Cited by 307Neurogenesis and neuroplasticity mechanismsCerebrospinal fluid and hydrocephalusDevelopmental Biology and Gene Regulation

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

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Silva-Vargas, Violeta, Maldonado-Soto, Angel R., Mizrak, Dogukan, Codega, Paolo, Doetsch, Fiona·2016·Cell stem cell

Abstract

Specialized niches support the lifelong maintenance and function of tissue-specific stem cells. Adult neural stem cells in the ventricular-subventricular zone (V-SVZ) contact the cerebrospinal fluid (CSF), which flows through the lateral ventricles. A largely ignored component of the V-SVZ stem cell niche is the lateral ventricle choroid plexus (LVCP), a primary producer of CSF. Here we show that the LVCP, in addition to performing important homeostatic support functions, secretes factors that promote colony formation and proliferation of purified quiescent and activated V-SVZ stem cells and transit-amplifying cells. The functional effect of the LVCP secretome changes throughout the lifespan, with activated neural stem cells being especially sensitive to age-related changes. Transcriptome analysis identified multiple factors that recruit colony formation and highlights novel facets of LVCP function. Thus, the LVCP is a key niche compartment that translates physiological changes into molecular signals directly affecting neural stem cell behavior.

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Crossref · 10.1016/j.stem.2016.06.013

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  • Bulk profiling indicates that each ChP retains a developmental blueprint of its origins along the body axis, with ventricle-specific transcriptomes and secretomes for the lateral and 4th ventricle ChPs.

    “Bulk profiling of whole tissue (Liddelow et al., 2010; Lun et al., 2015b; Silva-Vargas et al., 2016) or sorted subpopulations (Lun et al., 2015b) indicates that each ChP retains a developmental blueprint of its origins along the body axis, with ventricle-specific transcriptomes and secretomes for the lateral and 4th ventricle ChPs (Lun et al., 2015a).”

    From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Silva-Vargas et al., 2016

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Authors
Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P., & Doetsch, F.
Affiliations
  • University of Basel (CH)
  • Columbia University (US)
Corresponding author
Doetsch, Fiona
Venue
Cell stem cell
Publisher
Elsevier BV
Published
2016-11
Volume
19
Issue
5
Pages
643-652
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W2505422908
Cited by
306
References
27
Citations by year
2026: 19 · 2025: 24 · 2024: 20 · 2023: 26 · 2022: 30 · 2021: 35 · 2020: 51 · 2019: 46 · 2018: 25 · 2017: 24 · 2016: 5
FWCI
17.05
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Council
  • National Institute on Aging (R21AG042671)
  • National Institute of Neurological Disorders and Stroke (R01NS053884, R01NS074039, F31NS079057)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
choroid plexus, lateral ventricle, ventricular-subventricular zone, adult neural stem cells, stem cell niche, cerebrospinal fluid, aging, colony formation, transit amplifying cells, stem cell proliferation, quiescent stem cells
MeSH terms
Aging, Animals, Choroid Plexus, Clone Cells, Signal Transduction, Lateral Ventricles, Gene Expression Profiling, Cell Proliferation, Mice, Adult Stem Cells, Stem Cell Niche, Neural Stem Cells

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