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Cited by 59Spaceflight effects on biologyMuscle Physiology and DisordersExercise and Physiological Responses

Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning

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Arc-Chagnaud, Coralie, Py, Guillaume, Fovet, Théo, Roumanille, Rémi, Demangel, Rémi, Pagano, Allan F., Delobel, Pierre, Blanc, Stéphane +7 more·2020·Frontiers in Physiology
DOI 10.3389/fphys.2020.00071PMC PMC7028694
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Abstract

Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning.

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  • The presence of antioxidant molecules accentuates skeletal muscle waste, pointing that physiological amounts of ROS and reactive nitrogen species (RNS) could be key to triggering a positive adaptation that could compensate for part of the damages observed in the control group.

    “The presence of antioxidant molecules accentuate skeletal muscle waste pointing that physiological amounts of ROS and reactive nitrogen species (RNS) could be key to triggering a positive adaptation that could compensate for part of the damages observed in the control group54.”

    From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [54]

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  • Candidate antioxidant cocktails have been proposed based on the scientific knowledge of their effects, but their translation to the field, and specifically to astronauts, has not been successful.

    “Even if candidate antioxidant cocktails have been proposed based on the scientific knowledge of their effects, their translation to the field, and specifically to astronauts, has not been successful47,53,54.”

    From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [54]

    The Introduction describes an antioxidant/anti-inflammatory cocktail proposed as a countermeasure for simulated microgravity, and the Conclusions report that it did not prevent muscle mass or strength loss in a two-month head-down bed-rest study. The study did not test the cocktail in astronauts or establish that its translation to field use has been unsuccessful. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The use of an antioxidant and anti-inflammatory cocktail consisting of 741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3 did not show to be protective against human hypoactivity induced by skeletal muscle deconditioning by the head-down bed rest model.

    “Interestingly, the use of an antioxidant and anti-inflammatory cocktail consisting of 741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3 did not show to be protective against human hypoactivity induced by skeletal muscle deconditioning by the head-down bed rest model54.”

    From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [54]

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Authors
Arc-Chagnaud, C., Py, G., Fovet, T., Roumanille, R., Demangel, R., Pagano, A. F., Delobel, P., Blanc, S., Jasmin, B. J., Blottner, D., Salanova, M., Gomez-Cabrera, M.-C., Viña, J., Brioche, T., & Chopard, A.
Affiliations
  • Université de Montpellier (FR)
  • University of Ottawa (CA)
  • Centre National de la Recherche Scientifique (FR)
  • Charité – Universitätsmedizin Berlin (DE)
  • Universitat de València (ES)
Corresponding author
Brioche, Thomas
ORCID
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2020-02-12
Volume
11
Pages
71-71
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2020.00071
PMC
PMC7028694
OpenAlex
W3006005115
Cited by
59
References
86
Citations by year
2026: 8 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 12 · 2021: 14 · 2020: 3
FWCI
5.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, other-oa)
Funders
  • Centre National d’Etudes Spatiales
  • Canadian Space Agency
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
muscle deconditioning, disuse atrophy, antioxidant supplementation, anti-inflammatory supplementation, polyphenols, vitamin E, selenium, omega-3 fatty acids, head-down bed rest, redox homeostasis, oxidative damage, mitochondrial content, protein balance, mitochondrial biogenesis, muscle strength, remobilization, spaceflight countermeasures

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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