The DOI matches its Crossref record; 209 of the 211 references it cites were found in a registry or an index.
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases
Open accessAbstract
Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.
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“there is an increasing scientific interest in the effects of reactive oxygen species (ROS) accumulation that cause in vivo oxidative stress conditions, leading to many chronic inflammatory conditions in the gut, as well as degenerative systemic diseases (atherosclerosis, diabetes, Alzheimer’s disease, inflammatory bowel disease, cardiovascular diseases, aging, and cancer) [111,112].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [111]
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“a higher intake of antioxidant molecules is associated with lower occurrence of human diseases [111,112].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [111]
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“Physiological levels of reactive species (ROS and RNS) are important in cellular signaling, but higher concentrations and prolonged exposure can fight infections by damaging important microbial biomolecules [6].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [6]
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1 retracted
Miltonprabu, S., Sumedha, N. C., & Senthilraja, P. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.011 · Cited by 46
RetractedFree radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,837
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Sharma, P., Jha, A. B., Dubey, R. S., & Pessarakli, M. (2012) · Journal of Botany · doi:10.1155/2012/217037 · Cited by 5,723
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441
Oxidative Stress and Antioxidant Defense
Birben, E., Şahiner, Ü. M., Saçkesen, C., ERZURUM, S. C., & Kalaycı, Ö. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182439613 · Cited by 5,190
Chemistry and Biological Activities of Flavonoids: An Overview
Kumar, S., & Pandey, A. K. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/162750 · Cited by 5,178
Flagged first, then by citations
2 of the 211 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Nussbaum, 2017, Modern treatment approaches in psychoses. Pharmacogenetic, neuroimagistic and clinical implications., Farmacia, 65, 75
Cited by
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Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 806
Free radicals and their impact on health and antioxidant defenses: a review
Chandimali, N., Bak, S. G., Park, E. H., Lim, H. J., Won, Y., Kim, E., Park, S., & Lee, S. (2025) · Cell Death Discovery · doi:10.1038/s41420-024-02278-8 · Cited by 852
Oxidative Stress in Cardiovascular Diseases
Dubois‐Deruy, E., Peugnet, V., Turkieh, A., & Pinet, F. (2020) · Antioxidants · doi:10.3390/antiox9090864 · Cited by 694
Cellular Red-Ox system in health and disease: The latest update
Jena, A. B., Samal, R. R., Bhol, N. K., & Duttaroy, A. K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114606 · Cited by 587
Metadata
- Authors
- Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., Prakash Mishra, A., Nigam, M., El Rayess, Y., Beyrouthy, M. E., Polito, L., Iriti, M., Martins, N., Martorell, M., Docea, A. O., Setzer, W. N., Calina, D., Cho, W. C., & Sharifi-Rad, J.
- Affiliations
- University of Cagliari (IT)
- University of Milan (IT)
- University of Salento (IT)
- Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (IT)
- Hemwati Nandan Bahuguna Garhwal University (IN)
- Holy Spirit University of Kaslik (LB)
- Universidade do Porto (PT)
- University of Concepción (CL)
- University of Medicine and Pharmacy of Craiova (RO)
- University of Alabama in Huntsville (US)
- Queen Elizabeth Hospital (CN)
- Corresponding author
- Martorell, Miquel
- Cho, William C.
- ORCID
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-07-02
- Volume
- 11
- Pages
- 694-694
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC7347016
- OpenAlex
- W3039077710
- Cited by
- 1,971
- References
- 211
- Citations by year
- 2026: 181 · 2025: 371 · 2024: 474 · 2023: 467 · 2022: 323 · 2021: 129 · 2020: 25
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences) (submittedVersion)
- AIRUS (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (01-0145, NORTE-01-0145-FEDER-000012, UID/BIM/04293/2013, UID/BIM/04293, NORTE2020, NORTE-01-0145)
- Comisión Nacional de Investigación Científica y Tecnológica (CCTE AFB170007, AFB170007)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- oxidative stress, antioxidants, lifestyle, chronic disease, cardiovascular disease, diabetes mellitus, neurodegenerative diseases, cancer, mitochondrial DNA damage, processed foods, chemical exposure, physical inactivity, medicinal plants, antioxidant defense, disease prevention
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