Detection of Genetic Variants Associated with Behavioural Response During Milking in Simmental Dual-Purpose Cows
Open accessAbstract
Cattle breeding has traditionally focused on improving production traits; however, recent interest in positive animal welfare has shifted attention toward selecting for more robust animals that balance productivity with health and well-being. The aim of the current study was to assess whether behavioural responses during milking in dual-purpose cattle are associated with genetic markers, previously linked to temperament traits in dairy and beef breeds. We focused on 185 lactating cows belonging to the Simmental strain (Romanian Spotted, national name), which were evaluated for their milking behaviour. Genotyping was performed using an 88-SNP panel selected based on prior associations with dairy and beef cattle temperament. We identified five SNPs that were significantly associated with milking reactivity in the Romanian Spotted breed, located in genes previously linked to neural development, stress response and behavioural regulation (USH2A, ADAMTS7, TBC1D2B and ZMAT4). Our findings suggest that milking behaviour in dual-purpose Simmental cattle is influenced by genetics, supporting the potential for including behavioural traits in future selection strategies. This study contributes to a better understanding of the genetic mechanisms underlying stress-related behaviours in dual-purpose cattle breeds.
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In dual-purpose Simmental cattle, four candidate genes (ZMAT4, USH2A, ADAMTS7, TBC1D2B) have been linked to milking response.
“In dual-purpose Simmental cattle, four candidate genes have been linked to milking response: ZMAT4 (neural development), USH2A, ADAMTS7, and TBC1D2B (stress response) [129].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [129]
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- [22]Scholl F. Comparison Between Dual-Purpose and Specialized Dairy Cattle in Pasture-Based Systems: Change in Body Condition, Locomotion Score and Cleanliness from Summer to Winter Season Doctoral Dissertation Wageningen University Wageningen, The Netherlands 2017 Available online: https://orgprints.org/id/eprint/33604/ (accessed on 19 December 2024)
Cited by
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The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution
Liu, Y., Dao, W., Gao, R., Fan, X., Yang, R., & Miao, Y. (2026) · Animals · doi:10.3390/ani16050776 · Cited by 1 · see citing works
- Authors
- Mincu-Iorga, M., Mizeranschi, A. E., Gavojdian, D., Nicolae, I., Kusza, S., & Ilie, D. E.
- Affiliations
- Research and Development Institute for Bovine, 077015 Balotesti, Romania
- West University of Timişoara (RO)
- University of Debrecen (HU)
- Research and Development Station for Bovine Arad, 310059 Arad, Romania
- Corresponding author
- Mizeranschi, Alexandru Eugeniu
- ORCID
- Venue
- Animals
- Publisher
- MDPI AG
- Published
- 2025-06-15
- Volume
- 15
- Issue
- 12
- Pages
- 1766
- ISSN
- 2076-2615 (ISSN-L)
- PMC
- PMC12189442
- OpenAlex
- W4411327673
- Cited by
- 1
- References
- 55
- Citations by year
- 2026: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animals (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- milking behavior, Simmental cattle, dual-purpose cattle, genetic variants, single nucleotide polymorphisms, temperament, animal welfare, stress response, USH2A, ADAMTS7, behavioural selection, lactating dairy cows
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