Differential relationship of observer-rated and self-rated depression and anxiety scales with heart rate variability features
Open accessAbstract
Heart rate variability (HRV) is a known psychophysiological marker for diverse psychiatric symptoms. In this study, we aimed to explore the potential for clinical use of HRV by investigating the interrelationship between HRV indices and clinical measures mainly used to assess depressive and anxious symptoms. Participants who reported depressive and anxious symptoms were designated into the following groups: group 1, clinician-rated and self-rated depression; group 2, only self-rated depression; group 3, clinician-rated and self-rated anxiety; group 4, only self-rated anxiety. Statistical comparisons were performed between these groups to investigate the association between HRV and clinical measures. As a result, HRV variables showed significant correlations only with the clinician-rated assessments. Moreover, both time and frequency domain HRV indices were significantly different between groups 1 and 2, but groups 3 and 4 showed significant differences only in frequency domain HRV indices. Our study showed that HRV is an objective indicator for depressive or anxious symptoms. Additionally, it is considered a potential indicator for predicting the severity or state of depressive symptoms rather than of anxious symptoms. This study will contribute to increasing the diagnostic utility of discriminating those symptoms based on HRV in the future.
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Clinicians' ratings show stronger relationships with objective measures such as heart rate variability than self-ratings.
“Clinicians' ratings also show stronger relationships with objective measures such as heart rate variability (Ham et al., 2023), suggesting a potentially more reliable assessment.”
From Virtual Reality exposure therapy in the treatment of public speaking anxiety and social anxiety disorder (2024) · cites this paper as Ham et al., 2023
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Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · cited 14× · see citing works
“Several HRV indices showed significant correlations with only the clinician-rated assessments—HRSD and HAS.”
MethodInfluentialHeart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32279-7 · Cited by 13,867 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Murray, C. J. L., Aravkin, A. Y., Zheng, P., Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30752-2 · Cited by 9,854 · see citing works
(1976) · Medical Entomology and Zoology · Cited by 8,899 · see citing works
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · see citing works
An overview of heart rate variability metrics and norms
Shaffer, F., & Ginsberg, J. P. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00258 · Cited by 7,185 · see citing works
Santomauro, D. F., Mantilla Herrera, A. M., Shadid, J., Zheng, P., Ashbaugh, C., Pigott, D. M., Abbafati, C., Adolph, C., Amlag, J. O., Aravkin, A. Y., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)02143-7 · Cited by 5,444 · see citing works
Akselrod, S., Gordon, D., Ubel, F. A., Shannon, D. C., Berger, A. C., & Cohen, R. J. (1981) · Science · doi:10.1126/science.6166045 · Cited by 5,079 · see citing works
Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., Sandrone, G., Malfatto, G., Dell'Orto, S., & Piccaluga, E. (1986) · Circulation Research · doi:10.1161/01.res.59.2.178 · Cited by 4,130 · see citing works
State-Trait Anxiety Inventory for Adults
Spielberger, C. D. (2012) · PsycTESTS Dataset · doi:10.1037/t06496-000 · Cited by 3,479 · see citing works
Assessment of autonomic function in humans by heart rate spectral analysis
Pomeranz, B., Macaulay, R. J., Caudill, M. A., Kutz, I., Adam, D., Gordon, D., Kilborn, K. M., Barger, A. C., Shannon, D. C., Cohen, R. J., et al. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.1.h151 · Cited by 2,876 · see citing works
The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013
Steel, Z., Marnane, C., Iranpour, C., Chey, T., Jackson, J. W., Patel, V., & Silove, D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu038 · Cited by 2,846 · see citing works
Thayer, J. F., Hansen, A. L., Saus-Rose, E., & Johnsen, B. H. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9101-z · Cited by 1,872 · see citing works
Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.012 · Cited by 1,286 · see citing works
Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate
Hirsch, J. A., & Bishop, B. (1981) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1981.241.4.h620 · Cited by 1,105 · see citing works
Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis
Chalmers, J. A., Quintana, D. S., Abbott, M. J.-A., & Kemp, A. H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00080 · Cited by 1,067 · see citing works
Transdiagnostic approaches to mental health problems: Current status and future directions.
Dalgleish, T., Black, M., Johnston, D., & Bevan, A. (2020) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000482 · Cited by 883 · see citing works
Sztajzel, J. M. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.10321 · Cited by 782 · see citing works
An autonomic flexibility–neurovisceral integration model of anxiety and cardiac vagal tone
Friedman, B. H. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.08.009 · Cited by 739 · see citing works
Alvares, G. A., Quintana, D. S., Hickie, I. B., & Guastella, A. J. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140217 · Cited by 503 · see citing works
A meta-analysis of heart rate variability in major depression
Koch, C., Wilhelm, M., Salzmann, S., Rief, W., & Euteneuer, F. (2019) · Psychological Medicine · doi:10.1017/s0033291719001351 · Cited by 489 · see citing works
Time Domain Measurements of Heart Rate Variability
Kleiger, R. E., Stein, P. K., Bosner, M. S., & Rottman, J. N. (1992) · Cardiology Clinics · doi:10.1016/s0733-8651(18)30230-3 · Cited by 387 · see citing works
Rush, A. J., Bernstein, I. H., Trivedi, M. H., Carmody, T. J., Wisniewski, S., Mundt, J. C., Shores-Wilson, K., Biggs, M. M., Woo, A., Nierenberg, A. A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.022 · Cited by 385 · see citing works
Smith, L., Jacob, L., Yakkundi, A., McDermott, D., Armstrong, N. C., Barnett, Y., López-Sánchez, G. F., Martin, S., Butler, L., & Tully, M. A. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113138 · Cited by 385 · see citing works
Cuijpers, P., Li, J., Hofmann, S. G., & Andersson, G. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.06.001 · Cited by 383 · see citing works
Comparison of Aerobic Exercise, Clomipramine, and Placebo in the Treatment of Panic Disorder
Broocks, A., Bandelow, B., Pekrun, G., George, A., Meyer, T., Bartmann, U., Hillmer-Vogel, U., & Rüther, E. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.5.603 · Cited by 330 · see citing works
Carroll, B. J. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750330049009 · Cited by 316 · see citing works
Relationship between major depression and heart rate variability.
Agelink, M. W., Boz, C., Ullrich, H., & Andrich, J. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00225-1 · Cited by 312 · see citing works
Heart rate variability. Frequency domain analysis.
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · PubMed · Cited by 300 · see citing works
Kaiser, T., Herzog, P., Voderholzer, U., & Brakemeier, E. (2021) · Depression and Anxiety · doi:10.1002/da.23136 · Cited by 296 · see citing works
SELF-REPORT AND CLINICIAN-RATED MEASURES OF DEPRESSION SEVERITY: CAN ONE REPLACE THE OTHER?
Uher, R., Perlis, R. H., Placentino, A., Dernovšek, M. Z., Henigsberg, N., Mors, O. N., Maier, W., McGuffin, P., & FARMER, A. E. (2012) · Depression and Anxiety · doi:10.1002/da.21993 · Cited by 264 · see citing works
Hartley, S., Barrowclough, C., & Haddock, G. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12080 · Cited by 234 · see citing works
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · Cardiology Clinics · doi:10.1016/s0733-8651(18)30231-5 · Cited by 233 · see citing works
Stability of heart rate variability indices reflecting parasympathetic activity.
Bertsch, K., Hagemann, D., Naumann, E., Schächinger, H., & Schulz, A. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01341.x · Cited by 185 · see citing works
Heart rate variability in patients with anxiety disorders: A systematic review and meta‐analysis
Cheng, Y., Su, M., Liu, C., Huang, Y., & Huang, W. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13356 · Cited by 175 · see citing works
Heart rate variability in myocardial infarction and heart failure
Chattipakorn, N., Incharoen, T., Kanlop, N., & Chattipakorn, S. C. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.11.221 · Cited by 165 · see citing works
Heart rate variability: a diagnostic and prognostic tool in anesthesia and intensive care
Mazzeo, A. T., Monaca, E., Leo, R. D., Vita, G., & Santamaria, L. B. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02466.x · Cited by 159 · see citing works
Rush, A. J., Trivedi, M. H., Carmody, T. J., Ibrahim, H. M., Markowitz, J. C., Keitner, G. I., Kornstein, S. G., Arnow, B. A., Klein, D. N., Manber, R., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300614 · Cited by 135 · see citing works
. Comparison of self-report and clinician ratings on two inventories of depressive symptomatology.
Rush, A. J., Carmody, T. J., Ibrahim, H. M., Trivedi, M. H., Biggs, M. M., Shores-Wilson, K., Crismon, M. L., Toprac, M. G., & Kashner, T. M. (2006) · Psychiatric Services · doi:10.1176/ps.2006.57.6.829 · Cited by 128 · see citing works
Agelink, M. W. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00202-5 · Cited by 104 · see citing works
What do anxiety scales measure?
Keedwell, P., & Snaith, R. P. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb10627.x · Cited by 102 · see citing works
Concordance between self-report and clinician’s assessment of depression
Corruble, E., Legrand, J. M., Zvenigorowski, H., Duret, C., & Guelfi, J. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00011-4 · Cited by 80 · see citing works
Yeh, T., Kao, L.-C., Tzeng, N., Kuo, T. B. J., Huang, S., Chang, C.-C., & Chang, H. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.07.007 · Cited by 72 · see citing works
Zimmerman, M. A., Posternak, M. A., & Chelminski, I. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000155824.59585.46 · Cited by 58 · see citing works
Chang, H., Chang, C.-C., Tzeng, N., Kuo, T. B. J., Lu, R., & Huang, S. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.4.326 · Cited by 58 · see citing works
Levine, J. C., Fleming, R., Piedmont, J. I., Cain, S. M., & Chen, W. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.07.019 · Cited by 56 · see citing works
Sun, G., Shinba, T., Kirimoto, T., & Matsui, T. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00180 · Cited by 55 · see citing works
Dunlop, B. W., Li, T., Kornstein, S. G., Friedman, E. S., Rothschild, A. J., Pedersen, R., Ninan, P. T., Keller, M. B., & Trivedi, M. H. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.032 · Cited by 52 · see citing works
Seo, H. S., & Choi, M. H. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.04.014 · Cited by 44 · see citing works
Yohimbine Challenge in Children With Anxiety Disorders
Sallee, F. R., Sethuraman, G., SINE, L. E., & Liu, H. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1236 · Cited by 32 · see citing works
Yeragani, V. K., Srinivasan, K., Pohl, R. B., Berger, R. D., Balon, R., & Ramesh, C. (2008) · Neuropsychobiology · doi:10.1159/000119054 · Cited by 25 · see citing works
Bilgin, S., Arslan, E., Elmas, O., Yıldız, S., Çolak, Ö. H., BİLGİN, G., Koyuncuoğlu, H. R., Akkuş, S., Çömlekçı, S., & Köklükaya, E. (2015) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2015.10.003 · Cited by 18 · see citing works
Wang, S., Yeon, B., Hwang, S., Lee, H., Kweon, Y., Lee, C. T., Chae, J., & Lee, K. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.06.001 · Cited by 17 · see citing works
Assessment of Anxiety and the Anxiety Disorders: An Overview
Antony, M. M. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47628-2_2 · Cited by 14 · see citing works
Nezu, A. M., McClure, K. S., & Nezu, C. M. (2015) · doi:10.1002/9781119114482.ch2 · Cited by 14 · see citing works
Heart Rate Variability in Psychiatric Disorders
Yang, A. C., Hong, C., & Tsai, S. (2010) · 臺灣精神醫學 · doi:10.29478/tjp.201006.0004 · Cited by 13 · see citing works
Reliability and Validity of the Korean Version of Inventory for Depressive Symptomatology
윤지호, Jon, D., Ho, H. J., et al. (2012) · Mood and Emotion · Cited by 13 · see citing works
Basic study on architectural planning of psychiatric hospital
Zhou, Y., & Sun, Y. (2010) · Science China Technological Sciences · doi:10.1007/s11431-010-3077-6 · Cited by 2 · see citing works
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- Authors
- Ham, J., Kim, H. E., Kim, J.-J., Seok, J.-H., Kim, E., Park, J. Y., Lee, B., & Oh, J.
- Affiliations
- Yonsei University (KR)
- Gwangju Institute of Science and Technology (KR)
- Corresponding author
- Lee, Boreom
- Oh, Jooyoung
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2023-04-03
- Volume
- 14
- Pages
- 1124550-1124550
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC10109339
- OpenAlex
- W4362578674
- Cited by
- 7
- References
- 62
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Trade, Industry and Energy (20012603)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- heart rate variability, depression, anxiety, self-rated depression, self-rated anxiety, time-domain HRV, frequency-domain HRV, psychophysiological indicators, depression severity, diagnostic value
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