Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis
Open accessAbstract
Objective: Aging is associated with decreased nicotinamide adenine dinucleotide (NAD) levels, which in turn cause dysfunctional mitochondria and indirectly affect a myriad of diseases. Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) serves as a central rate-limiting enzyme in NAD synthesis, making it an indispensable health mediator. This meta-analysis examined the effect of exercise training on the expression of iNAMPT in humans. Methods: We searched PubMed, Scopus, ClinicalTrials.gov, and the International Clinical Trials Registry Platform for studies published between the inception of the database and July 5, 2023. Using the common-effect model, evidence for the change in iNAMPT following exercise training was synthesized as Cohen’s d. Results: The search yielded five eligible studies. The overall effect size is 0.81, with a 95% confidence interval of 0.55 to 1.07. Therefore, a random adult will have a 71.7% probability that iNAMPT will be up-regulated following exercise training. In general, exercise training resulted in a 1.46-fold increase in iNAMPT. Our probability statistics indicate that subgroups of interest may differ practically. Specifically, there is a 79.3% probability of increased iNAMPT in men, compared to a 69.0% probability in the overall population; young adults have a 75.6% probability of having an increased iNAMPT, whereas aged adults have a 68.7% probability; and, iNAMPT has a 75.1% probability increase after aerobic exercise and a 66.4% probability increase after resistance exercise. Conclusion: Exercise training is effective for increasing iNAMPT levels in skeletal muscles. This essential enzyme regulates not only cellular energetics but also healthspan. Therefore, exercise should be promoted as a natural slow-aging lifestyle.
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Aerobic exercise training can increase muscle NAMPT activity and NAD+.
“aerobic exercise training can increase muscle NAMPT activity and NAD+ [170, 172, 173].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [172]
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- Authors
- Sun, X., Su, L., Bu, T., & Zhang, Y.
- Affiliations
- Hunan Normal University (CN)
- Inner Mongolia University of Technology (CN)
- Corresponding author
- Su, Lide
- Zhang, Yang
- Venue
- Frontiers in Public Health
- Publisher
- Frontiers Media SA
- Published
- 2023-10-26
- Volume
- 11
- Pages
- 1287421-1287421
- ISSN
- 2296-2565 (ISSN-L)
- PMC
- PMC10639164
- OpenAlex
- W4387956204
- Cited by
- 10
- References
- 61
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- visfatin, exercise training, NAD+ synthesis, aging, skeletal muscle, aerobic exercise, resistance training, healthspan, mitochondrial function
- MeSH terms
- Aging, Humans, NAD, Exercise, Muscle, Skeletal, Nicotinamide Phosphoribosyltransferase
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