 7 · see citing works
López-Valencia, L., Moya, M., Escudero, B., García‐Bueno, B., & Orío, L. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100509 · Cited by 7 · see citing works
Treating Dementia Early: Limiting Cellular Damage in Brain Tissue
D'Arrigo, J. S. (2019) · OBM Geriatrics · doi:10.21926/obm.geriatr.1902057 · Cited by 7 · see citing works
Yu, Z., Sun, Z., Yuan, L., Wang, C., Li, W., Liu, J., Zhao, Q., Sun, Y., & Sun, C. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s545696 · Cited by 7 · see citing works
Self-citationPotapenko, A., Frey, K., Schlumpf, E., Robert, J., Wollscheid, B., von Eckardstein, A., & Rohrer, L. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100665 · Cited by 6 · see citing works
Grao‐Cruces, E., Millán-Linares, M. C., Martín, M. E., Toscano, R., Barrientos‐Trigo, S., Bermúdez, B., & la Paz, S. M. (2021) · Biomedicines · doi:10.3390/biomedicines9111722 · Cited by 6 · see citing works
Xie, L., Luo, H., Zhao, Y., Hao, Y., Gao, J., Sun, C., & Hu, H. (2025) · Biogerontology · doi:10.1007/s10522-025-10201-6 · Cited by 5 · see citing works
Biomaterial to Improve Drug Delivery in Alzheimer's Disease: Linking Major Pathogenic Pathways
D'Arrigo, J. S. (2020) · OBM Geriatrics · doi:10.21926/obm.geriatr.2001110 · Cited by 5 · see citing works
Xiao, L., Liu, D., Zuo, S., Zhu, X., Wang, Y., & Dong, C. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27789 · Cited by 5 · see citing works
Huang, Y., Chan, H., Khoo, J.-Y., Chan, M.-L., Bender, D. A., Ponnusamy, V. K., Belaidi, A. A., & Ke, L. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106104 · Cited by 4 · see citing works
Koehn, L. M., Cao, D., Steele, J. R., Rigopoulos, A., Burvenich, I. J. G., Chung-Lee, H., Tanuwidjaya, E., Schittenhelm, R. B., Scott, A. M., Gan, H. K., et al. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00609 · Cited by 4 · see citing works
Paraoxonase-1 and Other HDL Accessory Proteins in Neurological Diseases
Marsillach, J., & Cervellati, C. (2021) · Antioxidants · doi:10.3390/antiox10030454 · Cited by 4 · see citing works
- Authors
- Fung, K. Y., Wang, C., Nyegaard, S., Heit, B., Fairn, G. D., & Lee, W. L.
- Affiliations
- St. Michael's Hospital (CA)
- Hospital for Sick Children (CA)
- Western University (CA)
- Corresponding author
- Fairn, Gregory D.
- Lee, Warren L.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2017-10-30
- Volume
- 8
- Pages
- 841-841
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC5670330
- OpenAlex
- W2766769123
- Semantic Scholar
- 683becc9c1f56f8d9f86671083b9c0be75c2fea8
- Cited by
- 129
- References
- 46
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 13 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 18 · 2019: 16 · 2018: 8
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Heart and Stroke Foundation of Canada
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- scavenger receptor BI, brain microvascular endothelial cells, blood-brain barrier, caveolin-1, caveolae, clathrin, dynamin, PDZK1, endothelial nitric oxide synthase, nitric oxide, lipoprotein uptake
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review