Appropriate Handling, Processing and Analysis of Blood Samples Is Essential to Avoid Oxidation of Vitamin C to Dehydroascorbic Acid

Ascorbic acid: Chemistry, biology and the treatment of cancer

Du, J., Cullen, J. J., & Buettner, G. R. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.003 · Cited by 1,071 · see citing works

Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid

Buettner, G. R., & Jurkiewicz, B. A. (1996) · Radiation Research · doi:10.2307/3579271 · Cited by 884 · see citing works

Does vitamin C act as a pro‐oxidant under physiological conditions?

Carr, A. C., & Frei, B. B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9.1007 · Cited by 883 · see citing works

Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid

Rumsey, S. C., Kwon, O., Xu, G. W., Burant, C., Simpson, I. A., & Levine, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18982 · Cited by 474 · see citing works

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017) · Critical Care · doi:10.1186/s13054-017-1891-y · Cited by 413 · see citing works

Regulation of the epigenome by vitamin C

Young, J. I., Züchner, S., & Wang, G. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034228 · Cited by 319 · see citing works

Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients

Schorah, C., Downing, C. P., Piripitsi, A., Gallivan, L., Al-Hazaa, A., Sanderson, M., & Bodenham, A. R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.760 · Cited by 313 · see citing works

Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E)

Carr, A. C., Zhu, B., & Frei, B. B. (2000) · Circulation Research · doi:10.1161/01.res.87.5.349 · Cited by 305 · see citing works

The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes

Banfi, G., Salvagno, G. L., & Lippi, G. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.110 · Cited by 296 · see citing works

Ascorbic acid and dehydroascorbic acid analyses in biological samples

Washko, P. W., Welch, R. W., Dhariwal, K. R., Wang, Y., & Levine, M. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90131-p · Cited by 270 · see citing works

Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum

Dhariwal, K., Hartzell, W., & Levine, M. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.4.712 · Cited by 262 · see citing works

Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?

Carr, A. C., Shaw, G. M., Fowler, A. A., & Natarajan, R. (2015) · Critical Care · doi:10.1186/s13054-015-1131-2 · Cited by 258 · see citing works

The chemical nature of vitamin C

Svirbely, J. L., & Szent‐Györgyi, A. (1932) · Biochemical Journal · doi:10.1042/bj0260865 · Cited by 196 · see citing works

Accumulation of Vitamin C (Ascorbate) and Its Oxidized Metabolite Dehydroascorbic Acid Occurs by Separate Mechanisms

Welch, R. W., Wang, Y., Crossman, A. T., Park, J. B., Kirk, K. L., & Levine, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12584 · Cited by 181 · see citing works

Spontaneous decay of oxidized ascorbic acid (dehydro-L-ascorbic acid) evaluated by high-pressure liquid chromatography

Bode, A. M., Cunningham, L., & Rose, R. C. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.10.1807 · Cited by 177 · see citing works

Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking

Lykkesfeldt, J., Loft, S. H., Nielsen, J., & Poulsen, H. E. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.959 · Cited by 173 · see citing works

Model Studies of the Iron-Catalysed Haber-Weiss Cycle and the Ascorbate-Driven Fenton Reaction

Burkitt, M. J., & Gilbert, B. C. (1990) · Free Radical Research Communications · doi:10.3109/10715769009149895 · Cited by 161 · see citing works

The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA).

Lunec, J., & Blake, D. (1985) · Free Radical Research Communications · doi:10.3109/10715768509056534 · Cited by 144 · see citing works

Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking

Wilson, R., Willis, J. A., Gearry, R. B., Skidmore, P. M. L., Fleming, E., Frampton, C. M., & Carr, A. C. (2017) · Nutrients · doi:10.3390/nu9090997 · Cited by 125 · see citing works

Vitamin C Deficiency in a Population of Young Canadian Adults

Cahill, L. E., Corey, P., & El‐Sohemy, A. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp156 · Cited by 121 · see citing works

Measurement of Ascorbate and Dehydroascorbate Contents in Biological Fluids

Koshiishi, I., & Imanari, T. (1997) · Analytical Chemistry · doi:10.1021/ac960704k · Cited by 108 · see citing works

Stability of whole blood and plasma ascorbic acid

Karlsen, A. S., Blomhoff, R., & Gundersen, T. E. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602655 · Cited by 100 · see citing works

Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study

Pearson, J. F., Pullar, J. M., Wilson, R., Spittlehouse, J. K., Vissers, M. C. M., Skidmore, P. M. L., Willis, J. A., Cameron, V. A., & Carr, A. C. (2017) · Nutrients · doi:10.3390/nu9080831 · Cited by 99 · see citing works

Vitamin C Status of an Outpatient Population

Johnston, C. S., & Thompson, L. L. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718777 · Cited by 92 · see citing works

Ascorbate Oxidation: UV Absorbance of Ascorbate and ESR Spectroscopy of the Ascorbyl Radical as Assays for Iron

Buettner, G. R. (1990) · Free Radical Research Communications · doi:10.3109/10715769009145927 · Cited by 92 · see citing works

Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid

Tu, H., Li, H., Wang, Y., Niyyati, M., Wang, Y., Leshin, J. A., & Levine, M. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.09.049 · Cited by 89 · see citing works

Plasma ascorbic acid: measurement, stability and clinical utility revisited

Chung, W. Y., Chung, J. K.-O., Szeto, Y. T., Tomlinson, B., & Benzie, I. F. F. (2001) · Clinical Biochemistry · doi:10.1016/s0009-9120(01)00270-3 · Cited by 89 · see citing works

Reduction of dehydroascorbic acid at low pH

Wechtersbach, L., & Cigić, B. (2007) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2007.04.007 · Cited by 85 · see citing works

Determination of plasma ascorbic acid by high-performance liquid chromatography with ultraviolet and electrochemical detection

Liau, L. S., Lee, B. L., New, A. L., & Ong, C. N. (1993) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(93)80368-e · Cited by 85 · see citing works

Ascorbate and Dehydroascorbic Acid as Reliable Biomarkers of Oxidative Stress: Analytical Reproducibility and Long-term Stability of Plasma Samples Subjected to Acidic Deproteinization

Lykkesfeldt, J. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0639 · Cited by 82 · see citing works

Estimation of dehydroascorbic acid in blood of diabetic patients

Chatterjee, I., & Banerjee, A. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90155-6 · Cited by 75 · see citing works

Ascorbic acid status: biochemical and clinical considerations

Lee, W., Davis, K., Rettmer, R. L., & Labbe, R. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.2.286 · Cited by 67 · see citing works

Vitamin C deficiency in a university teaching hospital

Gan, R., Eintracht, S., & Hoffer, L. J. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719721 · Cited by 60 · see citing works

Determination of Dehydroascorbic Acid in Mouse Tissues and Plasma by Using Tris(2-carboxyethyl)phosphine Hydrochloride as Reductant in Metaphosphoric Acid/Ethylenediaminetetraacetic Acid Solution

Sato, Y., Uchiki, T., Iwama, M., Kishimoto, Y., Takahashi, R., & Ishigami, A. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.364 · Cited by 59 · see citing works

Bioavailability of vitamin C from kiwifruit in non-smoking males: determination of ‘healthy’ and ‘optimal’ intakes

Carr, A. C., Pullar, J. M., Moran, S., & Vissers, M. C. M. (2012) · Journal of Nutritional Science · doi:10.1017/jns.2012.15 · Cited by 57 · see citing works

Vitamin C in plasma: A comparative study of the vitamin stabilized with trichloroacetic acid or metaphosphoric acid and the effects of storage at − 70°, − 20°, 4°, and 25° on the stabilized vitamin

Bradley, D. W., Emery, G., & Maynard, J. E. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90158-7 · Cited by 55 · see citing works

Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: Validity of clinical data depends on vacutainer system used

Lykkesfeldt, J. (2012) · Nutrition Research · doi:10.1016/j.nutres.2011.11.005 · Cited by 43 · see citing works

Blood Dehydroascorbic Acid and Diabetes Mellitus in Human Beings

Banerjee, A. (1982) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328201900201 · Cited by 43 · see citing works

Evaluation of an acidic deproteinization for the measurement of ascorbate and dehydroascorbate in plasma samples

Koshiishi, I., Mamura, Y., Liu, J., & Imanari, T. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.4.863 · Cited by 41 · see citing works

Stability of ascorbic acid in serum and plasma prior to analysis

Ching, S., Prins, A. W., & Beilby, J. P. (2002) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456302320314566 · Cited by 38 · see citing works

Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer

Vissers, M. C. M., Kuiper, C., & Dachs, G. U. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140118 · Cited by 32 · see citing works

Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood

Cuerq, C., Peretti, N., Chikh, K., Mialon, A., Guillaumont, M., Drai, J., & Blond, E. (2014) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563214542471 · Cited by 32 · see citing works

Determination of ascorbic acid in human plasma with a view to stability using HPLC with UV detection

Kanďár, R., & Žáková, P. (2008) · Journal of Separation Science · doi:10.1002/jssc.200800303 · Cited by 31 · see citing works

Dehydroascorbic Acid Level in Blood of Patients Suffering from Various Infectious Diseases

Chakrabarti, B., & Banerjee, S. (1955) · Experimental Biology and Medicine · doi:10.3181/00379727-88-21659 · Cited by 31 · see citing works

Plasma ascorbic acid preparation and storage for epidemiological studies using TCA precipitation

Salminen, I., & Alfthan, G. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.01.026 · Cited by 30 · see citing works

The measurement of dehydroascorbic acid and diketogulonic acid in normal and diabetic plasma

Cox, B. D., & Whichelow, M. J. (1975) · Biochemical Medicine · doi:10.1016/0006-2944(75)90110-6 · Cited by 27 · see citing works

The Chemical Nature of Vitamin C

KING, C. G., & Waugh, W. A. (1932) · Science · doi:10.1126/science.75.1944.357-b · Cited by 25 · see citing works

Ascorbic acid, dehydroascorbic acid and glutathione in liver disease.

Dubey, S. S., Palodhi, G. R., & Jain, A. K. (1988) · PubMed · Cited by 8 · see citing works

Re: "Vitamin C Deficiency in a Population of Young Canadian Adults"

Hoffer, L. J. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp400 · Cited by 7 · see citing works

Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?

Rowe, S., & Carr, A. C. (2020) · Nutrients · doi:10.3390/nu12072008 · Cited by 239 · see citing works

Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective

Carr, A. C., & Rowe, S. (2020) · Nutrients · doi:10.3390/nu12071963 · Cited by 207 · see citing works

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence

Vissers, M. C. M., & Das, A. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00809 · Cited by 188 · see citing works

The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19

Carr, A. C., & Rowe, S. (2020) · Nutrients · doi:10.3390/nu12113286 · Cited by 155 · see citing works

Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge

Carr, A. C., & Cook, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01182 · Cited by 133 · see citing works

An Overview of Melatonin as an Antioxidant Molecule: A Biochemical Approach

Hacışevki, A., & Baba, B. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.79421 · Cited by 118 · see citing works

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach

Hill, A., Borosch, S., Benstoem, C., Neubauer, C., Meybohm, P., Langlois, P. L., Adhikari, N. K. J., Heyland, D. K., & Stoppe, C. (2018) · Nutrients · doi:10.3390/nu10080974 · Cited by 74 · see citing works

The Role of Physiological Vitamin C Concentrations on Key Functions of Neutrophils Isolated from Healthy Individuals

Bozonet, S. M., & Carr, A. C. (2019) · Nutrients · doi:10.3390/nu11061363 · Cited by 63 · see citing works

A surface chemistry perspective on SERS: revisiting the basics to push the field forward

Deriu, C., & Fabris, L. (2025) · Chemical Society Reviews · doi:10.1039/d4cs01242a · Cited by 61 · see citing works

Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevated Oxidative Stress

Carr, A. C., Spencer, E. S., Dixon, L., & Chambers, S. T. (2020) · Nutrients · doi:10.3390/nu12051318 · Cited by 58 · see citing works

Vitamin C supplementation for diabetes management: A comprehensive narrative review

Mason, S. A., Parker, L., van der Pligt, P., & Wadley, G. D. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.003 · Cited by 53 · see citing works

High Vitamin C Status Is Associated with Elevated Mood in Male Tertiary Students

Pullar, J., Carr, A., Bozonet, S., & Vissers, M. (2018) · Antioxidants · doi:10.3390/antiox7070091 · Cited by 52 · see citing works

SunGold Kiwifruit Supplementation of Individuals with Prediabetes Alters Gut Microbiota and Improves Vitamin C Status, Anthropometric and Clinical Markers

Wilson, R., Willis, J. A., Gearry, R. B., Hughes, A., Lawley, B., Skidmore, P. M. L., Frampton, C. M., Fleming, E., Anderson, A., Jones, L., et al. (2018) · Nutrients · doi:10.3390/nu10070895 · Cited by 47 · see citing works

The pharmacology of vitamin C

Lykkesfeldt, J., Carr, A. C., & Tveden‐Nyborg, P. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100043 · Cited by 44 · see citing works

Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk

McCall, S. J., Clark, A. B., Luben, R. N., Wareham, N. J., Khaw, K.-T., & Myint, P. K. (2019) · Nutrients · doi:10.3390/nu11071552 · Cited by 41 · see citing works

Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding

Xing, Y., Zhao, B., Yin, L., Guo, M., Shi, H., Zhu, Z., Zhang, L., He, J., Ling, Y., Gao, M., et al. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.113927 · Cited by 41 · see citing works

Stability of aqueous solutions of ascorbate for basic research and for intravenous administration

Wagner, B. A., & Buettner, G. R. (2023) · Advances in Redox Research · doi:10.1016/j.arres.2023.100077 · Cited by 37 · see citing works

Vitamin C measurement in critical illness: challenges, methodologies and quality improvements

Collie, J. T. B., Greaves, R. F., Jones, O. A. H., Eastwood, G. M., & Bellomo, R. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0912 · Cited by 35 · see citing works

Pharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock

Hudson, E. P., Collie, J. T. B., Fujii, T., Luethi, N., Udy, A. A., Doherty, S., Eastwood, G. M., Yanase, F., Naorungroj, T., Bitker, L., et al. (2019) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00548-3 · Cited by 35 · see citing works

Inter‐individual variability in redox and performance responses after antioxidant supplementation: A randomized double blind crossover study

Margaritelis, N. V., Nastos, G. G., Vasileiadou, O., Chatzinikolaou, P. N., Theodorou, A. A., Paschalis, V., Vrabas, I. S., Kyparos, A., Fatouros, I. G., & Nikolaidis, M. G. (2023) · Acta Physiologica · doi:10.1111/apha.14017 · Cited by 33 · see citing works

Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight

Carr, A. C., Spencer, E. S., Heenan, H. F., Lunt, H., Vollebregt, M. J., & Prickett, T. C. R. (2022) · Antioxidants · doi:10.3390/antiox11020245 · Cited by 29 · see citing works

KiwiC for Vitality: Results of a Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Tablets on Vitality in Adults with Low Vitamin C Levels

Conner, T. S., Fletcher, B. C., Haszard, J. J., Pullar, J. M., Spencer, E. S., Mainvil, L. A., & Vissers, M. C. M. (2020) · Nutrients · doi:10.3390/nu12092898 · Cited by 28 · see citing works

Erratum

Hudson, E. P., Collie, J. T. B., Fujii, T., Luethi, N., Udy, A. A., Doherty, S., Eastwood, G. M., Yanase, F., Naorungroj, T., Bitker, L., et al. (2020) · Critical Care and Resuscitation · doi:10.51893/2020.2.err2 · Cited by 28 · see citing works

Novel LC-MS-TOF method to detect and quantify ascorbic and uric acid simultaneously in different biological matrices

Borras, E., Schrumpf, L. A., Stephens, N., Weimer, B. C., Davis, C. E., & Schelegle, E. S. (2021) · Journal of Chromatography B · doi:10.1016/j.jchromb.2021.122588 · Cited by 27 · see citing works

Does Aging Have an Impact on Vitamin C Status and Requirements? A Scoping Review of Comparative Studies of Aging and Institutionalisation

Carr, A. C., & Zawari, M. (2023) · Nutrients · doi:10.3390/nu15040915 · Cited by 27 · see citing works

Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration

Pearson, A. G., Pullar, J. M., Cook, J., Spencer, E. S., Vissers, M. C. M., Carr, A. C., & Hampton, M. B. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101980 · Cited by 23 · see citing works

The effect of conservative oxygen therapy on systemic biomarkers of oxidative stress in critically ill patients

Carr, A. C., Spencer, E. S., Mackle, D., Hunt, A., Judd, H. L., Mehrtens, J. E., Parker, K., Stockwell, Z., Gale, C., Beaumont, M., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.06.018 · Cited by 23 · see citing works

Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models

Tveden‐Nyborg, P. (2021) · Nutrients · doi:10.3390/nu13051685 · Cited by 23 · see citing works

Prevalence, risk factors, and clinical outcomes of vitamin C deficiency in adult hospitalized patients in high-income countries: a scoping review

Golder, J. E., Bauer, J. D., Barker, L. A., Lemoh, C. N., Gibson, S., & Davidson, Z. E. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad157 · Cited by 22 · see citing works

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?

Rozemeijer, S., van der Horst, F. A. L., & de Man, A. (2021) · Critical Care · doi:10.1186/s13054-021-03670-x · Cited by 20 · see citing works

Vitamin C Differentially Impacts the Serum Proteome Profile in Female and Male Mice

Aumailley, L., Bourassa, S., Gotti, C., Droit, A., & Lebel, M. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00542 · Cited by 20 · see citing works

Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.709543 · Cited by 19 · see citing works

Biomarkers of food intake and their relevance to metabolic syndrome

Cifuentes, M., Vahid, F., Devaux, Y., & Bohn, T. (2024) · Food & Function · doi:10.1039/d4fo00721b · Cited by 18 · see citing works

EDTA-K2 Improves the Detection Sensitivity of SARS-CoV-2 IgM and IgG Antibodies by Chelating Colloidal Gold in the Immunochromatographic Assay

Hu, X., Wu, C.-M., Situ, B., Tian, P., An, T., Li, Q., Pan, W., Zhang, R., Yang, B., Sun, D., et al. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s281594 · Cited by 18 · see citing works

The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis

Travica, N., Ried, K., Hudson, I., Scholey, A., Pipingas, A., & Sali, A. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520004353 · Cited by 17 · see citing works

A High Vitamin C Micronutrient Supplement Is Unable to Attenuate Inflammation in People with Metabolic Syndrome but May Improve Metabolic Health Indices: A Randomised Controlled Trial

Vlasiuk, E., Zawari, M., Whitehead, R. N., Williman, J. A., & Carr, A. C. (2024) · Antioxidants · doi:10.3390/antiox13040404 · Cited by 14 · see citing works

Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation

Carr, A. C., Bradley, H. A., Vlasiuk, E., Pierard, H., Beddow, J., & Rucklidge, J. J. (2023) · Antioxidants · doi:10.3390/antiox12040941 · Cited by 16 · see citing works

Initial Evidence of Variation by Ethnicity in the Relationship between Vitamin C Status and Mental States in Young Adults

Fletcher, B. C., Flett, J. A. M., Wickham, S.-R., Pullar, J. M., Vissers, M. C. M., & Conner, T. S. (2021) · Nutrients · doi:10.3390/nu13030792 · Cited by 13 · see citing works

Stability of intravenous vitamin C solutions: a technical report

Carr, A. C., Wohlrab, C., Young, P. J., & Bellomo, R. (2018) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00688-9 · Cited by 13 · see citing works

Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival

Burgess, E. R., Crake, R., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.829524 · Cited by 13 · see citing works

Acute effects of fresh versus dried Hayward green kiwifruit on sleep quality, mood, and sleep-related urinary metabolites in healthy young men with good and poor sleep quality

Kanon, A. P., Giezenaar, C., Roy, N. C., McNabb, W. C., & Henare, S. J. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1079609 · Cited by 13 · see citing works

Dehydroascorbic acid quantification in human plasma: Simultaneous direct measurement of the ascorbic acid/dehydroascorbic acid couple by UPLC/MS-MS

Violet, P.-C., Munyan, N., Luecke, H. F., Wang, Y., Lloyd, J., Patra, K., Blakeslee, K. M., Ebenuwa, I., & Levine, M. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103425 · Cited by 12 · see citing works

Effect of Sub-Minimum Inhibitory Concentrations of Tyrosol and EDTA on Quorum Sensing and Virulence of Pseudomonas aeruginosa

Abdel-Rhman, S. H., Rizk, D. E., & Abdelmegeed, E. S. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s264805 · Cited by 12 · see citing works

Exploring the Ascorbate Requirement of the 2-Oxoglutarate-Dependent Dioxygenases

Smith-Díaz, C. C., Das, A. B., Jurkowski, T. P., Hore, T. A., & Vissers, M. C. M. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02342 · Cited by 10 · see citing works

Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson’s Disease

Spencer, E. S., Pitcher, T. L., Verón, G., Hannam, T., MacAskill, M. R., Anderson, T., Dalrymple‐Alford, J. C., & Carr, A. C. (2020) · Antioxidants · doi:10.3390/antiox9100906 · Cited by 10 · see citing works

Sources of nanomaterials

Rahman, M. U. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823823-3.00007-0 · Cited by 9 · see citing works

Scurvy and vitamin C deficiency in an Australian tertiary children's hospital

van Heerden, C., Cheng, D. R., McNab, S., Burgess, R., Russell, A., Wang, Y., Bleathman, F., Maharaj, I., Zhang, J., Easterbrook, M., et al. (2024) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.16594 · Cited by 9 · see citing works

Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C and Normal Intracellular Concentrations despite a Low Vitamin C Milieu

Carr, A. C., Bozonet, S. M., Pullar, J. M., Spencer, E. S., Rosengrave, P., & Shaw, G. M. (2021) · Antioxidants · doi:10.3390/antiox10101607 · Cited by 9 · see citing works

Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals

Pullar, J. M., Dunham, S., Dachs, G. U., Vissers, M. C. M., & Carr, A. C. (2020) · Nutrients · doi:10.3390/nu12020418 · Cited by 8 · see citing works

Exploring the relationship between vitamin C deficiency and protein‐energy malnutrition in adult hospitalised patients: A cross‐sectional study

Golder, J. E., Bauer, J. D., Barker, L. A., Lemoh, C. N., Gibson, S., & Davidson, Z. E. (2024) · Nutrition & Dietetics · doi:10.1111/1747-0080.12918 · Cited by 7 · see citing works

Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples

Wohlrab, C., Vissers, M. C. M., Burgess, E. R., Nonis, M., Phillips, E., Robinson, B. A., & Dachs, G. U. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000435 · Cited by 6 · see citing works

Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: feasibility of randomized controlled trial

Chambers, S. T., Storer, M., Scott-Thomas, A., Slow, S., Williman, J. A., Epton, M., Murdoch, D. R., Metcalf, S. C. L., Carr, A. C., Isenman, H. L., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-37934-z · Cited by 7 · see citing works

Effect of intravenous vitamin C on arterial blood gas analyser and Accu-Chek point-of-care glucose monitoring in critically ill patients

Rosengrave, P., Wohlrab, C., Spencer, E. S., Williman, J. A., Shaw, G., & Carr, A. C. (2022) · Critical Care and Resuscitation · doi:10.51893/2022.2.oa7 · Cited by 7 · see citing works

The Effects of Surgery on Plasma/Serum Vitamin C Concentrations: A Systematic Review and Meta-Analysis

Travica, N., Ried, K., Hudson, I., Scholey, A., Pipingas, A., & Sali, A. (2020) · Deakin Research Online (Deakin University) · Cited by 7 · see citing works

Ascorbate Uptake and Retention by Breast Cancer Cell Lines and the Intracellular Distribution of Sodium-Dependent Vitamin C Transporter 2

Praditi, C., Bozonet, S. M., Dachs, G. U., & Vissers, M. C. M. (2023) · Antioxidants · doi:10.3390/antiox12111929 · Cited by 6 · see citing works

Delayed Processing of Chilled Whole Blood for 24 Hours Does Not Affect the Concentration of the Majority of Micronutrient Status Biomarkers

Jones, K. S., Meadows, S., Chamberlain, K., Parkington, D. A., Collins, D. J., Page, P., & Koulman, A. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab267 · Cited by 6 · see citing works

People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C

Lunt, H., Carr, A. C., Heenan, H. F., Vlasiuk, E., Zawari, M., Prickett, T. C. R., & Frampton, C. M. (2023) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2023.100316 · Cited by 6 · see citing works

Effects of Low Vitamin C Intake on Fertility Parameters and Pregnancy Outcomes in Guinea Pigs

Coker, S. J., Dyson, R. M., Smith-Díaz, C. C., Vissers, M. C. M., & Berry, M. J. (2023) · Nutrients · doi:10.3390/nu15194107 · Cited by 6 · see citing works

Do Liposomal Vitamin C Formulations Have Improved Bioavailability? A Scoping Review Identifying Future Research Directions

Carr, A. C. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70067 · Cited by 6 · see citing works

Low Vitamin C Concentrations in Patients with Community-Acquired Pneumonia Resolved with Pragmatic Administration of Intravenous and Oral Vitamin C

Carr, A. C., Vlasiuk, E., Zawari, M., Scott-Thomas, A., Storer, M., Maze, M. J., & Chambers, S. T. (2023) · Antioxidants · doi:10.3390/antiox12081610 · Cited by 5 · see citing works

Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins

Mahdavi, A., Leclercq, M., Droit, A., Rudkowska, I., & Lebel, M. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109538 · Cited by 5 · see citing works

Role of Sodium‐Dependent Vitamin C Transporter‐2 and Ascorbate in Regulating the Hypoxic Pathway in Cultured Glioblastoma Cells

Burgess, E. R., Praditi, C., Phillips, E., Vissers, M. C. M., Robinson, B. A., Dachs, G. U., & Wiggins, G. A. R. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30658 · Cited by 4 · see citing works

Using redox potential as a feasible marker for banked blood quality and the state of oxidative stress in stored red blood cells

Daniels, R. C., Jun, H., Davenport, R. D., Collinson, M. M., & Ward, K. R. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23955 · Cited by 4 · see citing works

Recent Advances in Mechanisms of In Vitro and In Vivo Evaluation of Antioxidant Activity

Mohanarangam, K., Yaseen, A. S. M., Babu, A. B., Raj, M. C. C., Kumar, S. N., & Christyraj, J. R. S. S. (2026) · Springer eBooks · doi:10.1007/978-981-96-9670-3_7 · Cited by 3 · see citing works

Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit

Chiscano‐Camón, L., Ruiz‐Rodríguez, J. C., Plata-Menchaca, E. P., Martin, L., Bajaña, I., Martin-Rodríguez, C., Palmada, C., Ferrer, R., Camós, S., Villena-Ortiz, Y., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1301001 · Cited by 3 · see citing works

Chromatographic Methods

Khelfi, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-60738-7_15 · Cited by 2 · see citing works

Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials for Measurements of Pharmacological Ascorbate

Petronek, M. S., Wagner, B. A., Hollenbeck, N. J., Caster, J. M., Spitz, D. R., Cullen, J. J., Buettner, G. R., & Allen, B. G. (2019) · Radiation Research · doi:10.1667/rr15328.1 · Cited by 2 · see citing works

The effects of cardiovascular and orthopaedic surgery on vitamin concentrations: a narrative review of the literature and mechanisms of action

Travica, N., Ried, K., Hudson, I. L., Scholey, A. B., Pipingas, A., & Sali, A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1983762 · Cited by 2 · see citing works

New Insights into Co-Administration of Anti-Tuberculosis Drug Rifampicin with Acetaminophen and Vitamin C: Strong Electrochemical Evidence for the Detoxification

Zivari-Moshfegh, F., & Nematollahi, D. (2023) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/acf95c · Cited by 2 · see citing works

SNaP-C: Validation of a novel, selective silver nanoparticle antioxidant capacity assay for Vitamin C content in beverages

Lemon, E. N. R., Lowe, L. E., & Owens, J. E. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140112 · Cited by 2 · see citing works

Water-Soluble Vitamins Stability by Robust Liquid Chromatography-Mass Spectrometry

Luo, W., Wang, D., Tang, Y., Cheng, Q., Ma, X., Yu, S., & Qiu, L. (2024) · Annals of Nutrition and Metabolism · doi:10.1159/000541587 · Cited by 2 · see citing works

Streamlined three step total vitamin C analysis by HILIC-UV for laboratory testing

Fitzpatrick, M., Bonnitcha, P., & Nguyen, V. L. (2021) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2021-0614 · Cited by 2 · see citing works

Nutrition and Chronic Conditions

Ojo, O. (2019) · MDPI eBooks · doi:10.3390/books978-3-03897-603-5 · Cited by 3 · see citing works

A cross-sectional study to evaluate hypovitaminosis C prevalence and risk factors in an acute geriatric unit in Lyon, France: the HYPO-VIT-C protocol

Quillon, A., Guittard, L., Goldet, K., Etienne, M., Blond, E., Nourredine, M., Martin-Gaujard, G., & Doh, S. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-075924 · Cited by 1 · see citing works

SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial

Billows, M., Kakoschke, N., & Zajac, I. T. (2025) · Nutrients · doi:10.3390/nu17081375 · Cited by 1 · see citing works

Supplementation of orally drenched ascorbic acid and injectable α-tocopherol reduces markers of naturally acquired parasites in grazing hair sheep

Rojas-Reyes, J. A., Blad, T. J., Bulosan, J. S., Wanguba, A. S., Bustamante, Y., Thornton, K. J., Odani, J. S., & Reichhardt, C. C. (2025) · Small Ruminant Research · doi:10.1016/j.smallrumres.2025.107515 · Cited by 1 · see citing works

Vitamin C: Current Concepts in Human Physiology

Carr, A. C., & Natarajan, R. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-295-2 · Cited by 1 · see citing works

Effect of antioxidant protection against ultraviolet radiation and antibiotic susceptibility of Escherichia coli

Agbabiaka, T. O., Otuyelu, F. O., Abdulsalam, Z. B., & Mustapha, S. (2024) · Ife Journal of Science · doi:10.4314/ijs.v26i2.2 · Cited by 1 · see citing works

A Stabilizing Agent, PCA/DTPA, Improves Plasma Storage Life for the Chromsystems Vitamin C Assay up to Six Months

Collie, J. T. B., Hudson, E. P., Deane, A. M., Bellomo, R., & Greaves, R. F. (2021) · Annals of Laboratory Medicine · doi:10.3343/alm.2021.41.4.414 · Cited by 1 · see citing works

Measuring Vitamin C in Critically Ill Patients: Clinical Importance and Practical Difficulties—Is It Time for a Surrogate Marker?

Rozemeijer, S., van der Horst, F. A. L., & de Man, A. (2021) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-030-73231-8_3 · Cited by 1 · see citing works

Pre-analytical and analytical procedures to avoid loss of vitamin C. Comment on: “COVID-19: up to 82% critically ill patients had low vitamin C values”

Chiscano‐Camón, L., Ruiz‐Rodríguez, J. C., Ferrer, R., Camós, S., Ruiz‐Sanmartín, A., & Ferrer, R. (2022) · Nutrition Journal · doi:10.1186/s12937-022-00803-y · Cited by 1 · see citing works

Re: “Micronutrient Status in Diabetic Patients with Foot Ulcers” by Pena et al .

Pullar, J. M., & Vissers, M. C. M. (2020) · Advances in Wound Care · doi:10.1089/wound.2020.1184

EVALUATION OF A NOVEL LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY BASED METHOD FOR VITAMIN D ANALYSIS IN BLOOD

Naz, S., Aamir, M., Haroon, Z. H., Kirmani, S. I., Ahmed, N., & Ali, S. M. (2021) · Pakistan Armed Forces Medical Journal · doi:10.51253/pafmj.v71i4.6090

Faculty Opinions recommendation of Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.

Spiess, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733722280.793565778

Electrochemical analysis of antioxidant status of biological media in different sampling and storage conditions

Goroncharovskaya, I. V., Evseev, A. K., Курбанович, Ш. А., & Petrikov, S. S. (2024) · Journal of the Serbian Chemical Society · doi:10.2298/jsc231012017g

Snap-C: Validation and Application of Silver Nanoparticle Antioxidant Capacity Assay for Ascorbic Acid and Total Ascorbic Acid Content in BeveragesPreprint

Lemon, E. N. R., Lowe, L. E., & Owens, J. E. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4806874

Vitamin C and Its Requirements: A New Public Health Narrative

Carr, A. C. (2025) · Springer eBooks · doi:10.1007/978-3-031-32047-7_124-1

Plasma Vitamin C, 25-Hydroxyvitamin D, and the Lactate-to-Albumin Ratio at PICU Admission in Survivors and Non-Survivors of Phoenix-Defined Pediatric Sepsis and Septic Shock: An Exploratory Prospective Cohort Study

Martínez-García, J. J., Canizalez‐Román, A., Zatarain-Lopez, R., Cázarez-Aguilar, M. A., Bolívar-Rodríguez, M. A., Velazquez-Lopez, L., Osuna-Ramirez, C. A., Correa-Flores, M. Á., Leon, M. F. G.-D., Acosta-Smith, E., et al. (2026) · Pediatric Reports · doi:10.3390/pediatric18050132

Misleading review on vitamin C and cardiac patients by Hill et al. (2018)

Hemilä, H. (2019) · doi:10.5281/zenodo.19789076

Vitamin C deficiency in a Northern Saskatchewan Population, Canada

Irvine, J. D. C., Atreyu, Y. C., Carlson, M., Quinn, B., Irvine, J. D., & Ndubuka, N. (2026) · PLOS Global Public Health · doi:10.1371/journal.pgph.0007464

Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: Validity of clinical data depends on vacutainer system used

Lykkesfeldt, J. (2012) · Nutrition Research · doi:10.1016/j.nutres.2011.11.005 · Cited by 43 · see citing works

Setup and validation of a convenient sampling procedure to promptly and effectively stabilize vitamin C in blood and plasma specimens stored at routine temperatures

Rossi, B., Tittone, F., & Palleschi, S. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9560-6 · Cited by 10 · see citing works

Determination of ascorbic acid, dehydroascorbic acid, and isoascorbic acid in blood

Schreiber, J., Lohmann, W., Unverzagt, D., & Otten, A. (1986) · Fresenius Zeitschrift für Analytische Chemie · doi:10.1007/bf00489138 · Cited by 15 · see citing works

Evaluation of an acidic deproteinization for the measurement of ascorbate and dehydroascorbate in plasma samples

Koshiishi, I., Mamura, Y., Liu, J., & Imanari, T. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.4.863 · Cited by 41 · see citing works

Clinical Chemistry 44:4 863–868 (1998) General Clinical Chemistry

(2013)