A statewide analysis of the incidence and outcomes of acute mesenteric ischemia in Maryland from 2009 to 2013
Open accessAbstract
INTRODUCTION: Acute mesenteric ischemia is a surgical emergency that entails complex, multi-modal management, but its epidemiology and outcomes remain poorly defined. The aim of this study was to perform a population analysis of the contemporary incidence and outcomes of mesenteric ischemia. METHODS: This was a retrospective analysis of acute mesenteric ischemia in the state of Maryland during 2009-2013 using a comprehensive statewide hospital admission database. Demographics, illness severity, comorbidities, and outcomes were studied. The primary outcome was inpatient mortality. Survivors and non-survivors were compared using univariate analyses, and multivariable logistic regression analysis was performed to evaluate risk factors for mortality. RESULTS: During the 5-year study period, there were 3,157,499 adult hospital admissions in Maryland. A total of 2,255 patients (0.07%) had acute mesenteric ischemia, yielding an annual admission rate of 10/100,000. Increasing age, hypercoagulability, cardiac dysrhythmia, renal insufficiency, increasing illness severity, and tertiary hospital admission were associated with development of mesenteric ischemia. Inpatient mortality was high (24%). After multivariate analysis, independent risk factors for death were age >65 years, critical illness severity, mechanical ventilation, tertiary hospital admission, hypercoagulability, renal insufficiency, and dysrhythmia. CONCLUSION: Acute mesenteric ischemia occurs in approximately 1/1,000 admissions in Maryland. Patients with mesenteric ischemia have significant illness severity, substantial rates of organ dysfunction, and high mortality. Patients with chronic comorbidities and acute organ dysfunction are at increased risk of death, and recognition of these risk factors may enable prevention or earlier control of mesenteric ischemia in high-risk patients.
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The mean incidence of acute mesenteric ischaemia in the general population was 6.2 per 100 000 person years (95% CI 1.9 to 12.9).
“The mean incidence of AMI was 6.2 (95% CI 1.9 to 12.9) per 100 000 person years.”
From Incidence and outcomes of acute mesenteric ischaemia: a systematic review and meta-analysis (2022) · cites this paper as [19]
The Results report an annual admission rate of 10 per 100,000 Maryland adults, not 6.2 per 100,000 person-years. The Discussion cautions that this admission rate only approximates incidence; the paper does not report the claimed 95% confidence interval. (LLM, conf=0.87)
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Experimental — accuracy not yet measuredIn the general population studies, the proportion of women among acute mesenteric ischaemia cases was 58.3% (95% CI 56.5 to 60.2).
“The studies included in our analysis of the incidence in the general population, indicate a significantly higher proportion of women, at 58.3% (95% CI 56.5 to 60.2).”
From Incidence and outcomes of acute mesenteric ischaemia: a systematic review and meta-analysis (2022) · cites this paper as [19]
Table 1 (Results; page unavailable) reports that 1,321 of 2,255 Maryland patients with acute mesenteric ischemia were women, approximately 59%, supporting a female majority in this study. It does not report the cited 58.3% estimate or its 95% confidence interval, and this single-state study does not establish the pooled result attributed to general-population studies. (LLM, conf=0.87)
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
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Cites
Acute Mesenteric Ischemia: A Clinical Review
Oldenburg, W. A., Lau, L. L., Rodenberg, T. J., Edmonds, H. J., & Burger, C. D. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1054 · Cited by 714 · see citing works
Contemporary management of acute mesenteric ischemia: Factors associated with survival
Park, W. M., Gloviczki, P., Cherry, K. J., Hallett, J. W., Bower, T. C., Panneton, J. M., Schleck, C., Ilstrup, D., Harmsen, W. S., & Noel, A. A. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.120373 · Cited by 463 · see citing works
Epidemiology of Mesenteric Vascular Disease: Clinical Implications
Acosta, S. (2010) · Seminars in Vascular Surgery · doi:10.1053/j.semvascsurg.2009.12.001 · Cited by 340 · see citing works
Kougias, P., Lau, D., El Sayed, H. F., Zhou, W., Huynh, T. T., & Lin, P. H. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.04.045 · Cited by 303 · see citing works
Revascularization for acute mesenteric ischemia
Ryer, E. J., Kalra, M., Oderich, G. S., Duncan, A. A., Gloviczki, P., Cha, S., & Bower, T. C. (2012) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2011.12.017 · Cited by 188 · cited 1× · see citing works
“The complexity and heterogeneous pathogenesis of mesenteric ischemia has so far made it difficult to define specific risk factors for disease onset and mortality (2, 5, 20).”
BackgroundAcosta, S., Ögren, M., Sternby, N.-H., Bergqvist, D., & Björck, M. (2004) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2003.11.003 · Cited by 126 · see citing works
Santry, H. P., Janjua, S., Chang, Y., Petrovick, L., & Velmahos, G. C. (2011) · World Journal of Surgery · doi:10.1007/s00268-011-1292-3 · Cited by 61 · see citing works
Flagged first, then by citations
Research works printed but not linked: 14
- [4]Suzuki T Mehta RH Ince H Nagai R Sakomura Y Weber F Clinical profiles and outcomes of acute type B aortic dissection in the current era: lessons from the International Registry of Aortic Dissection (IRAD). Circulation (2003) 108(Suppl 1): II312– 7. 10.1161/01.cir.0000087386.07204.09 12970252 · DOI
- [8]Shaw RS Rutledge RH Superior-mesenteric-artery embolectomy in the treatment of massive mesenteric infarction. N Engl J Med (1957) 257: 595– 8. 10.1056/NEJM195709262571303 13477354 · DOI
- [9]Gajic O Urrutia LE Sewani H Schroeder DR Cullinane DC Peters SG. Acute abdomen in the medical intensive care unit. Crit Care Med (2002) 30: 1187– 90. 10.1097/00003246-200206000-00001 12072666 · DOI
- [10]Ingraham AM Cohen ME Bilimoria KY Raval MV Ko CY Nathens AB Comparison of 30-day outcomes after emergency general surgery procedures: potential for targeted improvement. Surgery (2010) 148: 217– 38. 10.1016/j.surg.2010.05.009 20633727 · DOI
- [11]Arenal JJ Bengoechea-Beeby M. Mortality associated with emergency abdominal surgery in the elderly. Can J Surg (2003) 46: 111– 6. 12691347 PMC3211694
- [12]Klempnauer J Grothues F Bektas H Pichlmayr R. Long-term results after surgery for acute mesenteric ischemia. Surgery (1997) 121: 239– 43. 10.1016/S0039-6060(97)90351-2 9068664 · DOI · Paper page
- [13]Beaulieu RJ Arnaoutakis KD Abularrage CJ Efron DT Schneider E Black JH. Comparison of open and endovascular treatment of acute mesenteric ischemia. J Vasc Surg (2014) 59: 159– 64. 10.1016/j.jvs.2013.06.084 24199769 · DOI · Paper page
- [14]Kastor JA Adashi EY Maryland’s hospital cost review commission at 40: a model for the country. JAMA (2011) 306: 1137– 8. 10.1001/jama.2011.1311 21917584 · DOI
- [15]Murray R. Setting hospital rates to control costs and boost quality: the Maryland experience. Health Aff (Millwood) (2009) 28: 1395– 405. 10.1377/hlthaff.28.5.1395 19738257 · DOI
- [16]Narayan M Tesoriero R Bruns BR Klyushnenkova EN Chen H Diaz JJ. Acute care surgery: defining mortality in emergency general surgery in the State of Maryland. J Am Coll Surg (2015) 220(4): 762– 70. 10.1016/j.jamcollsurg.2014.12.051 25797764 · DOI
- [17]Averill RF Goldfield N Steinbeck B Grant T Muldoon J Brough A All Patient Refined Diagnosis Related Groups (APR-DRGs) (Version) (Vol. 15). 3M Health Information Systems (2003). p. 98– 54.
- [18]Shafi S Aboutanos MB Agarwal S Brown CVR Crandall M Feliciano DV Emergency general surgery: definition and estimated burden of disease. J Trauma Acute Care Surg (2013) 74: 1092– 7. 10.1097/TA.0b013e31827e1bc7 23511150 · DOI
- [20]Acosta S Ögren M Sternby N Bergqvist D Björck M. Fatal nonocclusive mesenteric ischaemia: population-based incidence and risk factors. J Intern Med (2006) 259: 305– 13. 10.1111/j.1365-2796.2006.01613.x 16476108 · DOI · Paper page
- [22]Diaz JJ Norris PR Gunter OL Collier BR Riordan WP Morris JA. Does regionalization of acute care surgery decrease mortality? J Trauma (2011) 71: 442– 6. 10.1097/TA.0b013e3182281fa2 21825946 · DOI
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Matthaei, H., Klein, A., Branchi, V., Kalff, J. C., & Koscielny, A. (2019) · International Journal of Colorectal Disease · doi:10.1007/s00384-019-03388-x · Cited by 21 · see citing works
Wu, W., Liu, J., & Zhou, Z. (2020) · Emergency Medicine International · doi:10.1155/2020/1382475 · Cited by 20 · see citing works
Wu, W., He, J., Zhang, S., Zeng, C., & Wang, Q. (2023) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2022.2152289 · Cited by 13 · see citing works
Reintam Blaser, A., Forbes, A., & Björck, M. (2022) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000972 · Cited by 9 · see citing works
Elnaggar, M., Hassan, I., Bahdar, Z., El Aziz, M. A., & Dharan, M. (2026) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2026.2657151
- Authors
- Crawford, R. S., Harris, D. G., Klyushnenkova, E. N., Tesoriero, R. B., Rabin, J., Chen, H., & Diaz, J. J.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Harris, Donald G.
- Venue
- Frontiers in Surgery
- Publisher
- Frontiers Media SA
- Published
- 2016-04-14
- Volume
- 3
- Pages
- 22-22
- ISSN
- 2296-875X (ISSN-L)
- PMC
- PMC4830818
- OpenAlex
- W2337194101
- Cited by
- 43
- References
- 7
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 1
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Surgery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- acute mesenteric ischemia, incidence, in-hospital mortality, mortality risk factors, hypercoagulability, renal failure, cardiac arrhythmias, disease severity, mechanical ventilation, tertiary hospital admissions, organ dysfunction, Maryland
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