CoChat
Sign Up
Cited by 148

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Lipid Transport and Metabolism at the Blood-Brain Interface: Implications in Health and Disease

Pifferi, Fabien, Laurent, Benoit, Plourde, Mélanie·2021·Frontiers in Physiology
DOI 10.3389/fphys.2021.645646PMC PMC8044814
Open this paper in CoChat — free account

Abstract

Many prospective studies have shown that a diet enriched in omega-3 polyunsaturated fatty acids (n-3 PUFAs) can improve cognitive function during normal aging and prevent the development of neurocognitive diseases. However, researchers have not elucidated how n-3 PUFAs are transferred from the blood to the brain or how they relate to cognitive scores. Transport into and out of the central nervous system depends on two main sets of barriers: the blood-brain barrier (BBB) between peripheral blood and brain tissue and the blood-cerebrospinal fluid (CSF) barrier (BCSFB) between the blood and the CSF. In this review, the current knowledge of how lipids cross these barriers to reach the CNS is presented and discussed. Implications of these processes in health and disease, particularly during aging and neurodegenerative diseases, are also addressed. An assessment provided here is that the current knowledge of how lipids cross these barriers in humans is limited, which hence potentially restrains our capacity to intervene in and prevent neurodegenerative diseases.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphys.2021.645646

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 82

  1. Alberghina, 1994, Differential transport of docosahexaenoate and palmitate through the blood-retina and blood-brain barrier of the rat., Neurosci. Lett., 171, 133, 10.1016/0304-3940(94)90623-8 · DOI
  2. Alberghina, 1993, Palmitate transport through the blood-retina and blood-brain barrier of rat visual system during aging., Neurosci. Lett., 150, 17, 10.1016/0304-3940(93)90097-5 · DOI
  3. Andreone, 2017, Blood-Brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis., Neuron, 94, 581, 10.1016/j.neuron.2017.03.043 · DOI · Paper page
  4. Balusu, 2016, The choroid plexus-cerebrospinal fluid interface in Alzheimer’s disease: more than just a barrier., Neural Regen. Res., 11, 534, 10.4103/1673-5374.180372 · DOI
  5. Banks, 2016, From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery., Nat. Rev. Drug Discov., 15, 275, 10.1038/nrd.2015.21 · DOI · Paper page
  6. Benistant, 1995, Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes., J. Lipid Res., 36, 2311, 10.1016/S0022-2275(20)39712-1 · DOI
  7. Ben-Zvi, 2014, Mfsd2a is critical for the formation and function of the blood-brain barrier., Nature, 509, 507, 10.1038/nature13324 · DOI · Paper page
  8. Bernoud, 1998, Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro., J. Lipid Res., 39, 1816, 10.1016/S0022-2275(20)32169-6 · DOI
  9. Björkhem, 2004, Brain cholesterol: long secret life behind a barrier., Arterioscler. Thromb. Vasc. Biol., 24, 806, 10.1161/01.ATV.0000120374.59826.1b · DOI · Paper page
  10. Bourre, 1991, Protection contre les peroxidations radicalaires au cours du vieillissement cerebral dans les capillaires et microvaisseaux cérébraux., C.R. Seances Soc. Biol. Fil., 185, 5
  11. Bourre, 2006, Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients., J. Nutr. Health Aging, 10, 386
  12. Bourre, 1997, Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids., Neurosci. Lett., 224, 1, 10.1016/S0304-3940(97)13440-1 · DOI
  13. Brossard, 1997, Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells., J. Lipid Res., 38, 1571, 10.1016/S0022-2275(20)37175-3 · DOI
  14. Calon, 2011, Omega-3 polyunsaturated fatty acids in Alzheimer’s disease: key questions and partial answers., Curr. Alzheimer Res., 8, 470, 10.2174/156720511796391881 · DOI
  15. Chouinard-Watkins, 2018, Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence?, Curr. Opin. Clin. Nutr. Metab. Care, 21, 71, 10.1097/MCO.0000000000000440 · DOI
  16. Cunnane, 2012, Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer’s disease., J. Alzheimers Dis., 29, 691, 10.3233/JAD-2012-110629 · DOI
  17. Dehouck, 1997, A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier., J. Cell Biol., 138, 877, 10.1083/jcb.138.4.877 · DOI · Paper page
  18. Delton-Vandenbroucke, 1997, Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells., J. Lipid Res., 38, 147, 10.1016/S0022-2275(20)37284-9 · DOI
  19. Dhopeshwarkar, 1973, Uptake and transport of fatty acids into the brain and the role of the blood-brain barrier system., Adv. Lipid Res., 11, 109, 10.1016/b978-0-12-024911-4.50010-6 · DOI
  20. Dias, 2019, Molecular sciences structure and junctional complexes of endothelial, epithelial and glial brain barriers., Int. J. Mol. Sci., 20, 10.3390/ijms20215372 · DOI
  21. Dietschy, 2001, Cholesterol metabolism in the brain., Curr. Opin. Lipidol., 12, 105, 10.1097/00041433-200104000-00003 · DOI · Paper page
  22. Do, 2011, Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood-brain barrier., Mol. Cell. Biochem, 357, 397, 10.1007/s11010-011-0910-6 · DOI · Paper page
  23. Edmond, 2001, Essential polyunsaturated fatty acids and the barrier to the brain: the components of a model for transport., J. Mol. Neurosci., 16, 181, 10.1385/JMN:16:2-3:181 · DOI
  24. Edwards, 2002, BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis., J. Lipid Res., 43, 2, 10.1016/S0022-2275(20)30180-2 · DOI
  25. Erdö, 2017, Age-associated physiological and pathological changes at the blood-brain barrier: a review., J. Cereb. Blood Flow Metab., 37, 4, 10.1177/0271678X16679420 · DOI · Paper page
  26. Etschmaier, 2011, Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers., J. Neurochem., 119, 1016, 10.1111/j.1471-4159.2011.07498.x · DOI
  27. Fujiyoshi, 2007, 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression., J. Neurochem., 100, 968, 10.1111/j.1471-4159.2006.04240.x · DOI · Paper page
  28. Galea, 2018, The blood-brain interface: a culture change., Brain Behav. Immun., 68, 11, 10.1016/j.bbi.2017.10.014 · DOI
  29. Gomez-Zepeda, 2020, ABC transporters at the blood–brain interfaces, their study models, and drug delivery implications in gliomas., Pharmaceutics, 12, 10.3390/pharmaceutics12010020 · DOI
  30. Hamilton, 2007, A model for fatty acid transport into the brain., J. Mol. Neurosci., 33, 12, 10.1007/s12031-007-0050-3 · DOI
  31. Helmy, 1963, Histochemical and lipid studies on human choroid plexus., Proc. Soc. Exp. Biol. Med., 114, 361, 10.3181/00379727-114-28677 · DOI
  32. Hirsch-Reinshagen, 2004, Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain., J. Biol. Chem., 279, 41197, 10.1074/jbc.M407962200 · DOI · Paper page
  33. Holman, 2010, Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. II. In vitro arachnoid outflow model., J. R. Soc. Interface, 7, 1205, 10.1098/rsif.2010.0032 · DOI
  34. Homayoun, 1988, Alteration in fatty acid composition of adult rat brain capillaries and choroid plexus induced by a diet deficient in n-3 fatty acids: slow recovery after substitution with a nondeficient diet., J. Neurochem., 51, 45, 10.1111/j.1471-4159.1988.tb04833.x · DOI
  35. Iadecola, 2017, The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease., Neuron, 96, 17, 10.1016/j.neuron.2017.07.030 · DOI · Paper page
  36. Igarashi, 2007, Docosahexaenoic acid synthesis from α-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation., J. Lipid Res., 48, 1150, 10.1194/jlr.M600549-JLR200 · DOI
  37. Kamp, 2006, How fatty acids of different chain length enter and leave cells by free diffusion., Prostaglandins Leukot. Essent. Fatty Acids, 75, 149, 10.1016/j.plefa.2006.05.003 · DOI
  38. Karasinska, 2009, Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function., J. Neurosci., 29, 3579, 10.1523/JNEUROSCI.4741-08.2009 · DOI · Paper page
  39. Keaney, 2015, The dynamic blood-brain barrier., FEBS J., 282, 4067, 10.1111/febs.13412 · DOI · Paper page
  40. Kim, 1996, Human apolipoprotein E receptor 2: a novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain., J. Biol. Chem., 271, 8373, 10.1074/jbc.271.14.8373 · DOI · Paper page
  41. Kirchhausen, 2005, Single-molecule live-cell imaging of clathrin-based endocytosis., Biochem. Soc. Symp., 72, 71, 10.1042/bss0720071 · DOI
  42. Kounnas, 1994, Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues., In Vivo (Brooklyn), 8, 343
  43. Lacombe, 2018, Brain docosahexaenoic acid uptake and metabolism., Mol. Aspects Med., 64, 109, 10.1016/j.mam.2017.12.004 · DOI
  44. Lun, Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production., J. Neurosci., 35, 4903, 10.1523/JNEUROSCI.3081-14.2015 · DOI
  45. Lun, Development and functions of the choroid plexus-cerebrospinal fluid system., Nat. Rev. Neurosci., 16, 445, 10.1038/nrn3921 · DOI
  46. Mahley, 2016, Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism., Arterioscler. Thromb. Vasc. Biol., 36, 1305, 10.1161/ATVBAHA.116.307023 · DOI · Paper page
  47. Marinetti, 1971, Lipid metabolism in the rabbit choroid plexus., J. Neurochem., 18, 2003, 10.1111/j.1471-4159.1971.tb09606.x · DOI
  48. Marques, 2013, Blood-brain-barriers in aging and in Alzheimer’s disease., Mol. Neurodegener., 8, 10.1186/1750-1326-8-38 · DOI
  49. Mauch, 2001, CNS synaptogenesis promoted by glia-derived cholesterol., Science, 294, 1354, 10.1126/science.294.5545.1354 · DOI · Paper page
  50. Mitchell, 2011, Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells., J. Neurochem., 117, 735, 10.1111/j.1471-4159.2011.07245.x · DOI · Paper page
  51. Mooradian, 1988, Effect of aging on the blood-brain barrier., Neurobiol. Aging, 9, 31, 10.1016/S0197-4580(88)80013-7 · DOI
  52. Mooradian, 1992, The effect of age on lipid composition and order of rat cerebral microvessels., Neurochem. Res, 17, 233, 10.1007/BF00966664 · DOI
  53. Moore, 2001, Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro., J. Mol. Neurosci., 16, 195, 10.1385/JMN:16:2-3:195 · DOI
  54. Nguyen, 2014, Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid., Nature, 509, 503, 10.1038/nature13241 · DOI · Paper page
  55. Ouellet, 2009, Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: an in situ cerebral perfusion study., Neurochem. Int, 55, 476, 10.1016/j.neuint.2009.04.018 · DOI
  56. Pifferi, 2005, (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats., J. Nutr., 135, 2241, 10.1093/jn/135.9.2241 · DOI
  57. Plourde, 2007, Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements., Appl. Physiol. Nutr. Metab., 32, 619, 10.1139/H07-034 · DOI
  58. Qi, 2002, Long-chain polyunsaturated fatty acid accretion in brain., Curr. Opin. Clin. Nutr. Metab. Care, 5, 133, 10.1097/00075197-200203000-00003 · DOI
  59. Razmara, 2020, Novel neuroclinical findings of autosomal recessive primary microcephaly 15 in a consanguineous Iranian family., Eur. J. Med. Genet., 63, 10.1016/j.ejmg.2020.104096 · DOI
  60. Robinet, 2006, Dynamin is involved in endolysosomal cholesterol delivery to the endoplasmic reticulum: role in cholesterol homeostasis., Traffic, 7, 811, 10.1111/j.1600-0854.2006.00435.x · DOI
  61. Rosenberg, 2018, Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial., Alzheimers Dement., 14, 263, 10.1016/j.jalz.2017.09.006 · DOI · Paper page
  62. Rothberg, 1992, Caveolin, a protein component of caveolae membrane coats., Cell, 68, 673, 10.1016/0092-8674(92)90143-Z · DOI
  63. Saeed, 2014, Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain., J. Biol. Chem., 289, 23712, 10.1074/jbc.M114.556159 · DOI
  64. Schultz, 2000, Role of LXRs in control of lipogenesis., Genes Dev., 14, 2831, 10.1101/gad.850400 · DOI · Paper page
  65. Scott, 1989, Membrane docosahexaenoate is supplied to the developing brain and retina by the liver., Proc. Natl. Acad. Sci. U.S.A., 86, 2903, 10.1073/pnas.86.8.2903 · DOI
  66. Selivonchick, 1977, Lipid and fatty acyl composition of rat brain capillary endothelia isolated by a new technique., Lipids, 12, 165, 10.1007/BF02533288 · DOI
  67. Serot, 2003, Choroid plexus, ageing of the brain, and Alzheimer’s disease., Front. Biosci., 8, s515, 10.2741/1085 · DOI
  68. Smith, 1998, Clathrin coats at 21 Å resolution: a cellular assembly designed to recycle multiple membrane receptors., EMBO J., 17, 4943, 10.1093/emboj/17.17.4943 · DOI
  69. Spector, 2001, Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain., J. Mol. Neurosci., 16, 159, 10.1385/JMN:16:2-3:159 · DOI
  70. Strazielle, 2013, Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules., Mol. Pharm., 10, 1473, 10.1021/mp300518e · DOI
  71. Strosznajder, 1996, Arachidonate transport through the blood-retina and blood-brain barrier of the rat during aging., Neurosci. Lett., 209, 145, 10.1016/0304-3940(96)12624-0 · DOI
  72. Sturrock, 1988, An ultrastructural study of the choroid plexus of aged mice., Anat. Anz., 165, 379
  73. Tayarani, 1989, Antioxidant enzymes and related trace elements in aging brain capillaries and choroid plexus., J. Neurochem., 53, 817, 10.1111/j.1471-4159.1989.tb11778.x · DOI
  74. Thouvenot, 2006, The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells., Proteomics, 6, 5941, 10.1002/pmic.200600096 · DOI
  75. Vandal, 2014, Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2., J. Neurochem., 129, 516, 10.1111/jnc.12640 · DOI
  76. Wang, 2002, Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration., Proc. Natl. Acad. Sci. U.S.A., 99, 13878, 10.1073/pnas.172510899 · DOI
  77. Wang, 2004, ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins., Proc. Natl. Acad. Sci. U.S.A., 101, 9774, 10.1073/pnas.0403506101 · DOI
  78. Wang, 2000, Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1., J. Biol. Chem., 275, 33053, 10.1074/jbc.M005438200 · DOI
  79. Wong, 2020, Mfsd2a: a physiologically important lysolipid transporter in the brain and eye, Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease. Advances in Experimental Medicine and Biology, 223, 10.1007/978-981-15-6082-8_14 · DOI
  80. Yang, 2020, Deciphering the roles of caveolin in neurodegenerative diseases: the good, the bad and the importance of context., Ageing Res. Rev., 62, 10.1016/j.arr.2020.101116 · DOI
  81. Yassine, 2017, DHA brain uptake and APOE4 status: a PET study with [1-(11)C]-DHA., Alzheimers Res. Ther, 9, 10.1186/s13195-017-0250-1 · DOI
  82. Zhou, 2019, Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis., Sci. Adv., 5, 10.1126/sciadv.aax7142 · DOI

Cited by

Sorted by citations

Metadata

Authors
Pifferi, F., Laurent, B., & Plourde, M.
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2021-03-30
Volume
12
ISSN
1664-042X
DOI
10.3389/fphys.2021.645646
PMC
PMC8044814
Cited by
148
References
7
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Canadian Institutes of Health Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review