Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review
Open accessAbstract
The protein composition of high-density lipoprotein (HDL) is extremely fluid. The quantity and quality of protein constituents drive the multiple biological functions of these lipoproteins, which include the ability to contrast atherogenesis, sustained inflammation, and toxic effects of reactive species. Several diseases where inflammation and oxidative stress participate in the pathogenetic process are characterized by perturbation in the HDL proteome. This change inevitably affects the functionality of the lipoprotein. An enlightening example in this frame comes from the literature on Alzheimer's disease (AD). Growing lines of epidemiological evidence suggest that loss of HDL-associated proteins, such as lipoprotein phospholipase A2 (Lp-PLA2), glutathione peroxidase-3 (GPx-3), and paraoxonase-1 and paraoxonase-3 (PON1, PON3), may be a feature of AD, even at the early stage. Moreover, the decrease in these enzymes with antioxidant/defensive action appears to be accompanied by a parallel increase of prooxidant and proinflammatory mediators, in particular myeloperoxidase (MPO) and serum amyloid A (SAA). This type of derangement of balance between two opposite forces makes HDL dysfunctional, i.e., unable to exert its "natural" vasculoprotective property. In this review, we summarized and critically analyzed the most significant findings linking HDL accessory proteins and AD. We also discuss the most convincing hypothesis explaining the mechanism by which an observed systemic occurrence may have repercussions in the brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HDL has anti-infectious, anti-inflammatory, antioxidant, anti-thrombotic, and immunomodulatory properties.
“HDL also has pleiotropic protective functions, including anti-infectious, anti-inflammatory, antioxidant, anti-thrombotic, anti-inflammatory, and immunomodulatory properties (39, 47).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [47]
OS and inflammation can perturb the HDL proteome, possibly playing a role in AD pathogenesis.
“OS and inflammation can perturbate the high-density lipoprotein (HDL) proteome, possibly playing a role in AD pathogenesis.”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [147]
Loss of HDL-associated proteins with antioxidant action such as apolipoprotein phospholipase A2, glutathione peroxidase-3, and paraoxonase (PON)-1 and -3 are supposed to be related to the early stage of AD.
“Loss of HDL-associated proteins with antioxidant action such apolipoprotein phospholipase A2, glutathione peroxidase-3, and paraoxonase (PON)-1 and -3 are supposed to be related to the early stage of AD.”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [147]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works
Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
The AIM-HIGH Investigators (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1107579 · Cited by 2,911 · see citing works
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904 · see citing works
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330 · see citing works
Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3586 · Cited by 1,280 · see citing works
Iturria-Medina, Y., Sotero, R. C., Toussaint, P. J., Mateos-Pérez, J. M., Evans, A. C., Initiative, T. A. D. N., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11934 · Cited by 1,202 · see citing works
Serum amyloid A, the major vertebrate acute‐phase reactant
Uhlar, C., & Whitehead, A. S. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00657.x · Cited by 1,101 · see citing works
Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
de la Torre, J. C. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00683-0 · Cited by 834 · see citing works
Dysfunctional HDL and atherosclerotic cardiovascular disease
Rosenson, R. S., Brewer, H. B., Ansell, B. J., Barter, P., Chapman, M. J., Heinecke, J. W., Kontush, A., Tall, A. R., & Webb, N. R. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.124 · Cited by 822 · see citing works
Evacetrapib and cardiovascular outcomes in high-risk vascular disease
Lincoff, A. M., Nicholls, S. J., Riesmeyer, J. S., Barter, P. J., Brewer, H. B., Fox, K. A. A., Gibson, C. M., Granger, C., Menon, V., Montalescot, G., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1609581 · Cited by 801 · see citing works
High-Density Lipoprotein Subfractions - What the Clinicians Need to Know
Pirillo, A., Norata, G. D., & Catapano, A. L. (2013) · Cardiology · doi:10.1159/000346463 · Cited by 749 · see citing works
Draganov, D. I., Teiber, J. F., Speelman, A., Osawa, Y., Sunahara, R. K., & Du, B. N. L. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400511-jlr200 · Cited by 716 · see citing works
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease
Rinaldi, P., Polidori, M. C., Metastasio, A., Mariani, E., Mattioli, P., Cherubini, A., Catani, M., Cecchetti, R., Senin, U., & Mecocci, P. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00031-9 · Cited by 562 · see citing works
Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
Costa, L. G., Garrick, J. M., Roqué, P. J., & Pellacani, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2986796 · Cited by 550 · see citing works
Sack, G. H. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0047-0 · Cited by 507 · see citing works
Biological activities of HDL subpopulations and their relevance to cardiovascular disease
Camont, L., Chapman, M. J., & Kontush, A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.05.013 · Cited by 471 · see citing works
Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease
Ndrepepa, G. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.02.022 · Cited by 452 · see citing works
Ouimet, M., Barrett, T. J., & Fisher, E. (2019) · Circulation Research · doi:10.1161/circresaha.119.312617 · Cited by 416 · see citing works
Oxidation of LDL by Myeloperoxidase and Reactive Nitrogen Species
Carr, A. C., McCall, M. R., & Frei, B. B. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.7.1716 · Cited by 392 · see citing works
Padurariu, M., Ciobica, A., Hritcu, L., Stoica, B., Bild, W., & Stefanescu, C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.033 · Cited by 378 · see citing works
Björnstedt, M., Xue, J., Huang, W., Åkesson, B., & Holmgren, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43889-6 · Cited by 364 · see citing works
Anstey, K. J., Ashby-Mitchell, K., & Peters, R. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160826 · Cited by 360 · see citing works
Oxidative stress in autoimmune rheumatic diseases
Smallwood, M. J., Nissim, A., Knight, A. R., Whiteman, M., Haigh, R. C., & Winyard, P. G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.086 · Cited by 347 · see citing works
Draganov, D. I., Stetson, P. L., Watson, C. E., Billecke, S. S., & Du, B. N. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004543200 · Cited by 338 · see citing works
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease
Green, P. S., Mendez, A. J., Jacob, J. S., Crowley, J. R., Growdon, W., Hyman, B. T., & Heinecke, J. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02527.x · Cited by 332 · see citing works
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase
Breckwoldt, M. O., Chen, J. W., Stangenberg, L., Aikawa, E. R., Rodrı́guez, E., Qiu, S., Moskowitz, M. A., & Weissleder, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803945105 · Cited by 324 · see citing works
Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology
Ballatori, N., Krance, S. M., Marchan, R., & Hammond, C. L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.004 · Cited by 318 · see citing works
Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease
Zaplatić, E., Bule, M. H., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.055 · Cited by 298 · see citing works
Blood‐brain barrier breakdown, neuroinflammation, and cognitive decline in older adults
Bowman, G. L., Dayon, L., Kirkland, R. E., Wojcik, J., Peyratout, G., Severin, I. C., Henry, H., Oikonomidi, A., Migliavacca, E., Bacher, M., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.2857 · Cited by 295 · see citing works
Structure of HDL: Particle Subclasses and Molecular Components
Kontush, A., Lindahl, M. G., Lhomme, M., Calabresi, L., Chapman, M. J., & Davidson, W. S. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_1 · Cited by 284 · see citing works
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex
Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67478 · Cited by 269 · cited 2× · see citing works
“The oxidative challenge of this leukocyte-derived enzyme is facilitated by its physical association with ApoA1 and HDL particles [14].”
BackgroundRole of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
Zhang, Y., Roh, Y. J., Han, S.-J., Park, I., Lee, H. M., Ok, Y. S., Lee, B. C., & Lee, S.-R. (2020) · Antioxidants · doi:10.3390/antiox9050383 · Cited by 267 · see citing works
Brites, F. D., Martín, M., Guillas, I., & Kontush, A. (2017) · BBA Clinical · doi:10.1016/j.bbacli.2017.07.002 · Cited by 265 · see citing works
HDL and cholesterol handling in the brain
Vitali, C., Wellington, C. L., & Calabresi, L. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu148 · Cited by 254 · see citing works
Role of Serum Amyloid A During Metabolism of Acute-Phase HDL by Macrophages
Artl, A., Marsche, G., Lestavel, S., Sattler, W., & Malle, E. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.763 · Cited by 254 · see citing works
Qi, Y., Guo, L., Jiang, Y., Shi, Y., Sui, H., & Zhao, L. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1762262 · Cited by 239 · see citing works
Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease
Torres, L. H., Quaglio, N. B., de Souza, G. T., Garcia, R. C. T., Dati, L. M. M., Moreira, W. L., Loureiro, A. P. D. M., Souza‐Talarico, J. N., Smid, J., Porto, C. S., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110284 · Cited by 235 · see citing works
Vural, H., Demirin, H., Kara, Y. B., Eren, İ., & Delibaş, N. (2010) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2010.02.002 · Cited by 235 · see citing works
Novel Biological Functions of High-Density Lipoprotein Cholesterol
Mineo, C., & Shaul, P. W. (2012) · Circulation Research · doi:10.1161/circresaha.111.258673 · Cited by 228 · see citing works
Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer
Chang, C. A., Worley, B. L., Phaëton, R., & Hempel, N. (2020) · Cancers · doi:10.3390/cancers12082197 · Cited by 226 · see citing works
Plasma Amyloid-β as a Predictor of Dementia and Cognitive Decline
Koyama, A. K., Okereke, O. I., Yang, T., Blacker, D., Selkoe, D. J., & Grodstein, F. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.1841 · Cited by 220 · see citing works
Paraoxonases-1, -2 and -3: What are their functions?
Furlong, C. E., Marsillach, J., Jarvik, G. P., & Costa, L. G. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.05.036 · Cited by 208 · see citing works
Self-citationLipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias
Casado, Á., López-Fernández, M. E., Casado, M. C., & de la Torre, R. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9453-3 · Cited by 207 · see citing works
van Himbergen, T. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.670 · Cited by 198 · see citing works
Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues
Marsillach, J., Mackness, B., Mackness, M., Riu, F., Beltrán‐Debón, R., Joven, J., & Camps, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.023 · Cited by 196 · see citing works
Self-citationCosta, L. G., Giordano, G., & Furlong, C. E. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.11.008 · Cited by 188 · see citing works
Serum amyloid A impairs the antiinflammatory properties of HDL
Han, C. Y., Tang, C., Guevara, M. E., Hao, W., Wietecha, T., Shao, B., Subramanian, S., Omer, M., Wang, S., O’Brien, K. D., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83475 · Cited by 171 · see citing works
Teiber, J. F., Horke, S., Haines, D. C., Chowdhary, P. K., Xiao, J., Kramer, G. L., Haley, R. W., & Draganov, D. I. (2008) · Infection and Immunity · doi:10.1128/iai.01606-07 · Cited by 160 · see citing works
Tellis, C. C., & Tselepis, A. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.02.015 · Cited by 158 · see citing works
Guo, J.-T., Yu, J., Grass, D., de Beer, F. C., & Kindy, M. S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05900.2002 · Cited by 153 · see citing works
Chang, Y., Chang, W., Tsai, N., Huang, C., Kung, C., Su, Y., Lin, W.-C., Cheng, B., Su, C.-M., Chiang, Y.-F., et al. (2014) · BioMed Research International · doi:10.1155/2014/182303 · Cited by 143 · see citing works
Acharya, N. K., Levin, E. C., Clifford, P. M., Han, M. C., Tourtellotte, R., Chamberlain, D., Pollaro, M., Coretti, N. J., Kosciuk, M. C., Nagele, E. P., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122254 · Cited by 140 · see citing works
Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia
Puertas, M. C., Martı́nez-Martos, J. M., Cobo, M., Carrera-González, M. P., Mayas, M. D., & Ramı́rez-Expósito, M. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.05.019 · Cited by 140 · see citing works
Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery
Cervellati, C., Trentini, A., Pecorelli, A., & Valacchi, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8076 · Cited by 137 · see citing works
Self-citationCeballos-Picot, I., Merad-Boudia, M., Nicole, A., Thévenin, M., Hellier, G., Legrain, S., & Berr, C. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02058-6 · Cited by 130 · see citing works
Fung, K. Y., Wang, C., Nyegaard, S., Heit, B., Fairn, G. D., & Lee, W. L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00841 · Cited by 129 · see citing works
HDL from an Alzheimer's disease perspective
Button, E. B., Robert, J., Caffrey, T. M., Fan, J., Zhao, W., & Wellington, C. L. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000604 · Cited by 114 · see citing works
Lysophosphatidylcholine increases endothelial permeability: role of PKCα and RhoA cross talk
Huang, F., Subbaiah, P. V., Holian, O., Zhang, J., Johnson, A., Gertzberg, N., & Lum, H. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00003.2005 · Cited by 113 · see citing works
Yu, G., Liang, Y. S., Huang, Z., Jones, D. W., Pritchard, K. A., & Zhang, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0583-x · Cited by 103 · see citing works
Polymorphisms in the PON gene cluster are associated with Alzheimer disease
Erlich, P. M., Lunetta, K. L., Cupples, L. A., Huyck, M., Green, R. C., Baldwin, C. T., & Farrer, L. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi428 · Cited by 99 · see citing works
Bermingham, E. N., Hesketh, J. E., Sinclair, B. R., Koolaard, J. P., & Roy, N. C. (2014) · Nutrients · doi:10.3390/nu6104002 · Cited by 99 · see citing works
Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo
Üllen, A., Singewald, E., Kónya, V., Fauler, G., Reicher, H., Nusshold, C., Hammer, A., Kratky, D., Heinemann, Á., Holzer, P. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064034 · Cited by 96 · see citing works
Paraoxonase 1 and HDL maturation
Gugliucci, A., & Menini, T. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.09.016 · Cited by 95 · see citing works
Paterniti, I., Cordaro, M., Campolo, M., Siracusa, R., Cornelius, C., Navarra, M., Cuzzocrea, S., & Esposito, E. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140806124322 · Cited by 90 · cited 1× · see citing works
“It was found that co-ultramicronized palmitoylethanolamide/luteolin, an agent with neuroprotective properties [85], significantly attenuated the cytokine tumor necrosis factor-α (TNF-α)-induced increase in Saa1 gene expression in oligodendrocyte precursor cells [86].”
BackgroundSchweikert, E.-M., Devarajan, A., Witte, I., Wilgenbus, P., Amort, J., Förstermann, U., Shabazian, A., Grijalva, V. R., Shih, D. M., Farias‐Eisner, R., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.35 · Cited by 89 · see citing works
Pastori, D., Pignatelli, P., Farcomeni, A., Menichelli, D., Nocella, C., Carnevale, R., & Violi, F. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003682 · Cited by 83 · see citing works
Shridas, P., de Beer, M. C., & Webb, N. R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002428 · Cited by 82 · see citing works
Role of serum amyloid A in atherosclerosis
Shridas, P., & Tannock, L. R. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000616 · Cited by 81 · see citing works
Serum amyloid A primes microglia for ATP-dependent interleukin-1β release
Facci, L., Barbierato, M., Zusso, M., Skaper, S. D., & Giusti, P. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1205-6 · Cited by 79 · see citing works
Serum Amyloid A Is an Exchangeable Apolipoprotein
Wilson, P. G., Thompson, J. C., Shridas, P., McNamara, P. J., de Beer, M. C., de Beer, F. C., Webb, N. R., & Tannock, L. R. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310979 · Cited by 76 · see citing works
Increased Myeloperoxidase Plasma Levels in Patients with Alzheimer's Disease
Tzikas, S., Schlak, D., Sopova, K., Gatsiou, A., Stakos, D., Stamatelopoulos, K. S., Stellos, K., & Laske, C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131469 · Cited by 75 · see citing works
Soria-Florido, M. T., Castañer, O., Lassale, C. M., Estruch, R., Salas‐Salvadó, J., Martínez‐González, M. Á., Corella, D., Ros, E., Arós, F., Elosúa, R., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.041658 · Cited by 75 · see citing works
Marchi, C., Adorni, M. P., Caffarra, P., Ronda, N., Spallazzi, M., Barocco, F., Galimberti, D., Bernini, F., & Zimetti, F. (2019) · Journal of Lipid Research · doi:10.1194/jlr.p091033 · Cited by 74 · see citing works
Self-citationRobertson, K. S., Hawe, E., Miller, G. J., Talmud, P. J., & Humphries, S. E. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.09.008 · Cited by 72 · see citing works
Melchior, J., Street, S. E., Andraski, A. B., Furtado, J. D., Sacks, F. M., Shute, R. L., Greve, E. I., Swertfeger, D. K., Li, H., SHAH, A. S., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m075382 · Cited by 72 · see citing works
Volkman, R., Ben‐Zur, T., Kahana, A., Garty, B. Z., & Offen, D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00990 · Cited by 72 · see citing works
Systemic Oxidative Stress Associated with the Neurological Diseases of Aging
Serra, J. A., Domínguez, R. O., Marschoff, E. R., Guareschi, E. M., Famulari, A. L., & BOVERIS, A. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9997-5 · Cited by 70 · see citing works
Kriska, T., Marathe, G. K., Schmidt, J. C., McIntyre, T. M., & Girotti, A. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608135200 · Cited by 70 · see citing works
Rothem, L., Hartman, C., Dahan, A., Lachter, J., Eliakim, R., & Shamir, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.003 · Cited by 69 · see citing works
Manus, J. M., McEneny, J., Thompson, W., & Young, I. S. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00154-8 · Cited by 67 · see citing works
Lum, H., Qiao, J., Walter, R. J., Huang, F., Subbaiah, P. V., Kim, K. S., & Holian, O. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00359.2003 · Cited by 64 · see citing works
Marsillach, J., Becker, J. O., Vaisar, T., Hahn, B. H., Brunzell, J. D., Furlong, C. E., de Boer, I. H., McMahon, M. A., Hoofnagle, A. N., & DCCT/EDIC Research Group (2015) · Journal of Proteome Research · doi:10.1021/pr5011586 · Cited by 61 · see citing works
Self-citationNg, C. J., Bourquard, N., Hama, S. Y., Shih, D. M., Grijalva, V. R., Navab, M., Fogelman, A. M., & Reddy, S. T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.134189 · Cited by 60 · see citing works
Association between Alzheimer's Disease and a Functional Polymorphism in the Myeloperoxidase Gene
Crawford, F., Freeman, M. J., Schinka, J. A., Morris, M. D., Abdullah, L. I., Richards, D., Sevush, S., Duara, R., & MULLAN, M. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7560 · Cited by 59 · see citing works
A Role for the High-Density Lipoprotein Receptor SR-B1 in Synovial Inflammation via Serum Amyloid-A
Mullan, R. H., McCormick, J., Connolly, M. C., Bresnihan, B., Veale, D. J., & Fearon, U. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090014 · Cited by 57 · see citing works
HDL Proteome and Alzheimer’s Disease: Evidence of a Link
Marsillach, J., Adorni, M. P., Zimetti, F., Papotti, B., Zuliani, G., & Cervellati, C. (2020) · Antioxidants · doi:10.3390/antiox9121224 · Cited by 57 · see citing works
Self-citationLipoprotein-associated phospholipase A2 in coronary heart disease: Review and meta-analysis
Li, D., Zhao, L., Yu, J., Zhang, W., Du, R., Liu, X., Liu, Y., Chen, Y., Zeng, R., Cao, Y., et al. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.12.006 · Cited by 56 · see citing works
Maher‐Edwards, G., De'Ath, J., Barnett, C., Lavrov, A., & Lockhart, A. (2015) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2015.06.003 · Cited by 55 · see citing works
Buijsse, B., Lee, D., Steffen, L. M., Erickson, R. R., Luepker, R. V., Jacobs, D. R., & Holtzman, J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038901 · Cited by 55 · see citing works
Marksteiner, J., Imarhiagbe, D., Defrancesco, M., Deisenhammer, E., Kemmler, G., & Humpel, C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.001 · Cited by 54 · see citing works
Shao, B., & Heinecke, J. W. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1402680 · Cited by 53 · see citing works
Wu, C., Bawa, K. K., Ouk, M., Leung, N., Yu, D., Lanctôt, K. L., Herrmann, N., Pakosh, M. T., & Swardfager, W. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101130 · Cited by 52 · see citing works
Increased Risk for Alzheimer Disease With the Interaction of MPO and A2M Polymorphisms
Zappia, M., Manna, I., Serra, P., Cittadella, R., Andreoli, V., Russa, A. L., Annesi, F., Spadafora, P., Romeo, N., Nicoletti, G., et al. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.341 · Cited by 51 · see citing works
Shang, J., Yamashita, T., Fukui, Y., Song, D., Li, X., Zhai, Y., Nakano, Y., Morihara, R., Hishikawa, N., Ohta, Y., et al. (2018) · Journal of Clinical Neurology · doi:10.3988/jcn.2018.14.1.29 · Cited by 49 · see citing works
Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients.
Fernandes, M. A. S., Proenca, M. T., Nogueira, A. J. A., Grazina, M. M., Oliveira, L. M. V., Fernandes, A. I., Santiago, B., Santana, I. J., & Oliveira, C. R. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.4.2.179 · Cited by 48 · see citing works
La Lp-PLA2, marqueur d’inflammation vasculaire et de vulnérabilité de la plaque d’athérosclérose
Bonnefont‐Rousselot, D. (2015) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2015.09.002 · Cited by 48 · see citing works
Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction
Zimetti, F., VUONO, S. D., Gomaraschi, M., Adorni, M. P., Favari, E., Ronda, N., Ricci, M. A., Veglia, F., Calabresi, L., & Lupattelli, G. (2017) · Journal of Lipid Research · doi:10.1194/jlr.p076463 · Cited by 47 · see citing works
Self-citationBacchetti, T., Vignini, A., Giulietti, A., Nanetti, L., Provinciali, L., Luzzi, S., Mazzanti, L., & Ferretti, G. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143096 · Cited by 46 · see citing works
Serum amyloid A (SAA)-induced remodeling of CSF-HDL
Miida, T., Yamada, T., Seino, U., Ito, M., Fueki, Y., Takahashi, A., Kosuge, K., Soda, S., Hanyu, O., Obayashi, K., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.013 · Cited by 46 · see citing works
Lipoprotein Phospholipase A2 and Cerebral Microbleeds in the Framingham Heart Study
Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C. S., Lee, D. Y., Viswanathan, A., Benjamin, E. J., Fontes, J. D., Au, R., Pikula, A., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.656744 · Cited by 45 · see citing works
Dysfunctional HDL as a Therapeutic Target for Atherosclerosis Prevention
Ossoli, A., Pavanello, C., Giorgio, E., Calabresi, L., & Gomaraschi, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180316115726 · Cited by 45 · see citing works
Apolipoprotein Serum Amyloid A in Alzheimer's Disease
Kindy, M., Yu, J., Guo, J.-T., & Zhu, H. (1999) · Journal of Alzheimer's Disease · doi:10.3233/jad-1999-1303 · Cited by 44 · see citing works
PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis
Shih, D. M., Yu, J. M., Vergnes, L., Dali‐Youcef, N., Champion, M. D., Devarajan, A., Zhang, P., Castellani, L. W., Brindley, D. N., Jamey, C., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-260570 · Cited by 44 · see citing works
Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study
Fitzpatrick, A. L., Irizarry, M. C., Cushman, M., Jenny, N. S., Chi, G. C., & Koro, C. E. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.032 · Cited by 41 · see citing works
Lipoprotein‐associated phospholipase A2 is associated with risk of dementia
van Oijen, M., van der Meer, I. M., Albert Hofman, D., Witteman, J. C. M., Koudstaal, P. J., & Breteler, M. M. B. (2005) · Annals of Neurology · doi:10.1002/ana.20721 · Cited by 40 · see citing works
Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development
Cervellati, C., Valacchi, G., Tisato, V., Zuliani, G., & Marsillach, J. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05875-5 · Cited by 40 · see citing works
Self-citationBarbierato, M., Borri, M., Facci, L., Zusso, M., Skaper, S., & Giusti, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-12529-7 · Cited by 37 · see citing works
Blood-Derived Plasma Protein Biomarkers for Alzheimer’s Disease in Han Chinese
Cheng, Z., Yin, J., Yuan, H., Jin, C., Zhang, F., Wang, Z., Liu, X., Wu, Y., Wang, T., & Xiao, S. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00414 · Cited by 37 · see citing works
Chami, B., Barrie, N., Cai, X., Wang, X., Paul-Heng, M., Morton-Chandra, R., Sharland, A. F., Dennis, J. M., Freedman, S., & Witting, P. K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160511101 · Cited by 36 · see citing works
Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy
Campo, S., Sardo, M. A., Campo, G. M., Avenoso, A., Castaldo, M., D’Ascola, A., Giunta, E., Calatroni, A., & Saitta, A. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.11.007 · Cited by 36 · see citing works
Cervellati, C., Vigna, G. B., Trentini, A., Sanz, J. M., Zimetti, F., Nora, E. D., Morieri, M. L., Zuliani, G., & Passaro, A. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.04.218 · Cited by 36 · see citing works
Self-citationJang, S., Jang, W. Y., Choi, M., Lee, J., Kwon, W., Yi, J., Park, S. J., Yoon, D., Lee, S., Kim, M. O., et al. (2019) · Transgenic Research · doi:10.1007/s11248-019-00166-x · Cited by 35 · see citing works
Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study
Leininger‐Muller, B., Hoy, A., Herbeth, B., Pfister, M., Sérot, J., Stavljenic-Rukavina, M., Massana, L., Passmore, P., Siest, G., & Visvikis‐Siest, S. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00795-x · Cited by 34 · see citing works
Davidson, J. E., Lockhart, A., Amos, L., Stirnadel-Farrant, H. A., Mooser, V., Sollberger, M. A., Regeniter, A., Monsch, A. U., & Irizarry, M. C. (2012) · Alzheimer s Research & Therapy · doi:10.1186/alzrt154 · Cited by 34 · see citing works
Carlson, C. S., Heagerty, P. J., Hatsukami, T. S., Richter, R. J., Ranchalis, J., Lewis, J., Bacus, T. J., McKinstry, L. A., Schellenberg, G. D., Rieder, M. J., et al. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500517-jlr200 · Cited by 34 · see citing works
Lipoprotein‐associated phospholipase A2, homocysteine, and Alzheimer's disease
Doody, R. S., Demirovic, J., Ballantyne, C. M., Chan, W., Barber, R. C., Powell, S. Z.-E., & Pavlik, V. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.08.001 · Cited by 34 · see citing works
Gursky, O. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00888-y · Cited by 33 · see citing works
Vigna, G. B., Satta, E., Bernini, F., Boarini, S., Bosi, C., Giusto, L., Pinotti, E., Tarugi, P., Vanini, A., Volpato, S., et al. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.02.010 · Cited by 30 · see citing works
Self-citation(2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-159901 · Cited by 29 · see citing works
Rull, A., García, R., Fernández-Sénder, L., García‐Heredia, A., Aragonès, G., Beltrán‐Debón, R., Marsillach, J., Alegret, J. M., Martín-Paredero, V., Mackness, B., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.021 · Cited by 28 · see citing works
Self-citationCai, R., Huang, R., Han, J., Sun, H., Sun, J. L., Xia, W., Tian, S., Dong, X., Shen, Y., & Wang, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12515-z · Cited by 27 · see citing works
Cardioprotective Properties of HDL: Structural and Functional Considerations
Pappa, E. T., Elisaf, M., Kostara, C. E., Bairaktari, E. T., & Tsimihodimos, V. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190201142321 · Cited by 27 · see citing works
Cai, X., Ahmad, G., Hossain, F., Liu, Y., Wang, X., Dennis, J. M., Freedman, B., & Witting, P. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041316 · Cited by 26 · see citing works
Aragonès, G., García‐Heredia, A., Guardiola, M., Rull, A., Beltrán‐Debón, R., Marsillach, J., Alonso‐Villaverde, C., Mackness, B., Mackness, M., Pedro‐Botet, J., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p018457 · Cited by 23 · see citing works
Self-citationSans, T., Rull, A., Luna, J. D., Mackness, B., Mackness, M., Joven, J., Ibañez, M., Pariente, R., Rodriguez, M., Ortı́n, X., et al. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2011-0896 · Cited by 22 · see citing works
Myeloperoxidase: The Good, the Bad, and the Ugly
Lefkowitz, D. L., Mone, J., & Lefkowitz, S. S. (2010) · Current Immunology Reviews · doi:10.2174/157339510791111691 · Cited by 22 · see citing works
Hayek, J., Cervellati, C., Crivellari, I., Pecorelli, A., & Valacchi, G. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5694058 · Cited by 22 · see citing works
Self-citationTrentini, A., Rosta, V., Spadaro, S., Bellini, T., Rizzo, P., Sega, F. V. D., Passaro, A., Zuliani, G., Gentili, V., Campo, G. C., et al. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0817 · Cited by 22 · see citing works
Self-citationPassaro, A., Vigna, G. B., Romani, A., Sanz, J. M., Cavicchio, C., Bonaccorsi, G., Valacchi, G., & Cervellati, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1752940 · Cited by 21 · see citing works
Self-citationMatsumoto, J., Dohgu, S., Takata, F., Iwao, T., Kimura, I., Tomohiro, M., Aono, K., Kataoka, Y., & Yamauchi, A. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135352 · Cited by 21 · see citing works
García‐Heredia, A., Marsillach, J., Aragonès, G., Guardiola, M., Rull, A., Beltrán‐Debón, R., Folch, A., Mackness, B., Mackness, M., Pedro‐Botet, J., et al. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.08.003 · Cited by 19 · see citing works
Self-citationD'Arrigo, J. S. (2020) · Biomimetics · doi:10.3390/biomimetics5010011 · Cited by 19 · see citing works
Zhou, J., Lu, Y., Wang, S., & Chen, K. (2020) · Inflammation Research · doi:10.1007/s00011-020-01325-1 · Cited by 18 · see citing works
Ji, W., & Zhang, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.22330 · Cited by 17 · see citing works
Changes in Serum Amyloid A (SAA) and 8-OHdG in Patients with Senile Early Cognitive Impairment
Cao, X., & Chen, P. (2020) · Medical Science Monitor · doi:10.12659/msm.919586 · Cited by 16 · see citing works
Chang, C., Pan, Y., Du, H., Wang, X., & Li, X. (2020) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2020.08.005 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Wei, Y., Wang, T., Li, G., Feng, J., Deng, L., Xu, H., Yin, L., Ma, J., Chen, D., & Chen, J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.941728 · Cited by 99 · see citing works
Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review
Guerra-Vázquez, C. M., Ávila, M. M., Guajardo‐Flores, D., & Antunes‐Ricardo, M. (2022) · Foods · doi:10.3390/foods11030252 · Cited by 55 · see citing works
Zuin, M., Cervellati, C., Trentini, A., Passaro, A., Rosta, V., Zimetti, F., & Zuliani, G. (2021) · Diagnostics · doi:10.3390/diagnostics11060984 · Cited by 45 · see citing works
Self-citationEmerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders
Turri, M., Marchi, C., Adorni, M. P., Calabresi, L., & Zimetti, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159123 · Cited by 54 · see citing works
Self-citationWei, Y., Gao, H., Luo, Y., Feng, J., Li, G., Wang, T., Xu, H., Yin, L., Ma, J., & Chen, J. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.156 · Cited by 40 · see citing works
Sergi, D., Zauli, E., Tisato, V., Secchiero, P., Zauli, G., & Cervellati, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054403 · Cited by 32 · see citing works
Self-citationClementino, A., Marchi, C., Pozzoli, M., Bernini, F., Zimetti, F., & Sonvico, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716380 · Cited by 29 · see citing works
Self-citationParaoxonases at the Heart of Neurological Disorders
Khalaf, F. K., Connolly, J. A., Khatib-Shahidi, B. Z., Albehadili, A., Tassavvor, I., Ranabothu, M., Eid, N., Dube, P. R., Khouri, S. J., Malhotra, D. K., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086881 · Cited by 22 · see citing works
Kim, J., Lim, D.-K., Suh, Y., & Chang, K. (2021) · Antioxidants · doi:10.3390/antiox10081321 · Cited by 21 · see citing works
Mukherjee, S., & Im, S. (2025) · Biomedicines · doi:10.3390/biomedicines13020359 · Cited by 19 · see citing works
Rani, A., & Marsche, G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051504 · Cited by 19 · see citing works
Paraoxonase 1 activity in patients with Alzheimer disease: Systematic review and meta-analysis.
Zuin, M., Rosta, V., Trentini, A., Bosi, C., Zuliani, G., & Cervellati, C. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110601 · Cited by 16 · see citing works
Self-citationAshraf, H., Butt, M. S., Ul‐Haq, I., Nadeem, M., Aadil, R. M., Alexandru Vasile, R. U. S. U., & Trif, M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1026890 · Cited by 15 · see citing works
Pires, R. S., Braga, P. G. S., Santos, J. M. B., do Amaral, J. B., Amirato, G. R., Trettel, C. D. S., Santos, C. A. F., Vaisberg, M. W., Nali, L. H. D. S., Vieira, R. P., et al. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111584 · Cited by 14 · see citing works
Panyard, D. J., Reus, L. M., Ali, M., Liu, J., Deming, Y. K., Lu, Q., Kollmorgen, G., Carboni, M., Wild, N., Visser, P. J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13848 · Cited by 14 · see citing works
Kwak, I. H., Kim, Y. E., Kim, Y. J., Noh, H., Lee, J., Yu, J. K., & Ma, H. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107155 · Cited by 14 · see citing works
Alzheimer’s Disease Is a Multi-Organ Disorder: It May Already Be Preventable
Eiser, A. R., & Fülöp, T. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221078 · Cited by 14 · see citing works
Choi, M., Kim, D., Youn, Y.-J., Ryu, J., & Jeong, Y. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012296 · Cited by 13 · see citing works
Graham, A. (2023) · Biology · doi:10.3390/biology12091232 · Cited by 14 · see citing works
Lipoprotein-Associated Phospholipase A2 Activity as Potential Biomarker of Vascular Dementia
Zuliani, G., Marsillach, J., Trentini, A., Rosta, V., & Cervellati, C. (2023) · Antioxidants · doi:10.3390/antiox12030597 · Cited by 12 · see citing works
Self-citationEmir, B. S., Yıldız, S., Kılıçaslan, A. K., Kurt, O., Uğur, K., Tabara, M. F., & Aydın, S. (2023) · Medicina · doi:10.3390/medicina59101725 · Cited by 12 · see citing works
Papotti (2024) · doi:10.1177/13872877241284213 · Cited by 11 · see citing works
Self-citationChen, L., Zheng, C., Luan, H., & Chen, X. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s473528 · Cited by 10 · see citing works
Rojas, M., Prado, Y., Tapía, P., Carreño, L. J., Cabello‐Verrugio, C., & Simón, F. (2022) · Antioxidants · doi:10.3390/antiox11122469 · Cited by 10 · see citing works
Wei, Y., Zhang, C., Sun, B., Lin, J., Zhao, Y., Chen, Y., Gao, H., Li, J., Li, G., Feng, J., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119530 · Cited by 7 · see citing works
High-density Lipoprotein Over Midlife and Future Cognition in Women: The SWAN HDL Ancillary Study
Qi, M., Billheimer, J. T., Chang, C. H., Janssen, İ., Brooks, M. M., Orchard, T. J., Karlamangla, A. S., Barinas‐Mitchell, E., Derby, C. A., McConnell, D. S., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae697 · Cited by 6 · see citing works
Liu, Z., Shi, J., Tu, K., Ma, H., Chen, J., Xiang, X., Zou, P., Liao, C., Ding, R., Huang, Z., et al. (2025) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0618 · Cited by 7 · see citing works
Serum Apo J as a potential marker of conversion from mild cognitive impairment to dementia
Romagnoli, T., Ortolani, B., Sanz, J. M., Trentini, A., Seripa, D., Nora, E. D., Capatti, E., Cervellati, C., Passaro, A., Zuliani, G., et al. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117537 · Cited by 6 · see citing works
Self-citationCervellati, C., Trentini, A., Rosta, V., Zuliani, G., Sega, F. V. D., Fortini, F., Rizzo, P., Cimaglia, P., & Campo, G. C. (2023) · Current Vascular Pharmacology · doi:10.2174/1570161121666230221142131 · Cited by 5 · see citing works
Self-citationIşık, M., Tunç, A., Duran, H. E., Naldan, M. E., Yılmaz, A., Koçak, M. N., & Beydemir, Ş. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17953 · Cited by 5 · see citing works
Impact of Antioxidant and Anti-Inflammatory Functions of HDL in Diseases—2nd Edition
Cervellati, C., & Marsillach, J. (2025) · Antioxidants · doi:10.3390/antiox14030358 · Cited by 4 · see citing works
Self-citationPON1 and PON3 in Alzheimer’s Disease: Similar Functions but Different Roles
Trentini, A., Rosta, V., Riccetti, R., Mola, G., Galletti, R., Pinotti, M., Senia, V., Zuliani, G., & Cervellati, C. (2024) · Antioxidants · doi:10.3390/antiox13101216 · Cited by 5 · see citing works
Self-citationZhang, Z., Xiang, Q., Sun, Z., Chen, C., & Gu, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35635 · Cited by 4 · see citing works
The genetics of phospholipase A2 induced redox signaling in neuroinflammation and neuronal diseases
Maiti, A. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95698-7.00017-6 · Cited by 2 · see citing works
Ismail, A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., Papadakis, M., Faheem, S. A., & Batiha, G. E. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05493-1 · Cited by 2 · see citing works
Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache
Li, C., He, P., Li, Y., Ma, M., Chen, N., Liu, Q., Zhang, Y., Jiang, X., Li, S., Lang, H., et al. (2025) · Brain and Behavior · doi:10.1002/brb3.71004 · Cited by 2 · see citing works
Cho, K., Kim, J. E., & Baek, S. H. (2023) · Preprints.org · doi:10.20944/preprints202307.1004.v1 · Cited by 2 · see citing works
HDL Cholesterol Levels and Pancreatic Cancer Risk: Protective Effects Revealed
Shao, Y., Hao, R., Lin, S., Ma, B.-F., Ye, J., Maimaiti, M., & Maimaitiyiming, Y. (2025) · Current Cancer Drug Targets · doi:10.2174/0115680096334509241218141459 · Cited by 1 · see citing works
A comprehensive study of Alzheimer’s disease biomarkers in plasma and cerebrospinal fluid
Minochkin, A. K., Lobzin, V. Y., Emelin, А. Y., Kopteva, Y. P., Клиценко, О. А., Апалько, С. В., & Shcherbak, S. G. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512504243 · Cited by 1 · see citing works
Adeli, I., MohammadSadeghi, H., & Bameri, B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.01058-7
Константинович, М. А., Lobzin, V. Y., Николаевна, С. Н., Попов, О. С., Апалько, С. В., Kopteva, Y. P., Ponomareva, S., & Shcherbak, S. G. (2025) · Medical alphabet · doi:10.33667/2078-5631-2025-2-29-38
Mu, Y., Gao, N., Wang, Y., Wang, S., & Pang, L. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117663
Wang, Z., Jiang, H., Xu, L., Sun, P., Zhao, Y., Zong, L., & Wang, Z. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121286
High-density lipoprotein cholesterol and cognitive function in patients undergoing hemodialysis
Kato, K., Nakashima, A., Aizawa, C., Kobayashi, A., Shinagawa, S., Ohkido, I., Urashima, M., & Yokoo, T. (2026) · Clinical and Experimental Nephrology · doi:10.1007/s10157-026-02879-w
Life’s crucial 9, plasma proteomics, and the risk of major complications and mortality in MASLD
Zhang, B., Wang, Y.-X., Huang, H.-X., Tang, X.-L., Lai, S., Xiong, Z., Kuang, L., Chen, H., Zhu, H., Li, Y., et al. (2026) · npj Metabolic Health and Disease · doi:10.1038/s44324-026-00124-2
Jin, Y., Yang, K., & Yao, L. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1816471
Fan, D., Zhai, W., Zhang, Q., Li, J., Wang, Y., & Sun, L. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261499707
Cho, K., Lee, Y., Kang, M. J., & Yadav, D. (2026) · Nutrients · doi:10.3390/nu18213496
- Authors
- Zimetti, F., Adorni, M. P., Marsillach, J., Marchi, C., Trentini, A., Valacchi, G., & Cervellati, C.
- Affiliations
- University of Parma (IT)
- University of Washington (US)
- University of Ferrara (IT)
- North Carolina State University (US)
- Corresponding author
- Adorni, Maria Pia
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 2021
- Issue
- 1
- Pages
- 6695796-6695796
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC7811424
- OpenAlex
- W3119552585
- Cited by
- 49
- References
- 137
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 14 · 2022: 6 · 2021: 6
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (P50 AG05136)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- high-density lipoprotein, Alzheimer's disease, HDL proteome, glutathione peroxidase 3, paraoxonase 1, PON3, myeloperoxidase, serum amyloid A, oxidative stress, inflammation, antioxidant function, atherogenesis, vascular protection
- MeSH terms
- Alzheimer Disease, Animals, Anti-Inflammatory Agents, Antioxidants, Humans, Inflammation, Lipoproteins, HDL, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review