Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells
Open accessAbstract
Specialized niches support the lifelong maintenance and function of tissue-specific stem cells. Adult neural stem cells in the ventricular-subventricular zone (V-SVZ) contact the cerebrospinal fluid (CSF), which flows through the lateral ventricles. A largely ignored component of the V-SVZ stem cell niche is the lateral ventricle choroid plexus (LVCP), a primary producer of CSF. Here we show that the LVCP, in addition to performing important homeostatic support functions, secretes factors that promote colony formation and proliferation of purified quiescent and activated V-SVZ stem cells and transit-amplifying cells. The functional effect of the LVCP secretome changes throughout the lifespan, with activated neural stem cells being especially sensitive to age-related changes. Transcriptome analysis identified multiple factors that recruit colony formation and highlights novel facets of LVCP function. Thus, the LVCP is a key niche compartment that translates physiological changes into molecular signals directly affecting neural stem cell behavior.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bulk profiling indicates that each ChP retains a developmental blueprint of its origins along the body axis, with ventricle-specific transcriptomes and secretomes for the lateral and 4th ventricle ChPs.
“Bulk profiling of whole tissue (Liddelow et al., 2010; Lun et al., 2015b; Silva-Vargas et al., 2016) or sorted subpopulations (Lun et al., 2015b) indicates that each ChP retains a developmental blueprint of its origins along the body axis, with ventricle-specific transcriptomes and secretomes for the lateral and 4th ventricle ChPs (Lun et al., 2015a).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Silva-Vargas et al., 2016
Cites
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037 · see citing works
New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain
Sawamoto, K., Wichterle, H., González-Pérez, Ó., Cholfin, J. A., Yamada, M., Spassky, N., Murcia, N. S., García‐Verdugo, J. M., Marín, Ó., Rubenstein, J. L. R., et al. (2006) · Science · doi:10.1126/science.1119133 · Cited by 803 · see citing works
Development and functions of the choroid plexus–cerebrospinal fluid system
Lun, M. P., Monuki, E. S., & Lehtinen, M. K. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3921 · Cited by 682 · see citing works
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
Lehtinen, M. K., Zappaterra, M. W., Chen, X., Yang, Y. J., Hill, A. D., Lun, M., Maynard, T., Gonzalez, D., Kim, S., Ye, P., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.023 · Cited by 648 · see citing works
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634 · see citing works
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works
Pastrana, É., Cheng, L.-C., & Doetsch, F. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810407106 · Cited by 381 · see citing works
Adult Neural Stem Cells Bridge Their Niche
Fuentealba, L. C., Obernier, K., & Álvarez-Buylla, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.012 · Cited by 367 · see citing works
The Choroid Plexus‐Cerebrospinal Fluid System: From Development to Aging
Redzic, Z. B., Preston, J. E., Duncan, J. A., Chodobski, A., & Szmydynger‐Chodobska, J. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)71001-2 · Cited by 343 · see citing works
Mechanisms that Regulate Stem Cell Aging and Life Span
Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320 · see citing works
Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity
Bartke, A., Sun, L. Y., & Longo, V. D. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2012 · Cited by 286 · see citing works
Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B. (2013) · Nature Cell Biology · doi:10.1038/ncb2736 · Cited by 247 · see citing works
Kokovay, E., Wang, Y., Kusek, G., Wurster, R., Lederman, P. L., Lowry, N. A., Shen, Q., & Temple, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.016 · Cited by 199 · see citing works
Delgado, A. C., Ferrón, S. R., Vicente, D., Porlan, E., Pérez‐Villalba, A., Trujillo, C. M., D’Ocón, P., & Fariñas, I. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.015 · Cited by 183 · see citing works
Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging
Silva-Vargas, V., Crouch, E. E., & Doetsch, F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.004 · Cited by 157 · see citing works
Bouab, M., Paliouras, G. N., Aumont, A., Forest-Bérard, K., & Fernandes, K. J. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.032 · Cited by 153 · see citing works
Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array
Baird, G. S., Nelson, S. K., Keeney, T. R., Stewart, A., Williams, S., Kraemer, S., Peskind, E. R., & Montine, T. J. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.024 · Cited by 110 · see citing works
Ouzzine, M., Gulberti, S., Ramalanjaona, N., Magdalou, J., & Fournel‐Gigleux, S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00349 · Cited by 97 · see citing works
Transcriptome signature of the adult mouse choroid plexus
Marques, F., Sousa, J. C., Coppola, G., Gao, F., Puga, R., Brentani, H., Geschwind, D. H., Sousa, N., Correia‐Neves, M., & Palha, J. A. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-10 · Cited by 95 · see citing works
AGING OF THE SUBVENTRICULAR ZONE NEURAL STEM CELL NICHE.
Conover, J. C., & Shook, B. A. (2011) · Europe PMC (PubMed Central) · Cited by 92 · see citing works
Azim, K., Fischer, B., Hurtado‐Chong, A., Draganova, K., Cantù, C., Zemke, M., Sommer, L., Butt, A., & Raineteau, O. (2014) · Stem Cells · doi:10.1002/stem.1639 · Cited by 88 · see citing works
Strazielle, N., Creidy, R., Malcus, C., Boucraut, J., & Ghersi‐Egea, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150945 · Cited by 83 · see citing works
The choroid plexuses and their impact on developmental neurogenesis
Johansson, P. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00340 · Cited by 81 · see citing works
Chen, C. P. C., Chen, R. L., & Preston, J. E. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.01.008 · Cited by 55 · see citing works
Marques, F., & Sousa, J. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00136 · Cited by 42 · see citing works
Neural stem and progenitor cells in the aged subependyma are activated by the young niche
Piccin, D., Tufford, A., & Morshead, C. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.026 · Cited by 37 · see citing works
Bone Morphogenetic Protein 5 Regulates the Number of Keratinocyte Stem Cells from the Skin of Mice
Kangsamaksin, T., & Morris, R. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.378 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578 · see citing works
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works
The Meningeal Lymphatic System: A New Player in Neurophysiology
Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479 · see citing works
Human CNS barrier-forming organoids with cerebrospinal fluid production
Pellegrini, L., Bonfio, C., Chadwick, J., Begum, F., Skehel, M., & Lancaster, M. A. (2020) · Science · doi:10.1126/science.aaz5626 · Cited by 412 · see citing works
Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F., & Engelhardt, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1807-1 · Cited by 436 · see citing works
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Kalamakis, G., Brüne, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., Stiehl, T., Catalá-Martinez, F., Kupke, J., Zhao, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.040 · Cited by 399 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest
Urbán, N., Blomfield, I. M., & Guillemot, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.026 · Cited by 370 · see citing works
Aging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246 · see citing works
Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues
Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.012 · Cited by 233 · see citing works
“An aged circulatory environment can promote brain dysfunction (Silva-Vargas et al., 2016; Villeda et al., 2011; Yousef et al., 2019).”
Emergence and Developmental Roles of the Cerebrospinal Fluid System
Fame, R. M., & Lehtinen, M. K. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.027 · Cited by 199 · see citing works
A mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198 · see citing works
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Iram, T., Kern, F., Kaur, A., Myneni, S., Morningstar, A. R., Shin, H., García, M. Á., Yerra, L. P., Pálovics, R., Yang, A. C., et al. (2022) · Nature · doi:10.1038/s41586-022-04722-0 · Cited by 198 · see citing works
Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration
Pluvinage, J. V., & Wyss-Coray, T. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0255-9 · Cited by 191 · see citing works
Transforming Professional Development Into Student Results
Reeves, D. B. (2010) · Cited by 191 · see citing works
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186 · see citing works
Immune cell compartmentalization for brain surveillance and protection
Croese, T., Castellani, G., & Schwartz, M. (2021) · Nature Immunology · doi:10.1038/s41590-021-00994-2 · Cited by 188 · see citing works
Marchetti, B., Tirolo, C., L’Episcopo, F., Caniglia, S., Testa, N., Smith, J. A., Pluchino, S., & Serapide, M. F. (2020) · Aging Cell · doi:10.1111/acel.13101 · Cited by 185 · see citing works
Lizano, P. L., Lutz, O., Ling, G., Lee, A. M., Eum, S., Bishop, J. R., Kelly, S., Pasternak, O., Clementz, B. A., Pearlson, G. D., et al. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18070825 · Cited by 164 · see citing works
Jurisch‐Yaksi, N., Yaksi, E., & Kızıl, Ç. (2020) · Glia · doi:10.1002/glia.23849 · Cited by 156 · see citing works
Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis
Kjell, J., Fischer-Sternjak, J., Thompson, A. J., Friess, C., Sticco, M. J., Salinas, F., Cox, J., Martinelli, D. C., Ninkovic, J., Franze, K., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.01.002 · Cited by 163 · see citing works
LEWITT, M. S., & Boyd, G. W. (2019) · Biochemistry Insights · doi:10.1177/1178626419842176 · Cited by 160 · see citing works
Blood-to-brain communication in aging and rejuvenation
Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01238-8 · Cited by 156 · see citing works
The choroid plexus synergizes with immune cells during neuroinflammation
Xu, H., Lotfy, P., Gelb, S., Pragana, A., Hehnly, C., Byer, L. I. J., Shipley, F. B., Zawadzki, M. E., Cui, J., Deng, L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.002 · Cited by 161 · see citing works
Rejuvenating Strategies for Stem Cell-Based Therapies in Aging
Neves, J., Sousa‐Victor, P., & Jasper, H. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.01.008 · Cited by 156 · see citing works
Lipid Transport and Metabolism at the Blood-Brain Interface: Implications in Health and Disease
Pifferi, F., Laurent, B., & Plourde, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.645646 · Cited by 149 · see citing works
Neurogenesis in the aging brain
Apple, D. M., Fonseca, R. S., & Kokovay, E. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.116 · Cited by 140 · see citing works
Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis
Paul, A., Chaker, Z., & Doetsch, F. (2017) · Science · doi:10.1126/science.aal3839 · Cited by 137 · see citing works
NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis
Zhang, S.-Z., Wang, Q., Yang, Q., Gu, H., Yin, Y., Li, Y., Hou, J., Chen, R., Sun, Q., Sun, Y., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1439-x · Cited by 138 · see citing works
A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury
Zamboni, M., Llorens-Bobadilla, E., Magnusson, J. P., & Frisén, J. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.006 · Cited by 128 · see citing works
Yang, Q. Z., Wei, X., Deng, B., Chang, Z., Jin, D., Huang, Y., Zhang, J. H., Yenari, M. A., Jin, K., & Wang, Q. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105750 · Cited by 132 · see citing works
The role of motile cilia in the development and physiology of the nervous system
Ringers, C., Olstad, E. W., & Jurisch‐Yaksi, N. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0156 · Cited by 120 · see citing works
Neural stem cell niche heterogeneity
Andreotti, J. P., da Silva, W. N., Costa, A. C., Picoli, C. C., Bitencourt, F. C. O., Coimbra-Campos, L. M. C., Resende, R. R., Magno, L. A. V., Romano‐Silva, M. A., Mintz, A., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.005 · Cited by 115 · see citing works
Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.024 · Cited by 118 · see citing works
RNA-binding proteins balance brain function in health and disease
Schieweck, R., Ninkovic, J., & Kiebler, M. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00047.2019 · Cited by 104 · see citing works
Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner
Petrik, D., Myoga, M. H., Grade, S., Gerkau, N. J., Pusch, M., Rose, C. R., Grothe, B., & Götz, M. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.016 · Cited by 104 · see citing works
Winkler, C. C., Yabut, O., Fregoso, S. P., Gomez, H. G., Dwyer, B. E., Pleasure, S. J., & Franco, S. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3392-17.2018 · Cited by 106 · see citing works
Falk, S., & Götz, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.025 · Cited by 99 · see citing works
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Čarná, M. E., Onyango, I. G., Katina, S., Holub, D., Novotný, J., Nezvedová, M., Jha, D., Nedelská, Z., Lacovich, V., Vyvere, T. V., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12970 · Cited by 96 · see citing works
Current Understanding of the Neural Stem Cell Niches
Llorente, V., Velarde, P., Desco, M., & Gómez‐Gaviro, M. V. (2022) · Cells · doi:10.3390/cells11193002 · Cited by 94 · see citing works
Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain
Delgado, A. C., Maldonado‐Soto, A. R., Silva-Vargas, V., Mizrak, D., von Känel, T., Tan, K. R., Paul, A., Madar, A., Cuervo, H., Kitajewski, J., et al. (2021) · Science · doi:10.1126/science.abg8467 · Cited by 90 · see citing works
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
Marqués‐Torrejón, M. Á., Williams, C. A. C., Southgate, B., Alfazema, N., Clements, M., Garcia-Diaz, C., Blin, C., Arranz-Emparan, N., Dudley-Fraser, J., Gammoh, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22813-w · Cited by 89 · see citing works
Chavali, M., Klingener, M., Kokkosis, A. G., Garkun, Y., Felong, S., Maffei, A., & Aguirre, A. A. (2017) · Nature Communications · doi:10.1038/s41467-017-02440-0 · Cited by 85 · see citing works
Stem cells: Aging and transcriptional fingerprints
Keyes, B. E., & Fuchs, E. V. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201708099 · Cited by 84 · see citing works
Regulation of neurogenesis in the adult and aging brain
Katsimpardi, L., & Lledo, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.006 · Cited by 85 · see citing works
Storer, M. A., Gallagher, D., Fatt, M. P., Simonetta, J. V., Kaplan, D. R., & Miller, F. D. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.03.008 · Cited by 82 · see citing works
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity
bin Imtiaz, M. K., Jaeger, B. N., Bottes, S., Machado, R. A. C., Vidmar, M., Moore, D. L., & Jessberger, S. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.015 · Cited by 83 · see citing works
Pous, L., Deshpande, S. S., Nath, S., Mezey, S. E., Malik, S. C., Schildge, S., Bohrer, C., Topp, K., Pfeifer, D., Fernández‐Klett, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14466-y · Cited by 83 · see citing works
Choroid Plexus Enlargement and Allostatic Load in Schizophrenia
Zhou, Y., Huang, J., Zhang, P., Fan, F., Chen, S., Fan, H., Cui, Y., Luο, X., Tan, S., Wang, Z., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz100 · Cited by 80 · see citing works
Orts-Del’Immagine, A., Cantaut-Belarif, Y., Thouvenin, O., Roussel, J., Baskaran, A., Langui, D., Koëth, F., Bivas, P., Lejeune, F., Bardet, P., et al. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.071 · Cited by 81 · see citing works
Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
Thouvenin, O., Keiser, L., Cantaut-Belarif, Y., Tano, M. C., Verweij, F. J., Jurisch‐Yaksi, N., Bardet, P., van Niel, G., Gallaire, F., & Wyart, C. (2020) · eLife · doi:10.7554/elife.47699 · Cited by 87 · see citing works
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Ghosh, H. S. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519856876 · Cited by 77 · see citing works
Interaction between epigenetic and metabolism in aging stem cells
Brunet, A., & Rando, T. A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.12.009 · Cited by 76 · see citing works
Lepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M. A., Hasler, J., Huttner, H. B., Vandenbroucke, R. E., Vandendriessche, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100481 · Cited by 72 · see citing works
Bitanihirwe, B. K. Y., Lizano, P. L., & Woo, T.-U. W. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01623-6 · Cited by 78 · see citing works
Dillen, Y., Kemps, H., Gervois, P., Wolfs, E., & Bronckaers, A. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00717-8 · Cited by 75 · see citing works
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
Saul, J., Hutchins, E. D., Reiman, R. A., Saul, M., Ostrow, L. W., Harris, B. T., Keuren‐Jensen, K. R. V., Bowser, R. P., & Bakkar, N. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00968-9 · Cited by 67 · see citing works
Retinoic Acid Is Required for Neural Stem and Progenitor Cell Proliferation in the Adult Hippocampus
Mishra, S., Kelly, K. K., Rumian, N. L., & Siegenthaler, J. A. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.04.024 · Cited by 69 · see citing works
Borrett, M. J., Innes, B. T., Jeong, D., Tahmasian, N., Storer, M. A., Bader, G. D., Kaplan, D. R., & Miller, F. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108022 · Cited by 69 · see citing works
Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture
Marqués‐Torrejón, M. Á., Gangoso, E., & Pollard, S. M. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.031435 · Cited by 69 · see citing works
The systemic environment: at the interface of aging and adult neurogenesis
Smith, L. K., White, C., & Villeda, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2715-8 · Cited by 68 · see citing works
Boareto, M., Iber, D., & Taylor, V. (2017) · Development · doi:10.1242/dev.152520 · Cited by 65 · see citing works
Glial functions in the blood-brain communication at the circumventricular organs
Miyata, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.991779 · Cited by 66 · see citing works
Carradori, D., Eyer, J., Saulnier, P., Véronique Préat, A., & Rieux, A. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.032 · Cited by 63 · see citing works
Fame, R. M., Cortés‐Campos, C., & Sive, H. L. (2020) · BioEssays · doi:10.1002/bies.201900186 · Cited by 59 · see citing works
Neural Stem Cells for Early Ischemic Stroke
Hamblin, M. H., & Lee, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147703 · Cited by 59 · see citing works
Regulation of CNS precursor function by neuronal chemokines
Watson, A. E. S., Goodkey, K., Footz, T. K., & Voronova, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134533 · Cited by 57 · see citing works
OTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis
Planques, A., Moreira, V. O., Dubreuil, C., Prochiantz, A., & Nardo, A. A. D. (2019) · eNeuro · doi:10.1523/eneuro.0262-18.2019 · Cited by 57 · see citing works
Furube, E., Ishii, H., Nambu, Y., Kurganov, E., Nagaoka, S., Morita, M., & Miyata, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-59629-5 · Cited by 54 · see citing works
Mechanisms of enhanced quiescence in neural stem cell aging
Audesse, A. J., & Webb, A. E. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111323 · Cited by 53 · see citing works
Neural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche
Morante‐Redolat, J. M., & Porlan, E. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00102 · Cited by 50 · see citing works
Jang, A., Petrova, B., Cheong, T.-C., Zawadzki, M. E., Jones, J. K., Culhane, A. J., Shipley, F. B., Chiarle, R., Wong, E. T., Kanarek, N., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.009 · Cited by 50 · see citing works
Li, H., Xu, L., Jiang, W., Qiu, X., Xu, H., Zhu, F., Hu, Y., Liang, S., Cai, C., Qiu, W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113022 · Cited by 49 · see citing works
Ontogeny of adult neural stem cells in the mammalian brain
Bond, A. M., Ming, G., & Song, H. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.002 · Cited by 48 · see citing works
Choroid plexus epithelium and its role in neurological diseases
Liu, R., Zhang, Z., Chen, Y., Liao, J., Wang, Y.-C., Liu, J., Lin, Z., & Xiao, G. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.949231 · Cited by 45 · see citing works
Yuan, X., Sipe, C. W., Suzawa, M., Bland, M. L., & Siegrist, S. E. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000721 · Cited by 47 · see citing works
Kase, Y., Shimazaki, T., & Okano, H. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00122-x · Cited by 49 · see citing works
Assogna, M., Premi, E., Gazzina, S., Benussi, A., Ashton, N. J., Zetterberg, H., Blennow, K., Gasparotti, R., Padovani, A., Tadayon, E., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207600 · Cited by 46 · see citing works
Vancamp, P., Gothié, J. M., Luongo, C., Sébillot, A., Blay, K. L., Butruille, L., Pagnin, M., Richardson, S. J., DEMENEIX, B. A., & Remaud, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-56156-w · Cited by 45 · see citing works
Choroid Plexus Pathophysiology
Courtney, Y., Hochstetler, A., & Lehtinen, M. K. (2024) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-114051 · Cited by 47 · see citing works
Cilia-driven flows in the brain third ventricle
Gregor Eichele, C., Bodenschatz, E., Ditte, Z., Günther, A.-K., Kapoor, S., Wang, Y., & Westendorf, C. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0154 · Cited by 41 · see citing works
Álvarez‐Satta, M., Moreno‐Cugnon, L., & Matheu, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.04.004 · Cited by 42 · see citing works
Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS
Kaiser, K., & Bryja, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134760 · Cited by 38 · see citing works
Hamilton, L. K., & Fernandes, K. J. L. (2017) · Biology of the Cell · doi:10.1111/boc.201700037 · Cited by 40 · see citing works
Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging
Willis, C. M., Nicaise, A. M., Krzak, G., Ionescu, R.-B., Pappa, V., D’Angelo, A., Agarwal, R., Repollés-de-Dalmau, M., Peruzzotti‐Jametti, L., & Pluchino, S. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114124 · Cited by 41 · see citing works
Passarelli, J. P., Nimjee, S. M., & Townsend, K. L. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01109-1 · Cited by 40 · see citing works
Multi-omic analysis elucidates the genetic basis of hydrocephalus
Hale, A. T., Bastarache, L. A., Morales, D. M., Wellons, J. C., Limbrick, D. D., & Gamazon, E. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109085 · Cited by 39 · see citing works
Bicker, F., Vasić, V., Horta, G., Ortega, F., Nolte, H., Kavyanifar, A., Keller, S., Stanković, N. D., Harter, P. N., Benedito, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms15922 · Cited by 36 · see citing works
Pourabdolhossein, F., Gil‐Perotín, S., García‐Belda, P., Dauphin, A., Mozafari, S., Tepavčević, V., García‐Verdugo, J. M., & Evercooren, A. B. (2017) · Glia · doi:10.1002/glia.23124 · Cited by 36 · see citing works
Zhang, R., Wang, Z., Tian, Y., Yin, Q., Cheng, X., Lian, M., Zhou, B., Zhang, X., & Yang, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01175 · Cited by 36 · see citing works
Donega, V., van der Geest, A. T., Sluijs, J. A., van Dijk, R. E., Wang, C. C., Başak, O., Pasterkamp, R. J., & Hol, E. M. (2022) · Nature Communications · doi:10.1038/s41467-022-28626-9 · Cited by 36 · see citing works
Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis
Klistorner, S., van der Walt, A., Barnett, M. H., Butzkueven, H., Kolbe, S., Parratt, J. D. E., Yiannikas, C., & Klistorner, A. I. (2023) · Multiple Sclerosis Journal · doi:10.1177/13524585231157206 · Cited by 35 · see citing works
Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice
Gao, J., Wu, Y., He, D., Zhu, X., Li, H., Liu, H., & Liu, H. (2020) · Aging · doi:10.18632/aging.103955 · Cited by 35 · see citing works
The vasculature as a neural stem cell niche
Otsuki, L., & Brand, A. H. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.01.010 · Cited by 34 · see citing works
Schwartz, M., Ramos, J. M. P., & Ben-Yehuda, H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900844 · Cited by 31 · see citing works
Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells
Watson, A. E. S., de Almeida, M. M. A., Dittmann, N. L., Li, Y., Torabi, P., Footz, T. K., Vetere, G., Galleguillos, D., Sipione, S., Cardona, A. E., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.06.010 · Cited by 34 · see citing works
Bae, J. H., Choi, H. J., Cho, K. I. K., Kim, L. K., Kwon, J. S., & Cho, Y. M. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0018 · Cited by 33 · see citing works
Molecular Mechanisms of Neurogenic Aging in the Adult Mouse Subventricular Zone
Lupo, G., Gioia, R., Nisi, P. S., Biagioni, S., & Cacci, E. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519829040 · Cited by 34 · see citing works
Vandenbroucke, R. E. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201609-676aw · Cited by 32 · see citing works
Kuharić, J., Grabušić, K., Tokmadžić, V. S., Štifter, S., Tulić, K., Shevchuk, O., Lučin, P., & Šustić, A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5515 · Cited by 32 · see citing works
- Authors
- Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P., & Doetsch, F.
- Affiliations
- University of Basel (CH)
- Columbia University (US)
- Corresponding author
- Doetsch, Fiona
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 19
- Issue
- 5
- Pages
- 643-652
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2505422908
- Cited by
- 306
- References
- 27
- Citations by year
- 2026: 19 · 2025: 24 · 2024: 20 · 2023: 26 · 2022: 30 · 2021: 35 · 2020: 51 · 2019: 46 · 2018: 25 · 2017: 24 · 2016: 5
- FWCI
- 17.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- National Institute on Aging (R21AG042671)
- National Institute of Neurological Disorders and Stroke (R01NS053884, R01NS074039, F31NS079057)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- choroid plexus, lateral ventricle, ventricular-subventricular zone, adult neural stem cells, stem cell niche, cerebrospinal fluid, aging, colony formation, transit amplifying cells, stem cell proliferation, quiescent stem cells
- MeSH terms
- Aging, Animals, Choroid Plexus, Clone Cells, Signal Transduction, Lateral Ventricles, Gene Expression Profiling, Cell Proliferation, Mice, Adult Stem Cells, Stem Cell Niche, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review