Resistance Training and Timed Essential Amino Acids Protect against the Loss of Muscle Mass and Strength During 28 Days of Bed Rest and Energy Deficit
Open accessAbstract
Spaceflight and bed rest (BR) result in losses of muscle mass and strength. Resistance training (RT) and amino acid (AA) supplementation are potential countermeasures to minimize these losses. However, it is unknown if timing of supplementation with exercise can optimize benefits, particularly with energy deficit. We examined the effect of these countermeasures on body composition, strength, and insulin levels in 31 men (ages 31-55 yr) during BR (28 days) followed by active recovery (14 days). Subjects were randomly assigned to essential AA supplementation (AA group, n = 7); RT with AA given 3 h after training (RT group, n = 12); or RT with AA given 5 min before training (AART group, n = 12). Energy intake was reduced by 8 +/- 6%. Midthigh muscle area declined with BR for the AA > RT > AART groups: -11%, -3%, -4% (P = 0.05). Similarly, greatest losses in lower body muscle strength were seen in the AA group (-22%). These were attenuated in the exercising groups [RT (-8%) and AART (-6%; P < 0.05)]. Fat mass and midthigh intramuscular fat increased after BR in the AA group (+3% and +14%, respectively), and decreased in the RT (-5% and -4%) and AART groups (-1 and -5%; P = 0.05). Muscle mass and strength returned toward baseline after recovery, but the AA group showed the lowest regains. Combined resistance training with AA supplementation pre- or postexercise attenuated the losses in muscle mass and strength by approximately two-thirds compared with AA supplement alone during BR and energy deficit. These data support the efficacy of combined AA and RT as a countermeasure against muscle wasting due to low gravity.
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Combined resistance training with essential amino acid mixture supplementation protects against losses of muscle mass and strength in men during 28 days of bed rest and energy deficit.
“Combined resistance training with essential amino acid mixture (L-isoleucine, L-histidine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, and L-valine) supplementation protects against the losses of muscle mass and strength in man during 28 days of bed rest and energy deficit [25].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [25]
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- Authors
- Brooks, N., Cloutier, G. J., Cadena, S. M., Layne, J. E., Nelsen, C. A., Freed, A. M., Roubenoff, R., & Castaneda-Sceppa, C.
- Affiliations
- Tufts University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 105
- Issue
- 1
- Pages
- 241-248
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2494840
- OpenAlex
- W1975212848
- Cited by
- 102
- References
- 39
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 16 · 2012: 4
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Stirling Online Research Repository (University of Stirling) (submittedVersion)
- Funders
- U.S. Department of Agriculture
- Deutsches Krebsforschungszentrum
- National Institutes of Health
- Agricultural Research Service
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK062032)
- National Center for Research Resources (M01RR000054)
- NIH Clinical Center
- Accelerated Innovation Research Initiative Turning Top Science and Ideas into High-Impact Values
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- resistance training, essential amino acid supplementation, bed rest, negative energy balance, muscle mass loss, muscle strength, sarcopenia, countermeasures, spaceflight, body composition, intramuscular fat, insulin, muscle atrophy
- MeSH terms
- Adult, Amino Acids, Essential, Body Composition, Energy Intake, Energy Metabolism, Humans, Insulin, Male, Middle Aged, Organ Size, Physical Fitness, Rest, Tomography, X-Ray Computed, Weight Lifting, Absorptiometry, Photon, Muscle, Skeletal, Muscle Strength
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