The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Neurotransmitters as food supplements: the effects of GABA on brain and behavior
Open accessAbstract
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human cortex. The food supplement version of GABA is widely available online. Although many consumers claim that they experience benefits from the use of these products, it is unclear whether these supplements confer benefits beyond a placebo effect. Currently, the mechanism of action behind these products is unknown. It has long been thought that GABA is unable to cross the blood-brain barrier (BBB), but the studies that have assessed this issue are often contradictory and range widely in their employed methods. Accordingly, future research needs to establish the effects of oral GABA administration on GABA levels in the human brain, for example using magnetic resonance spectroscopy. There is some evidence in favor of a calming effect of GABA food supplements, but most of this evidence was reported by researchers with a potential conflict of interest. We suggest that any veridical effects of GABA food supplements on brain and cognition might be exerted through BBB passage or, more indirectly, via an effect on the enteric nervous system. We conclude that the mechanism of action of GABA food supplements is far from clear, and that further work is needed to establish the behavioral effects of GABA.
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2 retracted
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Self-citationRetractedSteenbergen, L., Sellaro, R., Stock, A., Beste, C., & Colzato, L. S. (2015) · Scientific Reports · doi:10.1038/srep12770 · Cited by 31
Self-citationRetractedMind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
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Drug-like properties and the causes of poor solubility and poor permeability
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JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN
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Response inhibition in the stop-signal paradigm
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Cited by
The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling
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The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326
“Whether the peripherally derived GABA is capable of crossing the BBB either through diffusion or through active transport remains a matter of dispute (Boonstra et al., 2015).”
BackgroundHepsomali, P., Groeger, J. A., Nishihira, J., & Scholey, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00923 · Cited by 281
Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions
Coelho, M. C., Malcata, F. X., & Silva, C. C. G. (2022) · Foods · doi:10.3390/foods11152276 · Cited by 276
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
Metadata
- Authors
- Boonstra, E., de Kleijn, R., Colzato, L. S., Alkemade, A., Forstmann, B. U., & Nieuwenhuis, S.
- Venue
- Frontiers in Psychology
- Publisher
- Frontiers Media SA
- Published
- 2015-10-06
- Volume
- 6
- Pages
- 1520-1520
- ISSN
- 1664-1078 (ISSN-L)
- OpenAlex
- W2109086173
- Cited by
- 329
- References
- 50
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- gold
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- Boonstra, E., de Kleijn, R., Colzato, L. S., Alkemade, A., Forstmann, B. U., & Nieuwenhuis, S. (2015). Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Frontiers in Psychology. https://doi.org/10.3389/fpsyg.2015.01520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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